DK144783D0 - Fremgangsmade til fremstilling af cycloalka(c)pyrrol-carboxylsyrederivater - Google Patents

Fremgangsmade til fremstilling af cycloalka(c)pyrrol-carboxylsyrederivater

Info

Publication number: DK144783D0
Authority: DK; Denmark
Prior art keywords: cycloalka; pyrrol; preparing; carboxylic acid; acid derivatives
Prior art date: 1982-03-30

Application number

DK1447/83A

Other languages

English (en)

Other versions

DK144783A (da

Inventor

Rainer Henning

Hansjoerg Urbach

Rolf Geiger

Volker Teetz

Reinhard Becker

Original Assignee

Hoechst Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1982-03-30

Filing date

1983-03-29

Publication date

1983-03-29

1983-03-29 Application filed by Hoechst Ag filed Critical Hoechst Ag

1983-03-29 Publication of DK144783D0 publication Critical patent/DK144783D0/da

1983-10-01 Publication of DK144783A publication Critical patent/DK144783A/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
- C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biophysics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Genetics & Genomics (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyrrole Compounds (AREA)
Indole Compounds (AREA)
Peptides Or Proteins (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

DK144783A 1982-03-30 1983-03-29 Fremgangsmaade til fremstilling af cycloalka(c)pyrrol-carboxylsyrederivater DK144783A (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE19823211676 DE3211676A1 (de)	1982-03-30	1982-03-30	Neue derivate von cycloalka (c) pyrrol-carbonsaeuren, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung sowie neue cycloalka (c) pyrrol-carbonsaeuren als zwischenstufen und verfahren zu deren herstellung

Publications (2)

Publication Number	Publication Date
DK144783D0 true DK144783D0 (da)	1983-03-29
DK144783A DK144783A (da)	1983-10-01

Family

ID=6159702

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK144783A DK144783A (da)	1982-03-30	1983-03-29	Fremgangsmaade til fremstilling af cycloalka(c)pyrrol-carboxylsyrederivater

Country Status (17)

Country	Link
EP (1)	EP0090362A3 (da)
JP (1)	JPS58177967A (da)
KR (1)	KR840004069A (da)
AU (1)	AU560124B2 (da)
CA (1)	CA1198118A (da)
DE (1)	DE3211676A1 (da)
DK (1)	DK144783A (da)
ES (2)	ES8401937A1 (da)
FI (1)	FI831049A7 (da)
GR (1)	GR78157B (da)
HU (1)	HU193876B (da)
IL (1)	IL68267A (da)
NO (2)	NO831168L (da)
NZ (1)	NZ203719A (da)
PH (1)	PH19003A (da)
PT (1)	PT76472B (da)
ZA (1)	ZA832229B (da)

Families Citing this family (44)

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DE3226768A1 (de) *	1981-11-05	1983-05-26	Hoechst Ag, 6230 Frankfurt	Derivate der cis, endo-2-azabicyclo-(3.3.0)-octan-3-carbonsaeure, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung
IE55867B1 (en) *	1981-12-29	1991-02-14	Hoechst Ag	New derivatives of bicyclic aminoacids,processes for their preparation,agents containing these compounds and their use,and new bicyclic aminoacids as intermediates and processes for their preparation
DE3246503A1 (de) *	1982-12-16	1984-06-20	Hoechst Ag, 6230 Frankfurt	Derivate der cis, endo-2-azabicyclo-(5.3.0)-decan-3-carbonsaeure, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung
US5175306A (en) *	1983-01-31	1992-12-29	Hoechst Aktiengesellschaft	Process for the resolution of racemates of optically active bicyclic imino-α-carboxylic esters
DE3303344A1 (de)	1983-02-02	1984-08-02	Hoechst Ag, 6230 Frankfurt	Verfahren zur herstellung von n-alkylierten aminosaeuren und deren estern
FI841052A7 (fi) *	1983-03-16	1984-09-17	Usv Pharma Corp	Foereningar foer behandling av blodtryckssjukdomar.
FR2546886B2 (fr) *	1983-06-06	1986-05-16	Adir	Derives d'acides isoindoledicarboxyliques, leur preparation et compositions pharmaceutiques les contenant
DE3333454A1 (de) *	1983-09-16	1985-04-11	Hoechst Ag, 6230 Frankfurt	Verfahren zur herstellung von n-alkylierten dipeptiden und deren estern
DE3333455A1 (de) *	1983-09-16	1985-04-11	Hoechst Ag, 6230 Frankfurt	Verfahren zur herstellung n-alkylierter dipeptide und deren estern
DE3410732A1 (de) *	1984-03-23	1985-09-26	Hoechst Ag, 6230 Frankfurt	Methode zur behandlung des glaukoms
DE3413710A1 (de) *	1984-04-12	1985-10-24	Hoechst Ag, 6230 Frankfurt	Verfahren zur behandlung der herzinsuffizienz
US5684016A (en) *	1984-04-12	1997-11-04	Hoechst Aktiengesellschaft	Method of treating cardiac insufficiency
EP0190224A1 (en) *	1984-07-30	1986-08-13	Schering Corporation	PROCESS FOR THE PREPARATION OF CIS, ENDOOCTAHYDROCYCLOPENTA [b] PYRROLE-2-CARBOXYLATE
DE3431541A1 (de) *	1984-08-28	1986-03-06	Hoechst Ag, 6230 Frankfurt	Cis,endo-2-azabicycloalkan-3-carbonsaeure-derivate, verfahren zu deren herstellung, deren verwendung sowie zwischenprodukte bei deren herstellung
US5231080A (en) *	1985-10-15	1993-07-27	Hoechst Aktiengesellschaft	Method for the treatment of atherosclerosis, thrombosis, and peripheral vessel disease
US5231084A (en) *	1986-03-27	1993-07-27	Hoechst Aktiengesellschaft	Compounds having a cognition adjuvant action, agents containing them, and the use thereof for the treatment and prophylaxis of cognitive dysfuncitons
DE3633496A1 (de) *	1986-10-02	1988-04-14	Hoechst Ag	Kombination von angiotensin-converting-enzyme-hemmern mit calciumantagonisten sowie deren verwendung in arzneimitteln
DE3639879A1 (de) *	1986-11-21	1988-06-01	Hoechst Ag	Verfahren zur herstellung von mono-, bi- und tricyclischen aminosaeuren, zwischenprodukte dieses verfahrens sowie ein verfahren zu deren herstellung
DE3722007A1 (de) *	1987-07-03	1989-01-12	Hoechst Ag	Verfahren zur herstellung bicyclischer aminocarbonsaeuren, zwischenprodukte dieses verfahrens und deren verwendung
JPH0278659A (ja) *	1988-09-12	1990-03-19	Shionogi & Co Ltd	アザビシクロアルカン類化合物
DE3839127A1 (de) *	1988-11-19	1990-05-23	Hoechst Ag	Pyrrolidon-2-carbonsaeure-derivate mit psychotroper wirkung
DD284030A5 (de)	1988-11-24	1990-10-31	Hoechst Ag,De	Verfahren zur herstellung von peptiden mit bradykinin-antagonistischer wirkung
LT3872B (en)	1993-12-06	1996-04-25	Hoechst Ag	Novel peptides and pharmaceutical compositions containing them
EP0796855B1 (de)	1996-03-20	2002-02-06	Hoechst Aktiengesellschaft	Inhibitoren der Knochenresorption und Vitronectinrezeptor-Antagonisten
FR2746394B1 (fr)	1996-03-20	1998-05-29	Roussel Uclaf	Nouveaux composes tricycliques, leur procede de preparation, et les intermediaires de ce procede, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant
UA66767C2 (uk)	1996-10-18	2004-06-15	Вертекс Фармасьютикалс Інкорпорейтед	Інгібітори серин-протеаз, фармацевтична композиція, спосіб інгібування активності та спосіб лікування або профілактики вірусної інфекції гепатиту с
DE19653647A1 (de)	1996-12-20	1998-06-25	Hoechst Ag	Vitronectin - Rezeptorantagonisten, deren Herstellung sowie deren Verwendung
DE19741235A1 (de)	1997-09-18	1999-03-25	Hoechst Marion Roussel De Gmbh	Neue Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
DE19741873A1 (de) *	1997-09-23	1999-03-25	Hoechst Marion Roussel De Gmbh	Neue 5-Ring-Heterocyclen, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
DE19751251A1 (de)	1997-11-19	1999-05-20	Hoechst Marion Roussel De Gmbh	Substituierte Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmezeutische Präparate
DE19821483A1 (de)	1998-05-14	1999-11-18	Hoechst Marion Roussel De Gmbh	Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
SV2003000617A (es)	2000-08-31	2003-01-13	Lilly Co Eli	Inhibidores de la proteasa peptidomimetica ref. x-14912m
AR045596A1 (es)	2003-09-05	2005-11-02	Vertex Pharma	Inhibidores de proteasas de serina en particular proteasa ns3-ns4a del vhc
US8399615B2 (en)	2005-08-19	2013-03-19	Vertex Pharmaceuticals Incorporated	Processes and intermediates
CN102382170A (zh)	2005-08-19	2012-03-21	弗特克斯药品有限公司	用于制备蛋白酶抑制剂的方法和中间体
US7964624B1 (en)	2005-08-26	2011-06-21	Vertex Pharmaceuticals Incorporated	Inhibitors of serine proteases
AR055395A1 (es)	2005-08-26	2007-08-22	Vertex Pharma	Compuestos inhibidores de la actividad de la serina proteasa ns3-ns4a del virus de la hepatitis c
CN101489557B (zh)	2006-02-27	2013-12-18	弗特克斯药品有限公司	包含vx-950的共晶体和包含所述共晶体的药物组合物
KR20080112303A (ko)	2006-03-16	2008-12-24	버텍스 파마슈티칼스 인코포레이티드	중수소화 ｃ형 간염 프로테아제 억제제
US8575208B2 (en)	2007-02-27	2013-11-05	Vertex Pharmaceuticals Incorporated	Inhibitors of serine proteases
WO2008106151A2 (en)	2007-02-27	2008-09-04	Vertex Pharmaceuticals Incorporated	Co-crystals and pharmaceutical compositions comprising the same
CA2704284A1 (en)	2007-08-30	2009-03-12	Vertex Pharmaceuticals Incorporated	Co-crystals and pharmaceutical compositions comprising the same
WO2010008828A2 (en)	2008-06-24	2010-01-21	Codexis, Inc.	Biocatalytic processes for the preparation of substantially stereomerically pure fused bicyclic proline compounds
JP5829529B2 (ja) *	2011-08-29	2015-12-09	日本曹達株式会社	光学活性４級アンモニウム塩、および光学活性化合物の製造方法

Family Cites Families (7)

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Publication number	Priority date	Publication date	Assignee	Title
IL58849A (en) *	1978-12-11	1983-03-31	Merck & Co Inc	Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them
FR2487829A2 (fr) *	1979-12-07	1982-02-05	Science Union & Cie	Nouveaux imino acides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
EP0050800B2 (en) *	1980-10-23	1995-06-07	Schering Corporation	Carboxyalkyl dipeptides, processes for their production and pharmaceutical compositions containing them
DE3276311D1 (en) *	1981-02-17	1987-06-19	Warner Lambert Co	Octahydro-2-(omega-mercaptoalkanoyl)3-oxo-1h-isoindole-1-carboxylic acids and esters
ZA826022B (en) *	1981-08-21	1983-08-31	Univ Miami	Novel complex amido and imido derivatives of carboxyalkyl peptides and thioethers and ethers of peptides
EP0081094A1 (en) *	1981-11-12	1983-06-15	Merck & Co. Inc.	Substituted omega-amino-carboxymethyldipeptide antihypertensive agents
DE3360065D1 (en) *	1982-03-08	1985-03-28	Schering Corp	Carboxyalkyl dipeptides, processes for their production and pharmaceutical compositions containing them

1982
- 1982-03-30 DE DE19823211676 patent/DE3211676A1/de not_active Withdrawn
1983
- 1983-03-24 EP EP83102961A patent/EP0090362A3/de not_active Withdrawn
- 1983-03-28 ES ES521041A patent/ES8401937A1/es not_active Expired
- 1983-03-28 NZ NZ203719A patent/NZ203719A/en unknown
- 1983-03-28 FI FI831049A patent/FI831049A7/fi not_active Application Discontinuation
- 1983-03-28 GR GR70912A patent/GR78157B/el unknown
- 1983-03-28 KR KR1019830001244A patent/KR840004069A/ko not_active Ceased
- 1983-03-29 PT PT76472A patent/PT76472B/pt unknown
- 1983-03-29 JP JP58051780A patent/JPS58177967A/ja active Pending
- 1983-03-29 PH PH28723A patent/PH19003A/en unknown
- 1983-03-29 NO NO831168A patent/NO831168L/no unknown
- 1983-03-29 ZA ZA832229A patent/ZA832229B/xx unknown
- 1983-03-29 DK DK144783A patent/DK144783A/da not_active Application Discontinuation
- 1983-03-29 CA CA000424770A patent/CA1198118A/en not_active Expired
- 1983-03-29 AU AU12970/83A patent/AU560124B2/en not_active Ceased
- 1983-03-29 HU HU831064A patent/HU193876B/hu unknown
- 1983-03-30 IL IL68267A patent/IL68267A/xx unknown
- 1983-04-22 ES ES521741A patent/ES521741A0/es active Granted
- 1983-11-25 NO NO834352A patent/NO834352L/no unknown

Also Published As

Publication number	Publication date
NZ203719A (en)	1986-02-21
ZA832229B (en)	1983-12-28
EP0090362A2 (de)	1983-10-05
GR78157B (da)	1984-09-26
NO834352L (no)	1983-10-03
JPS58177967A (ja)	1983-10-18
ES521041A0 (es)	1984-01-01
FI831049L (fi)	1983-10-01
IL68267A (en)	1987-03-31
AU1297083A (en)	1983-10-06
PT76472B (de)	1986-01-24
AU560124B2 (en)	1987-04-02
DE3211676A1 (de)	1983-10-06
CA1198118A (en)	1985-12-17
DK144783A (da)	1983-10-01
FI831049A7 (fi)	1983-10-01
FI831049A0 (fi)	1983-03-28
IL68267A0 (en)	1983-06-15
ES8401937A1 (es)	1984-01-01
ES8402570A1 (es)	1984-02-01
ES521741A0 (es)	1984-02-01
EP0090362A3 (de)	1985-09-18
KR840004069A (ko)	1984-10-06
NO831168L (no)	1983-10-03
PT76472A (de)	1983-04-01
HU193876B (en)	1987-12-28
PH19003A (en)	1985-12-03

Publication	Publication Date	Title
DK144783D0 (da)	1983-03-29	Fremgangsmade til fremstilling af cycloalka(c)pyrrol-carboxylsyrederivater
DK470583D0 (da)	1983-10-12	Fremgangsmade til fremstilling af 1-phenyl-2-piperidinopropanolderivater
DK336783D0 (da)	1983-07-22	Fremgangsmade til fremstilling af methylendiphosphonsyrederivater
DK225184D0 (da)	1984-05-07	Fremgangsmaade til fremstilling af n-phosphonomethylglycinsyre
DK492783D0 (da)	1983-10-27	Fremgangsmade til fremstilling af 3-aryl-5-pyrazol-derivater
DK95483D0 (da)	1983-02-25	Fremgangsmade til fremstilling af tetrahydropyranderivater
DK318982A (da)	1983-01-17	Fremgangsmaade til fremstilling af en inklusionsforbindelse afp-hexadecylaminobenzosyre
DK155783D0 (da)	1983-04-07	Fremgangsmade til fremstilling af phenoxyalkylcarboxylsyrederivater
DK183583D0 (da)	1983-04-26	Fremgangsmade til fremstilling af benzoazacycloalkyl-spiro-imidazolidiner
DK166087C (da)	1993-08-23	Fremgangsmaade til fremstilling af oe(3-amino-3-carboxy)-propyl-1aaphosphinsyrederivater
DK103683D0 (da)	1983-02-28	Fremgangsmade til fremstilling af 2-keto-l-gulonsyre
DK103583D0 (da)	1983-02-28	Fremgangsmade til fremstilling af 2-keto-l-gulonsyre
DK99980A (da)	1980-09-09	Fremgangsmaade til fremstilling af mercaptoacyldihydropyrazolcarboxylsyrederivater
DK540781A (da)	1982-06-09	Fremgangsmaade til fremstilling af 2-hydronaphthalen-6-carboxylsyre
DK159309C (da)	1991-03-11	Fremgangsmaade til fremstilling af 4-metyl-5-alkylthiometyl-imidazoler
DK158312C (da)	1990-10-01	Fremgangsmaade til fremstilling af diacetoneketogulonsyre
DK40883D0 (da)	1983-02-01	Fremgangsmade til fremstilling af benzothienylallylaminer
DK505583D0 (da)	1983-11-04	Fremgangsmade til fremstilling af thiophen-2-carboxylsyrederivater
DK57381A (da)	1981-08-13	Fremgansmaade til fremstilling af bifenyloxypropionsyrederivater
DK399783A (da)	1984-03-04	Fremgangsmaade til fremstilling af substituerede 1-pyridyloxy-3-indolylalkylamino-2-propanoler
DK518883A (da)	1984-05-17	Fremgangsmaade til fremstilling af 1-oxa-beta-lactam-forbindelser
DK228583A (da)	1983-11-25	Fremgangsmaade til fremstilling af 5-oxo-2-pyrrolidinpropansyrederivater
DK159446C (da)	1991-03-18	Fremgangsmaade til fremstilling af oxazolinoazetidinylhydroxymethylbutensyrederivater
DK139983D0 (da)	1983-03-28	Fremgangsmade til fremstilling af 2-thiopheneddikesyrederivater
DK145741C (da)	1983-08-01	Fremgangsmaade til fremstilling af 6-chlor-alfa-methyl-carbazol-2-eddikesyre

Legal Events

Date	Code	Title	Description
1986-12-22	PBP	Patent lapsed
1989-02-06	ATS	Application withdrawn