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MX2007008614A - Peptidos con actividad agonista del receptor del neuropeptido-2 (y2r). - Google Patents

Peptidos con actividad agonista del receptor del neuropeptido-2 (y2r).

Info

Publication number
MX2007008614A
MX2007008614A MX2007008614A MX2007008614A MX2007008614A MX 2007008614 A MX2007008614 A MX 2007008614A MX 2007008614 A MX2007008614 A MX 2007008614A MX 2007008614 A MX2007008614 A MX 2007008614A MX 2007008614 A MX2007008614 A MX 2007008614A
Authority
MX
Mexico
Prior art keywords
neuropeptide
receptor
peptides
agonist activity
obesity
Prior art date
Application number
MX2007008614A
Other languages
English (en)
Inventor
Waleed Danho
George Ehrlich
David C Fry
Wajiha Khan
Joseph Swistok
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MX2007008614A publication Critical patent/MX2007008614A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/57545—Neuropeptide Y
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente invencion se refiere a agonistas del receptor del neuropeptido-2 de la formula (I): Y-R1-R2-X-R3--R4-R5-R6-R7-R8-R9- R10-R11-R12-R13-R14-NH2 (I) asi como sales farmaceuticamente aceptables, derivados y fragmentos de los mismos, donde los sustituyentes son como aquellos discutidos en la especificacion. Estos compuestos, y las composiciones farmaceuticas que las contienen, son utiles para el tratamiento de enfermedades como, por ejemplo, obesidad.
MX2007008614A 2005-01-18 2006-01-11 Peptidos con actividad agonista del receptor del neuropeptido-2 (y2r). MX2007008614A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US64484005P 2005-01-18 2005-01-18
PCT/EP2006/000161 WO2006077035A1 (en) 2005-01-18 2006-01-11 Peptides with neuropeptide-2 receptor (y2r) agonist activity

Publications (1)

Publication Number Publication Date
MX2007008614A true MX2007008614A (es) 2007-09-11

Family

ID=36118121

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2007008614A MX2007008614A (es) 2005-01-18 2006-01-11 Peptidos con actividad agonista del receptor del neuropeptido-2 (y2r).

Country Status (22)

Country Link
US (1) US7410949B2 (es)
EP (1) EP1844070B1 (es)
JP (1) JP4633804B2 (es)
KR (1) KR100905380B1 (es)
CN (1) CN101107266A (es)
AR (1) AR051904A1 (es)
AT (1) ATE500268T1 (es)
AU (1) AU2006207659B2 (es)
BR (1) BRPI0606675A2 (es)
CA (1) CA2594423A1 (es)
DE (1) DE602006020407D1 (es)
DK (1) DK1844070T3 (es)
ES (1) ES2359850T3 (es)
IL (1) IL184428A0 (es)
MX (1) MX2007008614A (es)
NO (1) NO20073664L (es)
PL (1) PL1844070T3 (es)
PT (1) PT1844070E (es)
RU (1) RU2383553C2 (es)
TW (1) TWI309653B (es)
WO (1) WO2006077035A1 (es)
ZA (1) ZA200705674B (es)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ568772A (en) * 2005-12-07 2010-05-28 Hoffmann La Roche Truncated analogs of the peptide pYY3-36 that are neuropeptide-2 receptor-agonists
US8299023B2 (en) * 2008-09-17 2012-10-30 Hoffmann-La Roche Inc. Neuropeptide-2 receptor (Y-2R) agonists
JP2012507487A (ja) * 2008-11-05 2012-03-29 エフ．ホフマン−ラ ロシュ アーゲー 神経ペプチド２受容体（ｙ−２ｒ）アゴニスト及びその使用
EP2450374B9 (en) * 2009-07-02 2016-11-23 Takeda Pharmaceutical Company Limited Peptide and use thereof
EP2477643A1 (en) * 2009-09-18 2012-07-25 Novo Nordisk A/S Long-acting y2 receptor agonists
CA2776302A1 (en) * 2009-10-13 2011-04-21 F. Hoffmann-La Roche Ag Neuropeptide-2 receptor (y-2r) agonists
RS60321B1 (sr) 2010-12-16 2020-07-31 Novo Nordisk As Čvrste kompozicije koje sadrže glp-1 agonist i so n-(8-(2- hidroksibenzoil)amino)kaprilne kiseline
LT2827885T (lt) 2012-03-22 2018-10-10 Novo Nordisk A/S Glp-1 peptidų kompozicijos ir jų gavimas
CN104364239B (zh) 2012-06-13 2017-08-25 霍夫曼-拉罗奇有限公司 二氮杂螺环烷烃和氮杂螺环烷烃
CA2878442A1 (en) 2012-09-25 2014-04-03 F. Hoffmann-La Roche Ag Hexahydropyrrolo[3,4-c]pyrrole derivatives and related compounds as autotaxin (atx) inhibitors and as inhibitors of the lysophosphatidic acid (lpa) production for treating e.g. renal diseases
AR095079A1 (es) 2013-03-12 2015-09-16 Hoffmann La Roche Derivados de octahidro-pirrolo[3,4-c]-pirrol y piridina-fenilo
RU2671406C2 (ru) 2013-05-02 2018-10-31 Ново Нордиск А/С Пероральная дозированная форма соединений глюкагоноподобного пептида-1
AU2014350197B2 (en) 2013-11-15 2018-10-04 Novo Nordisk A/S Selective PYY compounds and uses thereof
EP3068795B1 (en) 2013-11-15 2019-03-06 Novo Nordisk A/S Hpyy(1-36) having a beta-homoarginine substitution at position 35
PE20160845A1 (es) 2013-11-26 2016-09-10 Hoffmann La Roche Nuevo octahidro-ciclobuta[1,2-c;3,4-c']dipirrol-2-ilo
HUE046820T2 (hu) 2014-03-26 2020-03-30 Hoffmann La Roche Biciklusos vegyületek autotaxin (ATX) és lizofoszfatidsav (LPA) termelésgátlókként
EA032357B1 (ru) 2014-03-26 2019-05-31 Ф. Хоффманн-Ля Рош Аг Конденсированные [1,4]диазепиновые соединения в качестве ингибиторов продукции аутотаксина (atx) и лизофосфатидиловой кислоты (lpa)
MA41898A (fr) 2015-04-10 2018-02-13 Hoffmann La Roche Dérivés de quinazolinone bicyclique
AR104984A1 (es) 2015-06-12 2017-08-30 Novo Nordisk As Compuestos selectivos para pyy y sus usos
MX377277B (es) 2015-09-04 2025-03-07 Hoffmann La Roche Derivados de fenoximetilo.
BR112018006034A2 (pt) 2015-09-24 2018-10-09 Hoffmann La Roche compostos bicíclicos como inibidores de atx
MA42923A (fr) 2015-09-24 2021-04-28 Hoffmann La Roche Composés bicycliques comme inhibiteurs mixtes de atx/ca
RU2725138C2 (ru) 2015-09-24 2020-06-30 Ф. Хоффманн-Ля Рош Аг Новые бициклические соединения в качестве двойных ингибиторов аутотаксина (atx)/карбоангидразы (ca)
WO2017050732A1 (en) 2015-09-24 2017-03-30 F. Hoffmann-La Roche Ag Bicyclic compounds as atx inhibitors
KR20190129924A (ko) 2017-03-16 2019-11-20 에프. 호프만-라 로슈 아게 이중 오토탁신(atx)/탄산 무수화효소(ca) 억제제로서 유용한 헤테로환형 화합물
CN110382484B (zh) 2017-03-16 2022-12-06 豪夫迈·罗氏有限公司 新的作为atx抑制剂的二环化合物
US20210171598A1 (en) 2017-12-01 2021-06-10 University Of Copenhagen Peptide hormone with one or more o-glycans
HUE063787T2 (hu) 2018-02-02 2024-01-28 Novo Nordisk As Egy GLP-1 agonistát, egy N-(8-(2-hidroxibenzoil)amino) kaprilsav sót és egy síkosítóanyagot tartalmazó szilárd készítmények
EP3800195A1 (en) 2019-10-03 2021-04-07 Universitat de Barcelona Peptide compounds for reducing side effects of cb1 receptor agonists

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US5080891A (en) 1987-08-03 1992-01-14 Ddi Pharmaceuticals, Inc. Conjugates of superoxide dismutase coupled to high molecular weight polyalkylene glycols
KR960701653A (ko) 1993-03-29 1996-03-28 발라수브라마니암 엠비카이파칸 펩타이드 yy의 유사체 및 그의 용도
US6017879A (en) * 1998-04-03 2000-01-25 B.M.R.A. Corporation B.V. Template associated NPY Y2-receptor agonists
HUP0202143A3 (en) * 1999-07-28 2003-12-29 Ortho Mcneil Pharm Inc Amine and amide derivatives as ligands for the neuropeptide y y5 receptor pharmaceutical compositions containing them and their use
WO2004066966A2 (en) * 2003-01-17 2004-08-12 Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S. Peptide yy analogs
US20090105122A1 (en) * 2003-11-25 2009-04-23 Bayer Pharmaceuticals Corporation Selective neuropeptide y2 receptor agonists
US8603969B2 (en) * 2004-02-11 2013-12-10 Amylin Pharmaceuticals, Llc Pancreatic polypeptide family motifs and polypeptides comprising the same

Also Published As

Publication number Publication date
TW200637874A (en) 2006-11-01
KR20070095422A (ko) 2007-09-28
RU2007131504A (ru) 2009-02-27
CN101107266A (zh) 2008-01-16
EP1844070B1 (en) 2011-03-02
CA2594423A1 (en) 2006-07-27
JP2008527017A (ja) 2008-07-24
AR051904A1 (es) 2007-02-14
WO2006077035A1 (en) 2006-07-27
TWI309653B (en) 2009-05-11
US7410949B2 (en) 2008-08-12
AU2006207659A1 (en) 2006-07-27
PT1844070E (pt) 2011-05-04
RU2383553C2 (ru) 2010-03-10
JP4633804B2 (ja) 2011-02-16
BRPI0606675A2 (pt) 2009-07-07
ATE500268T1 (de) 2011-03-15
IL184428A0 (en) 2007-10-31
KR100905380B1 (ko) 2009-06-30
US20060160742A1 (en) 2006-07-20
DK1844070T3 (da) 2011-06-14
WO2006077035A9 (en) 2006-10-26
DE602006020407D1 (de) 2011-04-14
NO20073664L (no) 2007-09-28
PL1844070T3 (pl) 2011-07-29
EP1844070A1 (en) 2007-10-17
ZA200705674B (en) 2009-08-26
ES2359850T3 (es) 2011-05-27
AU2006207659B2 (en) 2009-10-29

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