DK1667790T3 - Apparat og fremgangsmåde til fremstilling af partikler - Google Patents
Apparat og fremgangsmåde til fremstilling af partiklerInfo
- Publication number
- DK1667790T3 DK1667790T3 DK04769494T DK04769494T DK1667790T3 DK 1667790 T3 DK1667790 T3 DK 1667790T3 DK 04769494 T DK04769494 T DK 04769494T DK 04769494 T DK04769494 T DK 04769494T DK 1667790 T3 DK1667790 T3 DK 1667790T3
- Authority
- DK
- Denmark
- Prior art keywords
- feeding
- particle apparatus
- inlet
- homogenising
- compartment
- Prior art date
Links
- 239000002245 particle Substances 0.000 title abstract 2
- 239000008346 aqueous phase Substances 0.000 abstract 1
- 239000012074 organic phase Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/513—Organic macromolecular compounds; Dendrimers
- A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
- A61K9/5153—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5192—Processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
- B01F23/40—Mixing liquids with liquids; Emulsifying
- B01F23/41—Emulsifying
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
- B01F25/30—Injector mixers
- B01F25/31—Injector mixers in conduits or tubes through which the main component flows
- B01F25/313—Injector mixers in conduits or tubes through which the main component flows wherein additional components are introduced in the centre of the conduit
- B01F25/3131—Injector mixers in conduits or tubes through which the main component flows wherein additional components are introduced in the centre of the conduit with additional mixing means other than injector mixers, e.g. screens, baffles or rotating elements
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
- B01F27/27—Mixers with stator-rotor systems, e.g. with intermeshing teeth or cylinders or having orifices
- B01F27/271—Mixers with stator-rotor systems, e.g. with intermeshing teeth or cylinders or having orifices with means for moving the materials to be mixed radially between the surfaces of the rotor and the stator
- B01F27/2711—Mixers with stator-rotor systems, e.g. with intermeshing teeth or cylinders or having orifices with means for moving the materials to be mixed radially between the surfaces of the rotor and the stator provided with intermeshing elements
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/71—Feed mechanisms
- B01F35/712—Feed mechanisms for feeding fluids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/71—Feed mechanisms
- B01F35/717—Feed mechanisms characterised by the means for feeding the components to the mixer
- B01F35/71825—Feed mechanisms characterised by the means for feeding the components to the mixer using means for feeding one phase surrounded by another phase without mixing during the feeding
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/75—Discharge mechanisms
- B01F35/753—Discharging at the upper side of the receptacle, e.g. by pressurising the liquid in the receptacle or by centrifugal force
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nanotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Physics & Mathematics (AREA)
- Biomedical Technology (AREA)
- Optics & Photonics (AREA)
- Composite Materials (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- General Physics & Mathematics (AREA)
- Materials Engineering (AREA)
- Crystallography & Structural Chemistry (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Processing And Handling Of Plastics And Other Materials For Molding In General (AREA)
- Colloid Chemistry (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Mixers Of The Rotary Stirring Type (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH16642003 | 2003-10-01 | ||
| PCT/IB2004/003151 WO2005032703A1 (fr) | 2003-10-01 | 2004-09-28 | Dispositif et procede pour la fabrication de particules |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1667790T3 true DK1667790T3 (da) | 2007-09-24 |
Family
ID=34398333
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK04769494T DK1667790T3 (da) | 2003-10-01 | 2004-09-28 | Apparat og fremgangsmåde til fremstilling af partikler |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20070071825A1 (da) |
| EP (1) | EP1667790B1 (da) |
| JP (1) | JP2007507339A (da) |
| KR (1) | KR20060104989A (da) |
| CN (1) | CN100534597C (da) |
| AT (1) | ATE362395T1 (da) |
| AU (1) | AU2004277750B9 (da) |
| BR (1) | BRPI0414982A (da) |
| CA (1) | CA2539303C (da) |
| DE (1) | DE602004006523T2 (da) |
| DK (1) | DK1667790T3 (da) |
| ES (1) | ES2286674T3 (da) |
| IL (1) | IL174668A (da) |
| MX (1) | MXPA06003599A (da) |
| WO (1) | WO2005032703A1 (da) |
| ZA (1) | ZA200603365B (da) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2060253A1 (en) * | 2007-11-14 | 2009-05-20 | Laboratorios Farmaceuticos Rovi, S.A. | Pharmaceutical forms for the release of active compounds |
| ES2526092T3 (es) * | 2004-11-16 | 2015-01-05 | Alkermes Pharma Ireland Limited | Formulaciones de olanzapina en nanopartículas inyectables |
| US20090028948A1 (en) * | 2004-12-31 | 2009-01-29 | Iceutica Pty Ltd | Nanoparticle composition and methods of synthesis thereof |
| US20090053272A1 (en) * | 2005-05-10 | 2009-02-26 | Basf Se | Method for producing polymer nanoparticles |
| US20070298110A1 (en) * | 2006-06-22 | 2007-12-27 | Xerox Corporation | Methods for embedding nanoparticles |
| AU2007264418B2 (en) | 2006-06-30 | 2012-05-03 | Iceutica Pty Ltd | Methods for the preparation of biologically active compounds in nanoparticulate form |
| EP2063970A1 (en) * | 2006-09-19 | 2009-06-03 | FUJIFILM Manufacturing Europe B.V. | Preparation of fine particles |
| WO2008035962A1 (en) * | 2006-09-19 | 2008-03-27 | Fujifilm Manufacturing Europe B.V. | Process and device for the precipitation of an organic compound |
| JP5076424B2 (ja) | 2006-09-28 | 2012-11-21 | 日油株式会社 | 撹拌処理方法及び撹拌装置 |
| GB0714223D0 (en) * | 2007-07-20 | 2007-08-29 | Fujifilm Mfg Europe Bv | Preparation of fine particles |
| EP2213282A1 (en) * | 2009-01-30 | 2010-08-04 | Laboratorios Farmaceuticos Rovi, S.A. | Pharmaceutical forms for the release of active compounds |
| US8802156B2 (en) | 2007-11-14 | 2014-08-12 | Laboratorios Farmacéuticos Rovi, S.A. | Pharmaceutical forms for the release of active compounds |
| WO2010009291A1 (en) * | 2008-07-16 | 2010-01-21 | Surmodics Pharmaceuticals, Inc. | Process for preparing microparticles containing bioactive peptides |
| CN101530778B (zh) * | 2009-03-09 | 2011-05-11 | 神农氏奈米科技有限公司 | 液体纳米化装置 |
| KR20120101285A (ko) | 2009-04-24 | 2012-09-13 | 아이슈티카 피티와이 리미티드 | 신규 인도메타신 제제 |
| WO2011087689A2 (en) * | 2009-12-22 | 2011-07-21 | Surmodics Pharmaceuticals,Inc. | Emulsion-based process for preparing microparticles and workhead assembly for use with same |
| SG181949A1 (en) * | 2010-01-20 | 2012-07-30 | Xyleco Inc | Dispersing feedstocks and processing materials |
| MX362286B (es) * | 2011-11-18 | 2019-01-10 | Regeneron Pharma | Microparticulas de polimero y proteina. |
| CN104549078B (zh) * | 2013-10-10 | 2016-11-23 | 南京理工大学 | 一种开孔结构含能高分子微球的制备方法 |
| CN103521149B (zh) * | 2013-10-10 | 2015-11-04 | 南京理工大学 | 含能高分子微球的制备方法 |
| CN103553853B (zh) * | 2013-11-01 | 2016-04-20 | 南京理工大学 | 水溶性氧化剂在含能复合材料中的原位超细化分散方法 |
| CN103787799B (zh) * | 2014-01-22 | 2016-07-06 | 南京理工大学 | 含能高分子微球的连续制备系统及方法 |
| US9526734B2 (en) | 2014-06-09 | 2016-12-27 | Iceutica Pty Ltd. | Formulation of meloxicam |
| CN106475574B (zh) * | 2016-11-30 | 2018-06-08 | 燕山大学 | 一种制备金纳米花的方法 |
| CN112587505A (zh) * | 2020-10-16 | 2021-04-02 | 长春斯菲尔生物科技有限公司 | 一种奥氮平双羟萘酸盐缓释微粒制剂及其制备方法 |
| US20220362323A1 (en) * | 2021-05-02 | 2022-11-17 | Kula Llc | Systems and methods for producing a kava liquid dietary supplement |
| US11801514B1 (en) | 2023-02-10 | 2023-10-31 | CR Nano, Inc. | Mechanochemical production of tunable planar materials |
| WO2024260204A1 (zh) * | 2023-06-22 | 2024-12-26 | 台湾创新材料股份有限公司 | 一种微液滴产生装置和方法 |
| WO2025017533A1 (en) * | 2023-07-20 | 2025-01-23 | Ferring B.V. | Extended release drug-loaded microparticles |
| WO2025099253A1 (en) * | 2023-11-08 | 2025-05-15 | Debiopharm International Sa | Novel composition |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2641453A (en) * | 1951-04-21 | 1953-06-09 | Nat Gypsum Co | Pin mixer |
| JPS5323382B2 (da) * | 1972-07-03 | 1978-07-14 | ||
| DE2516561C3 (de) * | 1975-04-16 | 1979-10-11 | Basf Ag, 6700 Ludwigshafen | Verfahren zur Herstellung von Fibrillen aus Polymerisaten |
| US4141957A (en) * | 1976-06-29 | 1979-02-27 | Isovolta Osterreichische Isolierstoffwerke Aktiengesellschaft | Apparatus for producing polymers of high molecular weight by the two-phase interfacial method |
| SE445052C (sv) * | 1980-03-13 | 1987-11-09 | Sunds Defibrator | Sett och anordning for kontinuerlig inblandning av gas- och/eller vetskeformiga behandlingsmedel i en massasuspension |
| US4384975A (en) * | 1980-06-13 | 1983-05-24 | Sandoz, Inc. | Process for preparation of microspheres |
| FI61814C (fi) * | 1980-07-22 | 1982-10-11 | Finnreg Oy | Emulgeringsanordning |
| WO1991000297A1 (en) * | 1989-06-30 | 1991-01-10 | Loyola University Of Chicago | Improved cellulose chromatography support |
| WO1993010665A1 (en) * | 1991-12-03 | 1993-06-10 | Niro A/S | Process for producing a solid water-in-oil emulsion and an apparatus for carrying out the process |
| US5916596A (en) * | 1993-02-22 | 1999-06-29 | Vivorx Pharmaceuticals, Inc. | Protein stabilized pharmacologically active agents, methods for the preparation thereof and methods for the use thereof |
| AU668062B2 (en) * | 1994-03-07 | 1996-04-18 | Morton International, Inc. | Polyester dispersions, method of preparation |
| ES2078190B1 (es) * | 1994-05-20 | 1996-08-01 | Cusi Lab | Procedimiento para el recubrimiento de goticulas o particulas de tamaño nanometrico. |
| DE19616010C2 (de) * | 1996-04-23 | 1998-07-09 | Seitz Filter Werke | Verfahren und Vorrichtung zur Herstellung von Fibrets (Fibriden) aus Zellulosederivaten |
| US5945126A (en) * | 1997-02-13 | 1999-08-31 | Oakwood Laboratories L.L.C. | Continuous microsphere process |
| JP3255072B2 (ja) * | 1997-02-17 | 2002-02-12 | 日本ピー・エム・シー株式会社 | ロジン系物質の水性エマルションの製造方法、その水性エマルション組成物及びサイズ剤 |
| JP4587111B2 (ja) * | 2000-04-06 | 2010-11-24 | 栗田工業株式会社 | オゾン溶解水供給装置 |
| DE60210794T2 (de) * | 2001-10-17 | 2007-05-10 | E.I. Dupont De Nemours And Co., Wilmington | Rotor-stator apparat und verfahren zur bildung von partikeln |
-
2004
- 2004-09-28 EP EP04769494A patent/EP1667790B1/fr not_active Expired - Lifetime
- 2004-09-28 WO PCT/IB2004/003151 patent/WO2005032703A1/fr not_active Ceased
- 2004-09-28 CN CNB2004800288598A patent/CN100534597C/zh not_active Expired - Fee Related
- 2004-09-28 BR BRPI0414982-3A patent/BRPI0414982A/pt not_active IP Right Cessation
- 2004-09-28 ES ES04769494T patent/ES2286674T3/es not_active Expired - Lifetime
- 2004-09-28 JP JP2006530736A patent/JP2007507339A/ja active Pending
- 2004-09-28 DK DK04769494T patent/DK1667790T3/da active
- 2004-09-28 MX MXPA06003599A patent/MXPA06003599A/es active IP Right Grant
- 2004-09-28 AU AU2004277750A patent/AU2004277750B9/en not_active Ceased
- 2004-09-28 DE DE602004006523T patent/DE602004006523T2/de not_active Expired - Lifetime
- 2004-09-28 CA CA2539303A patent/CA2539303C/fr not_active Expired - Fee Related
- 2004-09-28 KR KR1020067006288A patent/KR20060104989A/ko not_active Abandoned
- 2004-09-28 AT AT04769494T patent/ATE362395T1/de active
- 2004-09-28 US US10/574,003 patent/US20070071825A1/en not_active Abandoned
-
2006
- 2006-03-30 IL IL174668A patent/IL174668A/en not_active IP Right Cessation
- 2006-04-26 ZA ZA200603365A patent/ZA200603365B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2004277750B2 (en) | 2010-03-11 |
| EP1667790A1 (fr) | 2006-06-14 |
| US20070071825A1 (en) | 2007-03-29 |
| JP2007507339A (ja) | 2007-03-29 |
| CA2539303A1 (fr) | 2005-04-14 |
| KR20060104989A (ko) | 2006-10-09 |
| DE602004006523D1 (de) | 2007-06-28 |
| CN1863588A (zh) | 2006-11-15 |
| AU2004277750A1 (en) | 2005-04-14 |
| AU2004277750B9 (en) | 2010-07-15 |
| BRPI0414982A (pt) | 2006-11-21 |
| IL174668A0 (en) | 2006-08-20 |
| EP1667790B1 (fr) | 2007-05-16 |
| IL174668A (en) | 2010-12-30 |
| CA2539303C (fr) | 2012-07-17 |
| ATE362395T1 (de) | 2007-06-15 |
| CN100534597C (zh) | 2009-09-02 |
| WO2005032703A1 (fr) | 2005-04-14 |
| ZA200603365B (en) | 2007-07-25 |
| DE602004006523T2 (de) | 2008-01-31 |
| MXPA06003599A (es) | 2006-06-20 |
| ES2286674T3 (es) | 2007-12-01 |
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