DE880197C - Process for the preparation of suspensions of penicillin salts - Google Patents
Process for the preparation of suspensions of penicillin saltsInfo
- Publication number
- DE880197C DE880197C DEF6240A DEF0006240A DE880197C DE 880197 C DE880197 C DE 880197C DE F6240 A DEF6240 A DE F6240A DE F0006240 A DEF0006240 A DE F0006240A DE 880197 C DE880197 C DE 880197C
- Authority
- DE
- Germany
- Prior art keywords
- penicillin
- suspensions
- salts
- bile
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000002960 penicillins Chemical class 0.000 title claims description 6
- 238000000034 method Methods 0.000 title claims description 3
- 239000000725 suspension Substances 0.000 title description 4
- 238000002360 preparation method Methods 0.000 title description 3
- 210000000941 bile Anatomy 0.000 claims description 7
- 150000007530 organic bases Chemical class 0.000 claims description 3
- 150000003839 salts Chemical class 0.000 claims description 3
- 239000007900 aqueous suspension Substances 0.000 claims description 2
- 239000003613 bile acid Substances 0.000 claims description 2
- 229940049954 penicillin Drugs 0.000 description 6
- 229930182555 Penicillin Natural products 0.000 description 5
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 5
- MFDFERRIHVXMIY-UHFFFAOYSA-N procaine Chemical compound CCN(CC)CCOC(=O)C1=CC=C(N)C=C1 MFDFERRIHVXMIY-UHFFFAOYSA-N 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 2
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 2
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 2
- HMUNWXXNJPVALC-UHFFFAOYSA-N 1-[4-[2-(2,3-dihydro-1H-inden-2-ylamino)pyrimidin-5-yl]piperazin-1-yl]-2-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)ethanone Chemical compound C1C(CC2=CC=CC=C12)NC1=NC=C(C=N1)N1CCN(CC1)C(CN1CC2=C(CC1)NN=N2)=O HMUNWXXNJPVALC-UHFFFAOYSA-N 0.000 description 1
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 1
- WZFUQSJFWNHZHM-UHFFFAOYSA-N 2-[4-[2-(2,3-dihydro-1H-inden-2-ylamino)pyrimidin-5-yl]piperazin-1-yl]-1-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)ethanone Chemical compound C1C(CC2=CC=CC=C12)NC1=NC=C(C=N1)N1CCN(CC1)CC(=O)N1CC2=C(CC1)NN=N2 WZFUQSJFWNHZHM-UHFFFAOYSA-N 0.000 description 1
- CONKBQPVFMXDOV-QHCPKHFHSA-N 6-[(5S)-5-[[4-[2-(2,3-dihydro-1H-inden-2-ylamino)pyrimidin-5-yl]piperazin-1-yl]methyl]-2-oxo-1,3-oxazolidin-3-yl]-3H-1,3-benzoxazol-2-one Chemical compound C1C(CC2=CC=CC=C12)NC1=NC=C(C=N1)N1CCN(CC1)C[C@H]1CN(C(O1)=O)C1=CC2=C(NC(O2)=O)C=C1 CONKBQPVFMXDOV-QHCPKHFHSA-N 0.000 description 1
- 241000416162 Astragalus gummifer Species 0.000 description 1
- 229920000084 Gum arabic Polymers 0.000 description 1
- 241000978776 Senegalia senegal Species 0.000 description 1
- 229920001615 Tragacanth Polymers 0.000 description 1
- 235000010489 acacia gum Nutrition 0.000 description 1
- 239000000205 acacia gum Substances 0.000 description 1
- 238000007792 addition Methods 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 229920003086 cellulose ether Polymers 0.000 description 1
- KXGVEGMKQFWNSR-LLQZFEROSA-N deoxycholic acid Chemical compound C([C@H]1CC2)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)[C@@H](O)C1 KXGVEGMKQFWNSR-LLQZFEROSA-N 0.000 description 1
- 229960003964 deoxycholic acid Drugs 0.000 description 1
- KXGVEGMKQFWNSR-UHFFFAOYSA-N deoxycholic acid Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)C(O)C2 KXGVEGMKQFWNSR-UHFFFAOYSA-N 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- FHHPUSMSKHSNKW-SMOYURAASA-M sodium deoxycholate Chemical compound [Na+].C([C@H]1CC2)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC([O-])=O)C)[C@@]2(C)[C@@H](O)C1 FHHPUSMSKHSNKW-SMOYURAASA-M 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/28—Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
- A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dermatology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
Verfahren zur Herstellung von Suspensionen von Penicillinsalzen Es wurde gefunden, daR man zu hochkonzentrierten, leicht flielBenden wäßrigen Suspensionen von schwer löslichen Penicillinsalzen rganischer Basen gelangen kann, wenn man den Penicillinsalzen Galle oder Zubereitungen aus Galle, wie gereinigte Ochsengalle (Fel tauri depuratum), ferner Gallensäuren, z. B. Desoxycholsäure, vorzugsweise in Form wasserlöslicher Salze zusetzt.Process for the preparation of suspensions of penicillin salts It it has been found that highly concentrated, easily flowing aqueous suspensions are obtained of sparingly soluble penicillin salts of organic bases, if one has the Penicillin salts of bile or preparations made from bile, such as purified ox bile (Fel tauri depuratum), also bile acids, z. B. deoxycholic acid, preferably added in the form of water-soluble salts.
Die Menge der erfindungsgemäß zu verwendenden Zusatzstoffe läßt sach durch Vofversuche leicht ermitteln, sie hängt häufig von der Korngröße des p-Aminobenzoyldiäthylaminoäthanol-Penicillins ab; im allgemeinen genügen Zusätze von O,I bis 1 0/o. The amount of the additives to be used according to the invention can be considered Easily determined by trial tests, it often depends on the grain size of the p-aminobenzoyl diethylaminoethanol penicillin away; In general, additions of 0.1 to 10% are sufficient.
Zur Erhöhung der Haltbarkeit können in an sich beliannter Weise noch Puffer zugesetzt werden. Da die Suspensionen so flüssig sind, daß sie zum Absetzen neigen, werden zweckmäßig Verdickungsmittel, wie Celluloseäther, Na-Alginat, Traganth, Polyvinylpyrrolidon usw. zugesetzt. In order to increase the shelf life, you can still use Buffers can be added. Because the suspensions are so fluid that they have to settle tend to use thickeners such as cellulose ether, sodium alginate, tragacanth, Polyvinylpyrrolidone, etc. added.
Beispiel I I g p-Aminobenzoyldiäthylaminoäthanol-Penicillin werden in 2 ccm einer o,0/0igen Lösung von Ochsengalle in Wasser suspendiert. Example I I g of p-aminobenzoyl diethylaminoethanol penicillin will be suspended in 2 cc of a 0.0 / 0 solution of ox bile in water.
Beispiel 2 1 g p-Aminohenzoyldiäthylaminoäthanol-Penicillin werden in 2 ccm einer Lösung von 0,2°/o Ochsengalle und 0,5 0/0 Polyvinylpyrrolidon in Wasser suspendiert. Example 2 1 g of p-Aminohenzoyldiäthylaminoäthanol-penicillin become in 2 cc of a solution of 0.2% ox gall and 0.5% polyvinylpyrrolidone in Suspended in water.
Beispiel 3 1 g p-Aminobenzoyldiäthylaminoäthanol-Penicillin werden in 2 ccm einer o,7°/oigen Lösung von desoxycholsaurem Natrium in Wasser suspendiert. Example 3 1 g of p-aminobenzoyl diethylaminoethanol penicillin are used suspended in 2 cc of a 0.7% solution of sodium desoxycholate in water.
Beispiel 4 1 g p-Aminobenzoyldiäthylaminoäthanol-Penicillin werden in 2 ccm einer Lösung von Ochsengalle und 0,I0/o Gummiarabikum in Wasser suspendiert. Example 4 1 g of p-aminobenzoyl diethylaminoethanol penicillin are used suspended in 2 cc of a solution of ox bile and 0.110 / o gum arabic in water.
Beispiel 5 1 g des Salzes aus Penicillin und 3-n-Butoxy-Nisobutylhenzylamin werden in 4 ccm einer 1%igen wäßrigen Lösung von gereinigter Ochsengalle (Fel tauri depuratum) suspendiert. Example 5 1 g of the salt of penicillin and 3-n-butoxy-nisobutylhenzylamine are in 4 ccm of a 1% aqueous solution of purified ox bile (Fel tauri depuratum).
In allen Fällen erhält man leicht fließende, gut injizierbare Suspensionen. Easily flowing, readily injectable suspensions are obtained in all cases.
Claims (1)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEF6240A DE880197C (en) | 1951-05-16 | 1951-05-16 | Process for the preparation of suspensions of penicillin salts |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEF6240A DE880197C (en) | 1951-05-16 | 1951-05-16 | Process for the preparation of suspensions of penicillin salts |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE880197C true DE880197C (en) | 1953-06-18 |
Family
ID=7084913
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DEF6240A Expired DE880197C (en) | 1951-05-16 | 1951-05-16 | Process for the preparation of suspensions of penicillin salts |
Country Status (1)
| Country | Link |
|---|---|
| DE (1) | DE880197C (en) |
-
1951
- 1951-05-16 DE DEF6240A patent/DE880197C/en not_active Expired
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE1093088B (en) | Method of crosslinking polyvinyl alcohol | |
| DE880197C (en) | Process for the preparation of suspensions of penicillin salts | |
| DE1807255A1 (en) | Prepared from suspensions of organic particles stabilized with regard to their number, shape and volume for the preservation of microscopic particles and for the production of standardized particle suspensions | |
| DE889132C (en) | Flotation of sludge-containing crude salts, in particular crude potash salts | |
| DE867135C (en) | Light stabilizers | |
| DE677381C (en) | Process for the production of fixing salts resistant to acidic decomposition | |
| DE889747C (en) | Process for the preparation of aqueous solutions of theophylline | |
| DE1228927B (en) | Process for the production of planographic printing forms | |
| DE444064C (en) | Process for the preparation of water-soluble double compounds of digitoglycotannoids, the totality of digitalis glycosides in their natural form | |
| DE958109C (en) | Process for the production of tetracyclines from their solutions | |
| DE897389C (en) | Process for the swimming pool treatment of sulphidic and oxidic minerals | |
| AT136519B (en) | Process for the production of a base material for metal cleaning agents. | |
| DE682021C (en) | Process for the preparation of durable complex gold compounds of catechol disulfonic acid | |
| DE679711C (en) | Process for the production of ethersic acids | |
| DE880303C (en) | Process for the production of a crystallized penicillin salt which is sparingly soluble in water | |
| DE680749C (en) | Process for activating technical grade sodium azide | |
| DE688047C (en) | Process for the production of stable aqueous, therapeutically usable solutions of the polyoxyalkylisoalloxazines | |
| DE694045C (en) | Process for the preparation of bicyclic amines | |
| DE862341C (en) | Process for the preparation of aqueous solutions of derivatives of p-aminobenzene sulfonamide | |
| DE676436C (en) | Process for the preparation of aqueous solutions of p-aminobenzene sulfonamide | |
| AT146967B (en) | Process for the production of heavy metal compounds of the porphine series. | |
| DE873599C (en) | Process for the preparation of penicillin compounds with extended action | |
| DE963294C (en) | Fine grain photographic development process | |
| DE952089C (en) | Process for the production of therapeutically valuable, water-soluble rhodan compounds | |
| DE648667C (en) | Acid-proof putty |