DK157031C - Fremgangsmaade til fremstilling af 4'-demethyl-epipodophyllotoxin-beta-d-ethylidenglycocid og acylderivater deraf til anvendelse som udgangsmaterialer i fremgangsmaaden - Google Patents

Fremgangsmaade til fremstilling af 4'-demethyl-epipodophyllotoxin-beta-d-ethylidenglycocid og acylderivater deraf til anvendelse som udgangsmaterialer i fremgangsmaaden

Info

Publication number: DK157031C
Authority: DK; Denmark
Prior art keywords: procedure; acyler; glycocide; epipodophyllotoxin; demethyl
Prior art date: 1982-11-26

Application number

DK425583A

Other languages

English (en)

Other versions

DK157031B (da

DK425583A (da

DK425583D0 (da

Inventor

Katsuhiko Kurabayashi

Hidefumi Kinoshita

Hitoshi Saito

Toshio Takahashi

Original Assignee

Nippon Kayaku Kk

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1982-11-26

Filing date

1983-09-19

Publication date

1990-03-26

1982-11-26 Priority claimed from JP20618882A external-priority patent/JPS5998098A/ja

1983-05-18 Priority claimed from JP8586883A external-priority patent/JPS59212500A/ja

1983-09-19 Application filed by Nippon Kayaku Kk filed Critical Nippon Kayaku Kk

1983-09-19 Publication of DK425583D0 publication Critical patent/DK425583D0/da

1984-05-27 Publication of DK425583A publication Critical patent/DK425583A/da

1989-10-30 Publication of DK157031B publication Critical patent/DK157031B/da

1990-03-26 Application granted granted Critical

1990-03-26 Publication of DK157031C publication Critical patent/DK157031C/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

DK425583A 1982-11-26 1983-09-19 Fremgangsmaade til fremstilling af 4'-demethyl-epipodophyllotoxin-beta-d-ethylidenglycocid og acylderivater deraf til anvendelse som udgangsmaterialer i fremgangsmaaden DK157031C (da)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
JP20618882		1982-11-26
JP20618882A JPS5998098A (ja)	1982-11-26	1982-11-26	４′―デメチル―エピポドフィロトキシン―β―Ｄ―エチリデングルコシドの新規製造法
JP8586883		1983-05-18
JP8586883A JPS59212500A (ja)	1983-05-18	1983-05-18	４′−デメチル−エピポドフイロトキシン−β−Ｄ−エチリデングルコシドの新規製造法

Publications (4)

Publication Number	Publication Date
DK425583D0 DK425583D0 (da)	1983-09-19
DK425583A DK425583A (da)	1984-05-27
DK157031B DK157031B (da)	1989-10-30
DK157031C true DK157031C (da)	1990-03-26

Family

ID=26426870

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK425583A DK157031C (da)	1982-11-26	1983-09-19	Fremgangsmaade til fremstilling af 4'-demethyl-epipodophyllotoxin-beta-d-ethylidenglycocid og acylderivater deraf til anvendelse som udgangsmaterialer i fremgangsmaaden

Country Status (7)

Country	Link
US (1)	US4564675A (da)
EP (1)	EP0111058B1 (da)
KR (1)	KR890000763B1 (da)
DE (1)	DE3374317D1 (da)
DK (1)	DK157031C (da)
ES (1)	ES525743A0 (da)
FI (1)	FI71942C (da)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
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JPS60246393A (ja) *	1984-05-22	1985-12-06	Nippon Kayaku Co Ltd	エトポシドの新規製造法
AU582758B2 (en) *	1984-06-28	1989-04-13	Mect Corporation	Sialic acid derivatives, galactose derivatives and method for producing the same
US4895727A (en) *	1985-05-03	1990-01-23	Chemex Pharmaceuticals, Inc.	Pharmaceutical vehicles for exhancing penetration and retention in the skin
IL77334A (en) *	1985-12-16	1991-04-15	Univ Bar Ilan	Synthesis of 9-epipodophyllotoxin glucoside derivatives and some novel intermediates therefor
KR890700022A (ko) *	1986-11-19	1989-03-02	원본미기재	피부 관통 유동을 감소시키는 약제 비히클
US4916217A (en) *	1987-01-08	1990-04-10	Bristol-Myers Company	Phosphorus containing derivatives of epipodophyllotoxin
US5716990A (en) *	1987-03-09	1998-02-10	Cancer Research Campaign Technology Limited	Drug delivery systems
US4874851A (en) *	1987-07-01	1989-10-17	Bristol-Meyers Company	3',4'-dinitrogen substituted epipodophyllotoxin glucoside derivatives
US4975278A (en) *	1988-02-26	1990-12-04	Bristol-Myers Company	Antibody-enzyme conjugates in combination with prodrugs for the delivery of cytotoxic agents to tumor cells
US4904768A (en) *	1987-08-04	1990-02-27	Bristol-Myers Company	Epipodophyllotoxin glucoside 4'-phosphate derivatives
US4868291A (en) *	1987-08-20	1989-09-19	Bristol-Myers Company	4'-deshydroxyepipodophyllotoxin glucosides: synthesis and use
US4935504A (en) *	1987-12-18	1990-06-19	Bristol-Myers Company	Epipodophyllotoxin glucoside 4'-acyl derivatives
ZA886810B (en) *	1987-12-18	1989-08-30	Bristol Myers Co	Epipodophyllotoxin glucoside 4'-acyl derivatives
US4958010A (en) *	1988-02-16	1990-09-18	Bristol-Myers Company	Epipodophyllotoxin glucoside lactam derivatives
US5632990A (en) *	1988-04-22	1997-05-27	Cancer Research Campaign Tech. Ltd.	Treatment for tumors comprising conjugated antibody A5B7 and a prodrug
US4912204A (en) *	1988-09-06	1990-03-27	Bristol-Myers Company	Fluoro-substituted epipodophyllotoxin glucosides
US5061791A (en) *	1988-12-21	1991-10-29	Warner-Lambert Company	4-bromo-4'-demethylepipodophyllotoxin derivatives
DE3913326A1 (de) *	1989-04-22	1990-11-08	Behringwerke Ag	Verfahren zur herstellung von etoposiden
US5036055A (en) *	1989-06-07	1991-07-30	Bristol-Myers Company	Acylated derivatives of etoposide
US5066645A (en) *	1989-09-01	1991-11-19	Bristol-Myers Company	Epipodophyllotoxin altroside derivatives
FR2658824B1 (fr) *	1990-02-27	1992-07-03	Pf Medicament	Tris acetyl-2",3",4' ethylidene-4",6" beta-d-glucopyranosides, leur preparation et leur utilisation pour la preparation d'ethylidene beta-d-glucopyranoside de demethyl-4' epipodophyllotoxine.
US5081234A (en) *	1990-04-30	1992-01-14	Bristol-Myers Squibb Co.	4'-demethylepipodophyllotoxin glycosides
IT1250692B (it) *	1991-07-23	1995-04-21		Procedimento per la preparazione di demetilepipodofillotossina- beta-d-glucosidi.
JP3061476B2 (ja) *	1992-04-24	2000-07-10	日本化薬株式会社	エトポシド燐酸エステルの製造法
US5459248A (en) *	1993-11-04	1995-10-17	Bristol-Myers Squibb Company	Process of preparing etoposide phosphate and etoposide
US5463040A (en) *	1994-06-28	1995-10-31	Teva Pharmaceutical Industries, Ltd.	Method of preparing etoposide
US6207673B1 (en)	1997-03-12	2001-03-27	The University Of North Carolina At Chapel Hill	Covalent conjugates of topoisomerase I and topoisomerase II inhibitors
US20040072889A1 (en) *	1997-04-21	2004-04-15	Pharmacia Corporation	Method of using a COX-2 inhibitor and an alkylating-type antineoplastic agent as a combination therapy in the treatment of neoplasia
WO2000015647A2 (en)	1998-09-10	2000-03-23	Phytogen Life Sciences Inc.	Synthetic method for the preparation of the antineoplastic agent etoposide
US6756063B2 (en)	2001-03-29	2004-06-29	Zoltan Laboratories, Llc	Methods and compositions for the treatment of human and animal cancers
US7200207B2 (en) *	2004-03-13	2007-04-03	Intrado Inc.	Communication network for providing emergency services
JP5475234B2 (ja)	2005-01-21	2014-04-16	アステックス・セラピューティクス・リミテッド	医薬化合物
EP2073803B1 (en)	2006-10-12	2018-09-19	Astex Therapeutics Limited	Pharmaceutical combinations
WO2008044045A1 (en)	2006-10-12	2008-04-17	Astex Therapeutics Limited	Pharmaceutical combinations
DK3311827T3 (da)	2011-10-03	2023-04-03	Canqura Oncology Ab	Nanopartikler, fremgangsmåde til fremstilling og anvendelse deraf som bærere for amfipatiske eller hydrofobe molekyler inden for det medicinske område, inklusiv cancerbehandling, samt fødevarerelaterede forbindelser
CN102603762A (zh) *	2012-02-14	2012-07-25	上海金和生物技术有限公司	一种依托泊甙中间体的制备方法
US9907846B2 (en)	2013-04-01	2018-03-06	Mx Adjuvac Ab	Nanoparticles, composed of sterol and saponin from Quillaja saponaria Molina for use in pharmaceutical compositions
CN108129525B (zh) *	2017-12-28	2019-11-22	山东铂源药业有限公司	一种依托泊苷中间体的制备方法
EP3616688A1 (en)	2018-08-27	2020-03-04	Centre National de la Recherche Scientifique - CNRS	Preparation of nanosuspension comprising nanocrystals of active pharmaceutical ingredients with little or no stabilizing agents
EP3669890A1 (en)	2018-12-18	2020-06-24	Croda International PLC	Filamentous nanoparticles having vaccine adjuvant effect
CN115141208B (zh) *	2022-08-05	2024-03-08	贵州大学	一种含各类酯基结构的鬼臼毒素类化合物及其制备方法和应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NL6613143A (da) *	1965-09-21	1967-03-22
CH514578A (de) *	1968-02-27	1971-10-31	Sandoz Ag	Verfahren zur Herstellung von Glucosiden
US4147860A (en) *	1976-07-13	1979-04-03	E. I. Du Pont De Nemours And Company	Process for preparing nitroaromatic glycosides

1983
- 1983-09-03 EP EP83108701A patent/EP0111058B1/en not_active Expired
- 1983-09-03 DE DE8383108701T patent/DE3374317D1/de not_active Expired
- 1983-09-06 US US06/529,749 patent/US4564675A/en not_active Expired - Lifetime
- 1983-09-12 KR KR1019830004276A patent/KR890000763B1/ko not_active Expired
- 1983-09-19 ES ES525743A patent/ES525743A0/es active Granted
- 1983-09-19 DK DK425583A patent/DK157031C/da not_active IP Right Cessation
- 1983-09-19 FI FI833334A patent/FI71942C/fi not_active IP Right Cessation

Also Published As

Publication number	Publication date
KR840006672A (ko)	1984-12-01
US4564675A (en)	1986-01-14
EP0111058B1 (en)	1987-11-04
FI833334A0 (fi)	1983-09-19
DK157031B (da)	1989-10-30
ES8506324A1 (es)	1985-07-01
DE3374317D1 (en)	1987-12-10
FI833334A7 (fi)	1984-05-27
DK425583A (da)	1984-05-27
ES525743A0 (es)	1985-07-01
KR890000763B1 (ko)	1989-04-05
FI71942B (fi)	1986-11-28
DK425583D0 (da)	1983-09-19
EP0111058A1 (en)	1984-06-20
FI71942C (fi)	1987-03-09

Publication	Publication Date	Title
DK157031C (da)	1990-03-26	Fremgangsmaade til fremstilling af 4'-demethyl-epipodophyllotoxin-beta-d-ethylidenglycocid og acylderivater deraf til anvendelse som udgangsmaterialer i fremgangsmaaden
DK301383A (da)	1984-01-02	Fremgangsmaade til fremstilling af imidazolderivater
DK95483A (da)	1983-08-28	Fremgangsmaade til fremstilling af tetrahydropyranderivater
DK241883A (da)	1983-12-04	Fremgangsmaade til fremstilling af 1-sulfo-2-oxoazetidinderivater
DK372283A (da)	1984-02-18	Fremgangsmaade til fremstilling af desoxyuridinderivater
DK155984D0 (da)	1984-03-14	Fremgangsmade til fremstilling af thiadiazolderivater
DK63683D0 (da)	1983-02-14	Fremgangsmade til fremstilling af cephemderivater
DK163379A (da)	1979-10-22	Fremgangsmaade til fremstilling af substituerede 1,3-diaryl-2-imino-imidazolidiner og 2-imino-hexahydro-pyrimidiner
DK323083A (da)	1984-01-15	Fremgangsmaade til fremstilling af 19-thio-androstanderivater
DK312584D0 (da)	1984-06-26	Fremgangsmaade til fremstilling af quinonderivater
DK140584A (da)	1984-09-09	Fremgangsmaade til fremstilling af carbapenemderivater
DK427083D0 (da)	1983-09-19	Fremgangsmade til fremstilling af cephemderivater
DK435483D0 (da)	1983-09-23	Fremgangsmade til fremstilling af fenylcyklobutylderivater
DK261883A (da)	1983-12-11	Fremgangsmaade til fremstilling af prostaglandin-d-derivater
DK162230C (da)	1992-03-02	Fremgangsmaade til fremstilling af 2-thiacephemderivater
DK426683D0 (da)	1983-09-19	Fremgangsmade til fremstilling af oxacephalosporinderivater
DK317283A (da)	1984-01-09	Fremgangsmaade til fremstilling af thiadiazolderivater
DK38493A (da)	1993-03-31	Fremgangsmaade til fremstilling af alkoxymethylether- og alkoxymethylesterderivater af glyceroler
DK340483D0 (da)	1983-07-25	Fremgangsmade til fremstilling af fluoralkylerede carbapenemderivater
DK482983A (da)	1984-04-22	Fremgangsmaade til fremstilling af phenylderivater
DK165583D0 (da)	1983-04-15	Fremgangsmade til fremstilling af furanderivater
DK542383D0 (da)	1983-11-25	Fremgangsmade til fremstilling af acridanonderivater
DK164283D0 (da)	1983-04-14	Fremgangsmade til fremstilling af benzimidazolderivater
DK283383D0 (da)	1983-06-20	Fremgangsmade til fremstilling af 6'-aminopenicillanoyloxymethylpenicillanat-1,1-dioxid og mellemprodukter anvendelige til fremgangsmadens udoevelse
DK133784A (da)	1984-09-25	Fremgangsmaade til fremstilling af azinomethylrifamyciner

Legal Events

Date	Code	Title	Description
2001-05-28	PBP	Patent lapsed