DK2513119T3 - 3,4,4a,10b-tetrahydro-1h-thiopyrano-[4,3-c]isoquinolin derivater - Google Patents

3,4,4a,10b-tetrahydro-1h-thiopyrano-[4,3-c]isoquinolin derivater

Info

Publication number: DK2513119T3
Authority: DK; Denmark
Prior art keywords: thiopyrano; derivates; isoquinoline; tetrahydro; isoquinoline derivates
Prior art date: 2009-12-18

Application number

DK10790569.7T

Other languages

English (en)

Inventor

Clemens Braun

Thomas Stengel

Hermann Tenor

Raimund Külzer

Christof Zitt

Armin Hatzelmann

Christian Hesslinger

Thomas Maier

Degenhard Marx

Dieter Flockerzi

Alexander Mann

Harald Ohmer

Ulrich Kautz

Steffen Weinbrenner

Stefan Fischer

Torsten Dunkern

Original Assignee

Takeda Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2009-12-18

Filing date

2010-12-15

Publication date

2014-10-06

2010-12-15 Application filed by Takeda Gmbh filed Critical Takeda Gmbh

2014-10-06 Application granted granted Critical

2014-10-06 Publication of DK2513119T3 publication Critical patent/DK2513119T3/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Immunology (AREA)
Pulmonology (AREA)
Diabetes (AREA)
Physical Education & Sports Medicine (AREA)
Dermatology (AREA)
Rheumatology (AREA)
Cardiology (AREA)
Orthopedic Medicine & Surgery (AREA)
Hematology (AREA)
Heart & Thoracic Surgery (AREA)
Psychiatry (AREA)
Ophthalmology & Optometry (AREA)
Urology & Nephrology (AREA)
Endocrinology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Pain & Pain Management (AREA)
Hospice & Palliative Care (AREA)
Gastroenterology & Hepatology (AREA)
Epidemiology (AREA)
Obesity (AREA)
Transplantation (AREA)

DK10790569.7T 2009-12-18 2010-12-15 3,4,4a,10b-tetrahydro-1h-thiopyrano-[4,3-c]isoquinolin derivater DK2513119T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP09179982		2009-12-18
US31555210P	2010-03-19	2010-03-19
PCT/EP2010/069704 WO2011073231A1 (en)	2009-12-18	2010-12-15	3,4,4A,10B-TETRAHYDRO-1H-THIOPYRANO-[4, 3-c] ISOQUINOLINE DERIVATIVES

Publications (1)

Publication Number	Publication Date
DK2513119T3 true DK2513119T3 (da)	2014-10-06

Family

ID=41718903

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK10790569.7T DK2513119T3 (da)	2009-12-18	2010-12-15	3,4,4a,10b-tetrahydro-1h-thiopyrano-[4,3-c]isoquinolin derivater

Country Status (29)

Country	Link
US (1)	US9018175B2 (da)
EP (2)	EP2513119B1 (da)
JP (1)	JP5645961B2 (da)
KR (1)	KR20120123313A (da)
CN (1)	CN102652136B (da)
AR (1)	AR079451A1 (da)
AU (1)	AU2010332955B8 (da)
BR (1)	BR112012014058A8 (da)
CA (1)	CA2784013A1 (da)
CO (1)	CO6551705A2 (da)
DK (1)	DK2513119T3 (da)
EA (1)	EA023212B1 (da)
ES (2)	ES2505290T3 (da)
GE (1)	GEP20146105B (da)
HR (1)	HRP20140893T1 (da)
ME (1)	ME01914B (da)
MX (1)	MX2012006696A (da)
NZ (1)	NZ601115A (da)
PH (1)	PH12012501125A1 (da)
PL (1)	PL2513119T3 (da)
PT (1)	PT2513119E (da)
RS (1)	RS53544B1 (da)
SG (2)	SG180824A1 (da)
SI (1)	SI2513119T1 (da)
SM (1)	SMT201400185B (da)
TW (1)	TWI468411B (da)
UA (1)	UA107689C2 (da)
WO (1)	WO2011073231A1 (da)
ZA (1)	ZA201204135B (da)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20110300432A1 (en)	2010-06-07	2011-12-08	Snyder Shawn W	Rechargeable, High-Density Electrochemical Device
EP2749280A3 (en) *	2011-02-17	2014-08-20	Cipla Limited	Combination of glycopyrronium and formoterol
US20140113877A1 (en) *	2011-06-15	2014-04-24	Takeda Gmbh	Novel 3,4,4a,10b-tetrahydro-1h-thiopyrano[4,3-c] isoquinoline compounds
WO2014016548A2 (en) *	2012-07-27	2014-01-30	Cipla Limited	Pharmaceutical composition
WO2014090990A1 (en) *	2012-12-13	2014-06-19	Ludwig Aigner	Leukotriene pathway antagonists for the treatment of dementia, cognitive deficits in parkinson's disease and/or learning and memory deficiencies in parkinson's disease
MX2015009678A (es)	2013-02-04	2015-11-25	Gruenenthal Gmbh	Compuestos de pirimidina condensada sustituida con amino en la posicion 4 como inhibidores de fosfodiesterasa 4 (pde4).
ES2638850T3 (es)	2013-02-19	2017-10-24	Pfizer Inc.	Compuestos de azabenzimidazol como inhibidores de las isoenzimas de la PDE4 para el tratamiento de trastornos del SNC y otros trastornos
JP6713982B2 (ja)	2014-07-24	2020-06-24	ファイザー・インク	ピラゾロピリミジン化合物
TN2017000031A1 (en)	2014-08-06	2018-07-04	Pfizer	Imidazopyridazine compounds
WO2017089347A1 (en)	2015-11-25	2017-06-01	Inserm (Institut National De La Sante Et De La Recherche Medicale)	Methods and pharmaceutical compositions for the treatment of braf inhibitor resistant melanomas
US12383547B2 (en)	2020-07-01	2025-08-12	Vanderbilt University	Methods of treatment for a kidney disease

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3899494A (en)	1970-05-13	1975-08-12	Sandoz Ltd	Substituted 6-phenyl benzo-naphthyridines
DE2047465A1 (de)	1970-09-26	1972-03-30	Farbwerke Hoechst AG, vorm Meister Lucius & Bruning, 6000 Frankfurt	Neue Oxdiazole und Verfahren zu lh rer Herstellung
CN1003445B (zh)	1984-10-03	1989-03-01	武田药品工业株式会社	噻唑烷二酮衍生物，其制备方法和用途
JPH01213284A (ja)	1988-02-22	1989-08-28	Sankyo Co Ltd	チエノピリミジン−２，４−ジオン誘導体
GB8828477D0 (en)	1988-12-06	1989-01-05	Riker Laboratories Inc	Medical aerosol formulations
ES2060040T5 (es)	1989-05-31	1999-09-16	Fisons Plc	Dispositivo y formulacion de inhalacion de medicamento.
GB8921222D0 (en)	1989-09-20	1989-11-08	Riker Laboratories Inc	Medicinal aerosol formulations
IL97065A (en)	1990-02-02	1994-01-25	Fisons Plc	Repellent preparations for aerosol
DE4003272A1 (de)	1990-02-03	1991-08-08	Boehringer Ingelheim Kg	Neue treibgasmischungen und ihre verwendung in arzneimittelzubereitungen
DE69131867T2 (de)	1990-03-23	2000-05-18	Minnesota Mining And Mfg. Co., Saint Paul	Anwendung von löslichen fluorhaltigen Tensiden zur Herstellung von Aerosol-Präparaten mit dosierter Abgabe
ATE114112T1 (de)	1990-10-18	1994-12-15	Minnesota Mining & Mfg	Aerosolzubereitung, die beclometason 17,21- dipropionat enthält.
AU650953B2 (en)	1991-03-21	1994-07-07	Novartis Ag	Inhaler
IL104068A (en)	1991-12-12	1998-10-30	Glaxo Group Ltd	Surfactant-free pharmaceutical aerosol formulation comprising 1,1,1,2-tetrafluoroethane or 1,1,1,2,3,3,3-heptafluoro-n- propane as propellant
GB9213874D0 (en)	1992-06-30	1992-08-12	Fisons Plc	Process to novel medicament form
GB9306703D0 (en)	1993-03-31	1993-05-26	Fisons Plc	Inhalation device
IL111194A (en)	1993-10-08	1998-02-08	Fisons Plc	Process for the production of medicament formulations
CA2270964C (en)	1996-11-11	2007-07-31	Byk Gulden Lomberg Chemische Fabrik Gmbh	Benzonaphthyridines as bronchial therapeutics
DE69807074T2 (de)	1997-05-08	2003-04-03	Merck Sharp & Dohme Ltd., Hoddesdon	Substituierte 1,2,4-triazolo[3,4,-a]phthalazin-derivate als gaba-alpha 5-liganden
CA2291153A1 (en)	1997-06-03	1998-12-10	Byk Gulden Lomberg Chemische Fabrik Gmbh	Benzonaphthyridine
US6475467B1 (en)	1998-08-04	2002-11-05	Jago Research Ag	Medicinal aerosol formulations
US6397838B1 (en)	1998-12-23	2002-06-04	Battelle Pulmonary Therapeutics, Inc.	Pulmonary aerosol delivery device and method
BR0009993A (pt)	1999-04-23	2002-01-08	Battelle Memorial Institute	Pulverizador de aerossol eletrohidrodinâmico direcionalmente controlado, dispositivo para liberar gotìculas de aerossol eletricamente neutras, aparelho para liberar gotìculas de aerossol terapêuticas, processo para liberar gotìculas de aerossol, e, dispositivo para liberar aerossol
DE60030103T2 (de)	1999-04-23	2007-02-08	Ventaira Pharmaceuticals, Inc., Columbus	Elektrostatisches versprühen mit transfer- hoher masse
ATE312820T1 (de)	1999-10-28	2005-12-15	Trine Pharmaceuticals Inc	Pumpeninhibitoren zur freisetzung von medikamenten
EP1286997B1 (en)	2000-06-07	2004-08-18	Almirall Prodesfarma, S.A.	6-phenylpyrrolopyrimidinedione derivatives
AU2001281965A1 (en)	2000-07-14	2002-01-30	Byk Gulden Lomberg Chemische Fabrik G.M.B.H.	Novel 6-phenylphenanthridines
HUP0302311A3 (en)	2000-10-09	2006-07-28	3M Innovative Properties Co	Medicinal aerosol formulations
EP1425029A4 (en)	2001-08-10	2006-06-07	Palatin Technologies Inc	PEPTIDOMIMETICS OF BIOLOGICALLY ACTIVE METALLOPEPTIDES
GB0202254D0 (en)	2002-01-31	2002-03-20	Pfizer Ltd	Prevention of scarring
US20030216407A1 (en)	2002-01-31	2003-11-20	Pfizer Inc.	Use of PDE5 inhibitors in the treatment of scarring
WO2004014916A1 (en)	2002-08-13	2004-02-19	Warner-Lambert Company Llc	Pyrimidine fused bicyclic metalloproteinase inhibitors
EP1755589A4 (en)	2004-04-23	2007-11-07	Celgene Corp	METHOD OF USING PDE4 MODULATORS AND COMPOSITIONS COMPRISING THEM FOR THE TREATMENT AND MANAGEMENT OF PULMONARY HYPERTENSION
DE602005027866D1 (de)	2004-09-08	2011-06-16	Nycomed Gmbh	3-oxa-10-aza-phenanthrene als pde4- oder pde3/4-inhibitoren
AU2005281703B2 (en)	2004-09-08	2011-11-17	Takeda Gmbh	Novel 3-thia-10-aza-phenanthrene derivatives
WO2006054560A1 (ja)	2004-11-17	2006-05-26	Kissei Pharmaceutical Co., Ltd.	芳香族アミド誘導体、それを含有する医薬組成物およびそれらの医薬用途
EP1858880A1 (en) *	2005-03-09	2007-11-28	Nycomed GmbH	Amido-substituted 6-phenylphenanthridines
WO2008128647A1 (en)	2007-04-23	2008-10-30	Sanofi-Aventis	Quinoline-carboxamide derivatives as p2y12 antagonists
US20140113877A1 (en) *	2011-06-15	2014-04-24	Takeda Gmbh	Novel 3,4,4a,10b-tetrahydro-1h-thiopyrano[4,3-c] isoquinoline compounds

2010
- 2010-12-14 AR ARP100104617A patent/AR079451A1/es unknown
- 2010-12-15 AU AU2010332955A patent/AU2010332955B8/en not_active Ceased
- 2010-12-15 CN CN201080057293.7A patent/CN102652136B/zh not_active Expired - Fee Related
- 2010-12-15 MX MX2012006696A patent/MX2012006696A/es active IP Right Grant
- 2010-12-15 EA EA201200891A patent/EA023212B1/ru not_active IP Right Cessation
- 2010-12-15 GE GEAP201012783A patent/GEP20146105B/en unknown
- 2010-12-15 SG SG2012034732A patent/SG180824A1/en unknown
- 2010-12-15 EP EP10790569.7A patent/EP2513119B1/en active Active
- 2010-12-15 PL PL10790569T patent/PL2513119T3/pl unknown
- 2010-12-15 KR KR1020127017957A patent/KR20120123313A/ko not_active Withdrawn
- 2010-12-15 PT PT107905697T patent/PT2513119E/pt unknown
- 2010-12-15 JP JP2012543701A patent/JP5645961B2/ja not_active Expired - Fee Related
- 2010-12-15 SG SG2014000335A patent/SG196785A1/en unknown
- 2010-12-15 UA UAA201208482A patent/UA107689C2/ru unknown
- 2010-12-15 SI SI201030746T patent/SI2513119T1/sl unknown
- 2010-12-15 WO PCT/EP2010/069704 patent/WO2011073231A1/en not_active Ceased
- 2010-12-15 ES ES10790569.7T patent/ES2505290T3/es active Active
- 2010-12-15 BR BR112012014058A patent/BR112012014058A8/pt not_active IP Right Cessation
- 2010-12-15 RS RSP20140499 patent/RS53544B1/sr unknown
- 2010-12-15 NZ NZ601115A patent/NZ601115A/en not_active IP Right Cessation
- 2010-12-15 ME MEP-2014-114A patent/ME01914B/me unknown
- 2010-12-15 ES ES14164018.5T patent/ES2621291T3/es active Active
- 2010-12-15 US US13/515,214 patent/US9018175B2/en not_active Expired - Fee Related
- 2010-12-15 DK DK10790569.7T patent/DK2513119T3/da active
- 2010-12-15 PH PH1/2012/501125A patent/PH12012501125A1/en unknown
- 2010-12-15 EP EP14164018.5A patent/EP2813509B1/en active Active
- 2010-12-15 CA CA2784013A patent/CA2784013A1/en not_active Abandoned
- 2010-12-15 HR HRP20140893AT patent/HRP20140893T1/hr unknown
- 2010-12-17 TW TW99144591A patent/TWI468411B/zh not_active IP Right Cessation
2012
- 2012-05-24 CO CO12085785A patent/CO6551705A2/es active IP Right Grant
- 2012-06-06 ZA ZA2012/04135A patent/ZA201204135B/en unknown
2014
- 2014-12-11 SM SM201400185T patent/SMT201400185B/xx unknown

Also Published As

Publication number	Publication date
CN102652136A (zh)	2012-08-29
AU2010332955A1 (en)	2012-08-02
AU2010332955B2 (en)	2015-01-22
SG196785A1 (en)	2014-02-13
ES2505290T3 (es)	2014-10-09
KR20120123313A (ko)	2012-11-08
US9018175B2 (en)	2015-04-28
ZA201204135B (en)	2013-03-27
RS53544B1 (sr)	2015-02-27
WO2011073231A1 (en)	2011-06-23
AU2010332955B8 (en)	2015-05-21
EP2513119B1 (en)	2014-06-25
JP5645961B2 (ja)	2014-12-24
NZ601115A (en)	2014-05-30
PL2513119T3 (pl)	2014-11-28
TW201130851A (en)	2011-09-16
JP2013514308A (ja)	2013-04-25
SG180824A1 (en)	2012-07-30
EP2813509A1 (en)	2014-12-17
US20120289474A1 (en)	2012-11-15
SI2513119T1 (sl)	2014-10-30
EA201200891A1 (ru)	2013-01-30
ES2621291T3 (es)	2017-07-03
MX2012006696A (es)	2012-07-17
EP2513119A1 (en)	2012-10-24
ME01914B (me)	2015-05-20
AR079451A1 (es)	2012-01-25
HRP20140893T1 (hr)	2014-11-07
EP2813509B1 (en)	2017-02-01
GEP20146105B (en)	2014-05-27
CA2784013A1 (en)	2011-06-23
HK1174326A1 (en)	2013-06-07
CO6551705A2 (es)	2012-10-31
PH12012501125A1 (en)	2012-10-29
BR112012014058A2 (pt)	2017-10-24
CN102652136B (zh)	2014-11-26
AU2010332955A8 (en)	2015-05-28
UA107689C2 (xx)	2015-02-10
SMT201400185B (it)	2015-01-15
TWI468411B (zh)	2015-01-11
PT2513119E (pt)	2014-09-05
EA023212B1 (ru)	2016-05-31
BR112012014058A8 (pt)	2018-02-06

Publication	Publication Date	Title
DK2513119T3 (da)	2014-10-06	3,4,4a,10b-tetrahydro-1h-thiopyrano-[4,3-c]isoquinolin derivater
BRPI0914657A2 (pt)	2019-09-24	piridin-2-onae piridazin-3-onas substituídas
IL208466A0 (en)	2010-12-30	Isoquinolinone derivatives as nk3 antagonists
BRPI0919948A2 (pt)	2015-08-25	Pirido[4,3-b]indois contendo porções rígidas
DK2276486T3 (da)	2013-11-25	Nye substituerede imidazo-quinoliner
BRPI1011683A2 (pt)	2016-03-22	derivado isoquinolina substituída
BRPI0908050A2 (pt)	2015-08-11	Furo-e tieno[3,2-c]piridinas
EP2257169A4 (en)	2012-01-11	TETRAHYDROTHIENPYRIDINE
IL213631A0 (en)	2011-07-31	Isoquinoline derivative
EP2143714A4 (en)	2011-09-07	TETRAHYDROISOQUINOLINE COMPOUND
EP2231155A4 (en)	2011-09-14	Tetrahydroisoquinoline DERIVATIVES
ZA201103119B (en)	2012-09-26	Isoquinolinone derivatives as nk3 antagonists
PL2657227T3 (pl)	2016-09-30	Nowa podstawiona pochodna izochinoliny
IL212107A0 (en)	2011-06-30	Isoquinolinone derivatives as nk3 antagonists
IL209663A0 (en)	2011-02-28	Isoquinolinone derivatives as nk3 antagonists
ZA201006563B (en)	2011-10-26	Novel tetrahydroisoquinoline derivative
IL216062A0 (en)	2012-01-31	Novel isoquinoline derivatives
GB2476643B (en)	2012-11-14	1,4-Dihydro-1,4-dioxonaphtalene derivatives as anticoagulants
EP2586772A4 (en)	2013-11-13	isoquinoline
EP2344472A4 (en)	2012-11-28	ISOCHINOLINONDERIVATE
PL391537A1 (pl)	2011-12-19	Barwne sulfoniany 9-(2-karboksyfenylo)-3,6-dihydroksy-9H-ksanten-9-yliowe oraz sposób ich otrzymywania
TH96521B (th)	2009-07-09	ลวดลายบนถ้วย
IL201721A0 (en)	2010-05-31	Isoquinolinone derivatives as nk3 antagonists
FI20086003L (fi)	2010-04-24	Lukittava panta
GB0913095D0 (en)	2009-09-02	Fair-teez or derivitive thereof