DK1583748T3 - Fremgangsmåde til fremstilling af 1,2-dichlorethanfrie krystaller af zonisamid og særdeles rene krystaller af zonisamid - Google Patents
Fremgangsmåde til fremstilling af 1,2-dichlorethanfrie krystaller af zonisamid og særdeles rene krystaller af zonisamidInfo
- Publication number
- DK1583748T3 DK1583748T3 DK03815138.7T DK03815138T DK1583748T3 DK 1583748 T3 DK1583748 T3 DK 1583748T3 DK 03815138 T DK03815138 T DK 03815138T DK 1583748 T3 DK1583748 T3 DK 1583748T3
- Authority
- DK
- Denmark
- Prior art keywords
- zonisamide
- crystals
- dichloroethane
- preparation
- extremely pure
- Prior art date
Links
- 239000013078 crystal Substances 0.000 title abstract 5
- UBQNRHZMVUUOMG-UHFFFAOYSA-N zonisamide Chemical compound C1=CC=C2C(CS(=O)(=O)N)=NOC2=C1 UBQNRHZMVUUOMG-UHFFFAOYSA-N 0.000 title abstract 4
- 229960002911 zonisamide Drugs 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- WSLDOOZREJYCGB-UHFFFAOYSA-N 1,2-Dichloroethane Chemical compound ClCCCl WSLDOOZREJYCGB-UHFFFAOYSA-N 0.000 abstract 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- 238000010533 azeotropic distillation Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pain & Pain Management (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34060103A | 2003-01-13 | 2003-01-13 | |
| PCT/JP2003/009530 WO2004063174A1 (en) | 2003-01-13 | 2003-07-28 | Process for the preparation of 1,2-dichloroethane free crystals of zonisamide and the highly pure crystals of zonisamide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1583748T3 true DK1583748T3 (da) | 2010-04-19 |
Family
ID=32711361
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK03815138.7T DK1583748T3 (da) | 2003-01-13 | 2003-07-28 | Fremgangsmåde til fremstilling af 1,2-dichlorethanfrie krystaller af zonisamid og særdeles rene krystaller af zonisamid |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US20050080269A1 (da) |
| EP (1) | EP1583748B1 (da) |
| KR (1) | KR101004187B1 (da) |
| CN (1) | CN100528849C (da) |
| AT (1) | ATE457304T1 (da) |
| AU (1) | AU2003249010A1 (da) |
| CY (1) | CY1110007T1 (da) |
| DE (1) | DE60331257D1 (da) |
| DK (1) | DK1583748T3 (da) |
| ES (1) | ES2338871T3 (da) |
| IL (1) | IL169451A (da) |
| PT (1) | PT1583748E (da) |
| SI (1) | SI1583748T1 (da) |
| TW (1) | TWI331035B (da) |
| WO (1) | WO2004063174A1 (da) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060188569A1 (en) * | 2005-01-21 | 2006-08-24 | Teva Pharmaceutical Industries Ltd. | Stable pharmaceutical formulations of zonisamide and methods for their manufacture |
| EP1913935A1 (en) * | 2005-01-21 | 2008-04-23 | Teva Pharmaceutical Industries Ltd | Stable pharmaceutical formulations of zonisamide and methods for their manufacture |
| US7268234B2 (en) * | 2005-09-16 | 2007-09-11 | Dainippon Sumitomo Pharma Co., Ltd. | Method for sulfonation of 1,2-benzisoxazole-3-acetic acid |
| CN104059120A (zh) * | 2014-05-27 | 2014-09-24 | 上海新华联制药有限公司 | 一种高纯度倍他米松醋酸酯制备工艺 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6033114B2 (ja) | 1976-12-16 | 1985-08-01 | 大日本製薬株式会社 | 1,2−ベンズイソキサゾ−ル誘導体 |
| US4172896A (en) * | 1978-06-05 | 1979-10-30 | Dainippon Pharmaceutical Co., Ltd. | Methane-sulfonamide derivatives, the preparation thereof and composition comprising the same |
| FR2428033A1 (fr) | 1978-06-09 | 1980-01-04 | Dainippon Pharmaceutical Co | Nouveaux derives heterocycliques de methanesulfonamide utiles notamment comme anticonvulsivants et leur procede de preparation |
| JPS54163823A (en) | 1978-06-12 | 1979-12-26 | Dainippon Pharmaceutical Co | Antiiepileptic agent based on 33sulphamoylmethyll 1*22benzisoxazole |
| JPS54163570A (en) | 1978-06-12 | 1979-12-26 | Dainippon Pharmaceutical Co | Benzooxazole derivative |
| US4533764A (en) | 1984-03-29 | 1985-08-06 | The Dow Chemical Company | Purification of bisphenols by removing residual solvent |
| GB8607294D0 (en) * | 1985-04-17 | 1986-04-30 | Ici America Inc | Heterocyclic amide derivatives |
| JPS63150220A (ja) | 1986-12-15 | 1988-06-22 | Dainippon Pharmaceut Co Ltd | 経口用固形製剤の製造方法 |
| US5082669A (en) | 1989-07-20 | 1992-01-21 | Dainippon Pharmaceutical Co., Ltd. | Rapid-releasing oral particle pharmaceutical preparation with unpleasant taste masked |
| US5811547A (en) | 1992-10-14 | 1998-09-22 | Nippon Shinyaju Co., Ltd. | Method for inducing crystalline state transition in medicinal substance |
| TW350757B (en) * | 1994-11-03 | 1999-01-21 | Ciba Geigy Ag | Benzisoxazole derivatives and pesticidal compositions containing them |
| AU5066101A (en) | 2000-04-13 | 2001-10-30 | Synthon B.V. | Modified release formulations containing a hypnotic agent |
| WO2003002116A1 (en) * | 2001-06-29 | 2003-01-09 | Elan Pharmaceuticals, Inc. | Zonisamide use in headache |
| JP2005506980A (ja) | 2001-08-30 | 2005-03-10 | テバ ファーマシューティカル インダストリーズ リミティド | ゾニスアミド中間体及び合成 |
| MXPA04008109A (es) * | 2002-02-22 | 2004-11-26 | Teva Pharma | Metodo para preparar cloruro de bencisoxasol metano sulfonilo y su amidacion para formar zonisamida. |
-
2003
- 2003-07-28 DK DK03815138.7T patent/DK1583748T3/da active
- 2003-07-28 WO PCT/JP2003/009530 patent/WO2004063174A1/en not_active Ceased
- 2003-07-28 CN CNB038257890A patent/CN100528849C/zh not_active Expired - Lifetime
- 2003-07-28 AU AU2003249010A patent/AU2003249010A1/en not_active Abandoned
- 2003-07-28 EP EP03815138A patent/EP1583748B1/en not_active Expired - Lifetime
- 2003-07-28 PT PT03815138T patent/PT1583748E/pt unknown
- 2003-07-28 DE DE60331257T patent/DE60331257D1/de not_active Expired - Lifetime
- 2003-07-28 ES ES03815138T patent/ES2338871T3/es not_active Expired - Lifetime
- 2003-07-28 SI SI200331754T patent/SI1583748T1/sl unknown
- 2003-07-28 AT AT03815138T patent/ATE457304T1/de active
- 2003-07-28 KR KR1020057012737A patent/KR101004187B1/ko not_active Expired - Fee Related
- 2003-07-29 TW TW092120721A patent/TWI331035B/zh not_active IP Right Cessation
- 2003-08-08 US US10/636,593 patent/US20050080269A1/en not_active Abandoned
- 2003-12-12 US US10/733,566 patent/US20040138474A1/en not_active Abandoned
- 2003-12-12 US US10/733,565 patent/US6900333B2/en not_active Expired - Lifetime
-
2005
- 2005-06-29 IL IL169451A patent/IL169451A/en active IP Right Grant
-
2010
- 2010-04-16 CY CY20101100345T patent/CY1110007T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HK1081555A1 (en) | 2006-05-19 |
| TWI331035B (en) | 2010-10-01 |
| WO2004063174A1 (en) | 2004-07-29 |
| EP1583748B1 (en) | 2010-02-10 |
| IL169451A (en) | 2010-12-30 |
| PT1583748E (pt) | 2010-03-03 |
| KR101004187B1 (ko) | 2010-12-24 |
| US6900333B2 (en) | 2005-05-31 |
| EP1583748A4 (en) | 2006-12-06 |
| SI1583748T1 (sl) | 2010-03-31 |
| DE60331257D1 (de) | 2010-03-25 |
| US20040138473A1 (en) | 2004-07-15 |
| KR20050098862A (ko) | 2005-10-12 |
| US20050080269A1 (en) | 2005-04-14 |
| EP1583748A1 (en) | 2005-10-12 |
| CN100528849C (zh) | 2009-08-19 |
| AU2003249010A1 (en) | 2004-08-10 |
| CN1720239A (zh) | 2006-01-11 |
| TW200412341A (en) | 2004-07-16 |
| ES2338871T3 (es) | 2010-05-13 |
| US20040138474A1 (en) | 2004-07-15 |
| CY1110007T1 (el) | 2015-01-14 |
| ATE457304T1 (de) | 2010-02-15 |
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