DE69812934D1 - Gemcitabin-derivate - Google Patents
Gemcitabin-derivateInfo
- Publication number
- DE69812934D1 DE69812934D1 DE69812934T DE69812934T DE69812934D1 DE 69812934 D1 DE69812934 D1 DE 69812934D1 DE 69812934 T DE69812934 T DE 69812934T DE 69812934 T DE69812934 T DE 69812934T DE 69812934 D1 DE69812934 D1 DE 69812934D1
- Authority
- DE
- Germany
- Prior art keywords
- eicosenoyl
- amides
- gemcitabine
- gemcitabine derivatives
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- SDUQYLNIPVEERB-QPPQHZFASA-N gemcitabine Chemical class O=C1N=C(N)C=CN1[C@H]1C(F)(F)[C@H](O)[C@@H](CO)O1 SDUQYLNIPVEERB-QPPQHZFASA-N 0.000 title abstract 3
- 125000002252 acyl group Chemical group 0.000 abstract 2
- 150000001408 amides Chemical class 0.000 abstract 2
- 230000001093 anti-cancer Effects 0.000 abstract 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 239000003443 antiviral agent Substances 0.000 abstract 1
- 125000004016 elaidoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])/C([H])=C([H])/C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 1
- 125000002811 oleoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])/C([H])=C([H])\C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- -1 trans-eicosenoyl Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9701427A GB2321454A (en) | 1997-01-24 | 1997-01-24 | Gemcitabine esters and amides |
| PCT/NO1998/000020 WO1998032762A1 (en) | 1997-01-24 | 1998-01-23 | Gemcitabine derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69812934D1 true DE69812934D1 (de) | 2003-05-08 |
| DE69812934T2 DE69812934T2 (de) | 2004-01-29 |
Family
ID=26310850
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69812934T Expired - Lifetime DE69812934T2 (de) | 1997-01-24 | 1998-01-23 | Gemcitabin-derivate |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US6384019B1 (de) |
| EP (1) | EP0986570B9 (de) |
| JP (1) | JP4352115B2 (de) |
| KR (1) | KR100483256B1 (de) |
| AT (1) | ATE236188T1 (de) |
| AU (1) | AU720451B2 (de) |
| CA (1) | CA2278056C (de) |
| DE (1) | DE69812934T2 (de) |
| DK (1) | DK0986570T3 (de) |
| HU (1) | HU224918B1 (de) |
| NZ (1) | NZ336676A (de) |
| PL (1) | PL186888B1 (de) |
| SK (1) | SK283879B6 (de) |
| UA (1) | UA67736C2 (de) |
| WO (1) | WO1998032762A1 (de) |
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| FI95384C (fi) * | 1989-04-06 | 1996-01-25 | Squibb Bristol Myers Co | Menetelmä 3'-deoksi-3'-substituoitujen metyylinukleosidien valmistamiseksi ja menetelmässä käytettäviä välituotteita |
| FI105556B (fi) * | 1991-09-30 | 2000-09-15 | Sankyo Co | Menetelmä lääkeaineina käyttökelpoisten pyrimidiiniukleosidijohdannaisten valmistamiseksi, joilla on kasvaimen vastaista vaikutusta |
| US5401838A (en) * | 1992-06-22 | 1995-03-28 | Eli Lilly And Company | Stereoselective fusion glycosylation process for preparing 2'-deoxy-2',2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides |
| GB9307043D0 (en) * | 1993-04-05 | 1993-05-26 | Norsk Hydro As | Chemical compounds |
| GB9515279D0 (en) * | 1995-07-25 | 1995-09-20 | Norsk Hydro As | Improved therapeutic agents |
-
1998
- 1998-01-23 HU HU0000721A patent/HU224918B1/hu not_active IP Right Cessation
- 1998-01-23 WO PCT/NO1998/000020 patent/WO1998032762A1/en not_active Ceased
- 1998-01-23 UA UA99084763A patent/UA67736C2/uk unknown
- 1998-01-23 AT AT98901592T patent/ATE236188T1/de active
- 1998-01-23 AU AU57827/98A patent/AU720451B2/en not_active Expired
- 1998-01-23 CA CA002278056A patent/CA2278056C/en not_active Expired - Lifetime
- 1998-01-23 DK DK98901592T patent/DK0986570T3/da active
- 1998-01-23 EP EP98901592A patent/EP0986570B9/de not_active Expired - Lifetime
- 1998-01-23 SK SK1029-99A patent/SK283879B6/sk not_active IP Right Cessation
- 1998-01-23 PL PL98334856A patent/PL186888B1/pl unknown
- 1998-01-23 US US09/355,112 patent/US6384019B1/en not_active Expired - Lifetime
- 1998-01-23 DE DE69812934T patent/DE69812934T2/de not_active Expired - Lifetime
- 1998-01-23 KR KR10-1999-7006584A patent/KR100483256B1/ko not_active Expired - Fee Related
- 1998-01-23 NZ NZ336676A patent/NZ336676A/xx not_active IP Right Cessation
- 1998-01-23 JP JP53186298A patent/JP4352115B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP0986570A1 (de) | 2000-03-22 |
| NZ336676A (en) | 2000-01-28 |
| CA2278056A1 (en) | 1998-07-30 |
| SK283879B6 (sk) | 2004-04-06 |
| JP4352115B2 (ja) | 2009-10-28 |
| US6384019B1 (en) | 2002-05-07 |
| AU5782798A (en) | 1998-08-18 |
| DE69812934T2 (de) | 2004-01-29 |
| AU720451B2 (en) | 2000-06-01 |
| EP0986570B9 (de) | 2004-01-02 |
| DK0986570T3 (da) | 2003-07-28 |
| HUP0000721A2 (hu) | 2001-05-28 |
| KR20000070351A (ko) | 2000-11-25 |
| HUP0000721A3 (en) | 2002-12-28 |
| PL186888B1 (pl) | 2004-03-31 |
| SK102999A3 (en) | 2000-05-16 |
| ATE236188T1 (de) | 2003-04-15 |
| UA67736C2 (uk) | 2004-07-15 |
| HU224918B1 (en) | 2006-04-28 |
| CA2278056C (en) | 2006-12-12 |
| PL334856A1 (en) | 2000-03-27 |
| US20020042391A1 (en) | 2002-04-11 |
| KR100483256B1 (ko) | 2005-04-15 |
| EP0986570B1 (de) | 2003-04-02 |
| WO1998032762A1 (en) | 1998-07-30 |
| JP2001509160A (ja) | 2001-07-10 |
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| 8364 | No opposition during term of opposition |