DK1047704T4 - Fremgangsmåde til fremstilling af lithium-, kalium-, calcium- og magnesiumsalte af fludarabin-phosphat og rensningsfremgangsmåde til fremstilling af fludarabin-phosphat og fludarabin-phosphat med en renhed på mindst 99,5% - Google Patents

Fremgangsmåde til fremstilling af lithium-, kalium-, calcium- og magnesiumsalte af fludarabin-phosphat og rensningsfremgangsmåde til fremstilling af fludarabin-phosphat og fludarabin-phosphat med en renhed på mindst 99,5%

Info

Publication number: DK1047704T4
Authority: DK; Denmark
Prior art keywords: fludarabine phosphate; purity; lithium; potassium; calcium
Prior art date: 1997-12-11

Application number

DK98965703T

Other languages

English (en)

Other versions

DK1047704T3 (da

Inventor

Ulf Tilstam

Klaus Nickisch

Thomas Schmitz

Original Assignee

Bayer Schering Pharma Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-12-11

Filing date

1998-11-30

Publication date

2008-03-25

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7852365&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1047704(T4) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1998-11-30 Application filed by Bayer Schering Pharma Ag filed Critical Bayer Schering Pharma Ag

2003-06-23 Application granted granted Critical

2003-06-23 Publication of DK1047704T3 publication Critical patent/DK1047704T3/da

2008-03-25 Publication of DK1047704T4 publication Critical patent/DK1047704T4/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/19—Purine radicals with arabinosyl as the saccharide radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

DK98965703T 1997-12-11 1998-11-30 Fremgangsmåde til fremstilling af lithium-, kalium-, calcium- og magnesiumsalte af fludarabin-phosphat og rensningsfremgangsmåde til fremstilling af fludarabin-phosphat og fludarabin-phosphat med en renhed på mindst 99,5% DK1047704T4 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE19756289		1997-12-11
PCT/EP1998/007651 WO1999029710A2 (de)	1997-12-11	1998-11-30	Reinigungsverfahren zur herstellung von fludarabin-phosphat

Publications (2)

Publication Number	Publication Date
DK1047704T3 DK1047704T3 (da)	2003-06-23
DK1047704T4 true DK1047704T4 (da)	2008-03-25

Family

ID=7852365

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK98965703T DK1047704T4 (da)	1997-12-11	1998-11-30	Fremgangsmåde til fremstilling af lithium-, kalium-, calcium- og magnesiumsalte af fludarabin-phosphat og rensningsfremgangsmåde til fremstilling af fludarabin-phosphat og fludarabin-phosphat med en renhed på mindst 99,5%

Country Status (20)

Country	Link
US (2)	US6046322A (da)
EP (1)	EP1047704B2 (da)
JP (2)	JP4261051B2 (da)
KR (2)	KR100532898B1 (da)
AT (2)	ATE231880T1 (da)
AU (1)	AU739574B2 (da)
CA (1)	CA2313486A1 (da)
CZ (1)	CZ296366B6 (da)
DE (2)	DE59807096D1 (da)
DK (1)	DK1047704T4 (da)
ES (1)	ES2190136T5 (da)
HU (1)	HU226997B1 (da)
IL (1)	IL136283A (da)
NO (1)	NO315324B1 (da)
PL (1)	PL195712B1 (da)
SI (1)	SI1047704T2 (da)
SK (1)	SK283475B6 (da)
TW (1)	TW424093B (da)
WO (1)	WO1999029710A2 (da)
ZA (1)	ZA9811338B (da)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK1047704T4 (da)	1997-12-11	2008-03-25	Bayer Schering Pharma Ag	Fremgangsmåde til fremstilling af lithium-, kalium-, calcium- og magnesiumsalte af fludarabin-phosphat og rensningsfremgangsmåde til fremstilling af fludarabin-phosphat og fludarabin-phosphat med en renhed på mindst 99,5%
KR100381930B1 (ko) *	2000-03-16	2003-04-26	(주)바이오니아	유전자 변형 농산물 검출방법 및 검출용 프라이머
WO2003049764A1 (en)	2001-12-12	2003-06-19	Fh Faulding & Co Limited	Composition for viral preservation
DE10164510A1 (de) *	2001-12-20	2003-07-10	Schering Ag	Orale Fludara reinst Formulierung mit schneller Freisetzung des Wirkstoffes
AU2003231834A1 (en) *	2002-05-24	2003-12-12	Sicor Inc.	Aqueous fludarabine phosphate composition
EP1464708A1 (en) *	2003-04-03	2004-10-06	Pro. Bio. Sint. S.p.A.	A process for the preparation of fludarabine phosphate from 2-fluoroadenine
US7698201B2 (en) *	2006-09-14	2010-04-13	The Prudential Insurance Company Of America	Financial instrument utilizing an optional benefit election
CN103040855B (zh) *	2012-12-28	2014-05-14	海南锦瑞制药股份有限公司	一种磷酸氟达拉滨的药物组合物及其制备方法
WO2017036356A1 (zh) *	2015-08-28	2017-03-09	浙江海正药业股份有限公司	磷酸氟达拉滨的晶型及其制备方法和用途
CN109265505A (zh) *	2018-09-12	2019-01-25	连云港杰瑞药业有限公司	一种磷酸氟达拉滨异构体杂质的合成方法
WO2025038371A1 (en) *	2023-08-11	2025-02-20	Purdue Research Foundation	Salt-loaded solid lipid nanoparticles loaded with an active agent

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BE756704A (fr) *	1969-09-26	1971-03-01	Parke Davis & Co	Procede de production du 5'-phosphate de 9-(beta-d- arabinofuranosyl) adenine et de ses sels
US4188378A (en) *	1978-01-04	1980-02-12	The United States Of America As Represented By The Department Of Health, Education And Welfare	Anticancer and antiviral activity of 9-β-D-arabinofuranosyl-2-fluoroadenine
US4210745A (en) *	1978-01-04	1980-07-01	The United States Of America As Represented By The Department Of Health, Education And Welfare	Procedure for the preparation of 9-β-D-arabinofuranosyl-2-fluoroadenine
US4357324A (en) *	1981-02-24	1982-11-02	The United States Of America As Represented By The Department Of Health And Human Services	Prodrug derivatives of 9β-D-arabinofuranosyl-2-fluoroadenine
DE3323621A1 (de)	1982-07-08	1984-03-01	Yamasa Shoyu K.K., Choshi, Chiba	Pharmazeutisches praeparat mit die antitumor-wirkung verstaerkender wirkung, ein solches praeparat enthaltende chemotherapeutische zusammensetzung und verwendung des praeparates zur unterstuetzung der antitumor-behandlung beim menschen und tier
US5110919A (en)	1989-12-04	1992-05-05	Ash Stevens, Inc.	Process for the preparation of 2-amino-9-(2,3,5-tri-o-benzyl-beta-d-arabinofuranosyl) adenine and novel intermediates
WO1992000312A1 (en) *	1990-06-27	1992-01-09	Ash Stevens, Inc.	Process for the preparation of 9-beta-d-arabinofuranosyl-2-fluoroadenine 5'-phosphate
US5602246A (en)	1992-11-25	1997-02-11	Schering Aktiengesellschaft	Process for the preparation of fludarabine or fludarabine phosphate from guanosine
FR2701027B1 (fr) *	1993-02-01	1997-07-18	Warner Lambert Co	Procede de synthese ameliore du 9-(beta-d-arabinofuranosyl)adenine 5'-phosphate.
DE19543052A1 (de) *	1995-11-06	1997-05-07	Schering Ag	Verfahren zur Herstellung und Reinigung von Fludarabin-Phosphat und die Verwendung von sauren Ionenaustauschern im Verfahren
IT1276126B1 (it)	1995-11-14	1997-10-27	Archimica Spa	Procedimento per la preparazine di 9-((2-idrossietossi)metil) guanina
DK1047704T4 (da)	1997-12-11	2008-03-25	Bayer Schering Pharma Ag	Fremgangsmåde til fremstilling af lithium-, kalium-, calcium- og magnesiumsalte af fludarabin-phosphat og rensningsfremgangsmåde til fremstilling af fludarabin-phosphat og fludarabin-phosphat med en renhed på mindst 99,5%
US6174873B1 (en)	1998-11-04	2001-01-16	Supergen, Inc.	Oral administration of adenosine analogs

1998
- 1998-11-30 DK DK98965703T patent/DK1047704T4/da active
- 1998-11-30 IL IL136283A patent/IL136283A/en not_active IP Right Cessation
- 1998-11-30 KR KR10-2000-7006262A patent/KR100532898B1/ko not_active Expired - Fee Related
- 1998-11-30 CZ CZ20002159A patent/CZ296366B6/cs not_active IP Right Cessation
- 1998-11-30 AU AU21550/99A patent/AU739574B2/en not_active Ceased
- 1998-11-30 EP EP98965703A patent/EP1047704B2/de not_active Expired - Lifetime
- 1998-11-30 SI SI9830374T patent/SI1047704T2/sl unknown
- 1998-11-30 CA CA002313486A patent/CA2313486A1/en not_active Abandoned
- 1998-11-30 HU HU0100169A patent/HU226997B1/hu not_active IP Right Cessation
- 1998-11-30 DE DE59807096T patent/DE59807096D1/de not_active Expired - Lifetime
- 1998-11-30 ES ES98965703T patent/ES2190136T5/es not_active Expired - Lifetime
- 1998-11-30 PL PL98341659A patent/PL195712B1/pl unknown
- 1998-11-30 AT AT98965703T patent/ATE231880T1/de active
- 1998-11-30 SK SK887-2000A patent/SK283475B6/sk not_active IP Right Cessation
- 1998-11-30 DE DE29825173U patent/DE29825173U1/de not_active Expired - Lifetime
- 1998-11-30 JP JP2000524302A patent/JP4261051B2/ja not_active Expired - Fee Related
- 1998-11-30 KR KR1020057012396A patent/KR20050085937A/ko not_active Ceased
- 1998-11-30 WO PCT/EP1998/007651 patent/WO1999029710A2/de not_active Ceased
- 1998-12-10 ZA ZA9811338A patent/ZA9811338B/xx unknown
- 1998-12-10 US US09/208,587 patent/US6046322A/en not_active Expired - Lifetime
- 1998-12-10 TW TW087120530A patent/TW424093B/zh not_active IP Right Cessation
1999
- 1999-12-23 US US09/471,040 patent/US7547776B1/en not_active Expired - Fee Related
2000
- 2000-06-09 NO NO20002962A patent/NO315324B1/no not_active IP Right Cessation
2005
- 2005-07-14 AT AT0048105U patent/AT8617U1/de not_active IP Right Cessation
2008
- 2008-10-27 JP JP2008276079A patent/JP2009040797A/ja active Pending

Also Published As

Publication number	Publication date
ES2190136T5 (es)	2008-03-01
SI1047704T1 (en)	2004-02-29
CZ296366B6 (cs)	2006-02-15
CZ20002159A3 (cs)	2000-09-13
PL341659A1 (en)	2001-04-23
JP4261051B2 (ja)	2009-04-30
SK8872000A3 (en)	2001-03-12
IL136283A0 (en)	2001-05-20
EP1047704B2 (de)	2007-11-07
US6046322A (en)	2000-04-04
SK283475B6 (sk)	2003-08-05
AU2155099A (en)	1999-06-28
JP2001525418A (ja)	2001-12-11
EP1047704A2 (de)	2000-11-02
CA2313486A1 (en)	1999-06-17
KR20010032919A (ko)	2001-04-25
EP1047704B1 (de)	2003-01-29
JP2009040797A (ja)	2009-02-26
KR100532898B1 (ko)	2005-12-05
AU739574B2 (en)	2001-10-18
ATE231880T1 (de)	2003-02-15
WO1999029710A3 (de)	1999-09-10
DE29825173U1 (de)	2005-12-22
HU226997B1 (en)	2010-04-28
AT8617U1 (de)	2006-10-15
NO20002962D0 (no)	2000-06-09
NO20002962L (no)	2000-06-09
WO1999029710A2 (de)	1999-06-17
SI1047704T2 (sl)	2008-02-29
HUP0100169A3 (en)	2002-04-29
US7547776B1 (en)	2009-06-16
DK1047704T3 (da)	2003-06-23
ES2190136T3 (es)	2003-07-16
PL195712B1 (pl)	2007-10-31
DE59807096D1 (de)	2003-03-06
ZA9811338B (en)	1999-06-10
HUP0100169A1 (hu)	2001-11-28
NO315324B1 (no)	2003-08-18
IL136283A (en)	2006-10-31
HK1033831A1 (en)	2001-09-28
TW424093B (en)	2001-03-01
KR20050085937A (ko)	2005-08-29

Publication	Publication Date	Title
DK1047704T4 (da)	2008-03-25	Fremgangsmåde til fremstilling af lithium-, kalium-, calcium- og magnesiumsalte af fludarabin-phosphat og rensningsfremgangsmåde til fremstilling af fludarabin-phosphat og fludarabin-phosphat med en renhed på mindst 99,5%
DK1527775T3 (da)	2010-09-27	Tramadolholdig sammensætning med kontrolleret frigivelse
BR9607389A (pt)	1997-11-25	Purificação de corrente de subproduto na preparação de poliésteres baseados em 1,3 propanediol
NO20013941L (no)	2001-08-14	Polynukleotider med forkortet kjede og fremgangsmåte ved fremstillingen derav
DK0737169T3 (da)	1999-09-27	Sammensætning til behandling af vand og rensning af jord
BR9407743A (pt)	1997-02-12	Composiçao oral de peróxido de cálcio-bicarbonato
DE69505361D1 (de)	1998-11-19	Verfahren zur herstellung von kautabletten aus troxerutin, kalziumcarbonat kalziumphosphat, argininaspartat, argininglutamat, amoxicillin, eine kombination aus kalziumcarbonat und magnesiumcarbonat und eine kombination aus aluminiumhydroxyd und magnesiumhydroxyd
FI955569A0 (fi)	1995-11-17	Hallitusti vapautuva kalium-kaksiarvoinen metallifosfaattilannoite
DK0748795T3 (da)	2000-12-18	Substituerede benzyloxycarbonylguanidiner som inhibitorer af Na+/H+-ombytningen, fremgangsmåde til deres fremstilling, dere
EP0830325A4 (en)	1999-07-21	PROCESS FOR SLOWING THE SETTING SPEED OF MAGNESIUM PHOSPHATE CEMENTS
JP2001521062A5 (da)	2006-01-05
FI962451A7 (fi)	1997-12-14	Menetelmä tuottaa erittäin puhtaita kaliumsuoloja
DK0840724T3 (da)	2002-12-09	Fremgangsmåde til fremstilling af enantiomerisk ren azetidin-2-caboxylsyre
YU28999A (sh)	2003-01-31	Postupak za kristalisanje derivata tetrahidropiridina i dobijeni kristalni oblici
BR9809286A (pt)	2000-07-04	Processos para redução de fibrinogênio
ES512344A0 (es)	1983-07-01	"procedimiento para la preparacion continua, en una etapa, de granulados de cloruro de magnesio".
DK0441760T3 (da)	1995-06-12	Fremgangsmåde til rensning af N,N-dimethylmandelsyreamid
ZA977515B (en)	1998-03-26	Aggregate crystals of phosphoric acid/lysine/magnesium composite salt and process for producing the same.
GB2308432B (en)	1998-03-18	Improvements relating to flue blocks
NO943008D0 (no)	1994-08-15	Renseblanding for gallegangen, samt fremgangsmåte for rensing av gallegangen
RU93036134A (ru)	1997-02-10	Бишофит как основа для лекарственных препаратов
NO20006393D0 (no)	2000-12-14	Enantiomerisk rene substituerte oksa-aza forbindelser, salter av de samme og fremgangsmåter for deres fremstilling
DK0770046T3 (da)	1999-06-14	Gødningsmidler med kontrolleret frigivelse
HN1998000014A (es)	1999-11-03	Metodo de purificacion de 1,3,5, trii sopropilbenceno
FR2708203B1 (fr)	1995-09-22	Procédé d'inhibition de la perception des odeurs.