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DK202189A - MONOCLONT ANTIBODY FOR SELECTIVE IMMUNOLOGICAL DETERMINATION OF INTACT PROCOLLAGEN-PEPTID (TYPE III) AND PROCOLLAGEN (TYPE III) IN BODY LIQUIDS - Google Patents

MONOCLONT ANTIBODY FOR SELECTIVE IMMUNOLOGICAL DETERMINATION OF INTACT PROCOLLAGEN-PEPTID (TYPE III) AND PROCOLLAGEN (TYPE III) IN BODY LIQUIDS Download PDF

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Publication number
DK202189A
DK202189A DK202189A DK202189A DK202189A DK 202189 A DK202189 A DK 202189A DK 202189 A DK202189 A DK 202189A DK 202189 A DK202189 A DK 202189A DK 202189 A DK202189 A DK 202189A
Authority
DK
Denmark
Prior art keywords
type iii
procollagen
antibody
monoclont
peptid
Prior art date
Application number
DK202189A
Other languages
Danish (da)
Other versions
DK169571B1 (en
DK202189D0 (en
Inventor
Dietrich Brocks
Henning Hachmann
Volkmar Guenzler-Pukall
Juergen Puenter
Rupert Timpl
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of DK202189D0 publication Critical patent/DK202189D0/en
Publication of DK202189A publication Critical patent/DK202189A/en
Application granted granted Critical
Publication of DK169571B1 publication Critical patent/DK169571B1/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6887—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids from muscle, cartilage or connective tissue
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6878—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids in epitope analysis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Organic Chemistry (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

The said peptide can be determined with great accuracy with the aid of a monoclonal antibody which is directed specifically against one epitope of amino-terminal procollagen peptide (type III) which is not present on the fragment Col 1 and of a second monoclonal or polyclonal antibody against an epitope of amino-terminal procollagen peptide (type III).
DK202189A 1988-04-27 1989-04-26 Monoclonal antibody, method for its preparation, hybridoma cell line producing the antibody, methods for quantitative immunological determination of procollagen peptide (type III) with the antibody, and diagnostic composition containing the monoclonal antibody DK169571B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3814216 1988-04-27
DE3814216 1988-04-27

Publications (3)

Publication Number Publication Date
DK202189D0 DK202189D0 (en) 1989-04-26
DK202189A true DK202189A (en) 1989-10-28
DK169571B1 DK169571B1 (en) 1994-12-05

Family

ID=6353005

Family Applications (1)

Application Number Title Priority Date Filing Date
DK202189A DK169571B1 (en) 1988-04-27 1989-04-26 Monoclonal antibody, method for its preparation, hybridoma cell line producing the antibody, methods for quantitative immunological determination of procollagen peptide (type III) with the antibody, and diagnostic composition containing the monoclonal antibody

Country Status (12)

Country Link
EP (1) EP0339443B1 (en)
JP (1) JPH07110880B2 (en)
AT (1) ATE115963T1 (en)
CA (1) CA1338324C (en)
DE (1) DE58908787D1 (en)
DK (1) DK169571B1 (en)
ES (1) ES2065350T3 (en)
FI (1) FI98705C (en)
GR (1) GR3014957T3 (en)
IE (1) IE66320B1 (en)
NO (1) NO179107C (en)
PT (1) PT90369B (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6010862A (en) * 1987-11-06 2000-01-04 Washington Research Foundation Methods of detecting collagen type III degradation in vivo
DE4225038C2 (en) * 1992-07-29 1995-11-30 Boehringer Mannheim Gmbh Production and use of antibodies against collagen
FI960392L (en) * 1993-07-28 1996-01-29 Boehringer Mannheim Gmbh Immunoassay for the detection of collagen or collagen fragments
GB9506050D0 (en) 1995-03-24 1995-05-10 Osteometer A S Assaying collagen fragments in body fluids
ES2154739T3 (en) 1994-10-17 2001-04-16 Osteometer Biotech As ESTIMATION OF THE COLLAGEN FRAGMENTATION MODEL IN BODY FLUIDS AND THE DIAGNOSIS OF DISORDERS ASSOCIATED WITH THE COLLAGEN METABOLISM.
US6107047A (en) * 1996-03-21 2000-08-22 Osteometer Biotech A/S Assaying protein fragments in body fluids
GB9617616D0 (en) 1996-08-22 1996-10-02 Osteometer Biotech As Assaying protein fragments in body fluids
DE69705423T2 (en) 1996-12-09 2002-05-16 Osteometer Biotech As Herlev SANDWEIGHT TEST FOR DETECTING COLLAGEN FRAGMENTS
US6117646A (en) * 1997-09-22 2000-09-12 Osteometer Biotech A/S Assaying protein fragments in body fluids
DE69915059T2 (en) 1998-05-28 2004-08-26 Bayer Healthcare Ag MONOCLONAL ANTIBODY AND ASSAY FOR DETERMINING N-TERMINAL PROCOLLAGEN PROPEPTIDE TYPE III (PIIINP)
US6602980B1 (en) 1998-06-19 2003-08-05 Washington Research Foundation Collagen type III synthetic peptides for collagen resorption assays
US6916903B2 (en) 1998-06-19 2005-07-12 Washington Research Foundation Collagen type III synthetic peptides for collagen resorption assays

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3209149A1 (en) * 1982-03-13 1983-10-06 Hoechst Ag METHOD FOR THE COMMON IMMUNOLOGICAL DETERMINATION OF PROCOLLAGEN PEPTIDE (TYPE III) AND PROCOLLAGEN PEPTIDE COL 1 (TYPE III) AND METHOD FOR THE PRODUCTION OF ANTI-PROCOLLAGEN PEPTIDE COL 1 (TYPE III) SERUM

Also Published As

Publication number Publication date
EP0339443B1 (en) 1994-12-21
NO179107C (en) 1996-08-07
NO179107B (en) 1996-04-29
IE66320B1 (en) 1995-12-27
ATE115963T1 (en) 1995-01-15
NO891732L (en) 1989-10-30
PT90369A (en) 1989-11-10
GR3014957T3 (en) 1995-05-31
PT90369B (en) 1994-08-31
EP0339443A3 (en) 1990-05-09
FI891953L (en) 1989-10-28
DE58908787D1 (en) 1995-02-02
FI891953A0 (en) 1989-04-25
NO891732D0 (en) 1989-04-26
ES2065350T3 (en) 1995-02-16
DK169571B1 (en) 1994-12-05
IE891372L (en) 1989-10-27
DK202189D0 (en) 1989-04-26
FI98705B (en) 1997-04-30
JPH0213396A (en) 1990-01-17
FI98705C (en) 1997-08-11
CA1338324C (en) 1996-05-14
JPH07110880B2 (en) 1995-11-29
EP0339443A2 (en) 1989-11-02

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Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
PUP Patent expired