DE871951C - Process for the preparation of rich aqueous solutions of dihalodioxybenzilen - Google Patents
Process for the preparation of rich aqueous solutions of dihalodioxybenzilenInfo
- Publication number
- DE871951C DE871951C DEF3319D DEF0003319D DE871951C DE 871951 C DE871951 C DE 871951C DE F3319 D DEF3319 D DE F3319D DE F0003319 D DEF0003319 D DE F0003319D DE 871951 C DE871951 C DE 871951C
- Authority
- DE
- Germany
- Prior art keywords
- aqueous solutions
- dihalodioxybenzilen
- preparation
- rich aqueous
- water
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000007864 aqueous solution Substances 0.000 title claims description 4
- 238000000034 method Methods 0.000 title claims description 3
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 claims description 5
- 239000004327 boric acid Substances 0.000 claims description 3
- 239000002904 solvent Substances 0.000 claims description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- 239000000243 solution Substances 0.000 description 5
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- ZOXJGFHDIHLPTG-UHFFFAOYSA-N Boron Chemical compound [B] ZOXJGFHDIHLPTG-UHFFFAOYSA-N 0.000 description 1
- 239000007836 KH2PO4 Substances 0.000 description 1
- 229910004835 Na2B4O7 Inorganic materials 0.000 description 1
- 229910052796 boron Inorganic materials 0.000 description 1
- ZPWVASYFFYYZEW-UHFFFAOYSA-L dipotassium hydrogen phosphate Chemical compound [K+].[K+].OP([O-])([O-])=O ZPWVASYFFYYZEW-UHFFFAOYSA-L 0.000 description 1
- UQGFMSUEHSUPRD-UHFFFAOYSA-N disodium;3,7-dioxido-2,4,6,8,9-pentaoxa-1,3,5,7-tetraborabicyclo[3.3.1]nonane Chemical compound [Na+].[Na+].O1B([O-])OB2OB([O-])OB1O2 UQGFMSUEHSUPRD-UHFFFAOYSA-N 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 229910000402 monopotassium phosphate Inorganic materials 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dermatology (AREA)
- Inorganic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Description
Verfahren zur Herstellung von gehaitreichen wäßrigen Lösungen von Dihalogendioxybenzilen Einer parenteralen Anwendung von Dihalogendioxybenzilen steht ihre sehr geringe Löslichkeit in Wasser entgegen. So ist beispielsweise das 2, 2'-Dioxy-5, 5'-dibrombenzil zu weniger als O,OOI°/o in Wasser löslich. Process for the preparation of rich aqueous solutions of Dihalodioxybencilene Parenteral use of dihalodioxybenzilene is available opposed to their very low solubility in water. For example, the 2, 2'-dioxy-5, 5'-dibromobenzil is less than 0.010 ° / o soluble in water.
Es wurde gefunden, daß man gehaltreiche wäßrige Lösungen von Dihalogendioxybenzilen erhalten kann, wenn man Borsäure bzw. borsaure Salze als Lösungsvermittler verwendet. Die so erhaltenen Lösungen sind für Injektionszwecke brauchbar. Die Wirksamkeit der Dihalogendioxybenzilen gegenüber Mikroorganismen wird durch den Borzusatz nicht beeinträchtigt. It has been found that rich aqueous solutions of dihalodioxybenzilene can be obtained can be obtained if boric acid or boric acid salts are used as solubilizers. The solutions thus obtained can be used for injection purposes. The effectiveness the dihalodioxybenzilene against microorganisms is not due to the addition of boron impaired.
Beispiel I 5 g 5, 5'-Dibrom-2, 2'-dioxybenzil ergeben mit 3,I g Borsäure und 2 g Natriumhydroxyd in 50 ccm Wasser eine klare, fast farblose Lösung vom PH 9,8. Example I 5 g of 5,5'-dibromo-2, 2'-dioxybenzil give 3.1 g of boric acid and 2 g of sodium hydroxide in 50 cc of water, a clear, almost colorless solution of the pH 9.8.
Beim Erhitzen wird die Farbe intensiv gelb, beim Erkalten geht sie wieder zurück.When heated, the color becomes intense yellow, when cooled it goes back again.
Beispiel 2 50 ccm der nach Beispiel 1 erhaltenen Lösung werden mit 50 ccm Wasser verdünnt und mit 2,5 g Kaliummonophosphat versetzt. Die Lösung bleibt klar, der pH-Wert beträgt 7,8. Example 2 50 ccm of the solution obtained according to Example 1 are mixed with Diluted 50 ccm of water and mixed with 2.5 g of potassium monophosphate. The solution remains clear, the pH is 7.8.
Beispiel 3 5 g 5, 5'-Dtbrom-2 2'-dioxybenzil und 6 g Na2B4O7 . 10 H2O werden in 3 1 Wasser gelöst, mit rund I00 ccm m/I5-KH2PO4 auf pn 7,5 gebracht und mit Wasser auf 5 1 aufgefüllt. Example 3 5 g of 5,5'-dtbromo-2 2'-dioxybenzil and 6 g of Na2B4O7. 10 H2O are dissolved in 3 liters of water, brought to pn 7.5 with around 100 ccm m / I5-KH2PO4 and made up to 5 liters with water.
In entsprechender Weise läßt sich auch das 5,5'-Dijod-2,2'-dioxybenzil in Lösung bringen. The 5,5'-diiodo-2,2'-dioxybenzil can also be used in a corresponding manner bring into solution.
Claims (1)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEF3319D DE871951C (en) | 1943-12-16 | 1943-12-16 | Process for the preparation of rich aqueous solutions of dihalodioxybenzilen |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEF3319D DE871951C (en) | 1943-12-16 | 1943-12-16 | Process for the preparation of rich aqueous solutions of dihalodioxybenzilen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE871951C true DE871951C (en) | 1953-03-26 |
Family
ID=7083766
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DEF3319D Expired DE871951C (en) | 1943-12-16 | 1943-12-16 | Process for the preparation of rich aqueous solutions of dihalodioxybenzilen |
Country Status (1)
| Country | Link |
|---|---|
| DE (1) | DE871951C (en) |
-
1943
- 1943-12-16 DE DEF3319D patent/DE871951C/en not_active Expired
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