[go: up one dir, main page]

DK1063228T5 - Cycloalkenderivater, fremgangsmåde til fremstilling deraf og anvendelse deraf - Google Patents

Cycloalkenderivater, fremgangsmåde til fremstilling deraf og anvendelse deraf

Info

Publication number
DK1063228T5
DK1063228T5 DK99907879T DK99907879T DK1063228T5 DK 1063228 T5 DK1063228 T5 DK 1063228T5 DK 99907879 T DK99907879 T DK 99907879T DK 99907879 T DK99907879 T DK 99907879T DK 1063228 T5 DK1063228 T5 DK 1063228T5
Authority
DK
Denmark
Prior art keywords
substituents
hydrocarbon group
group optionally
aliphatic hydrocarbon
hydrogen atom
Prior art date
Application number
DK99907879T
Other languages
Danish (da)
English (en)
Other versions
DK1063228T3 (da
Inventor
Yuzo Ichimori
Masayuki Ii
Katsumi Itoh
Tomoyuki Kitazaki
Junji Yamada
Original Assignee
Takeda Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceutical filed Critical Takeda Pharmaceutical
Publication of DK1063228T3 publication Critical patent/DK1063228T3/da
Application granted granted Critical
Publication of DK1063228T5 publication Critical patent/DK1063228T5/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D249/00Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/081,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00General protective or antinoxious agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/14Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of rings other than six-membered aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D249/00Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/041,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • C07D249/061,2,3-Triazoles; Hydrogenated 1,2,3-triazoles with aryl radicals directly attached to ring atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D257/00Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04Five-membered rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D275/00Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/04Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D275/06Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to the ring sulfur atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/06Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/10Systems containing only non-condensed rings with a five-membered ring the ring being unsaturated
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/12Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/18Systems containing only non-condensed rings with a ring being at least seven-membered

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Toxicology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Silicon Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Steroid Compounds (AREA)
DK99907879T 1998-03-09 1999-03-08 Cycloalkenderivater, fremgangsmåde til fremstilling deraf og anvendelse deraf DK1063228T5 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP5649298 1998-03-09
JP28436298 1998-10-06
PCT/JP1999/001103 WO1999046242A1 (en) 1998-03-09 1999-03-08 Cycloalkene derivatives, process for producing the same, and use

Publications (2)

Publication Number Publication Date
DK1063228T3 DK1063228T3 (da) 2005-04-25
DK1063228T5 true DK1063228T5 (da) 2009-06-15

Family

ID=26397446

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99907879T DK1063228T5 (da) 1998-03-09 1999-03-08 Cycloalkenderivater, fremgangsmåde til fremstilling deraf og anvendelse deraf

Country Status (19)

Country Link
US (1) US6495604B1 (pt)
EP (2) EP1524263A1 (pt)
JP (2) JP3665712B2 (pt)
KR (4) KR100577044B1 (pt)
CN (1) CN100432049C (pt)
AT (1) ATE287393T1 (pt)
AU (1) AU747521B2 (pt)
BR (1) BR9908610A (pt)
CA (1) CA2320467C (pt)
DE (1) DE69923300T2 (pt)
DK (1) DK1063228T5 (pt)
ES (1) ES2232114T3 (pt)
HU (1) HU230061B1 (pt)
ID (1) ID25649A (pt)
NO (1) NO326426B1 (pt)
NZ (1) NZ505874A (pt)
PT (1) PT1063228E (pt)
RU (1) RU2214398C2 (pt)
WO (1) WO1999046242A1 (pt)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9908610A (pt) 1998-03-09 2000-12-05 Takeda Chemical Industries Ltd Composto, processo para produzir o mesmo, composição farmacêutica, uso do composto, processos par ainibir a produção de óxido nìtrico e/ou citocina em mamìferos, e para impedir ou tratar doença cardìaca, doença autoimune ou choque séptico em mamìferos, e, pró medicamentos
US20040220103A1 (en) 1999-04-19 2004-11-04 Immunex Corporation Soluble tumor necrosis factor receptor treatment of medical disorders
AU6471200A (en) * 1999-08-06 2001-03-05 Takeda Chemical Industries Ltd. Substituted aromatic-ring compounds, process for producing the same, and use
AU1553001A (en) * 1999-11-29 2001-06-12 Takeda Chemical Industries Ltd. Process for the production of optically active cyclohexene derivatives and intermediates therefor
KR100784752B1 (ko) * 2000-02-04 2007-12-13 다케다 야쿠힌 고교 가부시키가이샤 안정한 에멀젼 조성물
JP4863553B2 (ja) * 2000-02-04 2012-01-25 武田薬品工業株式会社 安定な乳化組成物
US6951885B2 (en) 2000-08-10 2005-10-04 Takeda Pharmaceutical Company Limited Pharmaceutical composition
JP4922507B2 (ja) * 2000-08-10 2012-04-25 武田薬品工業株式会社 医薬組成物
US6982344B2 (en) 2000-10-18 2006-01-03 Takeda Pharmaceutical Company Limited Process for preparation of optically active sulfonamides and intermediates for their synthesis
AU2002221099A1 (en) * 2000-12-08 2002-06-18 Takeda Chemical Industries Ltd. Combination drugs
ATE442143T1 (de) 2001-03-21 2009-09-15 Eisai R&D Man Co Ltd Reduziertes vitamin b2 enthaltende arzneimittel
EP1420783A4 (en) * 2001-08-03 2009-09-30 Takeda Pharmaceutical STABLE EMULSION COMPOSITION
WO2003084527A1 (en) * 2002-04-08 2003-10-16 Takeda Chemical Industries, Ltd. Severe sepsis preventive therapeutic agent
JP4824576B2 (ja) * 2003-12-03 2011-11-30 ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド サイトカイン生成のインヒビターとしての1,2,3−トリアゾールアミド誘導体
TWI462745B (zh) * 2005-04-28 2014-12-01 Takeda Pharmaceutical 安定的乳化組成物
CA2622694C (en) * 2005-09-14 2011-02-08 Daiichi Sankyo Company, Limited Substituted cycloalkene derivative
US8329420B2 (en) 2006-03-30 2012-12-11 Hiroshima University Screening method for a substance that binds to an intracellular region of TLR4
EP2260869A3 (en) 2006-04-20 2011-03-23 Takeda Pharmaceutical Company Limited Pharmaceutical product
WO2007132825A1 (ja) 2006-05-15 2007-11-22 Takeda Pharmaceutical Company Limited 医薬
EP2039681A4 (en) 2006-07-07 2009-10-28 Takeda Pharmaceutical CYCLOALKENE DERIVATIVES, PROCESS FOR PRODUCTION OF DERIVATIVES, AND USE THEREOF
JP2008260760A (ja) * 2007-03-12 2008-10-30 Daiichi Sankyo Co Ltd 置換シクロアルケン誘導体を含有する医薬組成物
ME02364B (me) 2010-01-27 2016-06-20 Takeda Pharmaceuticals Co Jedinjenja za supresiju poremećaja perifernih nerava indukovanih anti-kancerogenim sredstvom
JP5778161B2 (ja) 2010-09-24 2015-09-16 第一三共株式会社 置換シクロアルケン誘導体の結晶
EP2866565A4 (en) * 2012-07-03 2016-04-13 Jay Pravda METHOD FOR TREATING, DIAGNOSIS AND / OR MONITORING THE PROGRESSION OF OXO ASSOCIATED STATES
WO2014050910A1 (ja) 2012-09-26 2014-04-03 武田薬品工業株式会社 固体粒子の製造方法
AR104539A1 (es) 2015-05-08 2017-07-26 Takeda Pharmaceuticals Co Compuestos cíclicos
EP3511320A4 (en) 2016-09-09 2020-04-15 Takeda Pharmaceutical Company Limited CYCLIC CONNECTION
WO2018156297A1 (en) * 2017-02-24 2018-08-30 Taiwanj Pharmaceuticals Co., Ltd Sulfonamide or amide compounds, compositions and methods for the prophylaxis and/or treatment of autoimmune, inflammation or infection related disorders

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU217808B (hu) 1990-11-06 2000-04-28 Nippon Shinyaku Co., Ltd. Eljárás liofilizált készítmény előállítására
AU653279B2 (en) * 1991-12-30 1994-09-22 Sanofi Novel 2-saccharinylmethyl heterocyclic carboxylates useful as proteolytic enzyme inhibitors and compositions and method of use thereof
US5576016A (en) 1993-05-18 1996-11-19 Pharmos Corporation Solid fat nanoemulsions as drug delivery vehicles
EP0746318A1 (en) 1994-02-25 1996-12-11 Takeda Chemical Industries, Ltd. Injectable emulsions containing antifungal triazole derivatives
AU3230895A (en) * 1994-08-18 1996-03-14 Chugai Seiyaku Kabushiki Kaisha Amino acid derivative having nitrogen monoxide synthetase inhibitor activity
JPH08109165A (ja) * 1994-08-18 1996-04-30 Chugai Pharmaceut Co Ltd 一酸化窒素合成酵素阻害作用を有するアミノ酸誘導体
BR9908610A (pt) 1998-03-09 2000-12-05 Takeda Chemical Industries Ltd Composto, processo para produzir o mesmo, composição farmacêutica, uso do composto, processos par ainibir a produção de óxido nìtrico e/ou citocina em mamìferos, e para impedir ou tratar doença cardìaca, doença autoimune ou choque séptico em mamìferos, e, pró medicamentos
KR100784752B1 (ko) 2000-02-04 2007-12-13 다케다 야쿠힌 고교 가부시키가이샤 안정한 에멀젼 조성물

Also Published As

Publication number Publication date
HK1031723A1 (en) 2001-06-22
HU230061B1 (hu) 2015-06-29
HUP0101192A3 (en) 2003-09-29
RU2214398C2 (ru) 2003-10-20
KR20050071719A (ko) 2005-07-07
BR9908610A (pt) 2000-12-05
ID25649A (id) 2000-10-19
ATE287393T1 (de) 2005-02-15
NZ505874A (en) 2003-09-26
CN100432049C (zh) 2008-11-12
JP4342453B2 (ja) 2009-10-14
JP2005232168A (ja) 2005-09-02
AU2746499A (en) 1999-09-27
EP1524263A1 (en) 2005-04-20
KR100779889B1 (ko) 2007-11-28
JP3665712B2 (ja) 2005-06-29
AU747521B2 (en) 2002-05-16
NO326426B1 (no) 2008-12-01
ES2232114T3 (es) 2005-05-16
KR20050026075A (ko) 2005-03-14
DE69923300T2 (de) 2006-01-05
CA2320467A1 (en) 1999-09-16
KR20060017921A (ko) 2006-02-27
WO1999046242A1 (en) 1999-09-16
HUP0101192A2 (hu) 2001-08-28
EP1063228B1 (en) 2005-01-19
CN1291184A (zh) 2001-04-11
PT1063228E (pt) 2005-05-31
PL342826A1 (en) 2001-07-02
KR100492098B1 (ko) 2005-06-01
EP1063228A4 (en) 2001-08-08
AU747521C (en) 1999-09-27
DK1063228T3 (da) 2005-04-25
DE69923300D1 (de) 2005-02-24
KR20010034555A (ko) 2001-04-25
KR100577044B1 (ko) 2006-05-08
EP1063228A1 (en) 2000-12-27
NO20004485D0 (no) 2000-09-08
US6495604B1 (en) 2002-12-17
JP2000178246A (ja) 2000-06-27
CA2320467C (en) 2010-05-04
NO20004485L (no) 2000-09-08

Similar Documents

Publication Publication Date Title
DK1063228T3 (da) Cycloalkenderivater, fremgangsmåde til fremstilling deraf og anvendelse deraf
NO992549D0 (no) Sukkerforbindelse, geleringsmiddel og fremgangsmÕte for fremstilling derav
FI104172B1 (fi) Herbisidiset 4-bentsoyyli-isoksatsolijohdannaiset
EP1092435A4 (en) ANTIDIABETIC DRUGS
ID24846A (id) Turunan-turunan bifenilamidina
NZ332923A (en) Distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents
ATE513821T1 (de) Thiadiazolin-derivate zur behandlung von krebs
ATE240949T1 (de) Epoxysuccinamid-derivate oder ihre salze
DK0882728T3 (da) 1-methylcarbapenemderivater
ATE239741T1 (de) Derivate der phosphonsäure zur inhibierung von carboxypeptidase b
EP0712398A1 (en) BENZOPYRANS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
DK0556813T3 (da) Amfotere tricykliske forbindelser som antihistaminske og antiallergiske midler
DE69425970D1 (de) Benzol-derivate, verwendbar für ischämische erkrankungen
DK360388D0 (da) Laegemiddel til behandling af hjerteinsufficiens
DE69828087D1 (de) Aminderivate
ATE139767T1 (de) Verfahren zur herstellung 5-pyrazolomerkaptan- derivate und dessen zwischenprodukte
ATE189813T1 (de) Prostaglandin-i-analoga
DE69007777D1 (de) Derivate der p-Guanidinobenzoesäure zur Behandlung der zerebrovaskulären Kontraktion.