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DK1667790T3 - Apparat og fremgangsmåde til fremstilling af partikler - Google Patents

Apparat og fremgangsmåde til fremstilling af partikler

Info

Publication number
DK1667790T3
DK1667790T3 DK04769494T DK04769494T DK1667790T3 DK 1667790 T3 DK1667790 T3 DK 1667790T3 DK 04769494 T DK04769494 T DK 04769494T DK 04769494 T DK04769494 T DK 04769494T DK 1667790 T3 DK1667790 T3 DK 1667790T3
Authority
DK
Denmark
Prior art keywords
feeding
particle apparatus
inlet
homogenising
compartment
Prior art date
Application number
DK04769494T
Other languages
English (en)
Inventor
Catherine Curdy
Bertrand Ducrey
Frederic Heimgartner
Francois Pfefferle
Original Assignee
Debio Rech Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Debio Rech Pharma Sa filed Critical Debio Rech Pharma Sa
Application granted granted Critical
Publication of DK1667790T3 publication Critical patent/DK1667790T3/da

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51Nanocapsules; Nanoparticles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682Processes
    • A61K9/1694Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51Nanocapsules; Nanoparticles
    • A61K9/5107Excipients; Inactive ingredients
    • A61K9/513Organic macromolecular compounds; Dendrimers
    • A61K9/5146Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A61K9/5153Polyesters, e.g. poly(lactide-co-glycolide)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51Nanocapsules; Nanoparticles
    • A61K9/5192Processes
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/40Mixing liquids with liquids; Emulsifying
    • B01F23/41Emulsifying
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/30Injector mixers
    • B01F25/31Injector mixers in conduits or tubes through which the main component flows
    • B01F25/313Injector mixers in conduits or tubes through which the main component flows wherein additional components are introduced in the centre of the conduit
    • B01F25/3131Injector mixers in conduits or tubes through which the main component flows wherein additional components are introduced in the centre of the conduit with additional mixing means other than injector mixers, e.g. screens, baffles or rotating elements
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F27/00Mixers with rotary stirring devices in fixed receptacles; Kneaders
    • B01F27/27Mixers with stator-rotor systems, e.g. with intermeshing teeth or cylinders or having orifices
    • B01F27/271Mixers with stator-rotor systems, e.g. with intermeshing teeth or cylinders or having orifices with means for moving the materials to be mixed radially between the surfaces of the rotor and the stator
    • B01F27/2711Mixers with stator-rotor systems, e.g. with intermeshing teeth or cylinders or having orifices with means for moving the materials to be mixed radially between the surfaces of the rotor and the stator provided with intermeshing elements
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71Feed mechanisms
    • B01F35/712Feed mechanisms for feeding fluids
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71Feed mechanisms
    • B01F35/717Feed mechanisms characterised by the means for feeding the components to the mixer
    • B01F35/71825Feed mechanisms characterised by the means for feeding the components to the mixer using means for feeding one phase surrounded by another phase without mixing during the feeding
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/75Discharge mechanisms
    • B01F35/753Discharging at the upper side of the receptacle, e.g. by pressurising the liquid in the receptacle or by centrifugal force
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B82NANOTECHNOLOGY
    • B82YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00Nanotechnology for materials or surface science, e.g. nanocomposites
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1629Organic macromolecular compounds
    • A61K9/1635Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1629Organic macromolecular compounds
    • A61K9/1641Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647Polyesters, e.g. poly(lactide-co-glycolide)
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B82NANOTECHNOLOGY
    • B82YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nanotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Optics & Photonics (AREA)
  • Composite Materials (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • General Physics & Mathematics (AREA)
  • Materials Engineering (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Processing And Handling Of Plastics And Other Materials For Molding In General (AREA)
  • Colloid Chemistry (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Mixers Of The Rotary Stirring Type (AREA)
DK04769494T 2003-10-01 2004-09-28 Apparat og fremgangsmåde til fremstilling af partikler DK1667790T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH16642003 2003-10-01
PCT/IB2004/003151 WO2005032703A1 (fr) 2003-10-01 2004-09-28 Dispositif et procede pour la fabrication de particules

Publications (1)

Publication Number Publication Date
DK1667790T3 true DK1667790T3 (da) 2007-09-24

Family

ID=34398333

Family Applications (1)

Application Number Title Priority Date Filing Date
DK04769494T DK1667790T3 (da) 2003-10-01 2004-09-28 Apparat og fremgangsmåde til fremstilling af partikler

Country Status (16)

Country Link
US (1) US20070071825A1 (da)
EP (1) EP1667790B1 (da)
JP (1) JP2007507339A (da)
KR (1) KR20060104989A (da)
CN (1) CN100534597C (da)
AT (1) ATE362395T1 (da)
AU (1) AU2004277750B9 (da)
BR (1) BRPI0414982A (da)
CA (1) CA2539303C (da)
DE (1) DE602004006523T2 (da)
DK (1) DK1667790T3 (da)
ES (1) ES2286674T3 (da)
IL (1) IL174668A (da)
MX (1) MXPA06003599A (da)
WO (1) WO2005032703A1 (da)
ZA (1) ZA200603365B (da)

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EP2060253A1 (en) * 2007-11-14 2009-05-20 Laboratorios Farmaceuticos Rovi, S.A. Pharmaceutical forms for the release of active compounds
ES2526092T3 (es) * 2004-11-16 2015-01-05 Alkermes Pharma Ireland Limited Formulaciones de olanzapina en nanopartículas inyectables
US20090028948A1 (en) * 2004-12-31 2009-01-29 Iceutica Pty Ltd Nanoparticle composition and methods of synthesis thereof
US20090053272A1 (en) * 2005-05-10 2009-02-26 Basf Se Method for producing polymer nanoparticles
US20070298110A1 (en) * 2006-06-22 2007-12-27 Xerox Corporation Methods for embedding nanoparticles
AU2007264418B2 (en) 2006-06-30 2012-05-03 Iceutica Pty Ltd Methods for the preparation of biologically active compounds in nanoparticulate form
EP2063970A1 (en) * 2006-09-19 2009-06-03 FUJIFILM Manufacturing Europe B.V. Preparation of fine particles
WO2008035962A1 (en) * 2006-09-19 2008-03-27 Fujifilm Manufacturing Europe B.V. Process and device for the precipitation of an organic compound
JP5076424B2 (ja) 2006-09-28 2012-11-21 日油株式会社 撹拌処理方法及び撹拌装置
GB0714223D0 (en) * 2007-07-20 2007-08-29 Fujifilm Mfg Europe Bv Preparation of fine particles
EP2213282A1 (en) * 2009-01-30 2010-08-04 Laboratorios Farmaceuticos Rovi, S.A. Pharmaceutical forms for the release of active compounds
US8802156B2 (en) 2007-11-14 2014-08-12 Laboratorios Farmacéuticos Rovi, S.A. Pharmaceutical forms for the release of active compounds
WO2010009291A1 (en) * 2008-07-16 2010-01-21 Surmodics Pharmaceuticals, Inc. Process for preparing microparticles containing bioactive peptides
CN101530778B (zh) * 2009-03-09 2011-05-11 神农氏奈米科技有限公司 液体纳米化装置
KR20120101285A (ko) 2009-04-24 2012-09-13 아이슈티카 피티와이 리미티드 신규 인도메타신 제제
WO2011087689A2 (en) * 2009-12-22 2011-07-21 Surmodics Pharmaceuticals,Inc. Emulsion-based process for preparing microparticles and workhead assembly for use with same
SG181949A1 (en) * 2010-01-20 2012-07-30 Xyleco Inc Dispersing feedstocks and processing materials
MX362286B (es) * 2011-11-18 2019-01-10 Regeneron Pharma Microparticulas de polimero y proteina.
CN104549078B (zh) * 2013-10-10 2016-11-23 南京理工大学 一种开孔结构含能高分子微球的制备方法
CN103521149B (zh) * 2013-10-10 2015-11-04 南京理工大学 含能高分子微球的制备方法
CN103553853B (zh) * 2013-11-01 2016-04-20 南京理工大学 水溶性氧化剂在含能复合材料中的原位超细化分散方法
CN103787799B (zh) * 2014-01-22 2016-07-06 南京理工大学 含能高分子微球的连续制备系统及方法
US9526734B2 (en) 2014-06-09 2016-12-27 Iceutica Pty Ltd. Formulation of meloxicam
CN106475574B (zh) * 2016-11-30 2018-06-08 燕山大学 一种制备金纳米花的方法
CN112587505A (zh) * 2020-10-16 2021-04-02 长春斯菲尔生物科技有限公司 一种奥氮平双羟萘酸盐缓释微粒制剂及其制备方法
US20220362323A1 (en) * 2021-05-02 2022-11-17 Kula Llc Systems and methods for producing a kava liquid dietary supplement
US11801514B1 (en) 2023-02-10 2023-10-31 CR Nano, Inc. Mechanochemical production of tunable planar materials
WO2024260204A1 (zh) * 2023-06-22 2024-12-26 台湾创新材料股份有限公司 一种微液滴产生装置和方法
WO2025017533A1 (en) * 2023-07-20 2025-01-23 Ferring B.V. Extended release drug-loaded microparticles
WO2025099253A1 (en) * 2023-11-08 2025-05-15 Debiopharm International Sa Novel composition

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Also Published As

Publication number Publication date
AU2004277750B2 (en) 2010-03-11
EP1667790A1 (fr) 2006-06-14
US20070071825A1 (en) 2007-03-29
JP2007507339A (ja) 2007-03-29
CA2539303A1 (fr) 2005-04-14
KR20060104989A (ko) 2006-10-09
DE602004006523D1 (de) 2007-06-28
CN1863588A (zh) 2006-11-15
AU2004277750A1 (en) 2005-04-14
AU2004277750B9 (en) 2010-07-15
BRPI0414982A (pt) 2006-11-21
IL174668A0 (en) 2006-08-20
EP1667790B1 (fr) 2007-05-16
IL174668A (en) 2010-12-30
CA2539303C (fr) 2012-07-17
ATE362395T1 (de) 2007-06-15
CN100534597C (zh) 2009-09-02
WO2005032703A1 (fr) 2005-04-14
ZA200603365B (en) 2007-07-25
DE602004006523T2 (de) 2008-01-31
MXPA06003599A (es) 2006-06-20
ES2286674T3 (es) 2007-12-01

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