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DK0508687T3 - ATP-analoger - Google Patents

ATP-analoger

Info

Publication number
DK0508687T3
DK0508687T3 DK92302927.6T DK92302927T DK0508687T3 DK 0508687 T3 DK0508687 T3 DK 0508687T3 DK 92302927 T DK92302927 T DK 92302927T DK 0508687 T3 DK0508687 T3 DK 0508687T3
Authority
DK
Denmark
Prior art keywords
alkyl
alkoxy
halogen
aryl
optionally substituted
Prior art date
Application number
DK92302927.6T
Other languages
English (en)
Inventor
Anthony Howard Ingall
Peter Alan Cage
Original Assignee
Astra Pharma Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB919107236A external-priority patent/GB9107236D0/en
Priority claimed from GB919123671A external-priority patent/GB9123671D0/en
Application filed by Astra Pharma Prod filed Critical Astra Pharma Prod
Application granted granted Critical
Publication of DK0508687T3 publication Critical patent/DK0508687T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3808—Acyclic saturated acids which can have further substituents on alkyl
    • C07F9/3821—Acyclic saturated acids which can have further substituents on alkyl substituted by B, Si, P or a metal
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Mechanical Treatment Of Semiconductor (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Color Television Image Signal Generators (AREA)
DK92302927.6T 1991-04-06 1992-04-02 ATP-analoger DK0508687T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB919107236A GB9107236D0 (en) 1991-04-06 1991-04-06 Compounds
GB919123671A GB9123671D0 (en) 1991-11-07 1991-11-07 Compounds

Publications (1)

Publication Number Publication Date
DK0508687T3 true DK0508687T3 (da) 1996-02-05

Family

ID=26298696

Family Applications (1)

Application Number Title Priority Date Filing Date
DK92302927.6T DK0508687T3 (da) 1991-04-06 1992-04-02 ATP-analoger

Country Status (18)

Country Link
EP (2) EP0508687B1 (da)
JP (1) JP3141028B2 (da)
CN (2) CN1031879C (da)
AT (1) ATE127808T1 (da)
CA (1) CA2107667A1 (da)
DE (1) DE69204717T2 (da)
DK (1) DK0508687T3 (da)
ES (1) ES2078654T3 (da)
FI (1) FI934366A7 (da)
GR (1) GR3018307T3 (da)
HU (2) HUT64967A (da)
IE (1) IE921091A1 (da)
IL (1) IL101485A0 (da)
MX (1) MX9201577A (da)
NO (1) NO933555D0 (da)
NZ (1) NZ242243A (da)
PL (1) PL297372A1 (da)
WO (1) WO1992017488A1 (da)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5760021A (en) * 1992-05-29 1998-06-02 The Procter & Gamble Company Phosphonocarboxylate compounds pharmaceutical compositions, and methods for treating abnormal calcium and phosphate metabolism
US5731299A (en) * 1992-05-29 1998-03-24 The Procter & Gamble Company Phosphonosulfonate compounds, pharmaceutical compositions, and methods for treating abnormal calcium and phosphate metabolism
CA2155673C (en) * 1993-02-10 2004-08-17 Anthony Howard Ingall N-alkyl-2-substituted atp analogues
FR2721929B1 (fr) * 1994-06-30 1996-12-20 Centre Nat Rech Scient Analogues stables, non hydrolysables, de diphosphates et leurs procedes de preparation
EP0929218A4 (en) * 1996-10-30 2001-05-16 Univ North Carolina P2Y RECEPTOR ANTAGONISTS
US6159952A (en) * 1996-11-07 2000-12-12 Inspire Pharmaceuticals, Inc. Method of treating bronchitis with uridine triphosphate and related compounds
US6686462B2 (en) * 1997-02-28 2004-02-03 The Regents Of The University Of California Antiviral compounds and methods of administration
FI104901B (fi) 1997-10-20 2000-04-28 Leiras Oy Uudet metyleenibisfosfonihappojohdannaiset
US6667306B1 (en) 1998-01-15 2003-12-23 Millennium Pharmaceuticals, Inc. Platelet ADP receptor inhibitors
TWI229674B (en) 1998-12-04 2005-03-21 Astra Pharma Prod Novel triazolo[4,5-d]pyrimidine compounds, pharmaceutical composition containing the same, their process for preparation and uses
EP1194441B1 (en) * 1999-06-22 2003-10-22 Cv Therapeutics, Inc. A2a receptor agonists
SE9903290D0 (sv) 1999-09-15 1999-09-15 Astra Pharma Prod Novel compounds
SE9904377D0 (sv) * 1999-12-01 1999-12-01 Astra Pharma Prod Pharmaceutical combinations
GB0013488D0 (en) * 2000-06-02 2000-07-26 Astrazeneca Ab Chemical compound
US6897201B2 (en) 2000-08-21 2005-05-24 Inspire Pharmaceuticals, Inc. Compositions and methods for the treatment of glaucoma or ocular hypertension
US7452870B2 (en) 2000-08-21 2008-11-18 Inspire Pharmaceuticals, Inc. Drug-eluting stents coated with P2Y12 receptor antagonist compound
US7132408B2 (en) 2000-08-21 2006-11-07 Inspire Pharmaceuticals, Inc. Composition and method for inhibiting platelet aggregation
US7115585B2 (en) 2000-08-21 2006-10-03 Inspire Pharmaceuticals, Inc. Compositions for treating epithelial and retinal tissue diseases
US7018985B1 (en) 2000-08-21 2006-03-28 Inspire Pharmaceuticals, Inc. Composition and method for inhibiting platelet aggregation
US7435724B2 (en) 2002-02-27 2008-10-14 Inspire Pharmaceutical, Inc. Degradation-resistant mononucleoside phosphate compounds
SE0401001D0 (sv) * 2004-03-31 2004-03-31 Astrazeneca Ab Chemical process
EP2021350B1 (en) 2006-03-21 2016-12-21 Rheinische Friedrich-Wilhelms-Universität Bonn Phosphorylated a2a receptor agonists
US9493502B2 (en) 2011-01-26 2016-11-15 Beijing Kbd Pharmaceuticals Co., Ltd. Ribofuranosyl purine compounds, methods for preparing the same and use thereof
CN102659691B (zh) * 2012-05-23 2014-04-02 山东诚创医药技术开发有限公司 一种4,6-二氯-5-氨基-2-丙硫基嘧啶的制备方法
CN103288748A (zh) * 2013-06-21 2013-09-11 四川铂瑞生物医药有限公司 一种4.6-二氯-5-氨基-2-丙硫基嘧啶的制备方法
CN104003943A (zh) * 2014-05-06 2014-08-27 南通常佑药业科技有限公司 一种替格瑞洛中间体的制备方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0464206A4 (en) * 1989-03-24 1992-05-13 Daiichi Pharmaceutical Co., Ltd. Drug for improving brain function

Also Published As

Publication number Publication date
NO933555L (no) 1993-10-05
IE921091A1 (en) 1992-10-07
WO1992017488A1 (en) 1992-10-15
ES2078654T3 (es) 1995-12-16
JP3141028B2 (ja) 2001-03-05
FI934366L (fi) 1993-10-05
EP0508687A1 (en) 1992-10-14
NO933555D0 (no) 1993-10-05
IL101485A0 (en) 1992-12-30
JPH06505987A (ja) 1994-07-07
MX9201577A (es) 1992-10-01
PL297372A1 (en) 1993-09-06
CN1120936A (zh) 1996-04-24
HUT64967A (en) 1994-03-28
HU9302812D0 (en) 1993-12-28
ATE127808T1 (de) 1995-09-15
FI934366A0 (fi) 1993-10-05
GR3018307T3 (en) 1996-03-31
FI934366A7 (fi) 1993-10-05
EP0579643A1 (en) 1994-01-26
DE69204717D1 (de) 1995-10-19
CN1068574A (zh) 1993-02-03
CA2107667A1 (en) 1992-10-07
HU211334A9 (en) 1995-11-28
AU1451992A (en) 1992-11-02
CN1031879C (zh) 1996-05-29
AU648885B2 (en) 1994-05-05
NZ242243A (en) 1993-06-25
DE69204717T2 (de) 1996-04-25
EP0508687B1 (en) 1995-09-13

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