DK1140018T3 - Polyol/olie-suspensioner til vedvarende frigørelse af proteiner - Google Patents
Polyol/olie-suspensioner til vedvarende frigørelse af proteinerInfo
- Publication number
- DK1140018T3 DK1140018T3 DK99968164T DK99968164T DK1140018T3 DK 1140018 T3 DK1140018 T3 DK 1140018T3 DK 99968164 T DK99968164 T DK 99968164T DK 99968164 T DK99968164 T DK 99968164T DK 1140018 T3 DK1140018 T3 DK 1140018T3
- Authority
- DK
- Denmark
- Prior art keywords
- oil suspensions
- polyol
- sustained release
- proteins
- active agent
- Prior art date
Links
- 239000012053 oil suspension Substances 0.000 title abstract 3
- 102000004169 proteins and genes Human genes 0.000 title abstract 3
- 108090000623 proteins and genes Proteins 0.000 title abstract 3
- 229920005862 polyol Polymers 0.000 title abstract 2
- 150000003077 polyols Chemical class 0.000 title abstract 2
- 238000013268 sustained release Methods 0.000 title abstract 2
- 239000012730 sustained-release form Substances 0.000 title abstract 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 abstract 3
- 239000013543 active substance Substances 0.000 abstract 2
- 102000004269 Granulocyte Colony-Stimulating Factor Human genes 0.000 abstract 1
- 108010017080 Granulocyte Colony-Stimulating Factor Proteins 0.000 abstract 1
- -1 e.g. Proteins 0.000 abstract 1
- 230000002459 sustained effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Dermatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Fats And Perfumes (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/221,181 US6245740B1 (en) | 1998-12-23 | 1998-12-23 | Polyol:oil suspensions for the sustained release of proteins |
| US44820599A | 1999-11-23 | 1999-11-23 | |
| PCT/US1999/030527 WO2000038652A1 (en) | 1998-12-23 | 1999-12-20 | Polyol/oil suspensions for the sustained release of proteins |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1140018T3 true DK1140018T3 (da) | 2004-02-02 |
Family
ID=26915566
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK99968164T DK1140018T3 (da) | 1998-12-23 | 1999-12-20 | Polyol/olie-suspensioner til vedvarende frigørelse af proteiner |
Country Status (16)
| Country | Link |
|---|---|
| EP (1) | EP1140018B1 (da) |
| JP (1) | JP2002533378A (da) |
| KR (1) | KR100491815B1 (da) |
| CN (1) | CN1158068C (da) |
| AT (1) | ATE251448T1 (da) |
| AU (1) | AU769610B2 (da) |
| CA (1) | CA2355618C (da) |
| DE (1) | DE69911993T2 (da) |
| DK (1) | DK1140018T3 (da) |
| ES (1) | ES2204187T3 (da) |
| HU (1) | HUP0104756A3 (da) |
| IL (2) | IL143706A0 (da) |
| PT (1) | PT1140018E (da) |
| SI (1) | SI1140018T1 (da) |
| TW (1) | TWI221777B (da) |
| WO (1) | WO2000038652A1 (da) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7022674B2 (en) | 1999-12-16 | 2006-04-04 | Eli Lilly And Company | Polypeptide compositions with improved stability |
| IL152360A0 (en) | 2000-04-19 | 2003-05-29 | Genentech Inc | Sustained release formulations |
| AU2587002A (en) | 2000-11-03 | 2002-05-15 | Biomedicines Inc | Method for short-term and long-term drug dosimetry |
| DK1397155T3 (da) | 2001-06-21 | 2015-12-07 | Genentech Inc | Depotformulering |
| US7731947B2 (en) | 2003-11-17 | 2010-06-08 | Intarcia Therapeutics, Inc. | Composition and dosage form comprising an interferon particle formulation and suspending vehicle |
| FR2868704B1 (fr) * | 2004-04-07 | 2007-09-14 | Ethypharm Sa | Utilisation de lipides pour ameliorer la biodisponibilite de principes actifs proteiques en formulations injectables sous cutanees ou intra-musculaires |
| US7772182B2 (en) * | 2004-08-05 | 2010-08-10 | Alza Corporation | Stable suspension formulations of erythropoietin receptor agonists |
| WO2006083761A2 (en) | 2005-02-03 | 2006-08-10 | Alza Corporation | Solvent/polymer solutions as suspension vehicles |
| US11246913B2 (en) | 2005-02-03 | 2022-02-15 | Intarcia Therapeutics, Inc. | Suspension formulation comprising an insulinotropic peptide |
| US8008453B2 (en) | 2005-08-12 | 2011-08-30 | Amgen Inc. | Modified Fc molecules |
| CN101453982B (zh) | 2006-05-30 | 2011-05-04 | 精达制药公司 | 两件式内部通道渗透递送系统流动调节器 |
| NZ593017A (en) | 2006-08-09 | 2011-08-26 | Intarcia Therapeutics Inc | Piston assembly for positioning lumen in an osmotic delivery system having groove to retain elastomeric O-ring |
| WO2008088422A2 (en) | 2006-10-25 | 2008-07-24 | Amgen Inc. | Toxin peptide therapeutic agents |
| JP4588791B2 (ja) * | 2007-02-16 | 2010-12-01 | あすか製薬株式会社 | 微粒子油性懸濁液を含む医薬組成物 |
| US20080227805A1 (en) | 2007-02-28 | 2008-09-18 | Abbott Laboratories | Sustained release parenteral formulations of buprenorphine |
| RU2440097C2 (ru) | 2007-04-23 | 2012-01-20 | Интарсия Терапьютикс, Инк. | Способ лечения диабета ii типа и ожирения, осмотическое устройство для доставки и способ его изготовления |
| EP2738257A1 (en) | 2007-05-22 | 2014-06-04 | Amgen Inc. | Compositions and methods for producing bioactive fusion proteins |
| WO2009102467A2 (en) | 2008-02-13 | 2009-08-20 | Intarcia Therapeutics, Inc. | Devices, formulations, and methods for delivery of multiple beneficial agents |
| SMT201700583T1 (it) | 2009-09-28 | 2018-01-11 | Intarcia Therapeutics Inc | Instaurazione e/o terminazione rapida di erogazione di farmaci in modo sostanzialmente stazionario |
| US20120208755A1 (en) | 2011-02-16 | 2012-08-16 | Intarcia Therapeutics, Inc. | Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers |
| HK1198173A1 (en) | 2011-03-16 | 2015-03-13 | Amgen Inc. | Potent and selective inhibitors of nav1.3 and nav1.7 |
| EP2935311B1 (en) | 2012-12-20 | 2021-03-31 | Amgen Inc. | Apj receptor agonists and uses thereof |
| WO2014165277A2 (en) | 2013-03-12 | 2014-10-09 | Amgen Inc. | POTENT AND SELECTIVE INHIBITORS OF Nav1.7 |
| MX370689B (es) | 2014-06-10 | 2019-12-19 | Amgen Inc | Polipeptidos apelina. |
| US9889085B1 (en) | 2014-09-30 | 2018-02-13 | Intarcia Therapeutics, Inc. | Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c |
| JP6993235B2 (ja) | 2015-06-03 | 2022-01-13 | インターシア セラピューティクス，インコーポレイティド | インプラントの設置及び撤去システム |
| EP3733694A1 (en) | 2016-05-16 | 2020-11-04 | Intarcia Therapeutics, Inc | Glucagon-receptor selective polypeptides and methods of use thereof |
| USD860451S1 (en) | 2016-06-02 | 2019-09-17 | Intarcia Therapeutics, Inc. | Implant removal tool |
| USD840030S1 (en) | 2016-06-02 | 2019-02-05 | Intarcia Therapeutics, Inc. | Implant placement guide |
| JP7286542B2 (ja) | 2017-01-03 | 2023-06-05 | インターシア セラピューティクス，インコーポレイティド | Ｇｌｐ－１受容体アゴニストの持続的投与及び薬物の同時投与を含む方法 |
| US11318190B2 (en) | 2017-05-05 | 2022-05-03 | United States Government As Represented By The Department Of Veterans Affairs | Methods and compositions for treating liver disease |
| EP4321152A4 (en) * | 2021-04-08 | 2025-05-21 | Tionlab Therapeutics | Sustained-release lipid preconcentrate |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0164397B1 (en) * | 1983-11-21 | 1990-07-04 | The Regents Of The University Of Minnesota | A buffered polyol-hormone mixture for use in chronic parenteral hormone administration |
| US5411951A (en) * | 1984-10-04 | 1995-05-02 | Monsanto Company | Prolonged release of biologically active somatotropin |
| EP0374120A3 (en) * | 1988-12-13 | 1991-07-31 | Monsanto Company | Comosition for controlled release of polypeptides |
| US5114929A (en) * | 1989-03-21 | 1992-05-19 | Beecham Group P.L.C. | Pharmaceutical formulation |
| US6004549A (en) * | 1994-12-14 | 1999-12-21 | Schering Corporation | Crystalline protein controlled release compositions |
-
1999
- 1999-12-20 SI SI9930434T patent/SI1140018T1/xx unknown
- 1999-12-20 PT PT99968164T patent/PT1140018E/pt unknown
- 1999-12-20 EP EP99968164A patent/EP1140018B1/en not_active Expired - Lifetime
- 1999-12-20 IL IL14370699A patent/IL143706A0/xx active IP Right Grant
- 1999-12-20 ES ES99968164T patent/ES2204187T3/es not_active Expired - Lifetime
- 1999-12-20 DE DE69911993T patent/DE69911993T2/de not_active Expired - Fee Related
- 1999-12-20 AT AT99968164T patent/ATE251448T1/de not_active IP Right Cessation
- 1999-12-20 HU HU0104756A patent/HUP0104756A3/hu unknown
- 1999-12-20 WO PCT/US1999/030527 patent/WO2000038652A1/en not_active Ceased
- 1999-12-20 DK DK99968164T patent/DK1140018T3/da active
- 1999-12-20 CN CNB99816271XA patent/CN1158068C/zh not_active Expired - Fee Related
- 1999-12-20 KR KR10-2001-7007843A patent/KR100491815B1/ko not_active Expired - Fee Related
- 1999-12-20 AU AU24838/00A patent/AU769610B2/en not_active Ceased
- 1999-12-20 CA CA002355618A patent/CA2355618C/en not_active Expired - Fee Related
- 1999-12-20 JP JP2000590606A patent/JP2002533378A/ja not_active Withdrawn
- 1999-12-21 TW TW088122540A patent/TWI221777B/zh active
-
2001
- 2001-06-12 IL IL143706A patent/IL143706A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CN1335765A (zh) | 2002-02-13 |
| JP2002533378A (ja) | 2002-10-08 |
| ES2204187T3 (es) | 2004-04-16 |
| AU2483800A (en) | 2000-07-31 |
| CA2355618C (en) | 2007-03-13 |
| KR20010099864A (ko) | 2001-11-09 |
| TWI221777B (en) | 2004-10-11 |
| IL143706A0 (en) | 2002-04-21 |
| KR100491815B1 (ko) | 2005-05-27 |
| EP1140018B1 (en) | 2003-10-08 |
| EP1140018A1 (en) | 2001-10-10 |
| HUP0104756A2 (hu) | 2002-04-29 |
| PT1140018E (pt) | 2004-02-27 |
| DE69911993D1 (de) | 2003-11-13 |
| SI1140018T1 (en) | 2003-12-31 |
| WO2000038652A1 (en) | 2000-07-06 |
| AU769610B2 (en) | 2004-01-29 |
| HUP0104756A3 (en) | 2006-04-28 |
| IL143706A (en) | 2008-04-13 |
| ATE251448T1 (de) | 2003-10-15 |
| DE69911993T2 (de) | 2004-05-19 |
| CA2355618A1 (en) | 2000-07-06 |
| CN1158068C (zh) | 2004-07-21 |
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