DK174905B1 - DNA-sekvens og fremgangsmåde til den fremstilling, gærhybridvektorer og Saccharomyces cerevisiae indeholdende sekvensen henholdsvis vektoren og fremgangsmåder til deres fremstilling samt deres anvendelse ved fremstilling af polypeptider - Google Patents

DNA-sekvens og fremgangsmåde til den fremstilling, gærhybridvektorer og Saccharomyces cerevisiae indeholdende sekvensen henholdsvis vektoren og fremgangsmåder til deres fremstilling samt deres anvendelse ved fremstilling af polypeptider Download PDF

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Publication number: DK174905B1
Authority: DK; Denmark
Prior art keywords: yeast; dna; plasmid; fragment; saccharomyces cerevisiae
Prior art date: 1982-08-09

Application number

DK198303614A

Other languages

Danish (da)

English (en)

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DK361483A (da

DK361483D0 (da

Inventor

Francois Meyer

Albert Hinnen

Bernd Meyhack

Original Assignee

Novartis Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1982-08-09

Filing date

1983-08-08

Publication date

2004-02-16

1983-06-02 Priority claimed from GB838315145A external-priority patent/GB8315145D0/en

1983-08-08 Application filed by Novartis Ag filed Critical Novartis Ag

1983-08-08 Publication of DK361483D0 publication Critical patent/DK361483D0/da

1984-02-10 Publication of DK361483A publication Critical patent/DK361483A/da

2004-02-16 Application granted granted Critical

2004-02-16 Publication of DK174905B1 publication Critical patent/DK174905B1/da

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VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 description 1
229960005486 vaccine Drugs 0.000 description 1
239000004474 valine Substances 0.000 description 1
230000003612 virological effect Effects 0.000 description 1
235000010374 vitamin B1 Nutrition 0.000 description 1
239000011691 vitamin B1 Substances 0.000 description 1
150000003722 vitamin derivatives Chemical class 0.000 description 1
101150069452 z gene Proteins 0.000 description 1
239000011701 zinc Substances 0.000 description 1
229910052725 zinc Inorganic materials 0.000 description 1
108010082737 zymolyase Proteins 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C07K14/56—IFN-alpha
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/036—Fusion polypeptide containing a localisation/targetting motif targeting to the medium outside of the cell, e.g. type III secretion
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2730/00—Reverse transcribing DNA viruses
- C12N2730/00011—Details
- C12N2730/10011—Hepadnaviridae
- C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
- C12N2730/10122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Genetics & Genomics (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Wood Science & Technology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Engineering & Computer Science (AREA)
Biotechnology (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Virology (AREA)
General Chemical & Material Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Mycology (AREA)
Biomedical Technology (AREA)
Physics & Mathematics (AREA)
Communicable Diseases (AREA)
Toxicology (AREA)
Plant Pathology (AREA)
Microbiology (AREA)
Oncology (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Saccharide Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

DK198303614A 1982-08-09 1983-08-08 DNA-sekvens og fremgangsmåde til den fremstilling, gærhybridvektorer og Saccharomyces cerevisiae indeholdende sekvensen henholdsvis vektoren og fremgangsmåder til deres fremstilling samt deres anvendelse ved fremstilling af polypeptider DK174905B1 (da)

Applications Claiming Priority (6)

Application Number	Priority Date	Filing Date	Title
GB8222883		1982-08-09
GB8222883		1982-08-09
GB8237026		1982-12-31
GB8237026		1982-12-31
GB8315145		1983-06-02
GB838315145A GB8315145D0 (en)	1982-08-09	1983-06-02	Yeast hybrid vectors

Publications (3)

Publication Number	Publication Date
DK361483D0 DK361483D0 (da)	1983-08-08
DK361483A DK361483A (da)	1984-02-10
DK174905B1 true DK174905B1 (da)	2004-02-16

Family

ID=27261693

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK198303614A DK174905B1 (da)	1982-08-09	1983-08-08	DNA-sekvens og fremgangsmåde til den fremstilling, gærhybridvektorer og Saccharomyces cerevisiae indeholdende sekvensen henholdsvis vektoren og fremgangsmåder til deres fremstilling samt deres anvendelse ved fremstilling af polypeptider

Country Status (20)

Country	Link
EP (1)	EP0100561B1 (no)
JP (2)	JPH0653073B2 (no)
AT (1)	ATE43636T1 (no)
AU (1)	AU566348B2 (no)
CA (1)	CA1341381C (no)
CY (1)	CY1451A (no)
DD (1)	DD218118A5 (no)
DE (1)	DE3379960D1 (no)
DK (1)	DK174905B1 (no)
ES (3)	ES8505724A1 (no)
FI (1)	FI80720C (no)
GB (1)	GB2125047B (no)
GR (1)	GR78924B (no)
HK (1)	HK90688A (no)
HU (1)	HU204095B (no)
IE (1)	IE55598B1 (no)
NO (1)	NO172548C (no)
NZ (1)	NZ205178A (no)
PH (1)	PH25617A (no)
PT (1)	PT77167B (no)

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GB2125047B (en) *	1982-08-09	1986-02-19	Ciba Geigy Ag	Yeast hybrid vectors and their use for the production of polypeptides
DE3381619D1 (de) *	1982-08-16	1990-07-05	Chemo Sero Therapeut Res Inst	Pendelvektor.
JPS5936699A (ja) *	1982-08-20	1984-02-28	Chemo Sero Therapeut Res Inst	シヤトルベクタ−
JPS5931799A (ja) *	1982-08-16	1984-02-20	Science & Tech Agency	Ｂ型肝炎ウイルス遺伝子を組込んだ組換えプラスミド
AU584580B2 (en) *	1982-09-08	1989-06-01	Smith Kline - Rit	Hepatitis B virus vaccine
JPS5974988A (ja) *	1982-10-20	1984-04-27	Suntory Ltd	酵母の誘導発現型プラスミドベクタ−およびその利用方法
ZA843275B (en) *	1983-05-05	1984-12-24	Hoffmann La Roche	Novel vectors for interferon expression
EP0143081B1 (en) *	1983-11-21	1989-08-23	Ciba-Geigy Ag	Synthesis of tissue plasminogen activator(tpa) by yeast
JPS60248181A (ja) *	1984-05-23	1985-12-07	Shiseido Co Ltd	酵母発現ベクタ−
US5723292A (en) *	1984-05-25	1998-03-03	Zymogenetics, Inc.	Stable DNA constructs
AU600885B2 (en) *	1984-05-25	1990-08-30	Zymogenetics Inc.	Stable DNA constructs
GB8415186D0 (en) *	1984-06-14	1984-07-18	Ciba Geigy Ag	Polypeptides
EP0188555A4 (en) *	1984-07-09	1988-04-18	Integrated Genetics Inc	YEAST CLONING VEHICLE.
EP0189463A4 (en) *	1984-07-09	1988-04-18	Jeffrey F Lemontt	YEAST CLONING VECTOR.
JPS61503002A (ja) *	1984-07-31	1986-12-25	アプライド・リサーチ・システムズ・エイアールエス・ホールディング・ナムローゼ・フェンノートシャップ	酵母クロ−ニングベクタ−
JPS61103895A (ja) *	1984-10-26	1986-05-22	Green Cross Corp:The	ＨＢｓＡｇの精製方法
ATE88754T1 (de) *	1984-12-06	1993-05-15	Fina Research	Transformierte hefen die lysozym produzieren, fuer diese transformation zu verwendende plasmide und deren verwendung.
DE3685044D1 (de) *	1985-02-01	1992-06-04	Ici Plc	Analoge interferon-polypeptide, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzungen.
GB8521496D0 (en) *	1985-08-29	1985-10-02	Ciba Geigy Ag	Repressible yeast promoters
JPS62151183A (ja) *	1985-09-18	1987-07-06	Green Cross Corp:The	酵母プロモ−タ−及び異種蛋白質の製造方法
EP0216573B1 (en) *	1985-09-18	1990-11-22	Green Cross Corporation	Yeast promoter and method of producing heterologous proteins
GB8530631D0 (en)	1985-12-12	1986-01-22	Ciba Geigy Ag	Thrombin inhibitors
GB2188049B (en) *	1986-03-15	1990-09-05	Ciba Geigy Ag	Insecticidal proteinaceous substance
EP0240224A3 (en) *	1986-03-31	1989-02-01	Interferon Sciences, Inc.	An alpha interferon analogue
US4857467A (en) *	1986-07-23	1989-08-15	Phillips Petroleum Company	Carbon and energy source markers for transformation of strains of the genes Pichia
EP0263072B1 (en)	1986-10-03	1994-03-23	Ciba-Geigy Ag	Novel lymphokine related peptides
US5013652A (en) *	1986-10-14	1991-05-07	Genex Corporation	Composite yeast vectors
ES2063161T3 (es) *	1988-03-07	1995-01-01	Ciba Geigy Ag	Proteinas modificadas.
US5180667A (en) *	1988-03-07	1993-01-19	Ciba-Geigy Corporation	Genes encoding eglin C mutants
JPH04500970A (ja)	1988-09-02	1992-02-20	ザロックフェラーユニヴァーシティ	マクロファージ由来炎症メディエーター　（ｍｉｐ―２）
JPH02145193A (ja) *	1988-11-19	1990-06-04	Lotte Confectionery Co Ltd	遺伝子の組換えによる酵母でのヒト・アルファ・インターフェロンの製造方法
AU648214B2 (en) *	1991-12-31	1994-04-14	Lucky Limited	Recombinant gene coding for human alpha interferon and expression vector thereof, etc.
EP0752853B1 (en)	1993-03-10	2005-09-21	Smithkline Beecham Corporation	Human brain phosphodiesterase
US6500645B1 (en)	1994-06-17	2002-12-31	Novo Nordisk A/S	N-terminally extended proteins expressed in yeast
AU2003272410A1 (en)	2002-09-13	2004-04-30	Cornell Research Foundation, Inc.	Using mutations to improve aspergillus phytases
DE102005030552B4 (de) *	2005-06-22	2009-05-28	Eucodis Bioscience	Selektion von Phosphatase-Aktivität
CN102059495A (zh) *	2010-11-06	2011-05-18	中国长江航运集团宜昌船厂	一种船体框架胎模及加工方法
CA2819552C (en)	2010-12-09	2023-09-26	Institut Pasteur	Mgmt-based method for obtaining high yield of recombinant protein expression
US8951752B2 (en)	2011-10-20	2015-02-10	University Of Iowa Research Foundation	N-demethyase genes and uses thereof
ES2648899T3 (es)	2011-12-09	2018-01-08	Institut Pasteur	Inmunoensayo de cribado múltiplex
EP2861740A1 (en)	2012-06-15	2015-04-22	University of Iowa Research Foundation	Caffeine responsive promoters and regulatory genes
WO2022049409A1 (en)	2020-09-02	2022-03-10	Sia Terragen	Express diagnosticum for sars-cov-2

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FR2458585A1 (fr) *	1979-06-07	1981-01-02	Pasteur Institut	Procede de production de proteines par expression des genes correspondants dans des micro-organismes et vecteurs susceptibles d'etre mis en oeuvre dans de tels procedes
WO1981002425A1 (en) *	1980-02-25	1981-09-03	R Axel	The use of eucaryotic promoter sequences in the production of proteinaceous materials
IL63270A0 (en) *	1980-08-05	1981-10-30	Univ Leland Stanford Junior	Eukaryotic autonomously replicating segment
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DK368882A (da) *	1981-08-25	1983-02-26	Alan John Kingsman	Expessions vektorer
NZ201705A (en) *	1981-08-31	1986-03-14	Genentech Inc	Recombinant dna method for production of hepatitis b surface antigen in yeast
GB2125047B (en) *	1982-08-09	1986-02-19	Ciba Geigy Ag	Yeast hybrid vectors and their use for the production of polypeptides
JPS5931799A (ja) *	1982-08-16	1984-02-20	Science & Tech Agency	Ｂ型肝炎ウイルス遺伝子を組込んだ組換えプラスミド

1983
- 1983-07-14 GB GB08319099A patent/GB2125047B/en not_active Expired
- 1983-08-05 FI FI832825A patent/FI80720C/fi not_active IP Right Cessation
- 1983-08-08 EP EP83107804A patent/EP0100561B1/en not_active Expired
- 1983-08-08 ES ES524816A patent/ES8505724A1/es not_active Expired
- 1983-08-08 AU AU17682/83A patent/AU566348B2/en not_active Expired
- 1983-08-08 AT AT83107804T patent/ATE43636T1/de not_active IP Right Cessation
- 1983-08-08 IE IE1860/83A patent/IE55598B1/en not_active IP Right Cessation
- 1983-08-08 NZ NZ205178A patent/NZ205178A/en unknown
- 1983-08-08 HU HU832799A patent/HU204095B/hu unknown
- 1983-08-08 GR GR72168A patent/GR78924B/el unknown
- 1983-08-08 CA CA000617149A patent/CA1341381C/en not_active Expired - Fee Related
- 1983-08-08 DK DK198303614A patent/DK174905B1/da not_active IP Right Cessation
- 1983-08-08 PT PT77167A patent/PT77167B/pt unknown
- 1983-08-08 NO NO832848A patent/NO172548C/no not_active IP Right Cessation
- 1983-08-08 DE DE8383107804T patent/DE3379960D1/de not_active Expired
- 1983-08-09 JP JP58144542A patent/JPH0653073B2/ja not_active Expired - Lifetime
- 1983-08-09 DD DD83253824A patent/DD218118A5/de not_active IP Right Cessation
- 1983-08-09 PH PH29374A patent/PH25617A/en unknown
1985
- 1985-03-01 ES ES540880A patent/ES8607391A1/es not_active Expired
- 1985-03-01 ES ES540881A patent/ES8607026A1/es not_active Expired
1988
- 1988-11-10 HK HK906/88A patent/HK90688A/xx not_active IP Right Cessation
1989
- 1989-03-10 CY CY1451A patent/CY1451A/en unknown
1990
- 1990-12-28 JP JP2419332A patent/JPH0813277B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
ES524816A0 (es)	1985-06-01
HK90688A (en)	1988-11-18
PT77167A (en)	1983-09-01
ES8607026A1 (es)	1986-05-16
FI832825A0 (fi)	1983-08-05
JPS5948082A (ja)	1984-03-19
IE55598B1 (en)	1990-11-21
DD218118A5 (de)	1985-01-30
EP0100561B1 (en)	1989-05-31
EP0100561A1 (en)	1984-02-15
DK361483A (da)	1984-02-10
DK361483D0 (da)	1983-08-08
NO172548C (no)	1993-08-04
GB2125047A (en)	1984-02-29
GB8319099D0 (en)	1983-08-17
ES540880A0 (es)	1986-05-16
GB2125047B (en)	1986-02-19
IE831860L (en)	1984-02-09
JPH0653073B2 (ja)	1994-07-20
AU1768283A (en)	1984-02-16
FI832825L (fi)	1984-02-10
NZ205178A (en)	1986-09-10
GR78924B (no)	1984-10-02
NO832848L (no)	1984-02-10
JPH0813277B2 (ja)	1996-02-14
ATE43636T1 (de)	1989-06-15
CY1451A (en)	1989-03-10
PT77167B (en)	1986-03-20
JPH0515379A (ja)	1993-01-26
NO172548B (no)	1993-04-26
CA1341381C (en)	2002-08-06
ES8607391A1 (es)	1986-05-16
AU566348B2 (en)	1987-10-15
FI80720C (fi)	1990-07-10
ES540881A0 (es)	1986-05-16
DE3379960D1 (en)	1989-07-06
ES8505724A1 (es)	1985-06-01
PH25617A (en)	1991-08-08
FI80720B (fi)	1990-03-30
HU204095B (en)	1991-11-28

Publication	Publication Date	Title
DK174905B1 (da)	2004-02-16	DNA-sekvens og fremgangsmåde til den fremstilling, gærhybridvektorer og Saccharomyces cerevisiae indeholdende sekvensen henholdsvis vektoren og fremgangsmåder til deres fremstilling samt deres anvendelse ved fremstilling af polypeptider
US5116750A (en)	1992-05-26	Selectable fusion protein having aminoglycoside phosphotransferase activity
EP0123544A2 (en)	1984-10-31	Process for expressing heterologous protein in yeast, expression vehicles and yeast organisms therefor
KR860001471B1 (ko)	1986-09-26	인체의 섬유아세포 인터페론(IFN-β)폴리펩티드의 제조방법
Clare et al.	1991	Production of mouse epidermal growth factor in yeast: high-level secretion using Pichia pastoris strains containing multiple gene copies
Hitzeman et al.	1983	Secretion of human interferons by yeast
DK175093B1 (da)	2004-05-24	DNA-fragment, fremgangsmåde til fremstilling deraf, gærhybridpromotor, indeholdende DNA-fragmentet, fremgangsmåde til fremstilling deraf......
NO830780L (no)	1983-09-09	Uttrykking, behandling og sekresjon av heterologt protein av gjaer
NO178035B (no)	1995-10-02	Ekspressjonsvektor, gjærcelle som er i stand til å utskille desulfatohirudin samt fremgangsmåte for fremstilling av et terapeutisk aktivt desulfatohirudin
FI105484B (fi)	2000-08-31	Pektiinilyaasin ilmentämisjärjestelmää koodittava yhdistelmä-DNA-molekyyli
EP0127304A1 (en)	1984-12-05	Process for producing heterologous protein in yeast, expression vehicle therefor, and yeast transformed therewith
US7198919B1 (en)	2007-04-03	Use of alpha factor sequences in yeast expression systems
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