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DK258283A - Fremgangsmaade til fremstilling af et heparinfragment med en molekylvaegt paa 2000 til 5500 og kovalent bundet til antithrombin iii - Google Patents

Fremgangsmaade til fremstilling af et heparinfragment med en molekylvaegt paa 2000 til 5500 og kovalent bundet til antithrombin iii Download PDF

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Publication number
DK258283A
DK258283A DK258283A DK258283A DK258283A DK 258283 A DK258283 A DK 258283A DK 258283 A DK258283 A DK 258283A DK 258283 A DK258283 A DK 258283A DK 258283 A DK258283 A DK 258283A
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DK
Denmark
Prior art keywords
iii
anthithrombine
procedure
preparation
molecule weight
Prior art date
Application number
DK258283A
Other languages
Danish (da)
English (en)
Other versions
DK258283D0 (da
Inventor
Desire J Collen
Original Assignee
Kabivitrum Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kabivitrum Ab filed Critical Kabivitrum Ab
Publication of DK258283D0 publication Critical patent/DK258283D0/da
Publication of DK258283A publication Critical patent/DK258283A/da

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08BPOLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Polymers & Plastics (AREA)
  • Materials Engineering (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Saccharide Compounds (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicinal Preparation (AREA)
DK258283A 1982-06-10 1983-06-07 Fremgangsmaade til fremstilling af et heparinfragment med en molekylvaegt paa 2000 til 5500 og kovalent bundet til antithrombin iii DK258283A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE8203611 1982-06-10

Publications (2)

Publication Number Publication Date
DK258283D0 DK258283D0 (da) 1983-06-07
DK258283A true DK258283A (da) 1983-12-11

Family

ID=20347038

Family Applications (1)

Application Number Title Priority Date Filing Date
DK258283A DK258283A (da) 1982-06-10 1983-06-07 Fremgangsmaade til fremstilling af et heparinfragment med en molekylvaegt paa 2000 til 5500 og kovalent bundet til antithrombin iii

Country Status (8)

Country Link
US (1) US4623718A (de)
EP (1) EP0098814B1 (de)
JP (1) JPS5925802A (de)
AT (1) ATE22899T1 (de)
CA (1) CA1205011A (de)
DE (2) DE3366933D1 (de)
DK (1) DK258283A (de)
NO (1) NO157783C (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3422518A1 (de) * 1984-06-16 1985-12-19 B. Braun Melsungen Ag, 3508 Melsungen Heparin-derivate, verfahren zu ihrer herstellung, diese enthaltende arzneimittel und ihre verwendung bei der behandlung von fettstoffwechselstoerungen
US4859581A (en) * 1986-03-10 1989-08-22 Board Of Regents, The University Of Texas System Endoglycosidase assay
EP0337327A1 (de) * 1988-04-09 1989-10-18 Bioiberica, S.A. Verfahren zur Herstellung von neuen Oligosaccharid-Fragmenten durch kontrollierte chemische Depolymerisation von Heparin
US5252557A (en) * 1988-07-25 1993-10-12 Kiyoshi Kita Administration method of antithrombin
US6562781B1 (en) * 1995-11-30 2003-05-13 Hamilton Civic Hospitals Research Development Inc. Glycosaminoglycan-antithrombin III/heparin cofactor II conjugates
US6491965B1 (en) * 1995-11-30 2002-12-10 Hamilton Civic Hospitals Research Development, Inc. Medical device comprising glycosaminoglycan-antithrombin III/heparin cofactor II conjugates
US7045585B2 (en) 1995-11-30 2006-05-16 Hamilton Civic Hospital Research Development Inc. Methods of coating a device using anti-thrombin heparin
US7498130B2 (en) * 2003-05-13 2009-03-03 Massachusetts General Hospital Method of reducing viral load
US20040229778A1 (en) * 2003-05-13 2004-11-18 Elmaleh David R. Pharmaceutical compositions of antithrombin III for the treatment of retroviral diseases
CA2535446A1 (en) * 2003-08-12 2005-02-17 Hamilton Civic Hospitals Research Development Inc. Methods for preventing neurological events
CN103743837B (zh) * 2013-12-24 2015-01-21 山东泰邦生物制品有限公司 人抗凝血酶ⅲ肝素结合比例检测方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4301153A (en) 1977-03-21 1981-11-17 Riker Laboratories, Inc. Heparin preparation
JPS6040859B2 (ja) 1977-07-27 1985-09-12 喜温 三浦 抗血栓性人工医療材料
CA1136620A (en) 1979-01-08 1982-11-30 Ulf P.F. Lindahl Heparin fragments having selective anticoagulation activity
US4351938A (en) 1980-05-19 1982-09-28 Riker Laboratories, Inc. Anticoagulant substance
US4446126A (en) 1980-09-30 1984-05-01 Cutter Laboratories, Inc. Antithrombin-heparin complex and method for its production
US4386025A (en) 1980-09-30 1983-05-31 Cutter Laboratories, Inc. Method of preparing antithrombin
EP0048898B1 (de) * 1980-09-30 1985-04-17 Bayer Ag Verfahren zur Herstellung eines Antithrombin-Heparin-Komplexes sowie diesen Komplex enthaltende pharmazeutische Mischungen
JPS57134419A (en) 1981-02-12 1982-08-19 Eisai Co Ltd Stable anticoagulant of blood
US4526714A (en) 1982-12-13 1985-07-02 Cordis Europa N.V. Conjugates of anticoagulant and protein
US4533549A (en) 1983-01-04 1985-08-06 Lasker Sigmund E Antithrombotic agent
US4689323A (en) 1983-09-26 1987-08-25 Miles Laboratories, Inc. Covalently bound heparin--antithrombin-III complex

Also Published As

Publication number Publication date
CA1205011A (en) 1986-05-27
ATE22899T1 (de) 1986-11-15
NO832092L (no) 1983-12-12
JPS5925802A (ja) 1984-02-09
DE3366933D1 (en) 1986-11-20
EP0098814B1 (de) 1986-10-15
US4623718A (en) 1986-11-18
DE98814T1 (de) 1984-06-20
NO157783C (no) 1988-05-18
NO157783B (no) 1988-02-08
EP0098814A1 (de) 1984-01-18
DK258283D0 (da) 1983-06-07

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DK258283A (da) Fremgangsmaade til fremstilling af et heparinfragment med en molekylvaegt paa 2000 til 5500 og kovalent bundet til antithrombin iii
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Legal Events

Date Code Title Description
AHB Application shelved due to non-payment