DK1071665T3 - Substituerede indolinoner med en inhiberende virkning på kinaser og cyclin/CDK-komplekser - Google Patents

Substituerede indolinoner med en inhiberende virkning på kinaser og cyclin/CDK-komplekser

Info

Publication number: DK1071665T3
Authority: DK; Denmark
Prior art keywords: cyclin; kinases; inhibitory effect; cdk complexes; substituted indolinones
Prior art date: 1998-04-15

Application number

DK99920635T

Other languages

Danish (da)

English (en)

Inventor

Armin Heckel

Rainer Walter

Wolfgang Grell

Meel Jacobus C A Van

Robert Redemann

Original Assignee

Boehringer Ingelheim Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-04-15

Filing date

1999-04-10

Publication date

2004-01-05

1999-04-10 Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma

2004-01-05 Application granted granted Critical

2004-01-05 Publication of DK1071665T3 publication Critical patent/DK1071665T3/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Oncology (AREA)
Engineering & Computer Science (AREA)
Communicable Diseases (AREA)
Bioinformatics & Cheminformatics (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Virology (AREA)
Neurosurgery (AREA)
AIDS & HIV (AREA)
Tropical Medicine & Parasitology (AREA)
Molecular Biology (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Indole Compounds (AREA)

DK99920635T 1998-04-15 1999-04-10 Substituerede indolinoner med en inhiberende virkning på kinaser og cyclin/CDK-komplekser DK1071665T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE19816624A DE19816624A1 (de)	1998-04-15	1998-04-15	Neue substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel
PCT/EP1999/002436 WO1999052869A1 (de)	1998-04-15	1999-04-10	Substituierte indolinone mit inhibierender wirkung auf kinasen und cyclin/cdk-komplexe

Publications (1)

Publication Number	Publication Date
DK1071665T3 true DK1071665T3 (da)	2004-01-05

Family

ID=7864562

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK99920635T DK1071665T3 (da)	1998-04-15	1999-04-10	Substituerede indolinoner med en inhiberende virkning på kinaser og cyclin/CDK-komplekser

Country Status (31)

Country	Link
EP (1)	EP1071665B1 (ja)
JP (1)	JP4015365B2 (ja)
KR (1)	KR100588250B1 (ja)
CN (1)	CN100338036C (ja)
AR (1)	AR015763A1 (ja)
AT (1)	ATE251138T1 (ja)
AU (1)	AU749829B2 (ja)
BG (1)	BG64443B1 (ja)
BR (1)	BR9909688A (ja)
CA (1)	CA2323111C (ja)
CO (1)	CO5011040A1 (ja)
DE (2)	DE19816624A1 (ja)
DK (1)	DK1071665T3 (ja)
EA (1)	EA003532B1 (ja)
EE (1)	EE04432B1 (ja)
ES (1)	ES2207209T3 (ja)
HU (1)	HUP0101568A3 (ja)
ID (1)	ID26420A (ja)
IL (1)	IL138036A0 (ja)
MY (1)	MY122357A (ja)
NO (1)	NO317298B1 (ja)
NZ (1)	NZ507967A (ja)
PL (1)	PL343314A1 (ja)
PT (1)	PT1071665E (ja)
SK (1)	SK283824B6 (ja)
TR (1)	TR200002980T2 (ja)
TW (1)	TW510897B (ja)
UA (1)	UA63009C2 (ja)
WO (1)	WO1999052869A1 (ja)
YU (1)	YU59800A (ja)
ZA (1)	ZA200004623B (ja)

Families Citing this family (39)

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US6569868B2 (en)	1998-04-16	2003-05-27	Sugen, Inc.	2-indolinone derivatives as modulators of protein kinase activity
GB9904995D0 (en) *	1999-03-04	1999-04-28	Glaxo Group Ltd	Substituted aza-oxindole derivatives
GB9904932D0 (en) *	1999-03-04	1999-04-28	Glaxo Group Ltd	Composition and method for preventing/reducing the severity of side effects of chemotherapy and/or radiation therapy
US6624171B1 (en)	1999-03-04	2003-09-23	Smithkline Beecham Corporation	Substituted aza-oxindole derivatives
GB9904933D0 (en)	1999-03-04	1999-04-28	Glaxo Group Ltd	Compounds
DE19924401A1 (de) *	1999-05-27	2000-11-30	Boehringer Ingelheim Pharma	Neue substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel
DE50012136D1 (en) *	1999-08-27	2006-04-13	Boehringer Ingelheim Pharma	Substituierte indolinone als tyrosinkinase inhibitoren
UA75054C2 (uk) *	1999-10-13	2006-03-15	Бьорінгер Інгельхайм Фарма Гмбх & Ко. Кг	Заміщені в положенні 6 індолінони, їх одержання та їх застосування як лікарського засобу
US6762180B1 (en)	1999-10-13	2004-07-13	Boehringer Ingelheim Pharma Kg	Substituted indolines which inhibit receptor tyrosine kinases
SK287142B6 (sk)	2000-02-15	2010-01-07	Sugen, Inc.	Inhibítory proteínkináz na báze pyrolom substituovaného 2-indolinónu, farmaceutický prípravok s ich obsahom a ich použitie
US6620818B1 (en)	2000-03-01	2003-09-16	Smithkline Beecham Corporation	Method for reducing the severity of side effects of chemotherapy and/or radiation therapy
TWI270545B (en)	2000-05-24	2007-01-11	Sugen Inc	Mannich base prodrugs of 3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives
WO2001094312A2 (en)	2000-06-02	2001-12-13	Sugen, Inc.	Indolinone derivatives as protein kinase/phosphatase inhibitors
AU2002215053A1 (en) *	2000-11-27	2002-06-24	Pharmacia Italia S.P.A.	Phenylacetamido- pyrazole derivatives and their use as antitumor agents
AR042586A1 (es)	2001-02-15	2005-06-29	Sugen Inc	3-(4-amidopirrol-2-ilmetiliden)-2-indolinona como inhibidores de la protein quinasa; sus composiciones farmaceuticas; un metodo para la modulacion de la actividad catalitica de la proteinquinasa; un metodo para tratar o prevenir una afeccion relacionada con la proteinquinasa
DE10117204A1 (de)	2001-04-06	2002-10-10	Boehringer Ingelheim Pharma	In 6-Stellung substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel
AR036042A1 (es)	2001-05-30	2004-08-04	Sugen Inc	Derivados aralquilsufonil-3-(pirrol-2-ilmetiliden)-2-indolinona, sus composiciones farmaceuticas y metodo para la modulacion de la actividad catalitica de una proteina quinasa
PL373043A1 (en)	2002-03-26	2005-08-08	Boehringer Ingelheim Pharmaceuticals, Inc.	Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
US7169936B2 (en)	2002-07-23	2007-01-30	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Indolinone derivatives substituted in the 6-position, their preparation and their use as medicaments
DE10233500A1 (de) *	2002-07-24	2004-02-19	Boehringer Ingelheim Pharma Gmbh & Co. Kg	3-Z-[1-(4-(N-((4-Methyl-piperazin-1-yl)-methylcarbonyl)-N-methyl-amino)-anilino)-1-phenyl-methylen]-6-methoxycarbonyl-2-indolinon-Monoethansulfonat und dessen Verwendung als Arzneimittel
DE10237423A1 (de) *	2002-08-16	2004-02-19	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Verwendung von LCK-Inhibitoren für die Behandlung von immunologischen Erkrankungen
JP4879492B2 (ja) *	2002-11-27	2012-02-22	アラーガン、インコーポレイテッド	疾患の治療のためのキナーゼ阻害剤
US20050043233A1 (en)	2003-04-29	2005-02-24	Boehringer Ingelheim International Gmbh	Combinations for the treatment of diseases involving cell proliferation, migration or apoptosis of myeloma cells or angiogenesis
UY28526A1 (es)	2003-09-24	2005-04-29	Boehringer Ingelheim Pharma	Miméticos de glucocorticoides, métodos de preparación composiciones farmacéuticas y usos de los mismos
WO2005033330A2 (en) *	2003-10-03	2005-04-14	Boehringer Ingelheim Pharmaceuticals, Inc.	Fluorescent probes for use in protein kinase inhibitor binding assay
DE102004012070A1 (de) *	2004-03-12	2005-09-29	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Neue cycloalkyl-haltige 5-Acylindolinone, deren Herstellung und deren Verwendung als Arzneimittel
US7795272B2 (en)	2004-03-13	2010-09-14	Boehringer Ingelheim Pharmaceutical, Inc.	Glucocorticoid mimetics, methods of making them, pharmaceutical compositions and uses thereof
PE20060777A1 (es)	2004-12-24	2006-10-06	Boehringer Ingelheim Int	Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas
WO2006071609A2 (en)	2004-12-27	2006-07-06	Boehringer Ingelheim Pharmaceuticals, Inc.	Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
JP5519932B2 (ja) *	2005-06-10	2014-06-11	メルクパテントゲゼルシャフトミットベシュレンクテルハフツング	キナーゼ阻害剤としてのオキシインドール
WO2007057399A2 (en) *	2005-11-15	2007-05-24	Boehringer Ingelheim International Gmbh	Treatment of cancer with indole derivatives
CN101547909A (zh)	2006-12-06	2009-09-30	贝林格尔.英格海姆国际有限公司	糖皮质激素模拟物、其制备方法、药物组合物及其用途
US20170065529A1 (en)	2015-09-09	2017-03-09	Boehringer Ingelheim International Gmbh	Pharmaceutical dosage form for immediate release of an indolinone derivative
BRPI0915680A2 (pt)	2008-06-06	2019-09-24	Boehringer Ingelheim Int	miméticos de glicocorticoide, métodos de prepará-los, composições farmacêuticas, e usos dos mesmos
WO2011032320A1 (en) *	2009-09-21	2011-03-24	F. Hoffmann-La Roche Ag	Novel alkene oxindole derivatives
CN104039761A (zh) *	2011-11-14	2014-09-10	利亘制药公司	与粒细胞集落刺激因子受体相关的方法和组合物
WO2014150252A1 (en) *	2013-03-15	2014-09-25	Ligand Pharmaceuticals Incorporated	Methods of treatment associated with the granulocyte colony-stimulating factor receptor
CN107033064B (zh) *	2017-04-28	2019-07-09	西安医学院	一种3-(吗啉取代芳亚胺基)吲哚类化合物及其制备方法和应用
CN111285872B (zh) *	2018-12-06	2022-05-17	北京志健金瑞生物医药科技有限公司	吲哚-2-酮衍生物及其制备方法与用途

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GB9501567D0 (en) *	1995-01-26	1995-03-15	Pharmacia Spa	Hydrosoluble 3-arylidene-2-oxindole derivatives as tyrosine kinase inhibitors
US5880141A (en) *	1995-06-07	1999-03-09	Sugen, Inc.	Benzylidene-Z-indoline compounds for the treatment of disease
GB9718913D0 (en) *	1997-09-05	1997-11-12	Glaxo Group Ltd	Substituted oxindole derivatives
DE19824922A1 (de) *	1998-06-04	1999-12-09	Boehringer Ingelheim Pharma	Neue substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel
UA75054C2 (uk) *	1999-10-13	2006-03-15	Бьорінгер Інгельхайм Фарма Гмбх & Ко. Кг	Заміщені в положенні 6 індолінони, їх одержання та їх застосування як лікарського засобу

1998
- 1998-04-15 DE DE19816624A patent/DE19816624A1/de not_active Withdrawn
1999
- 1999-04-10 EP EP99920635A patent/EP1071665B1/de not_active Expired - Lifetime
- 1999-04-10 NZ NZ507967A patent/NZ507967A/xx unknown
- 1999-04-10 AU AU38149/99A patent/AU749829B2/en not_active Ceased
- 1999-04-10 EE EEP200000598A patent/EE04432B1/xx not_active IP Right Cessation
- 1999-04-10 ES ES99920635T patent/ES2207209T3/es not_active Expired - Lifetime
- 1999-04-10 SK SK1513-2000A patent/SK283824B6/sk unknown
- 1999-04-10 CN CNB998050296A patent/CN100338036C/zh not_active Expired - Fee Related
- 1999-04-10 CA CA002323111A patent/CA2323111C/en not_active Expired - Fee Related
- 1999-04-10 HU HU0101568A patent/HUP0101568A3/hu unknown
- 1999-04-10 JP JP2000543432A patent/JP4015365B2/ja not_active Expired - Lifetime
- 1999-04-10 PL PL99343314A patent/PL343314A1/xx not_active Application Discontinuation
- 1999-04-10 KR KR1020007011454A patent/KR100588250B1/ko not_active Expired - Fee Related
- 1999-04-10 WO PCT/EP1999/002436 patent/WO1999052869A1/de not_active Ceased
- 1999-04-10 BR BR9909688-9A patent/BR9909688A/pt not_active Application Discontinuation
- 1999-04-10 ID IDW20002062A patent/ID26420A/id unknown
- 1999-04-10 EA EA200001021A patent/EA003532B1/ru not_active IP Right Cessation
- 1999-04-10 IL IL13803699A patent/IL138036A0/xx not_active IP Right Cessation
- 1999-04-10 YU YU59800A patent/YU59800A/sh unknown
- 1999-04-10 TR TR2000/02980T patent/TR200002980T2/xx unknown
- 1999-04-10 DE DE59907199T patent/DE59907199D1/de not_active Expired - Lifetime
- 1999-04-10 PT PT99920635T patent/PT1071665E/pt unknown
- 1999-04-10 DK DK99920635T patent/DK1071665T3/da active
- 1999-04-10 AT AT99920635T patent/ATE251138T1/de active
- 1999-04-13 MY MYPI99001427A patent/MY122357A/en unknown
- 1999-04-14 AR ARP990101700A patent/AR015763A1/es active IP Right Grant
- 1999-04-14 TW TW088105963A patent/TW510897B/zh active
- 1999-04-14 CO CO99022218A patent/CO5011040A1/es unknown
- 1999-10-04 UA UA2000116456A patent/UA63009C2/uk unknown
2000
- 2000-09-04 ZA ZA200004623A patent/ZA200004623B/xx unknown
- 2000-09-29 BG BG104813A patent/BG64443B1/bg unknown
- 2000-10-13 NO NO20005151A patent/NO317298B1/no unknown

Also Published As

Publication number	Publication date
NO20005151D0 (no)	2000-10-13
HUP0101568A3 (en)	2002-12-28
KR20010042731A (ko)	2001-05-25
EE200000598A (et)	2002-04-15
EP1071665A1 (de)	2001-01-31
PT1071665E (pt)	2004-02-27
TR200002980T2 (tr)	2001-02-21
NZ507967A (en)	2003-04-29
JP2002511449A (ja)	2002-04-16
CA2323111C (en)	2009-09-15
DE59907199D1 (de)	2003-11-06
CA2323111A1 (en)	1999-10-21
EP1071665B1 (de)	2003-10-01
EA200001021A1 (ru)	2001-06-25
DE19816624A1 (de)	1999-10-21
PL343314A1 (en)	2001-08-13
SK15132000A3 (sk)	2001-03-12
KR100588250B1 (ko)	2006-06-13
BG104813A (bg)	2001-08-31
YU59800A (sh)	2003-04-30
JP4015365B2 (ja)	2007-11-28
WO1999052869A1 (de)	1999-10-21
AU749829B2 (en)	2002-07-04
ES2207209T3 (es)	2004-05-16
ID26420A (id)	2000-12-21
UA63009C2 (en)	2004-01-15
NO317298B1 (no)	2004-10-04
EE04432B1 (et)	2005-02-15
TW510897B (en)	2002-11-21
BR9909688A (pt)	2000-12-19
CN100338036C (zh)	2007-09-19
EA003532B1 (ru)	2003-06-26
CN1297438A (zh)	2001-05-30
MY122357A (en)	2006-04-29
IL138036A0 (en)	2001-10-31
NO20005151L (no)	2000-10-13
ZA200004623B (en)	2001-05-30
ATE251138T1 (de)	2003-10-15
AR015763A1 (es)	2001-05-16
AU3814999A (en)	1999-11-01
BG64443B1 (en)	2005-02-28
SK283824B6 (sk)	2004-02-03
CO5011040A1 (es)	2001-02-28
HUP0101568A2 (hu)	2001-09-28

Publication	Publication Date	Title
DK1071665T3 (da)	2004-01-05	Substituerede indolinoner med en inhiberende virkning på kinaser og cyclin/CDK-komplekser
DK1115704T3 (da)	2003-09-29	Substituerede indolinoner med inhiberende virkning for forskellige kinaser og cyclin/CDK komplekser
NO20014659L (no)	2001-11-01	Arylsubstituerte pyrazoler, imidazoler, oksazoler, tiazoler og pyrroler samt deres anvendelse
DE69909584D1 (de)	2003-08-21	Schraube mit Vertiefung und Schraubenziehereinsatz hierfür
DE69920697D1 (de)	2004-11-04	Adenosinderivate
FI980640A0 (fi)	1998-03-20	Ytbelagd traebaserad skiva och foerfarande foer ytbelaeggning av en traebaserad skiva
DE69906152D1 (de)	2003-04-24	4-alkenyl (und alkinyl)oxoindole als inhibitoren cyclinabhängiger kinasen, insbesondere cdk2
NO990053D0 (no)	1999-01-07	Fresstyring med orienterings- og dybdebestemmelsesevne
NO984836D0 (no)	1998-10-16	Substituerte benzylaminer og deres anvendelse for behandling av depresjon
NO986174D0 (no)	1998-12-29	Triazinderivater og anvendelse derav
ZA200102260B (en)	2004-04-19	Novel substituted indolinones with an inhibitory effect on various kinases and cyclin/cdk complexes.
NO20013085D0 (no)	2001-06-21	Fosfororganiske forbindelser og deres anvendelse
NO20001718D0 (no)	2000-04-03	Benzen-fusjonerte heterocykliske derivater og anvendelse derav
DE59900242D1 (de)	2001-10-11	Bohr- bzw. fräskopf
NO20012606D0 (no)	2001-05-28	Forbindelse med inhibitorisk virkning på kolesteryloverförende protein samt fremstilling derav
SI1071665T1 (sl)	2004-02-29	Substituirani indolinoni, ki imajo inhibitorni učinek na kinaze in ciklin/CDK komplekse
FI965024A0 (fi)	1996-12-16	Elektronisk anslutningsanordning foersedd med vaermeskyddskrets
ES1034959Y (es)	1997-07-16	Tapon perfeccionado.
ES1035703Y (es)	1997-11-16	Tapon perfeccionado.
ES1039353Y (es)	1999-05-16	Tapon perfeccionado.
ES1033292Y (es)	1997-01-01	Tapon perfeccionado.
ES1039069Y (es)	1999-03-16	Tapon perfeccionado.
ES1040083Y (es)	1999-07-16	Conjunto de tuerca y tornillos.
ES1042708Y (es)	2000-02-16	Tapon corona perfeccionado.
ES1043985Y (es)	2000-08-01	Tapon perfeccionado.