DE69929354D1 - 2,4-disubstierte triazinderivate mit anti-hiv aktivität - Google Patents

2,4-disubstierte triazinderivate mit anti-hiv aktivität

Info

Publication number: DE69929354D1
Authority: DE; Germany
Prior art keywords: disubsted; triazine derivatives; hiv activity; hiv; activity
Prior art date: 1998-11-10
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

DE69929354T

Other languages

English (en)

Other versions

DE69929354T2 (de

Inventor

Corte Bart De

Jonge Renomega De

Jan Heeres

Adriaan Janssen

W Kavash

Maria Koymans

Joseph Kukla

William Ludovici

Aken Jeanne Van

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Janssen Pharmaceutica NV

Original Assignee

Janssen Pharmaceutica NV

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-11-10

Filing date

1999-11-04

Publication date

2006-03-30

1999-11-04 Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV

2006-03-30 Publication of DE69929354D1 publication Critical patent/DE69929354D1/de

2006-09-14 Application granted granted Critical

2006-09-14 Publication of DE69929354T2 publication Critical patent/DE69929354T2/de

2019-11-05 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/14—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom
- C07D251/16—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom to only one ring carbon atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/14—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom
- C07D251/16—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom to only one ring carbon atom
- C07D251/18—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom to only one ring carbon atom with nitrogen atoms directly attached to the two other ring carbon atoms, e.g. guanamines
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
- C07D251/40—Nitrogen atoms
- C07D251/42—One nitrogen atom
- C07D251/46—One nitrogen atom with oxygen or sulfur atoms attached to the two other ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
- C07D251/40—Nitrogen atoms
- C07D251/48—Two nitrogen atoms
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/70—Nanostructure
- Y10S977/773—Nanoparticle, i.e. structure having three dimensions of 100 nm or less
- Y10S977/775—Nanosized powder or flake, e.g. nanosized catalyst
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/902—Specified use of nanostructure
- Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
- Y10S977/915—Therapeutic or pharmaceutical composition

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Virology (AREA)
AIDS & HIV (AREA)
Tropical Medicine & Parasitology (AREA)
Molecular Biology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

DE69929354T 1998-11-10 1999-11-04 2,4-disubstierte triazinderivate mit anti-hiv aktivität Expired - Fee Related DE69929354T2 (de)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
US10779998P	1998-11-10	1998-11-10
US107799P		1998-11-10
EP99203128		1999-09-24
EP99203128		1999-09-24
PCT/EP1999/008688 WO2000027828A2 (en)	1998-11-10	1999-11-04	2,4-disubstituted triazine derivatives with anti hiv activity

Publications (2)

Publication Number	Publication Date
DE69929354D1 true DE69929354D1 (de)	2006-03-30
DE69929354T2 DE69929354T2 (de)	2006-09-14

Family

ID=26153374

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE69929354T Expired - Fee Related DE69929354T2 (de)	1998-11-10	1999-11-04	2,4-disubstierte triazinderivate mit anti-hiv aktivität

Country Status (34)

Country	Link
US (2)	US6638932B1 (de)
EP (1)	EP1129079B1 (de)
JP (1)	JP2002529457A (de)
KR (1)	KR100620402B1 (de)
CN (1)	CN1207290C (de)
AP (1)	AP1636A (de)
AR (1)	AR021137A1 (de)
AT (1)	ATE315031T1 (de)
AU (1)	AU764472B2 (de)
BG (1)	BG65160B1 (de)
BR (1)	BR9915176A (de)
CA (1)	CA2351203C (de)
CY (1)	CY1105596T1 (de)
CZ (1)	CZ20011532A3 (de)
DE (1)	DE69929354T2 (de)
DK (1)	DK1129079T3 (de)
EA (1)	EA004501B1 (de)
EE (1)	EE200100253A (de)
ES (1)	ES2257081T3 (de)
HR (1)	HRP20010310A2 (de)
HU (1)	HUP0104395A3 (de)
ID (1)	ID28545A (de)
IL (2)	IL143024A0 (de)
MY (1)	MY126781A (de)
NO (1)	NO319788B1 (de)
NZ (1)	NZ510919A (de)
OA (1)	OA11675A (de)
PL (1)	PL196523B1 (de)
PT (1)	PT1129079E (de)
SI (1)	SI1129079T1 (de)
SK (1)	SK6022001A3 (de)
TR (1)	TR200101319T2 (de)
TW (1)	TW541305B (de)
WO (1)	WO2000027828A2 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HRP20010310A2 (en) *	1998-11-10	2002-06-30	Janssen Pharmaceutica Nv	2,4-disubstituted triazine derivatives
DE19945982A1 (de)	1999-09-24	2001-03-29	Knoll Ag	Geschwindigkeitsbestimmte Partikel
ES2542326T3 (es)	2000-05-08	2015-08-04	Janssen Pharmaceutica Nv	Inhibidores de la replicación del VIH
AR039540A1 (es) *	2002-05-13	2005-02-23	Tibotec Pharm Ltd	Compuestos microbicidas con contenido de pirimidina o triazina
AP2005003365A0 (en) *	2003-02-07	2005-09-30	Janssen Pharmaceutica Nv	Hiv inhibiting 1, 2, 4-triazines.
JP5031564B2 (ja)	2004-08-10	2012-09-19	ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ	Ｈｉｖ抑制１，２，４−トリアジン−６−オン誘導体
GB201204756D0 (en) *	2012-03-19	2012-05-02	Lewi Paulus J	Triazines with suitable spacers for treatment and/or prevention of HIV infections

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS4927592B1 (de)	1970-05-13	1974-07-18
BE754242A (fr)	1970-07-15	1971-02-01	Geigy Ag J R	Diamino-s-triazines et dinitro-s-triazines
US4650867A (en) *	1985-03-26	1987-03-17	Ciba-Geigy Corporation	Process for the preparation of 2,4,6-tris(aminophenylamino)triazines
JPH02308248A (ja)	1989-05-24	1990-12-21	Fuji Photo Film Co Ltd	アミノピリミジン系色素形成カプラーおよび該カプラーを含有するハロゲン化銀カラー写真感光材料
KR960704855A (ko)	1993-10-12	1996-10-09	돈 엠. 커.	1n-알킬-n-아릴피리미딘아민 및 이들의 유도체 (1n-alkyl-n-arylpyrimidinamines and derivatives thereof)
US5691364A (en) *	1995-03-10	1997-11-25	Berlex Laboratories, Inc.	Benzamidine derivatives and their use as anti-coagulants
NO311614B1 (no) *	1996-10-01	2001-12-17	Janssen Pharmaceutica Nv	Substituerte diamino-1,3,5-triazinderivater
US6200977B1 (en)	1998-02-17	2001-03-13	Tularik Inc.	Pyrimidine derivatives
HRP20010310A2 (en) *	1998-11-10	2002-06-30	Janssen Pharmaceutica Nv	2,4-disubstituted triazine derivatives

1999
- 1999-11-04 HR HR20010310A patent/HRP20010310A2/hr not_active Application Discontinuation
- 1999-11-04 PT PT99953980T patent/PT1129079E/pt unknown
- 1999-11-04 HU HU0104395A patent/HUP0104395A3/hu unknown
- 1999-11-04 CA CA002351203A patent/CA2351203C/en not_active Expired - Fee Related
- 1999-11-04 JP JP2000581008A patent/JP2002529457A/ja active Pending
- 1999-11-04 ES ES99953980T patent/ES2257081T3/es not_active Expired - Lifetime
- 1999-11-04 ID IDW00200101017A patent/ID28545A/id unknown
- 1999-11-04 OA OA1200100114A patent/OA11675A/en unknown
- 1999-11-04 EP EP99953980A patent/EP1129079B1/de not_active Expired - Lifetime
- 1999-11-04 EA EA200100534A patent/EA004501B1/ru not_active IP Right Cessation
- 1999-11-04 AU AU10462/00A patent/AU764472B2/en not_active Ceased
- 1999-11-04 CZ CZ20011532A patent/CZ20011532A3/cs unknown
- 1999-11-04 AT AT99953980T patent/ATE315031T1/de not_active IP Right Cessation
- 1999-11-04 DE DE69929354T patent/DE69929354T2/de not_active Expired - Fee Related
- 1999-11-04 AP APAP/P/2001/002155A patent/AP1636A/en active
- 1999-11-04 NZ NZ510919A patent/NZ510919A/en unknown
- 1999-11-04 EE EEP200100253A patent/EE200100253A/xx unknown
- 1999-11-04 SI SI9930886T patent/SI1129079T1/sl unknown
- 1999-11-04 IL IL14302499A patent/IL143024A0/xx active IP Right Grant
- 1999-11-04 DK DK99953980T patent/DK1129079T3/da active
- 1999-11-04 SK SK602-2001A patent/SK6022001A3/sk unknown
- 1999-11-04 KR KR1020017003574A patent/KR100620402B1/ko not_active Expired - Fee Related
- 1999-11-04 TR TR2001/01319T patent/TR200101319T2/xx unknown
- 1999-11-04 US US09/831,808 patent/US6638932B1/en not_active Expired - Fee Related
- 1999-11-04 BR BR9915176-6A patent/BR9915176A/pt not_active IP Right Cessation
- 1999-11-04 PL PL348145A patent/PL196523B1/pl not_active IP Right Cessation
- 1999-11-04 CN CNB998130478A patent/CN1207290C/zh not_active Expired - Fee Related
- 1999-11-04 WO PCT/EP1999/008688 patent/WO2000027828A2/en not_active Ceased
- 1999-11-05 MY MYPI99004801A patent/MY126781A/en unknown
- 1999-11-09 AR ARP990105681A patent/AR021137A1/es active IP Right Grant
- 1999-12-23 TW TW088119615A patent/TW541305B/zh not_active IP Right Cessation
2001
- 2001-04-06 BG BG105419A patent/BG65160B1/bg unknown
- 2001-04-19 NO NO20011934A patent/NO319788B1/no unknown
- 2001-05-07 IL IL143024A patent/IL143024A/en not_active IP Right Cessation
2003
- 2003-08-27 US US10/649,017 patent/US7015221B2/en not_active Expired - Fee Related
2006
- 2006-03-31 CY CY20061100457T patent/CY1105596T1/el unknown

Also Published As

Publication number	Publication date
WO2000027828A3 (en)	2000-09-21
NZ510919A (en)	2003-11-28
ES2257081T3 (es)	2006-07-16
PT1129079E (pt)	2006-05-31
MY126781A (en)	2006-10-31
CA2351203C (en)	2009-03-24
CZ20011532A3 (cs)	2001-10-17
HUP0104395A3 (en)	2003-02-28
US20050277641A1 (en)	2005-12-15
BG105419A (en)	2001-11-30
DK1129079T3 (da)	2006-05-15
HK1038232A1 (en)	2002-03-08
NO20011934L (no)	2001-04-19
ID28545A (id)	2001-05-31
CY1105596T1 (el)	2010-07-28
SK6022001A3 (en)	2002-01-07
EA004501B1 (ru)	2004-04-29
SI1129079T1 (sl)	2006-06-30
EE200100253A (et)	2002-12-16
PL196523B1 (pl)	2008-01-31
CN1207290C (zh)	2005-06-22
AU1046200A (en)	2000-05-29
KR100620402B1 (ko)	2006-09-13
WO2000027828A2 (en)	2000-05-18
ATE315031T1 (de)	2006-02-15
CN1325387A (zh)	2001-12-05
AR021137A1 (es)	2002-06-12
TR200101319T2 (tr)	2001-10-22
US6638932B1 (en)	2003-10-28
IL143024A0 (en)	2002-04-21
KR20010075234A (ko)	2001-08-09
EP1129079B1 (de)	2006-01-04
EA200100534A1 (ru)	2001-10-22
US7015221B2 (en)	2006-03-21
TW541305B (en)	2003-07-11
BG65160B1 (bg)	2007-04-30
DE69929354T2 (de)	2006-09-14
JP2002529457A (ja)	2002-09-10
NO20011934D0 (no)	2001-04-19
EP1129079A2 (de)	2001-09-05
NO319788B1 (no)	2005-09-12
OA11675A (en)	2005-01-12
HUP0104395A2 (hu)	2002-04-29
AU764472B2 (en)	2003-08-21
AP1636A (en)	2006-07-17
IL143024A (en)	2006-06-11
BR9915176A (pt)	2001-08-14
CA2351203A1 (en)	2000-05-18
PL348145A1 (en)	2002-05-06
HRP20010310A2 (en)	2002-06-30

Publication	Publication Date	Title
DE69933287D1 (de)	2006-11-02	12,13-modifizierte epothilon-derivate
DE69826127D1 (de)	2004-10-14	2-substituierte 4,5-diarylimidazole
DE122005000003I1 (de)	2005-05-25	Heterocyclische Azahexanderivate mit Antiviraler wirkung.
IS4970A (is)	1999-02-05	Setnar 6,6-heteró-bísýklískar afleiður
DK1000048T3 (da)	2003-03-03	Substituerede 1,2,3,4-tetrahydronapthalenderivater
IS4963A (is)	1999-01-29	Setnar 6,5-heteró-bísýklískar afleiður
NL300150I1 (nl)	2004-08-02	4"-Gesubstitueerde 9-deoxo-9A-AZA-9A-homoërythromycine-A-derivaten.
ID29241A (id)	2001-08-16	Turunan-turunan kinolin teranelasi-1,2
DE69804273D1 (de)	2002-04-25	5h-Thiazolo[3,2-a]pyrimidinderivate
FI952424L (fi)	1995-11-20	11,21-bisfenyyli-19-norpregaanijohdannaisia
DE69718771D1 (de)	2003-03-06	Substituierte 1,2,3,4-tetrahydronaphthalinderivate
ATE227282T1 (de)	2002-11-15	2,4-diaminopyrimidin-derivate
MA26503A1 (fr)	2004-12-20	Derives de 5'-desoxy-cytidine.
DE69917327D1 (de)	2004-06-17	3,3-biarylpiperidin- und 3,3-biarylmorpholinderivate
DE69814441D1 (de)	2003-06-12	6,11-verbrückte erythromycinderivate
DE59808442D1 (de)	2003-06-26	Stirnplanfräsmaschine
EE04089B1 (et)	2003-08-15	1,3,4-oksadiasolooni derivaadid
ATE204279T1 (de)	2001-09-15	Diaza-spiro(3,5)nonan-derivate
DK1149106T3 (da)	2003-07-14	4,5-azolo-oxindoler
DE69714358D1 (de)	2002-09-05	9,10-disubstituierte campothecinderivate mit antitumoraktivität
DE69929354D1 (de)	2006-03-30	2,4-disubstierte triazinderivate mit anti-hiv aktivität
PT1010699E (pt)	2005-08-31	Derivados de 3-oxadiazolil-1,6-naftiridina-2(h)-ona substituido em 5
TR199700219A3 (tr)	1997-10-21	1,25-Dihidroksi-16, 22, 23-Trisdihidro-kolkalsiferol türevleri.

Legal Events

Date	Code	Title	Description
2007-01-25	8364	No opposition during term of opposition
2010-09-16	8339	Ceased/non-payment of the annual fee