DK228990A - Fremstilling af 2,6-dioxopiperidinderivater - Google Patents
Fremstilling af 2,6-dioxopiperidinderivater Download PDFInfo
- Publication number
- DK228990A DK228990A DK228990A DK228990A DK228990A DK 228990 A DK228990 A DK 228990A DK 228990 A DK228990 A DK 228990A DK 228990 A DK228990 A DK 228990A DK 228990 A DK228990 A DK 228990A
- Authority
- DK
- Denmark
- Prior art keywords
- carbon atoms
- fluoroalkyl
- alkyl
- reacting
- steps
- Prior art date
Links
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000004432 carbon atom Chemical group C* 0.000 abstract 3
- -1 fluoroalkyl iodide Chemical compound 0.000 abstract 2
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 abstract 1
- 206010006187 Breast cancer Diseases 0.000 abstract 1
- 208000026310 Breast neoplasm Diseases 0.000 abstract 1
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 1
- 230000001476 alcoholic effect Effects 0.000 abstract 1
- 239000000010 aprotic solvent Substances 0.000 abstract 1
- 125000003709 fluoroalkyl group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 150000005459 piperidine-2,6-diones Chemical class 0.000 abstract 1
- 229910052700 potassium Inorganic materials 0.000 abstract 1
- 239000011591 potassium Substances 0.000 abstract 1
- LPNYRYFBWFDTMA-UHFFFAOYSA-N potassium tert-butoxide Chemical compound [K+].CC(C)(C)[O-] LPNYRYFBWFDTMA-UHFFFAOYSA-N 0.000 abstract 1
- PTZQTYADHHANGW-UHFFFAOYSA-N pyridin-4-yl acetate Chemical compound CC(=O)OC1=CC=NC=C1 PTZQTYADHHANGW-UHFFFAOYSA-N 0.000 abstract 1
- 229910052708 sodium Inorganic materials 0.000 abstract 1
- 239000011734 sodium Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/86—Oxygen atoms
- C07D211/88—Oxygen atoms attached in positions 2 and 6, e.g. glutarimide
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB888806751A GB8806751D0 (en) | 1988-03-22 | 1988-03-22 | Preparation of 2 6-dioxopiperidine derivatives |
| GB8806751 | 1988-03-22 | ||
| GB888825501A GB8825501D0 (en) | 1988-11-01 | 1988-11-01 | Improvements relating to preparation of 2 6-dioxopiperidine derivatives |
| GB8825501 | 1988-11-01 | ||
| GB8900308 | 1989-03-22 | ||
| PCT/GB1989/000308 WO1989009216A1 (en) | 1988-03-22 | 1989-03-22 | Preparation of 2,6-dioxopiperidine derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DK228990D0 DK228990D0 (da) | 1990-09-21 |
| DK228990A true DK228990A (da) | 1990-09-21 |
| DK171067B1 DK171067B1 (da) | 1996-05-20 |
Family
ID=26293668
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK228990A DK171067B1 (da) | 1988-03-22 | 1990-09-21 | Fremgangsmåde til fremstilling af 3-alkyl- eller -fluoralkyl-3-(4-pyridyl)piperidin-2,6-dioner |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US5112976A (da) |
| EP (1) | EP0334633B1 (da) |
| JP (1) | JPH03503891A (da) |
| KR (1) | KR920003803B1 (da) |
| AU (1) | AU621602B2 (da) |
| CA (1) | CA1335290C (da) |
| DE (1) | DE68906449T2 (da) |
| DK (1) | DK171067B1 (da) |
| FI (1) | FI94637C (da) |
| GB (1) | GB2216524B (da) |
| IE (1) | IE64347B1 (da) |
| IL (1) | IL89631A (da) |
| NO (1) | NO176211C (da) |
| WO (1) | WO1989009216A1 (da) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9602516D0 (en) * | 1996-02-08 | 1996-04-10 | Chiroscience Ltd | Racemisation |
| KR970061867A (ko) * | 1996-02-23 | 1997-09-12 | 박민수 | 글루탐산 유도체, 그의 약제학적으로 허용가능한 염 및 이를 유효성분으루 함유하는 항경련제 |
| US9777116B2 (en) | 2014-10-16 | 2017-10-03 | International Business Machines Corporation | Porous/nanoporous PHT |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2673205A (en) * | 1951-02-13 | 1954-03-23 | Ciba Pharm Prod Inc | 3-disubstituted dioxopiperidines and the manufacture thereof |
| US2848455A (en) * | 1955-07-18 | 1958-08-19 | Ciba Pharm Prod Inc | Alpha-(p-amino-phenyl)-alpha-lower alkyl glutarimides |
| GB8332954D0 (en) * | 1983-12-09 | 1984-01-18 | Foster A B | A 2,6-dioxopiperidine derivative and pharmaceutical compositions |
| GB2151226B (en) * | 1983-12-09 | 1987-04-01 | Nationl Research Dev Corp | 2, 6-dioxopiperidine derivatives, their preparation and pharmaceutical compositions containing them |
| US4668689A (en) * | 1984-07-19 | 1987-05-26 | National Research Development Corporation | Glutarimide derivatives for treating oestrogen-dependent tumors |
-
1989
- 1989-03-16 IL IL89631A patent/IL89631A/xx not_active IP Right Cessation
- 1989-03-20 IE IE86789A patent/IE64347B1/en not_active IP Right Cessation
- 1989-03-21 CA CA000594265A patent/CA1335290C/en not_active Expired - Fee Related
- 1989-03-22 GB GB8906580A patent/GB2216524B/en not_active Expired - Lifetime
- 1989-03-22 KR KR1019890003564A patent/KR920003803B1/ko not_active Expired
- 1989-03-22 WO PCT/GB1989/000308 patent/WO1989009216A1/en not_active Ceased
- 1989-03-22 DE DE8989302841T patent/DE68906449T2/de not_active Expired - Fee Related
- 1989-03-22 JP JP1503628A patent/JPH03503891A/ja active Pending
- 1989-03-22 EP EP89302841A patent/EP0334633B1/en not_active Expired - Lifetime
- 1989-03-22 AU AU33458/89A patent/AU621602B2/en not_active Ceased
- 1989-05-10 US US07/701,641 patent/US5112976A/en not_active Expired - Fee Related
-
1990
- 1990-09-20 NO NO904108A patent/NO176211C/no unknown
- 1990-09-21 FI FI904673A patent/FI94637C/fi not_active IP Right Cessation
- 1990-09-21 DK DK228990A patent/DK171067B1/da not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| IL89631A (en) | 1993-05-13 |
| AU621602B2 (en) | 1992-03-19 |
| NO904108L (no) | 1990-09-20 |
| GB2216524B (en) | 1991-06-12 |
| IE890867L (en) | 1989-09-22 |
| IL89631A0 (en) | 1989-09-10 |
| FI94637C (fi) | 1995-10-10 |
| KR920003803B1 (ko) | 1992-05-15 |
| DE68906449T2 (de) | 1993-09-02 |
| FI904673A0 (fi) | 1990-09-21 |
| IE64347B1 (en) | 1995-07-26 |
| GB8906580D0 (en) | 1989-05-04 |
| DK228990D0 (da) | 1990-09-21 |
| AU3345889A (en) | 1989-10-16 |
| DE68906449D1 (de) | 1993-06-17 |
| JPH03503891A (ja) | 1991-08-29 |
| NO176211C (no) | 1995-02-22 |
| US5112976A (en) | 1992-05-12 |
| EP0334633A1 (en) | 1989-09-27 |
| DK171067B1 (da) | 1996-05-20 |
| WO1989009216A1 (en) | 1989-10-05 |
| GB2216524A (en) | 1989-10-11 |
| EP0334633B1 (en) | 1993-05-12 |
| NO176211B (no) | 1994-11-14 |
| NO904108D0 (no) | 1990-09-20 |
| CA1335290C (en) | 1995-04-18 |
| FI94637B (fi) | 1995-06-30 |
| KR890014518A (ko) | 1989-10-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B1 | Patent granted (law 1993) | ||
| PBP | Patent lapsed |