DK260881A - Bis- og mono-kvaternaere ammoniumderivater af 2beta, 16beta-diperidino-5alfa-androstaner fremgangsmaade til fremstilling deraf samt farmaceutiske praeparater indeholdende androstanforbindelserne - Google Patents
Bis- og mono-kvaternaere ammoniumderivater af 2beta, 16beta-diperidino-5alfa-androstaner fremgangsmaade til fremstilling deraf samt farmaceutiske praeparater indeholdende androstanforbindelserneInfo
- Publication number
- DK260881A DK260881A DK260881A DK260881A DK260881A DK 260881 A DK260881 A DK 260881A DK 260881 A DK260881 A DK 260881A DK 260881 A DK260881 A DK 260881A DK 260881 A DK260881 A DK 260881A
- Authority
- DK
- Denmark
- Prior art keywords
- ammonium derivatives
- androstanes
- preparing
- pharmaceutical preparations
- diperidino
- Prior art date
Links
- 239000000825 pharmaceutical preparation Substances 0.000 title abstract 2
- QZLYKIGBANMMBK-UGCZWRCOSA-N 5α-Androstane Chemical class C([C@@H]1CC2)CCC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CCC[C@@]2(C)CC1 QZLYKIGBANMMBK-UGCZWRCOSA-N 0.000 title 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical group N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 title 1
- 150000001441 androstanes Chemical class 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-O ammonium group Chemical group [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 abstract 5
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 4
- QUPDWYMUPZLYJZ-UHFFFAOYSA-N ethyl Chemical group C[CH2] QUPDWYMUPZLYJZ-UHFFFAOYSA-N 0.000 abstract 2
- KQNPFQTWMSNSAP-UHFFFAOYSA-N isobutyric acid Chemical compound CC(C)C(O)=O KQNPFQTWMSNSAP-UHFFFAOYSA-N 0.000 abstract 2
- NGNBDVOYPDDBFK-UHFFFAOYSA-N 2-[2,4-di(pentan-2-yl)phenoxy]acetyl chloride Chemical compound CCCC(C)C1=CC=C(OCC(Cl)=O)C(C(C)CCC)=C1 NGNBDVOYPDDBFK-UHFFFAOYSA-N 0.000 abstract 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical group C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 abstract 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 150000001350 alkyl halides Chemical class 0.000 abstract 1
- RMRFFCXPLWYOOY-UHFFFAOYSA-N allyl radical Chemical group [CH2]C=C RMRFFCXPLWYOOY-UHFFFAOYSA-N 0.000 abstract 1
- 150000008064 anhydrides Chemical class 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurology (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB7942883 | 1979-12-12 | ||
| GB7942883 | 1979-12-12 | ||
| PCT/EP1980/000143 WO1981001710A1 (fr) | 1979-12-12 | 1980-12-09 | Mono et bis piperidinium androstanes |
| EP8000143 | 1980-12-09 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DK260881A true DK260881A (da) | 1981-06-25 |
| DK158741B DK158741B (da) | 1990-07-09 |
| DK158741C DK158741C (da) | 1990-11-26 |
Family
ID=10509800
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK260881A DK158741C (da) | 1979-12-12 | 1981-06-15 | Analogifremgangsmaade til fremstilling af biskvaternaere ammoniumderivater af 2beta,16beta-dipiperidino-5alfa-androstaner |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US4348390A (da) |
| EP (1) | EP0032261B1 (da) |
| JP (1) | JPH026360B2 (da) |
| AU (1) | AU534992B2 (da) |
| CA (1) | CA1153366A (da) |
| DE (1) | DE3065088D1 (da) |
| DK (1) | DK158741C (da) |
| ES (1) | ES8204443A1 (da) |
| FI (1) | FI66394C (da) |
| HU (1) | HU185865B (da) |
| IE (1) | IE50675B1 (da) |
| WO (1) | WO1981001710A1 (da) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE53463B1 (en) * | 1981-06-15 | 1988-11-23 | Akzo Nv | Mono-and bisquaternary ammonium derivatives of 2 beta,16 beta-d-amino-5 alpha-androstane derivatives and pharmaceutical preparations containing same |
| US4726275A (en) * | 1983-05-10 | 1988-02-23 | Synthaxe Limited | Electronic musical instrument |
| US5418226A (en) * | 1992-04-22 | 1995-05-23 | Akzo N.V. | Monoquaternary 2,16-bispiperidinylandrostane derivatives |
| US5926516A (en) * | 1995-05-24 | 1999-07-20 | Siemens Aktiengesellschaft | Absorption structure for absorbing neutrons and method for producing an absorption structure |
| IT1277700B1 (it) * | 1995-12-22 | 1997-11-11 | Poli Ind Chimica Spa | Processo di preparazione di 2-beta, 16-beta-diamino 3-alfa, 17-beta- diacilossi 5-alfaandrostani, bloccanti neuromuscolari a struttura |
| US5990124A (en) | 1997-10-24 | 1999-11-23 | Gyermek; Laszlo | Neuromuscular relaxants |
| CN116925171B (zh) * | 2023-07-10 | 2025-06-27 | 时森海(杭州)医药科技有限公司 | 含环丙甲基甾体类季铵盐化合物、中间体及其制备方法和应用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1138605A (en) * | 1965-02-19 | 1969-01-01 | Organon Labor Ltd | Improvements in or relating to new 2-ß,16-ß-diamino-androstanes |
| GB1454749A (en) * | 1972-11-29 | 1976-11-03 | Akzo Nv | 2beta, 16beta-diamino-androstanes and their preparation |
| HU172522B (hu) * | 1975-08-01 | 1978-09-28 | Richter Gedeon Vegyeszet | Sposob poluchenija novykh proizvodnykh 2beta, 16beta-diamino-androstana i ikh chetvertichnykh solej |
| DE2962627D1 (en) * | 1978-09-05 | 1982-06-09 | Akzo Nv | Acid addition salts of 16-beta-monoquaternary ammonium derivatives of 2-beta, 16-beta-bis-piperidino-androstanes and pharmaceutical preparations containing same |
-
1980
- 1980-12-08 IE IE2566/80A patent/IE50675B1/en not_active IP Right Cessation
- 1980-12-09 EP EP80201186A patent/EP0032261B1/en not_active Expired
- 1980-12-09 JP JP56500158A patent/JPH026360B2/ja not_active Expired - Lifetime
- 1980-12-09 HU HU811180A patent/HU185865B/hu unknown
- 1980-12-09 DE DE8080201186T patent/DE3065088D1/de not_active Expired
- 1980-12-09 AU AU66405/81A patent/AU534992B2/en not_active Ceased
- 1980-12-09 WO PCT/EP1980/000143 patent/WO1981001710A1/de not_active Ceased
- 1980-12-10 US US06/214,650 patent/US4348390A/en not_active Expired - Lifetime
- 1980-12-11 CA CA000366536A patent/CA1153366A/en not_active Expired
- 1980-12-12 ES ES497724A patent/ES8204443A1/es not_active Expired
-
1981
- 1981-06-15 DK DK260881A patent/DK158741C/da not_active IP Right Cessation
- 1981-06-15 FI FI811857A patent/FI66394C/fi not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ES497724A0 (es) | 1982-05-01 |
| AU6640581A (en) | 1981-07-06 |
| FI811857L (fi) | 1981-06-15 |
| JPS56501761A (da) | 1981-12-03 |
| DK158741C (da) | 1990-11-26 |
| DE3065088D1 (en) | 1983-11-03 |
| CA1153366A (en) | 1983-09-06 |
| HU185865B (en) | 1985-04-28 |
| IE50675B1 (en) | 1986-06-11 |
| WO1981001710A1 (fr) | 1981-06-25 |
| DK158741B (da) | 1990-07-09 |
| US4348390A (en) | 1982-09-07 |
| EP0032261B1 (en) | 1983-09-28 |
| IE802566L (en) | 1981-06-12 |
| JPH026360B2 (da) | 1990-02-08 |
| FI66394B (fi) | 1984-06-29 |
| FI66394C (fi) | 1984-10-10 |
| EP0032261A1 (en) | 1981-07-22 |
| AU534992B2 (en) | 1984-02-23 |
| ES8204443A1 (es) | 1982-05-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PBP | Patent lapsed |