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DK0968283T3 - Dannelse af diversitet i kombinatoriske biblioteker - Google Patents

Dannelse af diversitet i kombinatoriske biblioteker

Info

Publication number
DK0968283T3
DK0968283T3 DK98910631T DK98910631T DK0968283T3 DK 0968283 T3 DK0968283 T3 DK 0968283T3 DK 98910631 T DK98910631 T DK 98910631T DK 98910631 T DK98910631 T DK 98910631T DK 0968283 T3 DK0968283 T3 DK 0968283T3
Authority
DK
Denmark
Prior art keywords
ligands
combinatorial libraries
creating diversity
phagemid
phage
Prior art date
Application number
DK98910631T
Other languages
English (en)
Inventor
John Collins
Peter Roettgen
Original Assignee
Cosmix Molecular Biolog Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cosmix Molecular Biolog Gmbh filed Critical Cosmix Molecular Biolog Gmbh
Application granted granted Critical
Publication of DK0968283T3 publication Critical patent/DK0968283T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00Libraries per se, e.g. arrays, mixtures
    • C40B40/02Libraries contained in or displayed by microorganisms, e.g. bacteria or animal cells; Libraries contained in or displayed by vectors, e.g. plasmids; Libraries containing only microorganisms or vectors
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034Isolating an individual clone by screening libraries
    • C12N15/1037Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/66General methods for inserting a gene into a vector to form a recombinant vector using cleavage and ligation; Use of non-functional linkers or adaptors, e.g. linkers containing the sequence for a restriction endonuclease

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Oscillators With Electromechanical Resonators (AREA)
  • Geophysics And Detection Of Objects (AREA)
  • Steroid Compounds (AREA)
  • Semiconductor Memories (AREA)
  • Fishing Rods (AREA)
  • Dram (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
DK98910631T 1997-01-31 1998-02-02 Dannelse af diversitet i kombinatoriske biblioteker DK0968283T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP97101539 1997-01-31
PCT/EP1998/000533 WO1998033901A2 (en) 1997-01-31 1998-02-02 Generation of diversity in combinatorial libraries

Publications (1)

Publication Number Publication Date
DK0968283T3 true DK0968283T3 (da) 2003-08-25

Family

ID=8226431

Family Applications (1)

Application Number Title Priority Date Filing Date
DK98910631T DK0968283T3 (da) 1997-01-31 1998-02-02 Dannelse af diversitet i kombinatoriske biblioteker

Country Status (11)

Country Link
EP (2) EP1302540A3 (da)
JP (1) JP2001509672A (da)
CN (1) CN1246150A (da)
AT (1) ATE239077T1 (da)
AU (1) AU749249B2 (da)
CA (1) CA2279341A1 (da)
DE (1) DE69814059T2 (da)
DK (1) DK0968283T3 (da)
ES (1) ES2199431T3 (da)
IL (1) IL131075A0 (da)
WO (1) WO1998033901A2 (da)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050191749A1 (en) * 2000-12-08 2005-09-01 Bowdish Katherine S. Novel plasmid vectors
DE10145553B4 (de) * 2001-09-16 2006-06-08 Gene Architects Ag Nukleinsäure für einen Klonierungsvektor
EP1384779A1 (en) * 2002-07-26 2004-01-28 Cosmix Molecular Biologicals GmbH Method for generating molecules with specific properties by recombination and selection
EP1384780A1 (en) * 2002-07-26 2004-01-28 Cosmix Molecular Biologicals GmbH Method for generating molecules with specific properties by recombination and selection
EP1398375A1 (en) * 2002-09-13 2004-03-17 Cosmix Molecular Biologicals GmbH Recombination process for recombining fragments of variant polynucleotides
DE10337407A1 (de) * 2003-08-13 2005-03-10 Transmit Technologietransfer Klonierungssystem
DK2940138T3 (da) 2014-04-30 2018-06-06 Fraunhofer Ges Forschung Fag-displaybibliotek
AU2017245737B2 (en) 2016-04-08 2022-12-01 Phico Therapeutics Ltd Modifying bacteriophage
ES2867029T3 (es) 2016-04-08 2021-10-20 Phico Therapeutics Ltd Bacteriófago modificado

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61132187A (ja) * 1984-11-30 1986-06-19 Banyu Pharmaceut Co Ltd 新規コスミドベクタ−及びそれを用いる遺伝子バンクの製造方法
IL99553A0 (en) * 1990-09-28 1992-08-18 Ixsys Inc Compositions containing oligonucleotides linked to expression elements,a kit for the preparation of vectors useful for the expression of a diverse population of random peptides and methods utilizing the same
IL99552A0 (en) * 1990-09-28 1992-08-18 Ixsys Inc Compositions containing procaryotic cells,a kit for the preparation of vectors useful for the coexpression of two or more dna sequences and methods for the use thereof
FR2715940B1 (fr) * 1994-02-10 1996-04-26 Pasteur Merieux Serums Vacc Procédé de préparation d'une banque multicombinatoire de vecteurs d'expression de gènes d'anticorps, banque et systèmes d'expression d'anticorps "coliclonaux" obtenus.
US5605793A (en) * 1994-02-17 1997-02-25 Affymax Technologies N.V. Methods for in vitro recombination
EP0699750A1 (en) * 1994-06-07 1996-03-06 Gesellschaft für biotechnologische Forschung mbH (GBF) A collection of phagemids, a collection of Escherichia coli cells carrying the phagemids, a collection of phagemid particles produced from said collection and phagemid particles obtained according to the process
US5702892A (en) * 1995-05-09 1997-12-30 The United States Of America As Represented By The Department Of Health And Human Services Phage-display of immunoglobulin heavy chain libraries

Also Published As

Publication number Publication date
CN1246150A (zh) 2000-03-01
AU6495198A (en) 1998-08-25
WO1998033901A3 (en) 1999-06-17
EP0968283B1 (en) 2003-05-02
AU749249B2 (en) 2002-06-20
ATE239077T1 (de) 2003-05-15
IL131075A0 (en) 2001-01-28
EP1302540A3 (en) 2003-11-05
DE69814059D1 (de) 2003-06-05
WO1998033901A2 (en) 1998-08-06
ES2199431T3 (es) 2004-02-16
JP2001509672A (ja) 2001-07-24
WO1998033901A9 (en) 1999-08-05
CA2279341A1 (en) 1998-08-06
EP1302540A2 (en) 2003-04-16
EP0968283A2 (en) 2000-01-05
DE69814059T2 (de) 2004-05-19

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