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DK3013813T3 - Heteroaromatiske forbindelser og anvendelse deraf som dopamin-d1-ligander - Google Patents

Heteroaromatiske forbindelser og anvendelse deraf som dopamin-d1-ligander Download PDF

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Publication number
DK3013813T3
DK3013813T3 DK14739554.5T DK14739554T DK3013813T3 DK 3013813 T3 DK3013813 T3 DK 3013813T3 DK 14739554 T DK14739554 T DK 14739554T DK 3013813 T3 DK3013813 T3 DK 3013813T3
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DK
Denmark
Prior art keywords
dopamine
ligands
heteroaromatic compounds
heteroaromatic
compounds
Prior art date
Application number
DK14739554.5T
Other languages
English (en)
Inventor
Michael Aaron Brodney
Jennifer Elizabeth Davoren
Amy Beth Dounay
Ivan Viktorovich Efremov
David Lawrence Firman Gray
Michael Eric Green
Chewah Lee
Scot Richard Mente
Steven Victor O'neil
Bruce Nelsen Rogers
Lei Zhang
Jaclyn Louise Henderson
Original Assignee
Pfizer
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Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=51205521&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK3013813(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer filed Critical Pfizer
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Publication of DK3013813T3 publication Critical patent/DK3013813T3/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

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  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Hematology (AREA)
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  • Pain & Pain Management (AREA)
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  • Psychology (AREA)
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  • Immunology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Addiction (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
DK14739554.5T 2013-06-27 2014-06-13 Heteroaromatiske forbindelser og anvendelse deraf som dopamin-d1-ligander DK3013813T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361840144P 2013-06-27 2013-06-27
PCT/IB2014/062217 WO2014207601A1 (en) 2013-06-27 2014-06-13 Heteroaromatic compounds and their use as dopamine d1 ligands

Publications (1)

Publication Number Publication Date
DK3013813T3 true DK3013813T3 (da) 2019-06-03

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ID=51205521

Family Applications (2)

Application Number Title Priority Date Filing Date
DK18180416.2T DK3421462T3 (da) 2013-06-27 2014-06-13 Heteroaromatiske forbindelser og anvendelse deraf som dopamin-D1-ligander
DK14739554.5T DK3013813T3 (da) 2013-06-27 2014-06-13 Heteroaromatiske forbindelser og anvendelse deraf som dopamin-d1-ligander

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DK18180416.2T DK3421462T3 (da) 2013-06-27 2014-06-13 Heteroaromatiske forbindelser og anvendelse deraf som dopamin-D1-ligander

Country Status (41)

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US (10) US9527831B2 (da)
EP (2) EP3013813B1 (da)
JP (1) JP6026024B2 (da)
KR (1) KR101781723B1 (da)
CN (1) CN105324376B (da)
AP (1) AP2015008844A0 (da)
AR (1) AR096748A1 (da)
AU (1) AU2014300673B2 (da)
BR (1) BR122023004130B1 (da)
CA (1) CA2916653C (da)
CL (1) CL2015003735A1 (da)
CR (1) CR20150634A (da)
CU (1) CU24334B1 (da)
DK (2) DK3421462T3 (da)
DO (1) DOP2015000302A (da)
EA (1) EA028637B1 (da)
EC (1) ECSP16003103A (da)
ES (2) ES2948192T3 (da)
FI (1) FI3421462T3 (da)
GT (1) GT201500350A (da)
HR (2) HRP20191163T1 (da)
HU (2) HUE062265T2 (da)
IL (1) IL242480B (da)
MA (1) MA38661A1 (da)
MD (1) MD20150122A2 (da)
MX (2) MX394241B (da)
NI (1) NI201500179A (da)
NZ (1) NZ713762A (da)
PE (1) PE20160664A1 (da)
PH (1) PH12015502502A1 (da)
PL (2) PL3013813T3 (da)
PT (2) PT3421462T (da)
RS (2) RS59018B1 (da)
SG (1) SG11201509186TA (da)
TN (1) TN2015000547A1 (da)
TR (1) TR201907981T4 (da)
TW (1) TWI508957B (da)
UA (1) UA112945C2 (da)
UY (1) UY35628A (da)
WO (1) WO2014207601A1 (da)
ZA (1) ZA201508252B (da)

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PT3421462T (pt) 2013-06-27 2023-06-29 Pfizer Compostos heteroaromáticos e a sua utilização como ligandos de d1 de dopamina
CR20160494A (es) 2014-04-25 2016-12-20 Pfizer Compuestos heteroaromáticos y su uso como ligandos de dopamina d1
CA2946471C (en) 2014-04-25 2018-08-07 Pfizer Inc. Fused bicyclic heteroaromatic compounds and their use as dopamine d1 ligands
US9868744B2 (en) 2014-04-25 2018-01-16 Pfizer Inc. Heteroaromatic compounds and their use as dopamine D1 ligands
US9745317B2 (en) 2014-04-28 2017-08-29 Pfizer Inc. Heterocyclic compounds and their use as dopamine D1 ligands
WO2015166370A1 (en) 2014-04-28 2015-11-05 Pfizer Inc. Heteroaromatic compounds and their use as dopamine d1 ligands
JOP20150177B1 (ar) 2014-08-01 2021-08-17 Janssen Pharmaceutica Nv مركبات 6 ، 7 ثاني هيدرو بيرازولو [ 1، 5 الفا ] بيرازين – 4 (5 يد) – اون واستخدامها كمنظمات الوسترية سلبية لمستقبلات ملجور 2
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BR112018007395A2 (pt) 2015-10-14 2018-10-23 Bristol-Myers Squibb Company 2,4-di-hidróxi-nicotinamidas como agonistas de apj
SMT202000591T1 (it) 2015-12-18 2020-11-10 Janssen Pharmaceutica Nv Ligandi pet radiomarcati mglur 2/3
ES2820823T3 (es) 2015-12-18 2021-04-22 Janssen Pharmaceutica Nv Ligandos PET mGluR2/3 radiomarcados
ES2837018T3 (es) 2016-01-15 2021-06-29 Pfizer Ligandos del receptor D3 de dopamina de 6,7,8,9-tetrahidro-5H-pirido[2,3-d]azepina
TWI744301B (zh) 2016-03-24 2021-11-01 美商必治妥美雅史谷比公司 做為apj促效劑之6-羥基-4-側氧-1,4-二氫嘧啶-5-甲醯胺
HRP20211071T1 (hr) 2016-03-30 2021-10-01 Ishihara Sangyo Kaisha, Ltd. Spoj piridazinona ili njegova sol te herbicid koji ga sadrži
WO2018157843A1 (zh) 2017-03-02 2018-09-07 中国科学院上海药物研究所 2-(取代苯杂基)芳香甲酸类fto抑制剂，其制备方法及其应用
US20210393621A1 (en) 2018-10-26 2021-12-23 The Research Foundation For The State University Of New York Combination serotonin specific reuptake inhibitor and serotonin 1a receptor partial agonist for reducing l-dopa-induced dyskinesia
CN116323588A (zh) * 2020-04-23 2023-06-23 奥普纳生物有限公司 用于cd73调节的化合物和方法及其适应症
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CN118401513A (zh) * 2022-01-29 2024-07-26 苏州科睿思制药有限公司 他伐帕敦的晶型及其制备方法和用途
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