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DK1844070T3 - Peptider med neuropeptid-2 receptor (Y2R) agonistaktivitet - Google Patents

Peptider med neuropeptid-2 receptor (Y2R) agonistaktivitet

Info

Publication number
DK1844070T3
DK1844070T3 DK06700451.5T DK06700451T DK1844070T3 DK 1844070 T3 DK1844070 T3 DK 1844070T3 DK 06700451 T DK06700451 T DK 06700451T DK 1844070 T3 DK1844070 T3 DK 1844070T3
Authority
DK
Denmark
Prior art keywords
neuropeptide
peptides
receptor
agonist activity
agonist
Prior art date
Application number
DK06700451.5T
Other languages
English (en)
Inventor
Waleed Danho
George Ehrlich
David C Fry
Wajiha Khan
Joseph Swistok
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of DK1844070T3 publication Critical patent/DK1844070T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/57545—Neuropeptide Y
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK06700451.5T 2005-01-18 2006-01-11 Peptider med neuropeptid-2 receptor (Y2R) agonistaktivitet DK1844070T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US64484005P 2005-01-18 2005-01-18
PCT/EP2006/000161 WO2006077035A1 (en) 2005-01-18 2006-01-11 Peptides with neuropeptide-2 receptor (y2r) agonist activity

Publications (1)

Publication Number Publication Date
DK1844070T3 true DK1844070T3 (da) 2011-06-14

Family

ID=36118121

Family Applications (1)

Application Number Title Priority Date Filing Date
DK06700451.5T DK1844070T3 (da) 2005-01-18 2006-01-11 Peptider med neuropeptid-2 receptor (Y2R) agonistaktivitet

Country Status (22)

Country Link
US (1) US7410949B2 (da)
EP (1) EP1844070B1 (da)
JP (1) JP4633804B2 (da)
KR (1) KR100905380B1 (da)
CN (1) CN101107266A (da)
AR (1) AR051904A1 (da)
AT (1) ATE500268T1 (da)
AU (1) AU2006207659B2 (da)
BR (1) BRPI0606675A2 (da)
CA (1) CA2594423A1 (da)
DE (1) DE602006020407D1 (da)
DK (1) DK1844070T3 (da)
ES (1) ES2359850T3 (da)
IL (1) IL184428A0 (da)
MX (1) MX2007008614A (da)
NO (1) NO20073664L (da)
PL (1) PL1844070T3 (da)
PT (1) PT1844070E (da)
RU (1) RU2383553C2 (da)
TW (1) TWI309653B (da)
WO (1) WO2006077035A1 (da)
ZA (1) ZA200705674B (da)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0619573A2 (pt) * 2005-12-07 2011-10-04 Hoffmann La Roche agonista receptor de neuropeptìdeo-2, formulações farmacêuticas, uso de agonista receptor de neuropeptìdeo-2 e método de tratamento de uma doença modulada por agonistas receptores de neuropeptìdeos-2
US8299023B2 (en) * 2008-09-17 2012-10-30 Hoffmann-La Roche Inc. Neuropeptide-2 receptor (Y-2R) agonists
CN102202681A (zh) * 2008-11-05 2011-09-28 霍夫曼-拉罗奇有限公司 神经肽-2受体(y-2r)激动剂及其用途
EP2450374B9 (en) 2009-07-02 2016-11-23 Takeda Pharmaceutical Company Limited Peptide and use thereof
CN102573888A (zh) * 2009-09-18 2012-07-11 诺和诺德公司 长效y2 受体激动剂
CN102596228A (zh) * 2009-10-13 2012-07-18 霍夫曼-拉罗奇有限公司 神经肽-2受体(y-2r)激动剂
RS56998B1 (sr) 2010-12-16 2018-05-31 Novo Nordisk As Čvrste kompozicije koje sadrže agonist glp-1 i so n-(8-(2-hidroksibenzoil)amino)kaprilne kiseline
LT2827885T (lt) 2012-03-22 2018-10-10 Novo Nordisk A/S Glp-1 peptidų kompozicijos ir jų gavimas
ES2618703T3 (es) 2012-06-13 2017-06-22 F. Hoffmann-La Roche Ag Nuevos compuestos diazaspirocicloalcano y azaspirocicloalcano
CN104684915B (zh) 2012-09-25 2017-10-31 霍夫曼-拉罗奇有限公司 新型双环衍生物
AR095079A1 (es) 2013-03-12 2015-09-16 Hoffmann La Roche Derivados de octahidro-pirrolo[3,4-c]-pirrol y piridina-fenilo
JP6672140B2 (ja) 2013-05-02 2020-03-25 ノヴォ ノルディスク アー／エス Ｇｌｐ−１化合物の経口投薬
CN105722526B (zh) 2013-11-15 2020-12-08 诺和诺德股份有限公司 选择性pyy化合物及其用途
CN105764919B (zh) 2013-11-15 2021-04-27 诺和诺德股份有限公司 在位置35具有β-高精氨酸置换的hPYY(1-36)
KR20160087900A (ko) 2013-11-26 2016-07-22 에프. 호프만-라 로슈 아게 신규한 옥타하이드로-사이클로부타[1,2-c；3,4-c'']다이피롤-2-일
AU2015238537B2 (en) 2014-03-26 2019-08-01 F. Hoffmann-La Roche Ag Bicyclic compounds as autotaxin (ATX) and lysophosphatidic acid (LPA) production inhibitors
CN106029667B (zh) 2014-03-26 2019-08-23 豪夫迈·罗氏有限公司 作为自分泌运动因子(atx)和溶血磷脂酸(lpa)生产抑制剂的稠合[1,4]二氮杂*化合物
MA41898A (fr) * 2015-04-10 2018-02-13 Hoffmann La Roche Dérivés de quinazolinone bicyclique
CN107849110B (zh) 2015-06-12 2021-11-26 诺和诺德股份有限公司 选择性pyy化合物及其用途
EP3344619B1 (en) 2015-09-04 2020-10-28 H. Hoffnabb-La Roche Ag Phenoxymethyl derivatives
KR20180054635A (ko) 2015-09-24 2018-05-24 에프. 호프만-라 로슈 아게 오토탁신(atx) 억제제로서 이환형 화합물
CN115124538A (zh) 2015-09-24 2022-09-30 豪夫迈·罗氏有限公司 作为atx抑制剂的二环化合物
RU2725138C2 (ru) 2015-09-24 2020-06-30 Ф. Хоффманн-Ля Рош Аг Новые бициклические соединения в качестве двойных ингибиторов аутотаксина (atx)/карбоангидразы (ca)
KR20180054634A (ko) 2015-09-24 2018-05-24 에프. 호프만-라 로슈 아게 이중 오토탁신(atx)/탄산 무수화효소(ca) 억제제로서 신규한 이환형 화합물
JP7157755B2 (ja) 2017-03-16 2022-10-20 エフ．ホフマン－ラ ロシュ アーゲー 二重ａｔｘ／ｃａ阻害剤として有用な複素環式化合物
JP7090099B2 (ja) 2017-03-16 2022-06-23 エフ．ホフマン－ラ ロシュ アーゲー Ａｔｘインヒビターとしての新規二環式化合物
EP3717508A1 (en) 2017-12-01 2020-10-07 The University of Copenhagen Peptide hormone with one or more o-glycans
MX2020007598A (es) 2018-02-02 2020-09-03 Novo Nordisk As Composiciones solidas que comprenden un agonista del peptido similar al glucagon tipo 1 (glp-1), una sal del acido n-(8-(2-hidroxibenzoil)amino)caprilico y un lubricante.
EP3800195A1 (en) 2019-10-03 2021-04-07 Universitat de Barcelona Peptide compounds for reducing side effects of cb1 receptor agonists

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5080891A (en) 1987-08-03 1992-01-14 Ddi Pharmaceuticals, Inc. Conjugates of superoxide dismutase coupled to high molecular weight polyalkylene glycols
NZ265452A (en) 1993-03-29 1997-09-22 Univ Cincinnati Analogues of peptide yy, dimers and pharmaceutical compositions
US6017879A (en) * 1998-04-03 2000-01-25 B.M.R.A. Corporation B.V. Template associated NPY Y2-receptor agonists
AR030676A1 (es) * 1999-07-28 2003-09-03 Ortho Mcneil Pharm Inc Derivados de aminas y amidas como ligandos para el receptor del neuropeptido y y5 utiles en el tratamiento de la obesidad y otros trastornos, uso de los mismos para la elaboracion de medicamentos y composiciones farmaceuticas que los comprenden
US7811989B2 (en) * 2003-01-17 2010-10-12 Ipsen Pharma S.A.S. Peptide YY analogs
EP1689421A4 (en) * 2003-11-25 2009-06-24 Bayer Healthcare Ag SELECTIVE AGONISTS OF NEUROPEPTIDE Y2 RECEPTOR
US8603969B2 (en) * 2004-02-11 2013-12-10 Amylin Pharmaceuticals, Llc Pancreatic polypeptide family motifs and polypeptides comprising the same

Also Published As

Publication number Publication date
WO2006077035A1 (en) 2006-07-27
KR100905380B1 (ko) 2009-06-30
AU2006207659B2 (en) 2009-10-29
ES2359850T3 (es) 2011-05-27
TW200637874A (en) 2006-11-01
ZA200705674B (en) 2009-08-26
JP4633804B2 (ja) 2011-02-16
ATE500268T1 (de) 2011-03-15
JP2008527017A (ja) 2008-07-24
TWI309653B (en) 2009-05-11
PL1844070T3 (pl) 2011-07-29
IL184428A0 (en) 2007-10-31
KR20070095422A (ko) 2007-09-28
AR051904A1 (es) 2007-02-14
NO20073664L (no) 2007-09-28
CA2594423A1 (en) 2006-07-27
RU2007131504A (ru) 2009-02-27
EP1844070A1 (en) 2007-10-17
US7410949B2 (en) 2008-08-12
CN101107266A (zh) 2008-01-16
BRPI0606675A2 (pt) 2009-07-07
EP1844070B1 (en) 2011-03-02
MX2007008614A (es) 2007-09-11
US20060160742A1 (en) 2006-07-20
WO2006077035A9 (en) 2006-10-26
RU2383553C2 (ru) 2010-03-10
AU2006207659A1 (en) 2006-07-27
DE602006020407D1 (de) 2011-04-14
PT1844070E (pt) 2011-05-04

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