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DK3036320T3 - Styring af proteinglycosylering ved hjælp af dyrkningsmedietilsætning og cellekulturprocesparametre - Google Patents

Styring af proteinglycosylering ved hjælp af dyrkningsmedietilsætning og cellekulturprocesparametre Download PDF

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Publication number
DK3036320T3
DK3036320T3 DK14761736.9T DK14761736T DK3036320T3 DK 3036320 T3 DK3036320 T3 DK 3036320T3 DK 14761736 T DK14761736 T DK 14761736T DK 3036320 T3 DK3036320 T3 DK 3036320T3
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DK
Denmark
Prior art keywords
management
cell culture
process parameters
culture process
protein glycosylation
Prior art date
Application number
DK14761736.9T
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English (en)
Other versions
DK3036320T4 (da
Inventor
William Yang
Yao-Ming Huang
Kyle Mcelearney
Lia Tescione
An Zhang
Valerie Tsang
Thomas Ryll
James Lambropoulos
Sangil Lee
Dae Sung Lee
Original Assignee
Biogen Ma Inc
Samsung Bioepis
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=51494503&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK3036320(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Biogen Ma Inc, Samsung Bioepis filed Critical Biogen Ma Inc
Application granted granted Critical
Publication of DK3036320T3 publication Critical patent/DK3036320T3/da
Publication of DK3036320T4 publication Critical patent/DK3036320T4/da

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018—Culture media for cell or tissue culture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/005—Glycopeptides, glycoproteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/05—Inorganic components
    • C12N2500/10—Metals; Metal chelators
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/34—Sugars
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/40—Nucleotides, nucleosides or bases

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DK14761736.9T 2013-08-19 2014-08-19 Styring af proteinglycosylering ved hjælp af dyrkningsmedietilsætning og cellekulturprocesparametre DK3036320T4 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361867592P 2013-08-19 2013-08-19
PCT/US2014/051727 WO2015026846A1 (en) 2013-08-19 2014-08-19 Control of protein glycosylation by culture medium supplementation and cell culture process parameters

Publications (2)

Publication Number Publication Date
DK3036320T3 true DK3036320T3 (da) 2021-07-12
DK3036320T4 DK3036320T4 (da) 2024-05-06

Family

ID=51494503

Family Applications (1)

Application Number Title Priority Date Filing Date
DK14761736.9T DK3036320T4 (da) 2013-08-19 2014-08-19 Styring af proteinglycosylering ved hjælp af dyrkningsmedietilsætning og cellekulturprocesparametre

Country Status (4)

Country Link
EP (2) EP3036320B2 (da)
DK (1) DK3036320T4 (da)
PL (1) PL3036320T5 (da)
WO (1) WO2015026846A1 (da)

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WO2013158273A1 (en) 2012-04-20 2013-10-24 Abbvie Inc. Methods to modulate c-terminal lysine variant distribution
US9067990B2 (en) 2013-03-14 2015-06-30 Abbvie, Inc. Protein purification using displacement chromatography
US9150645B2 (en) 2012-04-20 2015-10-06 Abbvie, Inc. Cell culture methods to reduce acidic species
US9512214B2 (en) 2012-09-02 2016-12-06 Abbvie, Inc. Methods to control protein heterogeneity
WO2014151878A2 (en) 2013-03-14 2014-09-25 Abbvie Inc. Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosacharides
US9017687B1 (en) 2013-10-18 2015-04-28 Abbvie, Inc. Low acidic species compositions and methods for producing and using the same using displacement chromatography
WO2015051293A2 (en) 2013-10-04 2015-04-09 Abbvie, Inc. Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins
US9181337B2 (en) 2013-10-18 2015-11-10 Abbvie, Inc. Modulated lysine variant species compositions and methods for producing and using the same
US9085618B2 (en) 2013-10-18 2015-07-21 Abbvie, Inc. Low acidic species compositions and methods for producing and using the same
US20150139988A1 (en) 2013-11-15 2015-05-21 Abbvie, Inc. Glycoengineered binding protein compositions
EP3122869B2 (en) 2014-03-24 2022-08-10 Biogen MA Inc. Methods for overcoming glutamine deprivation during mammalian cell culture
MA41685A (fr) * 2014-10-17 2017-08-22 Biogen Ma Inc Supplémentation en cuivre pour la régulation de la glycosylation dans un procédé de culture cellulaire de mammifère
KR102007930B1 (ko) 2014-12-31 2019-08-06 주식회사 엘지화학 재조합 당단백질의 글리코실화 조절 방법
EP3072957B1 (en) * 2015-03-23 2019-07-10 Lonza Ltd Methods for controlling protein glycosylation
WO2016162514A1 (en) * 2015-04-10 2016-10-13 Ares Trading S.A. Methods for modulating protein glycosylation profiles of recombinant proteins
EP3925970A1 (en) 2015-11-02 2021-12-22 F. Hoffmann-La Roche AG Methods of making fucosylated and afucosylated forms of a protein
EP3390438A1 (en) * 2015-12-15 2018-10-24 CSL Behring Recombinant Facility AG Method for increasing the heterogeneity of o-glycosylation of recombinant factor vii
EP3824906A1 (en) 2016-12-21 2021-05-26 Amgen Inc. Anti-tnf alpha antibody formulations

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Also Published As

Publication number Publication date
EP3916081A3 (en) 2022-03-23
DK3036320T4 (da) 2024-05-06
PL3036320T3 (pl) 2021-11-02
EP3916081A2 (en) 2021-12-01
EP3036320B1 (en) 2021-04-28
PL3036320T5 (pl) 2024-06-10
EP3036320A1 (en) 2016-06-29
WO2015026846A1 (en) 2015-02-26
EP3036320B2 (en) 2024-04-03

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