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TW200637559A - 3-propenylcefem derivative - Google Patents

3-propenylcefem derivative

Info

Publication number
TW200637559A
TW200637559A TW095110632A TW95110632A TW200637559A TW 200637559 A TW200637559 A TW 200637559A TW 095110632 A TW095110632 A TW 095110632A TW 95110632 A TW95110632 A TW 95110632A TW 200637559 A TW200637559 A TW 200637559A
Authority
TW
Taiwan
Prior art keywords
group
following formula
single bond
optionally substituted
acyl
Prior art date
Application number
TW095110632A
Other languages
Chinese (zh)
Inventor
Koji Ishikura
Kenji Yamawaki
Katsuki Yokoo
Shuji Yonezawa
Makoto Kii
Original Assignee
Shionogi & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi & Co filed Critical Shionogi & Co
Publication of TW200637559A publication Critical patent/TW200637559A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

The present invention provides a compound with the following formula: (wherein Acyl represents an acyl group, which can used in the β-lactam field; T represents S, SO or O; the group of the following formula: , represents a hetercycle group having a cationic N atom in ring, which can be substituted by a group other than "-Y1-Ar1-Y2-R1"; each of the Y1 and Y2 represents: (1) a single bond, (2) a group which contains hetero atom selected from -NR2, -CO-, -NR2CO-, -CONR2-, -NR2CONR3-, -NR2SO2-, -SO2NR2-, -NR2SO2NR3-, (each of the R2 and R3 represents a hydrogen or a lower alkyl group), -O-, -S-, -SO-, and -SO2-, or (3) a lower alkyl group or a lower alkenyl group which may mediated with a hetero-atom containing group of the (2); Ar1 represents a single bond or an optionally substituted carbon cyclic group or an optionally substituted heterocyclic group; R1 represents -CONHCN, -C(OH)=NCN, or -COOH, and the biological equivalent acidic group thereof; wave line represents cis, trans or their mixture).
TW095110632A 2005-03-29 2006-03-28 3-propenylcefem derivative TW200637559A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2005093962 2005-03-29
JP2005226577 2005-08-04

Publications (1)

Publication Number Publication Date
TW200637559A true TW200637559A (en) 2006-11-01

Family

ID=37053397

Family Applications (1)

Application Number Title Priority Date Filing Date
TW095110632A TW200637559A (en) 2005-03-29 2006-03-28 3-propenylcefem derivative

Country Status (3)

Country Link
JP (1) JP3928086B2 (en)
TW (1) TW200637559A (en)
WO (1) WO2006104141A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107501171A (en) * 2017-08-15 2017-12-22 南京红太阳生物化学有限责任公司 A kind of synthetic method of the pyridine carboxaldehyde of 2 chlorine 3

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1937643T3 (en) 2006-03-16 2016-10-10 Second Genome Inc Bicycloheteroarylforbindelser som p2x7-modulatorer og anvendelser deraf
WO2008011560A2 (en) * 2006-07-20 2008-01-24 Mehmet Kahraman Benzothiophene inhibitors of rho kinase
BRPI0921701B8 (en) 2008-10-31 2022-11-29 Shionogi & Co Cepharosporin having a catechol group, its use and pharmaceutical composition comprising it
WO2011031745A1 (en) 2009-09-09 2011-03-17 Achaogen, Inc. Antibacterial fluoroquinolone analogs
US8883773B2 (en) 2010-04-05 2014-11-11 Shionogi & Co., Ltd. Cephem compound having pseudo-catechol group
AU2011236933A1 (en) 2010-04-05 2013-05-02 Shionogi & Co., Ltd. Cephem compound having catechol group
DK2588465T3 (en) 2010-06-30 2017-05-01 Ironwood Pharmaceuticals Inc SGC stimulators
JP2012041325A (en) * 2010-08-23 2012-03-01 Bayer Cropscience Ag Oxadiazolinone derivative and controlling application of pest
WO2012052412A1 (en) 2010-10-22 2012-04-26 Bayer Cropscience Ag Novel heterocyclic compounds as pesticides
RU2582679C2 (en) 2010-11-09 2016-04-27 Айронвуд Фармасьютикалз, Инк. sGC STIMULATORS
CA2833121A1 (en) * 2011-04-28 2012-11-01 Shionogi & Co., Ltd. Novel cephem compound having catechol or pseudo-catechol structure
US9242999B2 (en) 2011-06-27 2016-01-26 Shionogi & Co., Ltd. Cephem compound having pyridinium group
EP2797915B1 (en) 2011-12-27 2016-07-13 Ironwood Pharmaceuticals, Inc. 2-benzyl-3-(oxazole/thiazole)-5-(pyrimidin-2-yl)-1(H)-pyrazole derivatives as stimulators of the soluble guanylate cyclase (sGC) for the treatment of e.g. hypertension or heart failure
SG11201507221VA (en) 2013-03-13 2015-10-29 Theravance Biopharma Antibiotics Ip Llc Crystalline form of a substituted thiazolylacetic acid triethylamine salt
WO2014154723A1 (en) * 2013-03-29 2014-10-02 F. Hoffmann-La Roche Ag Novel pyrrole derivatives for the treatment of cancer
EP3016951B1 (en) 2013-07-02 2017-05-31 Bristol-Myers Squibb Company Tricyclic pyrido-carboxamide derivatives as rock inhibitors
EP3016950B1 (en) 2013-07-02 2017-06-07 Bristol-Myers Squibb Company Tricyclic pyrido-carboxamide derivatives as rock inhibitors
CN104478795A (en) * 2014-11-24 2015-04-01 苏州乔纳森新材料科技有限公司 Preparation method of 2-chloro nicotinaldehyde
CN104513194A (en) * 2014-11-29 2015-04-15 南京红太阳生物化学有限责任公司 2-chloro-3-aldehyde pyridine synthetic method
WO2016141279A1 (en) * 2015-03-04 2016-09-09 Dana-Farber Cancer Institute, Inc. Salicylate inhibitors of melk and methods of use

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA826538B (en) * 1981-09-08 1984-04-25 Lilly Co Eli Thieno and furopyridinium-substituted cephalosporin derivatives
GB2112382B (en) * 1981-11-06 1985-03-06 Erba Farmitalia Ergoline derivatives
WO1986005184A1 (en) * 1985-03-01 1986-09-12 Takeda Chemical Industries, Ltd. Antibacterial compound
JPS62158291A (en) * 1986-01-07 1987-07-14 Sagami Chem Res Center Cephalosporin derivative
FR2663332B1 (en) * 1990-06-15 1997-11-07 Roussel Uclaf NOVEL CEPHALOSPORINS COMPRISING IN POSITION 3 A RADICAL PROPENYL SUBSTITUTED BY A QUATERNARY AMMONIUM, THEIR PREPARATION PROCESS, THEIR APPLICATION AS MEDICAMENTS, THE COMPOSITIONS CONTAINING THEM AND THE NEW INTERMEDIATES OBTAINED.
JPH0741484A (en) * 1993-07-29 1995-02-10 Katayama Seiyakushiyo:Kk Cephem compound and antimicrobial agent
WO1997003875A1 (en) * 1995-07-18 1997-02-06 Rubio Ortega, Amadeo Rear suspension for bicycle frame
JPH09110877A (en) * 1995-10-17 1997-04-28 Katayama Seiyakushiyo:Kk Cephem compound, its production and antibacterial agent containing the compound
KR20000005238A (en) * 1996-04-04 2000-01-25 시오노 요시히코 Cephem compound and drug containing the compound
WO1999033839A1 (en) * 1997-12-26 1999-07-08 Cheil Jedang Corporation Cephem derivatives and a method for producing the compounds and an antibacterial composition containing the compounds
HUP0102350A2 (en) * 1998-06-22 2001-11-28 F.Hoffmann-La Roche Ag. Propenyl cephalosporin derivatives, process for their preparation, pharmaceutical compositions thereof and intermediates

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107501171A (en) * 2017-08-15 2017-12-22 南京红太阳生物化学有限责任公司 A kind of synthetic method of the pyridine carboxaldehyde of 2 chlorine 3
CN107501171B (en) * 2017-08-15 2020-09-18 南京红太阳生物化学有限责任公司 Synthetic method of 2-chloro-3-pyridylaldehyde

Also Published As

Publication number Publication date
JP3928086B2 (en) 2007-06-13
JPWO2006104141A1 (en) 2008-09-11
WO2006104141A1 (en) 2006-10-05

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