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NO179107C - Monoclonal antibody for selective immunological determination of intact procollagen peptide (type III) and procollagen (type III) in body fluids, hybridoma cell line, use of the antibodies and diagnostic kits - Google Patents

Monoclonal antibody for selective immunological determination of intact procollagen peptide (type III) and procollagen (type III) in body fluids, hybridoma cell line, use of the antibodies and diagnostic kits

Info

Publication number
NO179107C
NO179107C NO891732A NO891732A NO179107C NO 179107 C NO179107 C NO 179107C NO 891732 A NO891732 A NO 891732A NO 891732 A NO891732 A NO 891732A NO 179107 C NO179107 C NO 179107C
Authority
NO
Norway
Prior art keywords
type iii
procollagen
monoclonal antibody
antibodies
cell line
Prior art date
Application number
NO891732A
Other languages
Norwegian (no)
Other versions
NO179107B (en
NO891732L (en
NO891732D0 (en
Inventor
Dietrich Brocks
Volkmar Gunzler-Pukall
Henning Hachmann
Jurgen Punter
Rupert Timpl
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of NO891732D0 publication Critical patent/NO891732D0/en
Publication of NO891732L publication Critical patent/NO891732L/en
Publication of NO179107B publication Critical patent/NO179107B/en
Publication of NO179107C publication Critical patent/NO179107C/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6887—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids from muscle, cartilage or connective tissue
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6878—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids in epitope analysis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Organic Chemistry (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

The said peptide can be determined with great accuracy with the aid of a monoclonal antibody which is directed specifically against one epitope of amino-terminal procollagen peptide (type III) which is not present on the fragment Col 1 and of a second monoclonal or polyclonal antibody against an epitope of amino-terminal procollagen peptide (type III).
NO891732A 1988-04-27 1989-04-26 Monoclonal antibody for selective immunological determination of intact procollagen peptide (type III) and procollagen (type III) in body fluids, hybridoma cell line, use of the antibodies and diagnostic kits NO179107C (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3814216 1988-04-27

Publications (4)

Publication Number Publication Date
NO891732D0 NO891732D0 (en) 1989-04-26
NO891732L NO891732L (en) 1989-10-30
NO179107B NO179107B (en) 1996-04-29
NO179107C true NO179107C (en) 1996-08-07

Family

ID=6353005

Family Applications (1)

Application Number Title Priority Date Filing Date
NO891732A NO179107C (en) 1988-04-27 1989-04-26 Monoclonal antibody for selective immunological determination of intact procollagen peptide (type III) and procollagen (type III) in body fluids, hybridoma cell line, use of the antibodies and diagnostic kits

Country Status (12)

Country Link
EP (1) EP0339443B1 (en)
JP (1) JPH07110880B2 (en)
AT (1) ATE115963T1 (en)
CA (1) CA1338324C (en)
DE (1) DE58908787D1 (en)
DK (1) DK169571B1 (en)
ES (1) ES2065350T3 (en)
FI (1) FI98705C (en)
GR (1) GR3014957T3 (en)
IE (1) IE66320B1 (en)
NO (1) NO179107C (en)
PT (1) PT90369B (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6010862A (en) * 1987-11-06 2000-01-04 Washington Research Foundation Methods of detecting collagen type III degradation in vivo
DE4225038C2 (en) * 1992-07-29 1995-11-30 Boehringer Mannheim Gmbh Production and use of antibodies against collagen
FI960392L (en) * 1993-07-28 1996-01-29 Boehringer Mannheim Gmbh Immunoassay for the detection of collagen or collagen fragments
GB9506050D0 (en) 1995-03-24 1995-05-10 Osteometer A S Assaying collagen fragments in body fluids
ES2154739T3 (en) 1994-10-17 2001-04-16 Osteometer Biotech As ESTIMATION OF THE COLLAGEN FRAGMENTATION MODEL IN BODY FLUIDS AND THE DIAGNOSIS OF DISORDERS ASSOCIATED WITH THE COLLAGEN METABOLISM.
US6107047A (en) * 1996-03-21 2000-08-22 Osteometer Biotech A/S Assaying protein fragments in body fluids
GB9617616D0 (en) 1996-08-22 1996-10-02 Osteometer Biotech As Assaying protein fragments in body fluids
DE69705423T2 (en) 1996-12-09 2002-05-16 Osteometer Biotech As Herlev SANDWEIGHT TEST FOR DETECTING COLLAGEN FRAGMENTS
US6117646A (en) * 1997-09-22 2000-09-12 Osteometer Biotech A/S Assaying protein fragments in body fluids
DE69915059T2 (en) 1998-05-28 2004-08-26 Bayer Healthcare Ag MONOCLONAL ANTIBODY AND ASSAY FOR DETERMINING N-TERMINAL PROCOLLAGEN PROPEPTIDE TYPE III (PIIINP)
US6602980B1 (en) 1998-06-19 2003-08-05 Washington Research Foundation Collagen type III synthetic peptides for collagen resorption assays
US6916903B2 (en) 1998-06-19 2005-07-12 Washington Research Foundation Collagen type III synthetic peptides for collagen resorption assays

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3209149A1 (en) * 1982-03-13 1983-10-06 Hoechst Ag METHOD FOR THE COMMON IMMUNOLOGICAL DETERMINATION OF PROCOLLAGEN PEPTIDE (TYPE III) AND PROCOLLAGEN PEPTIDE COL 1 (TYPE III) AND METHOD FOR THE PRODUCTION OF ANTI-PROCOLLAGEN PEPTIDE COL 1 (TYPE III) SERUM

Also Published As

Publication number Publication date
EP0339443B1 (en) 1994-12-21
NO179107B (en) 1996-04-29
IE66320B1 (en) 1995-12-27
ATE115963T1 (en) 1995-01-15
NO891732L (en) 1989-10-30
PT90369A (en) 1989-11-10
GR3014957T3 (en) 1995-05-31
PT90369B (en) 1994-08-31
EP0339443A3 (en) 1990-05-09
FI891953L (en) 1989-10-28
DE58908787D1 (en) 1995-02-02
FI891953A0 (en) 1989-04-25
NO891732D0 (en) 1989-04-26
ES2065350T3 (en) 1995-02-16
DK169571B1 (en) 1994-12-05
IE891372L (en) 1989-10-27
DK202189D0 (en) 1989-04-26
FI98705B (en) 1997-04-30
JPH0213396A (en) 1990-01-17
FI98705C (en) 1997-08-11
CA1338324C (en) 1996-05-14
DK202189A (en) 1989-10-28
JPH07110880B2 (en) 1995-11-29
EP0339443A2 (en) 1989-11-02

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Legal Events

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