DK1668017T3 - Disulfid-, sulfid-, sulfoxid- og sulfonderivater af cykliske sukkerarter og anvendelser deraf - Google Patents
Disulfid-, sulfid-, sulfoxid- og sulfonderivater af cykliske sukkerarter og anvendelser derafInfo
- Publication number
- DK1668017T3 DK1668017T3 DK04765682T DK04765682T DK1668017T3 DK 1668017 T3 DK1668017 T3 DK 1668017T3 DK 04765682 T DK04765682 T DK 04765682T DK 04765682 T DK04765682 T DK 04765682T DK 1668017 T3 DK1668017 T3 DK 1668017T3
- Authority
- DK
- Denmark
- Prior art keywords
- disulfide
- sulfoxide
- sulfide
- sulfone derivatives
- cyclic sugars
- Prior art date
Links
- BWGNESOTFCXPMA-UHFFFAOYSA-N Dihydrogen disulfide Chemical compound SS BWGNESOTFCXPMA-UHFFFAOYSA-N 0.000 title 1
- UCKMPCXJQFINFW-UHFFFAOYSA-N Sulphide Chemical compound [S-2] UCKMPCXJQFINFW-UHFFFAOYSA-N 0.000 title 1
- 235000000346 sugar Nutrition 0.000 title 1
- -1 sulfone derivatives of cyclic sugars Chemical class 0.000 title 1
- 150000003462 sulfoxides Chemical class 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Neurosurgery (AREA)
- Hospice & Palliative Care (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Toxicology (AREA)
- Psychiatry (AREA)
- Gynecology & Obstetrics (AREA)
- Reproductive Health (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES200302368A ES2258365B1 (es) | 2003-10-03 | 2003-10-03 | Derivados de disulfuro, sulfuro, sulfoxido y sulfona de azucares ciclicos y sus usos. |
| PCT/EP2004/010882 WO2005037842A1 (en) | 2003-10-03 | 2004-09-29 | Disulfide, sulfide, sulfoxide, and sulfone derivatives of cyclic sugars and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1668017T3 true DK1668017T3 (da) | 2009-05-11 |
Family
ID=34451643
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK04765682T DK1668017T3 (da) | 2003-10-03 | 2004-09-29 | Disulfid-, sulfid-, sulfoxid- og sulfonderivater af cykliske sukkerarter og anvendelser deraf |
Country Status (34)
| Country | Link |
|---|---|
| US (3) | US7521571B2 (da) |
| EP (1) | EP1668017B1 (da) |
| JP (2) | JP4809769B2 (da) |
| KR (1) | KR101141683B1 (da) |
| CN (1) | CN1863805B (da) |
| AP (1) | AP1976A (da) |
| AR (1) | AR045962A1 (da) |
| AT (1) | ATE423781T1 (da) |
| AU (1) | AU2004281916B2 (da) |
| BR (1) | BRPI0415020A (da) |
| CA (1) | CA2540500C (da) |
| DE (2) | DE602004019666D1 (da) |
| DK (1) | DK1668017T3 (da) |
| EA (1) | EA008942B1 (da) |
| EC (1) | ECSP066542A (da) |
| ES (2) | ES2258365B1 (da) |
| GB (1) | GB2421241B (da) |
| GE (1) | GEP20084490B (da) |
| GT (1) | GT200400200A (da) |
| HR (1) | HRP20090152T3 (da) |
| IL (1) | IL174371A0 (da) |
| IS (1) | IS8436A (da) |
| MX (1) | MXPA06003610A (da) |
| NO (1) | NO20061872L (da) |
| NZ (1) | NZ546043A (da) |
| PA (1) | PA8614201A1 (da) |
| PE (1) | PE20050436A1 (da) |
| PL (1) | PL1668017T3 (da) |
| PT (1) | PT1668017E (da) |
| RS (1) | RS20060241A (da) |
| SI (1) | SI1668017T1 (da) |
| UY (1) | UY28547A1 (da) |
| WO (1) | WO2005037842A1 (da) |
| ZA (1) | ZA200603475B (da) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2258365B1 (es) * | 2003-10-03 | 2007-12-01 | Lacer, S.A. | Derivados de disulfuro, sulfuro, sulfoxido y sulfona de azucares ciclicos y sus usos. |
| EP1941876A1 (en) * | 2006-12-28 | 2008-07-09 | Lacer, S.A. | Isosorbide mononitrate derivatives for the treatment of Inflammation and ocular hypertension |
| ES2332565B1 (es) * | 2007-01-23 | 2010-10-21 | Lacer, S.A. | Uso de derivados de mononitrato de dianhidrohexita como agentes antiinflamatorios. |
| EP2136780A1 (en) * | 2007-02-13 | 2009-12-30 | CV Therapeutics Inc. | Use of ranolazine for the treatment of cardiovascular diseases |
| US20090111826A1 (en) * | 2007-02-13 | 2009-04-30 | Louis Lange | Use of ranolazine for the treatment of cardiovascular diseases |
| US20080248112A1 (en) * | 2007-02-13 | 2008-10-09 | Brent Blackburn | Use of ranolazine for the treatment of coronary microvascular diseases |
| WO2008101012A1 (en) * | 2007-02-13 | 2008-08-21 | Cv Therapeutics, Inc. | Use of ranolazine for the treatment of non-coronary microvascular diseases |
| US20080233191A1 (en) * | 2007-03-22 | 2008-09-25 | Brent Blackburn | Use of ranolazine for elevated brain-type natriuretic peptide |
| CN101896181A (zh) * | 2007-05-31 | 2010-11-24 | 吉利德帕洛阿尔托股份有限公司 | 用于升高的脑钠肽的雷诺嗪 |
| IE20070934A1 (en) | 2007-12-21 | 2009-06-24 | Trinity College Dublin | Efficient aspirin prodrugs |
| EP2238143B1 (en) * | 2008-02-07 | 2012-08-15 | Nicox S.A. | Nitric oxide donor compounds |
| EP2149576A1 (en) * | 2008-07-22 | 2010-02-03 | Lacer, S.A. | Isosorbide Nitrates having vasodilating activity |
| EP2149577B1 (en) * | 2008-07-22 | 2011-04-27 | Lacer, S.A. | New stereospecific method for the preparation of dioxa-bicyclooctane compounds |
| EP2177216A1 (en) | 2008-10-13 | 2010-04-21 | Lacer, S.A. | Use of dianhydrohexite mononitrate derivatives as healing agents |
| WO2010055138A1 (en) * | 2008-11-14 | 2010-05-20 | Lacer, S.A. | New stereospecific method for the preparation of dioxa-bicyclooctane compounds |
| EP2199294A1 (en) | 2008-12-19 | 2010-06-23 | Lacer, S.A. | New stereospecific method for the preparation of dioxa bicyclooctane nitrate compounds |
| EP2515899B1 (en) * | 2009-12-23 | 2016-05-25 | ARCA biopharma, Inc. | Methods and compositions for cardiovascular diseases and conditions |
| FR2977252B1 (fr) * | 2011-06-30 | 2013-08-02 | Seppic Sa | Nouveaux esters de derives n-acyles d'acides amines et d'isosorbide, procede pour leur preparation, et utilisation en cosmetique et comme medicament. |
| WO2013090138A1 (en) | 2011-12-16 | 2013-06-20 | 3M Innovative Properties Company | Mercapto-containing bisanhydrohexitol derivatives and uses thereof |
| US20160016969A1 (en) * | 2013-03-05 | 2016-01-21 | Archer Daniels Midland Company | Isohexide monotriflates and process for synthesis thereof |
| CN116173012A (zh) * | 2022-12-05 | 2023-05-30 | 温州医科大学 | 白当归脑在制备缺血性脑卒中神经保护用药物中的应用 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3886186A (en) | 1971-04-29 | 1975-05-27 | American Home Prod | Mononitrate esters of 1,4:3,6-dianhydro-d-glucitol |
| AU465217B2 (en) * | 1971-04-29 | 1975-09-18 | American Home Products Corporation | Mononitrte esters of 1,4:3, 6-dianhydro-d-glucitol |
| DE3102947A1 (de) | 1981-01-29 | 1982-09-02 | Heinrich Mack Nachf., 7918 Illertissen | Verfahren zur herstellung von isosorbid-5-nitrat |
| IT1204571B (it) * | 1987-05-08 | 1989-03-10 | Chiesi Farma Spa | Esteri di 1,4:3,6-dianidrosorbitolo-2-mononitrato e 5-mononitrato,loro procedimento di preparazione e loro composizioni farmaceutiche |
| US4891373A (en) * | 1988-11-23 | 1990-01-02 | Pfizer Inc. | Aminopropanol derivatives of 1,4:3,6-dianhydrohexitol nitrates, processes for their preparation and their use as medicaments |
| FR2680173A1 (fr) * | 1991-08-07 | 1993-02-12 | Hoechst Lab | Nitrates organiques, leurs procedes de preparation et leur utilisation dans le traitement de maladies cardiovasculaires . |
| DE69321596T2 (de) * | 1992-07-30 | 1999-04-22 | Cal International Ltd., Dublin | Ester und kombinationen von einem organischen nitrat und einem salicyclat |
| DE4410997A1 (de) * | 1994-03-30 | 1995-10-26 | Isis Pharma Gmbh | Pharmazeutische Zubereitungen und Arzneistoffe zur Prävention und Behandlung endothelialer Dysfunktionen |
| IL120531A (en) * | 1997-03-26 | 2006-12-31 | Yissum Res Dev Co | Nitric oxide donors and pharmaceutical compositions containing them |
| ES2142773B1 (es) * | 1998-10-07 | 2001-01-01 | Lacer Sa | Derivados de mononitrato de isosorbida y su empleo como agentes vasodilatadores con tolerancia desminuida. |
| US20020013483A1 (en) * | 2000-07-13 | 2002-01-31 | Consortium Fur Elektrochemische Industrie Gmbh | Process for the preparation of dianhydrohexitol bisacylates |
| CA2421885A1 (en) * | 2000-10-27 | 2002-05-02 | Nitromed, Inc. | Methods of treating vascular diseases characterized by nitric oxide insufficiency |
| UA63467A (en) | 2003-04-22 | 2004-01-15 | Pharmaceutical composition of organic nitrates, dosage form based on pharmaceutical composition of organic nitrates and method of manufacture | |
| ES2258365B1 (es) * | 2003-10-03 | 2007-12-01 | Lacer, S.A. | Derivados de disulfuro, sulfuro, sulfoxido y sulfona de azucares ciclicos y sus usos. |
-
2003
- 2003-10-03 ES ES200302368A patent/ES2258365B1/es not_active Expired - Fee Related
-
2004
- 2004-09-29 GE GEAP20049372A patent/GEP20084490B/en unknown
- 2004-09-29 PT PT04765682T patent/PT1668017E/pt unknown
- 2004-09-29 EP EP04765682A patent/EP1668017B1/en not_active Expired - Lifetime
- 2004-09-29 SI SI200431109T patent/SI1668017T1/sl unknown
- 2004-09-29 WO PCT/EP2004/010882 patent/WO2005037842A1/en not_active Ceased
- 2004-09-29 AP AP2006003605A patent/AP1976A/xx active
- 2004-09-29 DE DE602004019666T patent/DE602004019666D1/de not_active Expired - Lifetime
- 2004-09-29 ES ES04765682T patent/ES2322468T3/es not_active Expired - Lifetime
- 2004-09-29 MX MXPA06003610A patent/MXPA06003610A/es active IP Right Grant
- 2004-09-29 DE DE112004001860T patent/DE112004001860T5/de not_active Withdrawn
- 2004-09-29 CA CA2540500A patent/CA2540500C/en not_active Expired - Fee Related
- 2004-09-29 DK DK04765682T patent/DK1668017T3/da active
- 2004-09-29 AU AU2004281916A patent/AU2004281916B2/en not_active Ceased
- 2004-09-29 JP JP2006530042A patent/JP4809769B2/ja not_active Expired - Fee Related
- 2004-09-29 AT AT04765682T patent/ATE423781T1/de not_active IP Right Cessation
- 2004-09-29 KR KR1020067006283A patent/KR101141683B1/ko not_active Expired - Fee Related
- 2004-09-29 HR HR20090152T patent/HRP20090152T3/xx unknown
- 2004-09-29 EA EA200600694A patent/EA008942B1/ru not_active IP Right Cessation
- 2004-09-29 BR BRPI0415020-1A patent/BRPI0415020A/pt not_active IP Right Cessation
- 2004-09-29 US US10/544,237 patent/US7521571B2/en not_active Expired - Fee Related
- 2004-09-29 PL PL04765682T patent/PL1668017T3/pl unknown
- 2004-09-29 CN CN2004800289355A patent/CN1863805B/zh not_active Expired - Fee Related
- 2004-09-29 RS YUP-2006/0241A patent/RS20060241A/sr unknown
- 2004-09-29 GB GB0605574A patent/GB2421241B/en not_active Expired - Fee Related
- 2004-09-29 NZ NZ546043A patent/NZ546043A/en unknown
- 2004-09-30 PE PE2004000957A patent/PE20050436A1/es not_active Application Discontinuation
- 2004-10-01 AR ARP040103576A patent/AR045962A1/es unknown
- 2004-10-01 UY UY28547A patent/UY28547A1/es not_active Application Discontinuation
- 2004-10-01 PA PA20048614201A patent/PA8614201A1/es unknown
- 2004-10-01 GT GT200400200A patent/GT200400200A/es unknown
-
2006
- 2006-03-16 IL IL174371A patent/IL174371A0/en unknown
- 2006-04-27 NO NO20061872A patent/NO20061872L/no not_active Application Discontinuation
- 2006-05-02 ZA ZA200603475A patent/ZA200603475B/xx unknown
- 2006-05-03 IS IS8436A patent/IS8436A/is unknown
- 2006-05-03 EC EC2006006542A patent/ECSP066542A/es unknown
-
2009
- 2009-03-09 US US12/400,394 patent/US7777058B2/en not_active Expired - Fee Related
-
2010
- 2010-04-06 US US12/755,103 patent/US8541607B2/en not_active Expired - Fee Related
- 2010-10-08 JP JP2010228789A patent/JP2011012081A/ja active Pending
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