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DK1149078T3 - Selektive 5-HT6-receptorligander - Google Patents

Selektive 5-HT6-receptorligander

Info

Publication number
DK1149078T3
DK1149078T3 DK99967248T DK99967248T DK1149078T3 DK 1149078 T3 DK1149078 T3 DK 1149078T3 DK 99967248 T DK99967248 T DK 99967248T DK 99967248 T DK99967248 T DK 99967248T DK 1149078 T3 DK1149078 T3 DK 1149078T3
Authority
DK
Denmark
Prior art keywords
selective
receptor ligands
receptors
compounds
treatment
Prior art date
Application number
DK99967248T
Other languages
English (en)
Inventor
Bryan L Roth
Richard A Glennon
Original Assignee
Univ Virginia Commonwealth
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Virginia Commonwealth filed Critical Univ Virginia Commonwealth
Application granted granted Critical
Publication of DK1149078T3 publication Critical patent/DK1149078T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/86—Carbazoles; Hydrogenated carbazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Escalators And Moving Walkways (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Electric Double-Layer Capacitors Or The Like (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Control Of High-Frequency Heating Circuits (AREA)
  • Superconductors And Manufacturing Methods Therefor (AREA)
  • Conductive Materials (AREA)
DK99967248T 1998-12-11 1999-12-10 Selektive 5-HT6-receptorligander DK1149078T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US11178798P 1998-12-11 1998-12-11

Publications (1)

Publication Number Publication Date
DK1149078T3 true DK1149078T3 (da) 2006-07-10

Family

ID=22340454

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99967248T DK1149078T3 (da) 1998-12-11 1999-12-10 Selektive 5-HT6-receptorligander

Country Status (10)

Country Link
EP (1) EP1149078B1 (da)
AT (1) ATE319683T1 (da)
AU (1) AU767009B2 (da)
CA (1) CA2353962C (da)
DE (1) DE69930308T2 (da)
DK (1) DK1149078T3 (da)
ES (1) ES2260958T3 (da)
MX (1) MXPA01005905A (da)
PT (1) PT1149078E (da)
WO (1) WO2000034242A1 (da)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002032863A1 (en) 2000-10-20 2002-04-25 Biovitrum Ab 2-, 3-, 4-, or 5-substituted-n1-(benzensulfonyl)indoles and their use in therapy
CZ305838B6 (cs) 2001-03-29 2016-04-06 Eli Lilly And Company N-(2-arylethyl)benzylaminy jako antagonisté receptoru 5-HT6
EP1859798B1 (en) * 2001-03-29 2015-12-30 Eli Lilly And Company N-(2-arylethyl) benzylamines as antagonists of the 5-ht6 receptor
JP4731114B2 (ja) 2001-06-11 2011-07-20 プロキシマゲン・リミテッド 置換スルホンアミド化合物、ｃｎｓ障害、肥満およびｉｉ型糖尿病の処置のための医薬としてのそれらの使用方法
ITRM20010356A1 (it) 2001-06-21 2002-12-23 Sigma Tau Ind Farmaceuti "5-alogeno derivati della triptamina utili come ligandi del recettore5-ht6 e/o 5-ht7 della serotonina.
EP1897881A3 (en) 2002-06-20 2009-03-18 Biovitrum AB (publ) Compounds useful for the treatment of obesity, type II diabetes and CNS disorders
WO2004000849A2 (en) 2002-06-21 2003-12-31 Suven Life Sciences Limited Tetracyclic arylsulfonyl indoles having serotonin receptor affinity
WO2004055026A1 (en) 2002-12-18 2004-07-01 Suven Life Sciences Limited Tetracyclic 3-substituted indoles having serotonin receptor affinity
SI1637527T1 (sl) 2003-06-26 2013-07-31 Takeda Pharmaceutical Company Limited Modulator kanabinoidnega receptorja
DK1648904T3 (da) * 2003-07-31 2007-10-22 Wyeth Corp N-sulfonylheterocyclopyrrolalkylaminforbindelser som 5-hydroxytryptamin-6-ligander
SE0303480D0 (sv) 2003-12-19 2003-12-19 Biovitrum Ab Benzofuranes
EP1807427A2 (en) 2004-11-01 2007-07-18 Wyeth Substituted indolizines and derivatives as cns agents
US7582767B2 (en) 2005-06-17 2009-09-01 Biovitrum Ab (Publ.) Substituted sulphonamide compound and uses thereof
US8143303B2 (en) * 2005-10-19 2012-03-27 Suven Life Sciences Limited Carbazole derivatives as functional 5-HT6 ligands
NZ579360A (en) 2007-03-13 2011-06-30 Proximagen Ltd Tricyclic isoquinoline derivatives for treatment of obesity
AU2008331920A1 (en) * 2007-12-04 2009-06-11 Merck Sharp & Dohme Corp. Tryptamine sulfonamides as 5-HT6 antagonists
EP2103596A1 (en) 2008-03-18 2009-09-23 Laboratorios Del. Dr. Esteve, S.A. Process for the preparation of N-(phenylethyl) anilines salts and solvates thereof useful as serotonin 5-HT6 antagonists
GB0905328D0 (en) * 2009-03-27 2009-05-13 Ge Healthcare Ltd Indole derivatives
FR2961097B1 (fr) * 2010-06-09 2012-07-13 Oreal Procede cosmetique de traitement des odeurs corporelles humaines utilisant un compose 6-alkoxy tryptamine
FR2961095B1 (fr) * 2010-06-09 2012-06-15 Oreal Composition cosmetique et/ou dermatologique comprenant au moins un compose 6-alcoxy tryptamine
CA2853729A1 (en) 2011-10-28 2013-05-02 Board Of Regents, The University Of Texas System Novel compositions and methods for treating cancer
JO3459B1 (ar) 2012-09-09 2020-07-05 H Lundbeck As تركيبات صيدلانية لعلاج مرض الزهايمر
AU2021276656A1 (en) 2020-05-19 2022-11-24 Cybin Irl Limited Deuterated tryptamine derivatives and methods of use
US12343328B2 (en) 2020-12-09 2025-07-01 Caamtech, Inc. Dialkyl tryptamines and their therapeutic uses
CN118715204A (zh) * 2021-12-24 2024-09-27 普赛洛私人有限公司 化合物

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3939177A (en) * 1972-11-22 1976-02-17 Sterling Drug Inc. 4-Aminomethyl-9-benzyl-1,2,3,4-tetrahydrocarbazoles
GB8416724D0 (en) * 1984-06-30 1984-08-01 Sorbio Sa Lab Active compounds

Also Published As

Publication number Publication date
ES2260958T3 (es) 2006-11-01
CA2353962A1 (en) 2000-06-15
DE69930308D1 (de) 2006-05-04
PT1149078E (pt) 2006-07-31
EP1149078A1 (en) 2001-10-31
ATE319683T1 (de) 2006-03-15
AU767009B2 (en) 2003-10-30
AU2356200A (en) 2000-06-26
MXPA01005905A (es) 2002-09-18
EP1149078A4 (en) 2003-01-29
DE69930308T2 (de) 2006-11-30
WO2000034242A1 (en) 2000-06-15
CA2353962C (en) 2009-09-29
EP1149078B1 (en) 2006-03-08

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