DK1218378T3 - Tert.-butyl-(7-methylimidazo[1,2-a]pyridin-3-yl) aminderivater - Google Patents

Tert.-butyl-(7-methylimidazo[1,2-a]pyridin-3-yl) aminderivater

Info

Publication number: DK1218378T3
Authority: DK; Denmark
Prior art keywords: methylimidazo; pyridin; tert; butyl; amine derivatives
Prior art date: 1999-10-08

Application number

DK00969439T

Other languages

Danish (da)

English (en)

Inventor

Corinna Maul

Bernd Sundermann

Hagen-Heinrich Hennies

Johannes Schneider

Matthias Gerlach

Original Assignee

Gruenenthal Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-10-08

Filing date

2000-10-06

Publication date

2003-07-21

2000-10-06 Application filed by Gruenenthal Gmbh filed Critical Gruenenthal Gmbh

2003-07-21 Application granted granted Critical

2003-07-21 Publication of DK1218378T3 publication Critical patent/DK1218378T3/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Diabetes (AREA)
Pain & Pain Management (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Psychology (AREA)
Emergency Medicine (AREA)
Rheumatology (AREA)
Obesity (AREA)
Hematology (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Endocrinology (AREA)
Dermatology (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

DK00969439T 1999-10-08 2000-10-06 Tert.-butyl-(7-methylimidazo[1,2-a]pyridin-3-yl) aminderivater DK1218378T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE19948434A DE19948434A1 (de)	1999-10-08	1999-10-08	Substanzbibliothek enthaltend bicyclische Imidazo-5-amine und/oder bicyclische Imidazo-3-amine
PCT/EP2000/009791 WO2001027109A2 (de)	1999-10-08	2000-10-06	Tert.-butyl-(7-methyl-imidazo[1,2-a]pyridin-3-yl)-amin-derivate

Publications (1)

Publication Number	Publication Date
DK1218378T3 true DK1218378T3 (da)	2003-07-21

Family

ID=7924888

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK00969439T DK1218378T3 (da)	1999-10-08	2000-10-06	Tert.-butyl-(7-methylimidazo[1,2-a]pyridin-3-yl) aminderivater

Country Status (28)

Country	Link
US (1)	US6703404B2 (es)
EP (1)	EP1218378B1 (es)
JP (1)	JP2003511450A (es)
KR (1)	KR100793619B1 (es)
CN (1)	CN1208336C (es)
AR (2)	AR025960A1 (es)
AT (1)	ATE238304T1 (es)
AU (2)	AU7419900A (es)
BR (1)	BR0014827A (es)
CA (1)	CA2386804A1 (es)
CO (2)	CO5210861A1 (es)
CZ (1)	CZ20021241A3 (es)
DE (2)	DE19948434A1 (es)
DK (1)	DK1218378T3 (es)
ES (1)	ES2198355T3 (es)
HK (1)	HK1047749B (es)
HU (1)	HUP0203545A3 (es)
IL (3)	IL148997A0 (es)
MX (1)	MXPA02003546A (es)
NO (1)	NO20021564L (es)
NZ (1)	NZ518438A (es)
PE (2)	PE20010706A1 (es)
PL (1)	PL355109A1 (es)
PT (1)	PT1218378E (es)
RU (1)	RU2002110281A (es)
SK (1)	SK4622002A3 (es)
WO (2)	WO2001027119A2 (es)
ZA (2)	ZA200203579B (es)

Families Citing this family (83)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6083966A (en)	1998-08-31	2000-07-04	University Of Florida	Thiazoline acid derivatives
CA2344913A1 (en)	1998-09-21	2000-03-30	University Of Florida Research Foundation, Inc.	Antimalarial agents
AU2001251444A1 (en)	2000-04-10	2001-10-23	Merck And Co., Inc.	Inhibitors of prenyl-protein transferase
DE10043845A1 (de) *	2000-09-06	2002-03-14	Gruenenthal Gmbh	Verfahren zur Messung der Aktivität der NO-Synthase
DE10050663A1 (de) *	2000-10-13	2002-04-18	Gruenenthal Gmbh	Verwendung von substituierten Imidazo[1,2-a]pyridin-, -pyrimidin- und pyrazin-3-yl-amin-Derivaten zur Herstellung von Medikamenten zur NOS-Inhibierung
WO2002048146A2 (de) *	2000-12-13	2002-06-20	Basf Aktiengesellschaft	Verwendung von substituierten imidazoazinen, neue imidazoazine, verfahren zu deren herstellung, sowie sie enthaltende mittel
DE10117183A1 (de) *	2001-04-05	2002-10-10	Gruenenthal Gmbh	Verwendung von substituierten Imidazo[1,2-a]-pyridinverbindungen als Arzneimittel
DE10117184A1 (de) *	2001-04-05	2002-10-17	Gruenenthal Gmbh	Substituierte Imidazol[1,2-a]-pyridin-3-yl-amid- und -aminverbindungen
DE10132726A1 (de) *	2001-07-05	2003-02-27	Gruenenthal Gmbh	Verwendung von substituierten gamma-Lactonverbindungen als Arzneimittel
SI1483247T1 (sl)	2002-03-13	2009-12-31	Euro Celtique Sa	Arilno substituirani pirimidini in njihova uporaba
KR20050008691A (ko)	2002-04-19	2005-01-21	셀룰러 지노믹스 아이엔씨	이미다조[1,2-ａ]피라진-8-일 아민, 그의 제조방법 및사용방법
US20050197435A1 (en) *	2002-06-14	2005-09-08	Dotson Darin L.	Polymer additive compositions for bimolecular nucleation in thermoplastics
US7312341B2 (en)	2002-09-09	2007-12-25	Cgi Pharmaceuticals, Inc.	6-aryl-imidazo[1,2-a] pyrazin-8-ylamines, method of making, and method of use thereof
DE10246890A1 (de) *	2002-10-08	2004-04-22	Grünenthal GmbH	Substituierte C-Imidazo[1,2-alpyridin-3-yl-methylamine
WO2004058755A2 (en) *	2002-12-24	2004-07-15	Biofocus Plc	Compound libraries of imidazo[1,5-a]pyridin-3-yl derivatives and related heterobicycles for targetting compounds capable of binding to g-protein coupled receptors
US7160885B2 (en)	2003-02-10	2007-01-09	Cgi Pharmaceuticals, Inc.	Certain 6, 8-(heteroaryl or aryl) disubstituted imidazo[1,2-a]pyrazines as modulators of Hsp90 complex activity
WO2005014599A1 (en)	2003-06-04	2005-02-17	Cellular Genomics, Inc.	Imidazo[1,2-a]pyrazin-8-ylamines and method of inhibition of bruton’s tyrosine kinase by such compounds
US7393848B2 (en)	2003-06-30	2008-07-01	Cgi Pharmaceuticals, Inc.	Certain heterocyclic substituted imidazo[1,2-A]pyrazin-8-ylamines and methods of inhibition of Bruton's tyrosine kinase by such compounds
WO2005019220A2 (en)	2003-08-11	2005-03-03	Cellular Genomics Inc.	Substituted imidazo[1,2-a]pyrazines as modulators of kinase activity
AU2003270473A1 (en)	2003-09-09	2005-04-27	University Of Florida	Desferrithiocin derivatives and their use as iron chelators
DE102004021716A1 (de) *	2004-04-30	2005-12-01	Grünenthal GmbH	Substituierte Imidazo[1,2-a]pyridin-Verbindungen und Arzneimittel enthaltend substituierte Imidazo[1,2-a]pyridin-Verbindungen
DE102004044884A1 (de) *	2004-09-14	2006-05-24	Grünenthal GmbH	Substituierte bizyklische Imidazo-3-yl-amin-Verbindungen
RU2007110731A (ru)	2004-09-23	2008-10-27	Редди Юс Терапевтикс	Новые соединения пиримидина, способ их получения и содержащие их композиции
PL1866296T3 (pl)	2005-04-04	2017-05-31	University Of Florida Research Foundation, Inc.	Polieterowe analogi desferritiocyny
DE102005016547A1 (de) *	2005-04-08	2006-10-12	Grünenthal GmbH	Substituierte 5,6,7,8-Tetrahydro-imidazo(1,2-a)pyridin-2-ylamin-Verbindungen und deren Verwendung zur Herstellung von Arzneimitteln
US7777040B2 (en)	2005-05-03	2010-08-17	Cgi Pharmaceuticals, Inc.	Certain substituted ureas, as modulators of kinase activity
WO2006125101A2 (en)	2005-05-20	2006-11-23	Array Biopharma Inc.	Raf inhibitor compounds and methods of use thereof
US8088928B2 (en)	2005-08-04	2012-01-03	Sirtris Pharmaceuticals, Inc.	Sirtuin modulating compounds
EP2468752A1 (en)	2005-08-04	2012-06-27	Sirtris Pharmaceuticals, Inc.	Thiazolopyridine derivatives as sirtuin-modulators
US8093401B2 (en)	2005-08-04	2012-01-10	Sirtris Pharmaceuticals, Inc.	Sirtuin modulating compounds
US7855289B2 (en)	2005-08-04	2010-12-21	Sirtris Pharmaceuticals, Inc.	Sirtuin modulating compounds
WO2007028051A2 (en)	2005-09-02	2007-03-08	Abbott Laboratories	Novel imidazo based heterocycles
CA2634923C (en)	2005-12-23	2015-05-05	Ariad Pharmaceuticals, Inc.	Acetylenic bicyclic heteroaryl compounds useful as kinase inhibitors
DE102006011574A1 (de) *	2006-03-10	2007-10-31	Grünenthal GmbH	Substituierte Imidazo[2,1-b]thiazol-Verbindungen und ihre Verwendung zur Herstellung von Arzneimitteln
AU2007227495B2 (en)	2006-03-17	2013-02-21	Ambit Biosciences Corporation	Imidazolothiazole compounds for the treatment of disease
US8324397B2 (en)	2007-03-15	2012-12-04	University Of Florida Research Foundation, Inc.	Desferrithiocin polyether analogues
WO2008134553A1 (en) *	2007-04-26	2008-11-06	Xenon Pharmaceuticals Inc.	Methods of using bicyclic compounds in treating sodium channel-mediated diseases
GB0708188D0 (en) *	2007-04-27	2007-06-06	Merck Sharp & Dohme	Therapeutic compounds
CL2008001822A1 (es)	2007-06-20	2009-03-13	Sirtris Pharmaceuticals Inc	Compuestos derivados de tiazolo[5,4-b]piridina; composicion farmaceutica que comprende a dichos compuestos; y uso del compuesto en el tratamiento de la resistencia a la insulina, sindrome metabolico, diabetes, entre otras.
CL2008001821A1 (es)	2007-06-20	2009-03-13	Sirtris Pharmaceuticals Inc	Compuestos derivados de imidazo[2,1-b]-tiazol; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento de diabetes, sindrome metabolico, resistencia a la insulina, entre otras.
DE102007040336A1 (de) *	2007-08-27	2009-03-05	Johann Wolfgang Goethe-Universität Frankfurt am Main	Neue Inhibitoren der 5-Lipoxygenase und deren Verwendungen
WO2009038757A2 (en)	2007-09-19	2009-03-26	Ambit Biosciences Corporation	Solid forms comprising n-(5-tert-butyl-isoxazol-3-yl)-n'-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea, compositions thereof, and uses therewith
WO2009102468A1 (en)	2008-02-13	2009-08-20	Cgi Pharmaceuticals, Inc.	6-aryl-imidaz0[l, 2-a] pyrazine derivatives, method of making, and method of use thereof
WO2009128383A1 (ja) *	2008-04-15	2009-10-22	エーザイ・アール・アンド・ディー・マネジメント株式会社	３－フェニルピラゾロ［５，１－ｂ］チアゾール化合物
WO2010032195A1 (en) *	2008-09-16	2010-03-25	Csir	Imidazopyridines and imidazopyrimidines as hiv-i reverse transcriptase inhibitors
US8450321B2 (en)	2008-12-08	2013-05-28	Gilead Connecticut, Inc.	6-(1H-indazol-6-yl)-N-[4-(morpholin-4-yl)phenyl]imidazo-[1,2-A]pyrazin-8-amine, or a pharmaceutically acceptable salt thereof, as a SYK inhibitor
AU2009325133B2 (en)	2008-12-08	2016-02-04	Gilead Connecticut, Inc.	Imidazopyrazine Syk inhibitors
KR101745732B1 (ko)	2008-12-08	2017-06-12	질레드 코네티컷 인코포레이티드	이미다조피라진 ｓｙｋ 억제제
UA104447C2 (uk)	2008-12-19	2014-02-10	Сіртріз Фармасьютікалз, Інк.	Тіазолопіридинові сполуки, що модулюють сиртуїн
AR078521A1 (es) *	2009-10-08	2011-11-16	Eisai R&D Man Co Ltd	Compuesto pirazolotiazol
KR101717809B1 (ko)	2010-03-11	2017-03-17	질레드 코네티컷 인코포레이티드	이미다조피리딘 ｓｙｋ 억제제
ES2761200T3 (es)	2011-12-16	2020-05-19	Univ Florida	Usos de análogos de 4'-desferritiocina
JP6181744B2 (ja)	2012-04-26	2017-08-16	ブリストル−マイヤーズスクイブカンパニーＢｒｉｓｔｏｌ−ＭｙｅｒｓＳｑｕｉｂｂＣｏｍｐａｎｙ	血小板凝集を治療するためのプロテアーゼ活性化受容体４（ｐａｒ４）阻害剤としてのイミダゾチアジアゾール誘導体
CN104640869B (zh)	2012-04-26	2017-12-12	百时美施贵宝公司	作为用于治疗血小板聚集的蛋白酶激活受体4(par4)抑制剂的咪唑并噻二唑和咪唑并哒嗪衍生物
CN104583218B (zh)	2012-04-26	2018-04-24	百时美施贵宝公司	作为蛋白酶活化受体4(par4)抑制剂用于治疗血小板聚集的咪唑并噻二唑和咪唑并吡嗪的衍生物
EP2920169A1 (en) *	2012-11-14	2015-09-23	F. Hoffmann-La Roche AG	Imidazopyridine derivatives
WO2015017460A1 (en)	2013-07-30	2015-02-05	Gilead Connecticut, Inc.	Polymorph of syk inhibitors
WO2015017466A1 (en)	2013-07-30	2015-02-05	Gilead Connecticut, Inc.	Formulation of syk inhibitors
EP3071201A4 (en)	2013-11-22	2017-04-26	University of Florida Research Foundation, Inc.	Desferrithiocin analogs and uses thereof
JP6298539B2 (ja)	2013-12-04	2018-03-20	ギリアードサイエンシーズ，インコーポレイテッド	がんを処置する方法
UY35898A (es)	2013-12-23	2015-07-31	Gilead Sciences Inc	?compuestos inhibidores de syk y composiciones que los comprenden?.
US9290505B2 (en)	2013-12-23	2016-03-22	Gilead Sciences, Inc.	Substituted imidazo[1,2-a]pyrazines as Syk inhibitors
SMT201900620T1 (it)	2014-02-13	2020-01-14	Incyte Corp	Ciclopropilammine come inibitori di lsd1
HUE046273T2 (hu)	2014-02-13	2020-02-28	Incyte Corp	Ciklopropilaminok mint LSD1 inhibitorok
US9527835B2 (en)	2014-02-13	2016-12-27	Incyte Corporation	Cyclopropylamines as LSD1 inhibitors
WO2015123408A1 (en)	2014-02-13	2015-08-20	Incyte Corporation	Cyclopropylamines as lsd1 inhibitors
US9617279B1 (en)	2014-06-24	2017-04-11	Bristol-Myers Squibb Company	Imidazooxadiazole compounds
US9598419B1 (en)	2014-06-24	2017-03-21	Universite De Montreal	Imidazotriazine and imidazodiazine compounds
WO2016007731A1 (en)	2014-07-10	2016-01-14	Incyte Corporation	Imidazopyridines and imidazopyrazines as lsd1 inhibitors
TW201613925A (en)	2014-07-10	2016-04-16	Incyte Corp	Imidazopyrazines as LSD1 inhibitors
WO2016007722A1 (en)	2014-07-10	2016-01-14	Incyte Corporation	Triazolopyridines and triazolopyrazines as lsd1 inhibitors
WO2016007727A1 (en)	2014-07-10	2016-01-14	Incyte Corporation	Triazolopyridines and triazolopyrazines as lsd1 inhibitors
EA201790086A1 (ru)	2014-07-14	2017-07-31	Джилид Сайэнс, Инк.	Комбинации для лечения раковых заболеваний
CN107660205B (zh)	2015-04-03	2021-08-27	因赛特公司	作为lsd1抑制剂的杂环化合物
AU2016255770A1 (en)	2015-04-27	2017-11-16	University Of Florida Research Foundation, Incorporated	Metabolically programmed metal chelators and uses thereof
HUE070538T2 (hu)	2015-08-12	2025-06-28	Incyte Holdings Corp	Egy LSD1 inhibitor sói
CA3021678A1 (en)	2016-04-22	2017-10-26	Incyte Corporation	Formulations of an lsd1 inhibitor
US11098043B2 (en) *	2017-07-14	2021-08-24	University Of Massachusetts	Certain imidazopyridines as cyclic AMP response element binding (CREB) binding protein (CBP) inhibitors and uses thereof
CN111051311A (zh)	2017-08-25	2020-04-21	吉利德科学公司	Syk抑制剂的多晶型物
US11530209B2 (en) *	2017-10-04	2022-12-20	Dana-Farber Cancer Institute, Inc.	Small molecule inhibition of transcription factor SALL4 and uses thereof
WO2020047198A1 (en)	2018-08-31	2020-03-05	Incyte Corporation	Salts of an lsd1 inhibitor and processes for preparing the same
AU2020225455A1 (en)	2019-02-22	2021-09-09	Kronos Bio, Inc.	Solid forms of condensed pyrazines as Syk inhibitors
WO2024220541A1 (en) *	2023-04-18	2024-10-24	Kallyope, Inc.	Nk3 modulators and uses thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3489755A (en)	1966-08-03	1970-01-13	Pfizer & Co C	Imidazo (1,2-b) pyridazines
FR2463774A1 (fr) *	1979-08-21	1981-02-27	Yamanouchi Pharma Co Ltd	Derives du 2-phenylimidazo(2,1-b)benzothiazole
DE3269604D1 (en) *	1981-06-26	1986-04-10	Schering Corp	Novel imidazo(1,2-a)pyridines and pyrazines, processes for their preparation and pharmaceutical compositions containing them
EP0266890A1 (en) *	1986-10-07	1988-05-11	Yamanouchi Pharmaceutical Co. Ltd.	Imidazopyridine derivatives, their production, and pharmaceutical compositions containing them
FR2638161B1 (fr) *	1988-10-24	1991-01-11	Centre Nat Rech Scient	Nouvelles benzoyl-2 imidazo (1,2-a) pyridines et leurs sels, leur procede de preparation, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant
JPH08333258A (ja) *	1994-12-14	1996-12-17	Japan Tobacco Inc	チアジン又はチアゼピン誘導体及びそれら化合物を含有してなる一酸化窒素合成酵素阻害剤
GB9506188D0 (en) *	1995-03-27	1995-05-17	Fujisawa Pharmaceutical Co	Amidine derivatives
US5908842A (en) *	1995-12-08	1999-06-01	Merck & Co., Inc.	Substituted 2-acylamino-pyridines as inhibitors of nitric oxide synthase
AU3783497A (en) *	1996-08-09	1998-03-06	Yamanouchi Pharmaceutical Co., Ltd.	Metabotropic glutamate receptor agonists
AUPP278498A0 (en) *	1998-04-03	1998-04-30	Australian Nuclear Science & Technology Organisation	Peripheral benzodiazepine receptor binding agents

1999
- 1999-10-08 DE DE19948434A patent/DE19948434A1/de not_active Withdrawn
2000
- 2000-09-18 AU AU74199/00A patent/AU7419900A/en not_active Abandoned
- 2000-09-18 IL IL14899700A patent/IL148997A0/xx not_active IP Right Cessation
- 2000-09-18 WO PCT/EP2000/009098 patent/WO2001027119A2/de not_active Ceased
- 2000-10-02 CO CO00074640A patent/CO5210861A1/es not_active Application Discontinuation
- 2000-10-05 AR ARP000105251A patent/AR025960A1/es not_active Application Discontinuation
- 2000-10-05 AR ARP000105250A patent/AR025959A1/es not_active Application Discontinuation
- 2000-10-06 DK DK00969439T patent/DK1218378T3/da active
- 2000-10-06 HK HK02109385.2A patent/HK1047749B/zh not_active IP Right Cessation
- 2000-10-06 CA CA002386804A patent/CA2386804A1/en not_active Abandoned
- 2000-10-06 PL PL00355109A patent/PL355109A1/xx not_active IP Right Cessation
- 2000-10-06 PE PE2000001062A patent/PE20010706A1/es not_active Application Discontinuation
- 2000-10-06 CO CO00076179A patent/CO5251429A1/es not_active Application Discontinuation
- 2000-10-06 SK SK462-2002A patent/SK4622002A3/sk unknown
- 2000-10-06 ES ES00969439T patent/ES2198355T3/es not_active Expired - Lifetime
- 2000-10-06 PT PT00969439T patent/PT1218378E/pt unknown
- 2000-10-06 PE PE2000001063A patent/PE20010632A1/es not_active Application Discontinuation
- 2000-10-06 HU HU0203545A patent/HUP0203545A3/hu unknown
- 2000-10-06 NZ NZ518438A patent/NZ518438A/en not_active IP Right Cessation
- 2000-10-06 WO PCT/EP2000/009791 patent/WO2001027109A2/de not_active Ceased
- 2000-10-06 AU AU79153/00A patent/AU780526B2/en not_active Ceased
- 2000-10-06 AT AT00969439T patent/ATE238304T1/de active
- 2000-10-06 KR KR1020027004518A patent/KR100793619B1/ko not_active Expired - Fee Related
- 2000-10-06 EP EP00969439A patent/EP1218378B1/de not_active Expired - Lifetime
- 2000-10-06 DE DE50001911T patent/DE50001911D1/de not_active Expired - Lifetime
- 2000-10-06 RU RU2002110281/04A patent/RU2002110281A/ru not_active Application Discontinuation
- 2000-10-06 MX MXPA02003546A patent/MXPA02003546A/es active IP Right Grant
- 2000-10-06 IL IL14899900A patent/IL148999A0/xx active IP Right Grant
- 2000-10-06 CN CNB008167079A patent/CN1208336C/zh not_active Expired - Fee Related
- 2000-10-06 CZ CZ20021241A patent/CZ20021241A3/cs unknown
- 2000-10-06 BR BR0014827-0A patent/BR0014827A/pt not_active IP Right Cessation
- 2000-10-06 JP JP2001530327A patent/JP2003511450A/ja active Pending
2002
- 2002-04-03 NO NO20021564A patent/NO20021564L/no not_active Application Discontinuation
- 2002-04-04 IL IL148999A patent/IL148999A/en not_active IP Right Cessation
- 2002-04-08 US US10/117,339 patent/US6703404B2/en not_active Expired - Fee Related
- 2002-05-06 ZA ZA200203579A patent/ZA200203579B/xx unknown
- 2002-05-06 ZA ZA200203581A patent/ZA200203581B/xx unknown

Also Published As

Publication number	Publication date
EP1218378A2 (de)	2002-07-03
DE19948434A1 (de)	2001-06-07
NZ518438A (en)	2004-08-27
KR20020069003A (ko)	2002-08-28
KR100793619B1 (ko)	2008-01-11
HUP0203545A3 (en)	2004-07-28
AR025960A1 (es)	2002-12-26
CN1407983A (zh)	2003-04-02
AU7419900A (en)	2001-04-23
SK4622002A3 (en)	2002-09-10
RU2002110281A (ru)	2003-12-20
ZA200203579B (en)	2003-10-29
WO2001027119A2 (de)	2001-04-19
BR0014827A (pt)	2003-07-08
WO2001027109A3 (de)	2001-09-20
AR025959A1 (es)	2002-12-26
PL355109A1 (en)	2004-04-05
PT1218378E (pt)	2003-09-30
HUP0203545A2 (hu)	2003-02-28
AU7915300A (en)	2001-04-23
NO20021564D0 (no)	2002-04-03
CA2386804A1 (en)	2001-04-19
EP1218378B1 (de)	2003-04-23
PE20010706A1 (es)	2001-08-13
US20030022914A1 (en)	2003-01-30
IL148997A0 (en)	2002-11-10
HK1047749A1 (en)	2003-03-07
DE50001911D1 (de)	2003-05-28
CO5251429A1 (es)	2003-02-28
JP2003511450A (ja)	2003-03-25
HK1047749B (zh)	2003-08-22
ATE238304T1 (de)	2003-05-15
IL148999A (en)	2007-03-08
WO2001027109A2 (de)	2001-04-19
ES2198355T3 (es)	2004-02-01
PE20010632A1 (es)	2001-07-07
CN1208336C (zh)	2005-06-29
MXPA02003546A (es)	2002-09-18
IL148999A0 (en)	2002-11-10
US6703404B2 (en)	2004-03-09
AU780526B2 (en)	2005-03-24
WO2001027119A3 (de)	2001-10-11
CO5210861A1 (es)	2002-10-30
ZA200203581B (en)	2004-02-25
NO20021564L (no)	2002-06-04
CZ20021241A3 (cs)	2002-08-14

Publication	Publication Date	Title
DK1218378T3 (da)	2003-07-21	Tert.-butyl-(7-methylimidazo[1,2-a]pyridin-3-yl) aminderivater
NO20020687L (no)	2002-04-03	3(5)-ureido-pyrazolderivater, fremgangsmåte for fremstilling av disse og deres anvendelse som antitumormidler
NO20015477D0 (no)	2001-11-08	4,5,6,7-tetrahydroindazol-derivater som anti-tumor midler
NO20020684L (no)	2002-04-03	3(5)-aminopyrazolderivater, fremgangsmåtet for deres fremstilling og deres anvendelse som antitumormidler
NO20012057D0 (no)	2001-04-26	2-amino-tiazolderivater, fremgangsmåte for deres fremstilling og anvendelse som antitumormidler
ATE251625T1 (de)	2003-10-15	8-phenyl-6,9-dihydro-(1,2,4)triazolo(3,4-i)puri - 5-on derivate
FR17C1012I2 (fr)	2018-06-08	2-(pyridin-2-ylamino)-pyrido [2,3-d]pyrimidin-7-ones
IL160707A0 (en)	2004-08-31	1, 8-naphthyridine derivatives as antidiabetics
DE60016615D1 (de)	2005-01-13	Pyrazolo[4,3-d]pyrimidinderivate
NO20012058L (no)	2001-06-28	2-ureido-tiazolderivater, fremgangsmåte for deres fremstilling og anvendelse som antitumormidler
AU7556800A (en)	2001-05-10	Amine derivatives
IL155974A0 (en)	2003-12-23	Novel pyridine-substituted pyrazolopyridine derivatives
ZA200306341B (en)	2004-11-15	Imidazo (1,2-a)-pyridine derivatives as mGluR5 antagonists.
NO20002217D0 (no)	2000-04-28	Cyclopentan-heptansyre, 2-heteroarylalkenylderivater som terapeutiske midler
TR199800085A3 (tr)	1998-08-21	8-Sübstitüye edilmis-1,3,8-triaza- spiro(4,5)dekan-4-on türevleri.
TR199802520A3 (tr)	1999-06-21	1,3,8-Triaza-spiro(4,5) dekan -4-on türevleri.
PT1210349E (pt)	2003-06-30	Pirazolo-¬4,3-d\|-pirimidinas
NO20016404D0 (no)	2001-12-28	Naftyridinderivater, fremgangsmåter for deres fremstilling, deres anvendelse og farmasöytiske preparater omfattende disse
HUP0102444A3 (en)	2003-09-29	Protein c derivatives
GB0214544D0 (en)	2002-08-07	6-Crbamoylpyrimido[4,5-b]Indole derivatives
ZA200005185B (en)	2001-06-18	Indole-2,3-Dione-3-Oxime derivatives for therapeutic use.
DK1124810T3 (da)	2005-08-22	2-amino-thiazolderivater, fremgangsmåde til deres fremstilling og deres anvendelse som antitumormidler
SI1218378T1 (en)	2003-08-31	Tert.-butyl-(7-methyl-imidazo(1,2-a)pyridine-3-yl)-amine derivatives
ES1043557Y (es)	2000-06-01	Bolso perfeccionado.
ES1042295Y (es)	2000-01-01	Bolsa perfeccionda.