AR104539A1 - Compuestos cíclicos - Google Patents
Compuestos cíclicosInfo
- Publication number
- AR104539A1 AR104539A1 ARP160101293A ARP160101293A AR104539A1 AR 104539 A1 AR104539 A1 AR 104539A1 AR P160101293 A ARP160101293 A AR P160101293A AR P160101293 A ARP160101293 A AR P160101293A AR 104539 A1 AR104539 A1 AR 104539A1
- Authority
- AR
- Argentina
- Prior art keywords
- optionally substituted
- group
- ring
- substituents selected
- hydroxy
- Prior art date
Links
- 150000001923 cyclic compounds Chemical class 0.000 title 1
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
- HGCIXCUEYOPUTN-UHFFFAOYSA-N cyclohexene Chemical compound C1CCC=CC1 HGCIXCUEYOPUTN-UHFFFAOYSA-N 0.000 abstract 2
- LPIQUOYDBNQMRZ-UHFFFAOYSA-N cyclopentene Chemical compound C1CC=CC1 LPIQUOYDBNQMRZ-UHFFFAOYSA-N 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 125000006376 (C3-C10) cycloalkyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- RGSFGYAAUTVSQA-UHFFFAOYSA-N pentamethylene Natural products C1CCCC1 RGSFGYAAUTVSQA-UHFFFAOYSA-N 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/72—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 spiro-condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/12—Sulfones; Sulfoxides having sulfone or sulfoxide groups bound to carbon atoms of rings other than six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
- C07C317/46—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Pyrane Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Reivindicación 1: Un compuesto representado por la fórmula (1) o una sal del mismo (caracterizado porque, el anillo A es ciclopenteno o ciclohexeno; el anillo B es un anillo de benceno sustituido en forma opcional por 1 a 3 sustituyentes seleccionados entre un átomo de halógeno y un grupo alquilo C₁₋₆; en cuanto a R¹ y R², (i) R¹ y R² son ambos átomos de hidrógeno, o (ii) uno de R¹ y R² es un átomo de hidrógeno, y el otro es un grupo hidroxi, o R¹ y R² se pueden unir entre sí para formar un heterociclo monocíclico no aromático de 3 a 8 miembros, que está sustituido en forma opcional por 1 a 3 grupos alquilo C₁₋₆ sustituidos en forma opcional por 1 a 3 sustituyentes seleccionados de un grupo hidroxi y un grupo alcoxi C₁₋₆; W es CH₂ u O; y R³ es un grupo alcoxi C₁₋₆ sustituido en forma opcional por 1 a 3 grupos cicloalquilo C₃₋₁₀ sustituidos en forma opcional por 1 a 3 grupos alquilo C₁₋₆).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2015095817 | 2015-05-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR104539A1 true AR104539A1 (es) | 2017-07-26 |
Family
ID=56132991
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP160101293A AR104539A1 (es) | 2015-05-08 | 2016-05-06 | Compuestos cíclicos |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US9611244B2 (es) |
| EP (1) | EP3294706B1 (es) |
| JP (1) | JP6718884B2 (es) |
| CN (1) | CN107835800B (es) |
| AR (1) | AR104539A1 (es) |
| CA (1) | CA2985325C (es) |
| EA (1) | EA033083B1 (es) |
| ES (1) | ES2772703T3 (es) |
| TW (1) | TW201704206A (es) |
| UY (1) | UY36675A (es) |
| WO (1) | WO2016182036A1 (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR104539A1 (es) * | 2015-05-08 | 2017-07-26 | Takeda Pharmaceuticals Co | Compuestos cíclicos |
| EP3511320A4 (en) | 2016-09-09 | 2020-04-15 | Takeda Pharmaceutical Company Limited | CYCLIC CONNECTION |
| FR3095755A1 (fr) * | 2019-05-10 | 2020-11-13 | Balmes Transplantation | Nouveaux médicaments cytoprotecteurs |
| CN114425054A (zh) * | 2022-01-20 | 2022-05-03 | 中国人民解放军军事科学院军事医学研究院 | 一种蛋白酶体抑制剂Bortezomib在抗辐射损伤中的用途 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR9908610A (pt) | 1998-03-09 | 2000-12-05 | Takeda Chemical Industries Ltd | Composto, processo para produzir o mesmo, composição farmacêutica, uso do composto, processos par ainibir a produção de óxido nìtrico e/ou citocina em mamìferos, e para impedir ou tratar doença cardìaca, doença autoimune ou choque séptico em mamìferos, e, pró medicamentos |
| AU6471200A (en) | 1999-08-06 | 2001-03-05 | Takeda Chemical Industries Ltd. | Substituted aromatic-ring compounds, process for producing the same, and use |
| JP2004002370A (ja) * | 2002-04-08 | 2004-01-08 | Takeda Chem Ind Ltd | 重症セプシス予防治療剤 |
| WO2003084527A1 (en) | 2002-04-08 | 2003-10-16 | Takeda Chemical Industries, Ltd. | Severe sepsis preventive therapeutic agent |
| CA2622694C (en) * | 2005-09-14 | 2011-02-08 | Daiichi Sankyo Company, Limited | Substituted cycloalkene derivative |
| JP2008260760A (ja) * | 2007-03-12 | 2008-10-30 | Daiichi Sankyo Co Ltd | 置換シクロアルケン誘導体を含有する医薬組成物 |
| US20100137787A1 (en) * | 2008-12-02 | 2010-06-03 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Delivery devices for modulating inflammation |
| ME02364B (me) | 2010-01-27 | 2016-06-20 | Takeda Pharmaceuticals Co | Jedinjenja za supresiju poremećaja perifernih nerava indukovanih anti-kancerogenim sredstvom |
| AR104539A1 (es) * | 2015-05-08 | 2017-07-26 | Takeda Pharmaceuticals Co | Compuestos cíclicos |
-
2016
- 2016-05-06 AR ARP160101293A patent/AR104539A1/es unknown
- 2016-05-06 EP EP16729646.6A patent/EP3294706B1/en active Active
- 2016-05-06 EA EA201792469A patent/EA033083B1/ru not_active IP Right Cessation
- 2016-05-06 JP JP2017555812A patent/JP6718884B2/ja active Active
- 2016-05-06 CA CA2985325A patent/CA2985325C/en active Active
- 2016-05-06 TW TW105114092A patent/TW201704206A/zh unknown
- 2016-05-06 WO PCT/JP2016/064204 patent/WO2016182036A1/en not_active Ceased
- 2016-05-06 UY UY0001036675A patent/UY36675A/es not_active Application Discontinuation
- 2016-05-06 ES ES16729646T patent/ES2772703T3/es active Active
- 2016-05-06 CN CN201680040064.1A patent/CN107835800B/zh active Active
- 2016-05-06 US US15/148,210 patent/US9611244B2/en active Active
- 2016-06-07 US US15/175,292 patent/US9533966B2/en active Active
- 2016-11-21 US US15/356,906 patent/US9828357B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EA201792469A1 (ru) | 2018-06-29 |
| JP2018516875A (ja) | 2018-06-28 |
| US20160326133A1 (en) | 2016-11-10 |
| CA2985325C (en) | 2023-09-26 |
| WO2016182036A1 (en) | 2016-11-17 |
| US9533966B2 (en) | 2017-01-03 |
| CN107835800A (zh) | 2018-03-23 |
| US20160326102A1 (en) | 2016-11-10 |
| UY36675A (es) | 2016-12-30 |
| EA033083B1 (ru) | 2019-08-30 |
| JP6718884B2 (ja) | 2020-07-08 |
| US20170066737A1 (en) | 2017-03-09 |
| EP3294706A1 (en) | 2018-03-21 |
| US9828357B2 (en) | 2017-11-28 |
| ES2772703T3 (es) | 2020-07-08 |
| CN107835800B (zh) | 2019-11-26 |
| TW201704206A (zh) | 2017-02-01 |
| EP3294706B1 (en) | 2019-12-04 |
| US9611244B2 (en) | 2017-04-04 |
| CA2985325A1 (en) | 2016-11-17 |
| BR112017023818A2 (pt) | 2018-07-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |