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DK1278763T3 - 3-Nitrogen-6,7-dioxygensteroider og anvendelser relateret dertil - Google Patents

3-Nitrogen-6,7-dioxygensteroider og anvendelser relateret dertil

Info

Publication number
DK1278763T3
DK1278763T3 DK01925262T DK01925262T DK1278763T3 DK 1278763 T3 DK1278763 T3 DK 1278763T3 DK 01925262 T DK01925262 T DK 01925262T DK 01925262 T DK01925262 T DK 01925262T DK 1278763 T3 DK1278763 T3 DK 1278763T3
Authority
DK
Denmark
Prior art keywords
dioxygen
steroids
nitrogen
related applications
applications
Prior art date
Application number
DK01925262T
Other languages
English (en)
Inventor
Jeffery R Raymond
Claudia E Kasserra
Yaping Shen
Original Assignee
Inflazyme Pharm Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inflazyme Pharm Ltd filed Critical Inflazyme Pharm Ltd
Application granted granted Critical
Publication of DK1278763T3 publication Critical patent/DK1278763T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J41/00Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/06Antiarrhythmics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J41/00Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J41/00Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • C07J41/0011Unsubstituted amino radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J43/00Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J71/00Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0036Nitrogen-containing hetero ring
    • C07J71/0042Nitrogen only
    • C07J71/0047Nitrogen only at position 2(3)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J71/00Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0036Nitrogen-containing hetero ring
    • C07J71/0057Nitrogen and oxygen
    • C07J71/0063Nitrogen and oxygen at position 2(3)
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Virology (AREA)
  • Cardiology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • AIDS & HIV (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Vascular Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK01925262T 2000-04-28 2001-04-30 3-Nitrogen-6,7-dioxygensteroider og anvendelser relateret dertil DK1278763T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20061700P 2000-04-28 2000-04-28
PCT/CA2001/000581 WO2001083512A1 (en) 2000-04-28 2001-04-30 3-nitrogen-6,7-dioxygen steroids and uses related thereto

Publications (1)

Publication Number Publication Date
DK1278763T3 true DK1278763T3 (da) 2007-06-11

Family

ID=22742458

Family Applications (1)

Application Number Title Priority Date Filing Date
DK01925262T DK1278763T3 (da) 2000-04-28 2001-04-30 3-Nitrogen-6,7-dioxygensteroider og anvendelser relateret dertil

Country Status (33)

Country Link
US (4) US6635629B2 (da)
EP (1) EP1278763B1 (da)
JP (1) JP2003531916A (da)
KR (1) KR20030045671A (da)
CN (1) CN1214039C (da)
AP (1) AP1825A (da)
AT (1) ATE353909T1 (da)
AU (2) AU5208401A (da)
BG (1) BG107289A (da)
BR (1) BR0110419A (da)
CA (1) CA2418748A1 (da)
CO (1) CO5590904A2 (da)
DE (1) DE60126597T2 (da)
DK (1) DK1278763T3 (da)
DZ (1) DZ3355A1 (da)
EE (1) EE200200613A (da)
ES (1) ES2282247T3 (da)
HR (1) HRP20020944A2 (da)
HU (1) HUP0300908A2 (da)
IL (2) IL152448A0 (da)
MA (1) MA25808A1 (da)
MX (1) MXPA02010645A (da)
NO (1) NO324873B1 (da)
NZ (1) NZ522181A (da)
OA (1) OA12255A (da)
PL (1) PL365798A1 (da)
PT (1) PT1278763E (da)
RU (1) RU2291873C2 (da)
SK (1) SK15692002A3 (da)
UA (1) UA79229C2 (da)
WO (1) WO2001083512A1 (da)
YU (1) YU88102A (da)
ZA (1) ZA200208631B (da)

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DZ3355A1 (fr) * 2000-04-28 2001-11-08 Inflazyme Pharm Ltd Steroides 3-azote-6,7-dioxyde et les emplois qui s'y rapportent
US20050070487A1 (en) * 2001-04-24 2005-03-31 Nyce Jonathan W. Composition, formulations and kit for treatment of respiratory and lung disease with non-glucocorticoid steroids and/or ubiquinone and a bronchodilating agent
US20040266744A1 (en) 2001-05-22 2004-12-30 Burgoyne David L Process for the production of 6, 7- dihydroxy steroid compounds by allylic oxidation of steroid - 5 - ene compounds to steroid - 5 - ene - 7 - one compounds followed by hydroboration and oxidation and intermediates of this process
CA2480427C (en) * 2002-08-01 2010-08-31 Yamanouchi Pharmaceutical Co., Ltd. Novel potassium-dependent sodium-calcium exchanger
US20050026884A1 (en) * 2003-07-31 2005-02-03 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a beta-agonist bronchodilator for treatment of asthma or chronic obstructive pulmonary disease
US20050038004A1 (en) * 2003-07-31 2005-02-17 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with an anticholinergic bronchodilator for treatment of asthma or chronic obstructive pulmonary disease
US20050101545A1 (en) * 2003-07-31 2005-05-12 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with an anticholinergic bronchodilator for treatment of asthma or chronic obstructive pulmonary disease
US20050113318A1 (en) * 2003-07-31 2005-05-26 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a beta-agonist bronchodilator for treatment of asthma or chronic obstructive pulmonary disease
US20090317476A1 (en) * 2003-07-31 2009-12-24 Robinson Cynthia B Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a leukotriene receptor antagonist for treatment of asthma or chronic obstructive pulmonary disease
US20050026881A1 (en) * 2003-07-31 2005-02-03 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with an anti-IgE antibody for treatment of asthma or chronic obstructive pulmonary disease
US20050026879A1 (en) * 2003-07-31 2005-02-03 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a tyrosine kinase inhibitor, delta opioid receptor antagonist, neurokinin receptor antagonist, or VCAM inhibitor for treatment of asthma or chronic obstructive pulmonary disease
US20050026882A1 (en) * 2003-07-31 2005-02-03 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a leukotriene receptor antagonist for treatment of asthma or chronic obstructive pulmonary disease
US20110209699A1 (en) * 2003-07-31 2011-09-01 Robinson Cynthia B Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a lipoxygenase inhibitor for treatment of asthma or chronic obstructive pulmonary disease
US20090285900A1 (en) * 2003-07-31 2009-11-19 Robinson Cynthia B Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a beta-agonist bronchodilator for treatment of asthma or chronic obstructive pulmonary disease
US20050043282A1 (en) * 2003-07-31 2005-02-24 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a lipoxygenase inhibitor for treatment of asthma or chronic obstructive pulmonary disease
US20090297611A1 (en) * 2003-07-31 2009-12-03 Robinson Cynthia B Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a tyrosine kinase inhibitor, delta opioid receptor antagonist, neurokinin receptor antagonist, or vcam inhibitor for treatment of asthma or chronic obstructive pulmonary disease
US20090263381A1 (en) * 2003-07-31 2009-10-22 Robinson Cynthia B Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with an anti-ige antibody for treatment of asthma or chronic obstructive pulmonary disease
FR2861077B1 (fr) * 2003-10-20 2006-03-03 Aventis Pharma Sa Formes cristallines du chlorydrate de 3-beta-amino, 17-methylene, androstane-6-alpha, 7-beta-diol
US20080051382A1 (en) * 2003-10-20 2008-02-28 Inflazyme Pharmaceuticals Ltd. Crystalline Forms of 3-Beta-Amino 17-Methylene Androstane-6-Alpha 7-Beta-Diol Hydrochloride
RU2006117320A (ru) * 2003-10-20 2007-11-27 Инфлазим Фармасьютикалз, Лтд. (Ca) Кристаллические формы гидрохлорида 3-бета-амино-17-метиленандростан-6-альфа-7-бета-диола
US20090317477A1 (en) * 2004-03-31 2009-12-24 Robinson Cynthia B Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a glucocorticosteroid for treatment of asthma, chronic obstructive pulmonary disease or allergic rhinitis
US20050222049A1 (en) * 2004-03-31 2005-10-06 Robinson Cynthia B Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a glucocorticosteroid for treatment of asthma, chronic obstructive pulmonary disease or allergic rhinitis
US20050227927A1 (en) * 2004-03-31 2005-10-13 Robinson Cynthia B Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a glucocorticosteroid for treatment of asthma, chronic obstructive pulmonary disease or allergic rhinitis
EP2217279B1 (en) * 2007-11-21 2017-11-01 The Procter & Gamble Company Preparations useful for treatment of cough
JP5655243B2 (ja) * 2009-10-19 2015-01-21 国立大学法人 熊本大学 インドキシル硫酸の産生の阻害剤のスクリーニング方法、インドキシル硫酸代謝産生阻害剤、及び腎障害軽減剤
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US9340570B2 (en) 2012-04-29 2016-05-17 Neupharma, Inc. Certain chemical entities, compositions, and methods
EP2900328A4 (en) 2012-09-25 2016-05-11 Biogen Ma Inc PROCESS FOR USE OF FIXED POLYPEPTIDES
CN105209429B (zh) 2013-03-14 2018-05-29 阿奎诺克斯药物(加拿大)公司 Ship1调节剂和与其相关的方法
WO2014158654A1 (en) 2013-03-14 2014-10-02 Aquinox Pharmaceuticals Inc. Ship1 modulators and methods related thereto
WO2014144549A1 (en) 2013-03-15 2014-09-18 Biogen Idec Ma Inc. Factor ix polypeptide formulations
CN104744547B (zh) * 2013-12-27 2017-02-15 天津医科大学 一种抗乳腺癌转移作用的孕甾烷生物碱衍生物及医药用途
WO2016210146A1 (en) 2015-06-26 2016-12-29 Aquinox Pharmaceuticals (Canada) Inc. Crystalline solid forms of the acetate salt of (1s,3s,4r)-4-((3as,4r,5s,7as)-4-(aminomethyl)-7a-methyl-1-methyleneoctahydro-1h-inden-5-yl)-3-(hydroxymethyl)-4-methylcyclohexanol
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EP3774836B1 (en) 2018-04-06 2023-10-04 Taro Pharmaceuticals Inc. Hexadecahydro-1h-cyclopenta[a]phenanthrene derivatives useful in treating pain and inflammation
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JP2021526545A (ja) 2018-04-06 2021-10-07 アキノックス ファーマシューティカルス(カナダ)インク. 疼痛及び炎症を治療するのに有用なインデン誘導体

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Also Published As

Publication number Publication date
US20020072510A1 (en) 2002-06-13
AP2002002659A0 (en) 2002-12-31
EP1278763A1 (en) 2003-01-29
DZ3355A1 (fr) 2001-11-08
BG107289A (bg) 2003-07-31
ZA200208631B (en) 2004-02-23
ATE353909T1 (de) 2007-03-15
HRP20020944A2 (en) 2004-02-29
HUP0300908A2 (hu) 2003-07-28
DE60126597T2 (de) 2007-10-31
MA25808A1 (fr) 2003-07-01
NO20025106D0 (no) 2002-10-24
YU88102A (sh) 2006-01-16
JP2003531916A (ja) 2003-10-28
NZ522181A (en) 2005-04-29
NO324873B1 (no) 2007-12-17
CN1214039C (zh) 2005-08-10
EP1278763B1 (en) 2007-02-14
HK1050694A1 (en) 2003-07-04
AU5208401A (en) 2001-11-12
CA2418748A1 (en) 2001-11-08
KR20030045671A (ko) 2003-06-11
US6635629B2 (en) 2003-10-21
PT1278763E (pt) 2007-05-31
ES2282247T3 (es) 2007-10-16
IL152448A (en) 2006-12-31
AU2001252084B2 (en) 2006-07-06
CO5590904A2 (es) 2005-12-30
AP1825A (en) 2008-02-03
PL365798A1 (en) 2005-01-10
US7112580B2 (en) 2006-09-26
CN1430625A (zh) 2003-07-16
OA12255A (en) 2006-05-11
UA79229C2 (en) 2007-06-11
DE60126597D1 (de) 2007-03-29
US20040034216A1 (en) 2004-02-19
SK15692002A3 (sk) 2003-11-04
RU2291873C2 (ru) 2007-01-20
MXPA02010645A (es) 2004-04-20
BR0110419A (pt) 2004-02-25
US20040138186A1 (en) 2004-07-15
IL152448A0 (en) 2003-05-29
EE200200613A (et) 2004-04-15
WO2001083512A1 (en) 2001-11-08
US20070060553A1 (en) 2007-03-15
NO20025106L (no) 2002-12-18
US20050215534A9 (en) 2005-09-29

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