[go: up one dir, main page]

DE69716443D1 - Antitumor-wirksame bis-platin komplexe mit polymethylen-derivaten als liganden - Google Patents

Antitumor-wirksame bis-platin komplexe mit polymethylen-derivaten als liganden

Info

Publication number
DE69716443D1
DE69716443D1 DE69716443T DE69716443T DE69716443D1 DE 69716443 D1 DE69716443 D1 DE 69716443D1 DE 69716443 T DE69716443 T DE 69716443T DE 69716443 T DE69716443 T DE 69716443T DE 69716443 D1 DE69716443 D1 DE 69716443D1
Authority
DE
Germany
Prior art keywords
antitumor
ligands
platinum complexes
bis
polymethylene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69716443T
Other languages
English (en)
Other versions
DE69716443T2 (de
Inventor
P Farrell
Ernesto Menta
Domenico Roberto Di
Silvano Spinelli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Virginia Commonwealth University
Original Assignee
F Hoffmann La Roche AG
Virginia Commonwealth University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG, Virginia Commonwealth University filed Critical F Hoffmann La Roche AG
Publication of DE69716443D1 publication Critical patent/DE69716443D1/de
Application granted granted Critical
Publication of DE69716443T2 publication Critical patent/DE69716443T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C277/00—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C277/08—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups of substituted guanidines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/14—Preparation of carboxylic acid amides by formation of carboxamide groups together with reactions not involving the carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C273/00—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C273/18—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas
    • C07C273/1809—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas with formation of the N-C(O)-N moiety
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C273/00—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C273/18—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas
    • C07C273/1809—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas with formation of the N-C(O)-N moiety
    • C07C273/1818—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas with formation of the N-C(O)-N moiety from -N=C=O and XNR'R"
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/34—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfuric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
    • C07F15/0086—Platinum compounds
    • C07F15/0093—Platinum compounds without a metal-carbon linkage

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69716443T 1996-07-22 1997-07-22 Antitumor-wirksame bis-platin komplexe mit polymethylen-derivaten als liganden Expired - Lifetime DE69716443T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2226996P 1996-07-22 1996-07-22
PCT/US1997/012552 WO1998003518A2 (en) 1996-07-22 1997-07-22 New bis-platinum complexes with polymethylene derivatives as ligands having antitumor activity

Publications (2)

Publication Number Publication Date
DE69716443D1 true DE69716443D1 (de) 2002-11-21
DE69716443T2 DE69716443T2 (de) 2003-08-14

Family

ID=21808732

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69716443T Expired - Lifetime DE69716443T2 (de) 1996-07-22 1997-07-22 Antitumor-wirksame bis-platin komplexe mit polymethylen-derivaten als liganden

Country Status (13)

Country Link
US (1) US6060616A (de)
EP (1) EP0920434B1 (de)
JP (2) JP4167301B2 (de)
AR (1) AR012826A1 (de)
AT (1) ATE226211T1 (de)
AU (1) AU732101B2 (de)
DE (1) DE69716443T2 (de)
DK (1) DK0920434T3 (de)
ES (1) ES2187799T3 (de)
PT (1) PT920434E (de)
TW (1) TW461892B (de)
WO (1) WO1998003518A2 (de)
ZA (1) ZA976422B (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA976422B (en) * 1996-07-22 1998-01-22 Boehringer Mannheim Italia New bis-platinum complexes with polymethylene derivatives as ligands having antitumor activity.
JP3739282B2 (ja) 1998-09-04 2006-01-25 旭化成ケミカルズ株式会社 新規発色剤および記録材料
US7635662B2 (en) 1998-09-04 2009-12-22 Chemipro Kasei Kaisha, Ltd. Compound for color-producing composition, and recording material
ITMI991508A1 (it) * 1999-07-09 2001-01-09 Novuspharma Spa Nitrati di bis-platino complessi con ligandi poliamminici
US6310047B1 (en) * 1999-08-24 2001-10-30 Virginia Commonwealth University High affinity DNA binding compounds as adjuvants in antisense technology
US7138520B2 (en) * 2003-01-13 2006-11-21 Massachusetts Institute Of Technology Coordination complexes having tethered therapeutic agents and/or targeting moieties, and methods of making and using the same
ITMI20052449A1 (it) * 2005-12-22 2007-06-23 Cell Therapeutics Europe Srl Nuovi bis-platino complessi ad attivita' antitumorale
US7943793B2 (en) * 2007-03-29 2011-05-17 Osaka University Optically active organic acidate-bridged dinuclear platinum(II) complex
CN103435657B (zh) * 2013-06-15 2016-07-13 德州学院 具有抗癌作用的有机金属铂类化合物及其合成方法
CN103467526A (zh) * 2013-06-16 2013-12-25 德州学院 具有抑制癌细胞增值作用的有机金属铂类化合物及其合成方法
US11104763B2 (en) * 2017-04-06 2021-08-31 Alliance For Sustainable Energy, Llc Renewable polymers and resins and methods of making the same

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3204168A1 (de) * 1982-02-06 1983-08-11 Basf Ag, 6700 Ludwigshafen Verfahren zur herstellung von sulfonamiden
JPS6153256A (ja) * 1984-08-21 1986-03-17 Fujisawa Pharmaceut Co Ltd アルカイン誘導体
US4871729A (en) * 1986-07-25 1989-10-03 University Of Vermont And State Agricultural College Bisplatinum complexes as chemotherapeutic agents
US5770591A (en) * 1986-07-25 1998-06-23 The University Of Vermont And State Agricultural College Bis-platinum complexes as chemotherapeutic agents
US5107007A (en) * 1989-09-01 1992-04-21 The University Of Vermont And State Agricultural College Bis-platinum complexes as chemotherapeutic agents
US4797393A (en) * 1986-07-25 1989-01-10 University Of Vermont And State Agricultural College Bis-platinum complexes as chemotherapeutic agents
US4895840A (en) * 1987-06-10 1990-01-23 A. H. Robins Company, Incorporated N-(aryl-,aryloxy-,arylthio-arylsulfinyl-and arylsulfonyl-)alkyl-N,N'-(or n'n')alkylaminoalkyl ureas and cyanoguanidines
EP0396588A1 (de) * 1987-12-18 1990-11-14 Boehringer Mannheim Italia S.P.A. Aminoanthracendion-bis-platin-komplexe, verwendbar als antitumormittel
JPH04193853A (ja) * 1990-11-26 1992-07-13 Fujisawa Pharmaceut Co Ltd 置換アセトアミド化合物の製造法
JPH0782225A (ja) * 1993-09-14 1995-03-28 Fuji Photo Film Co Ltd アミノ酸誘導体及びその用途
JPH07206811A (ja) * 1994-01-18 1995-08-08 Wakunaga Pharmaceut Co Ltd チオウレア誘導体、その製造法及びその利用
IT1273391B (it) * 1994-03-31 1997-07-08 Boehringer Mannheim Italia Platino complessi cationici trinucleari ad attivita' antitumorale e composizioni farmaceutiche che li contengono
JPH07165740A (ja) * 1994-11-07 1995-06-27 Banyu Pharmaceut Co Ltd ２−（２−アミノチアゾリル）−２−（１−カルボキシ−１−ビニルオキシイミノ）酢酸及びその製法
ZA976421B (en) * 1996-07-22 1998-01-22 Boehringer Mannheim Italia New bis-platinum complexes with polyamine ligands as antitumor agents.
ZA976422B (en) * 1996-07-22 1998-01-22 Boehringer Mannheim Italia New bis-platinum complexes with polymethylene derivatives as ligands having antitumor activity.

Also Published As

Publication number Publication date
AU3732097A (en) 1998-02-10
AR012826A1 (es) 2000-11-22
AU732101B2 (en) 2001-04-12
JP2008303216A (ja) 2008-12-18
ZA976422B (en) 1998-01-22
WO1998003518A3 (en) 2003-04-17
ES2187799T3 (es) 2003-06-16
DK0920434T3 (da) 2003-02-17
TW461892B (en) 2001-11-01
EP0920434A3 (de) 2003-06-04
PT920434E (pt) 2003-03-31
EP0920434B1 (de) 2002-10-16
WO1998003518A2 (en) 1998-01-29
DE69716443T2 (de) 2003-08-14
ATE226211T1 (de) 2002-11-15
JP4167301B2 (ja) 2008-10-15
EP0920434A2 (de) 1999-06-09
JP2002514166A (ja) 2002-05-14
US6060616A (en) 2000-05-09

Similar Documents

Publication Publication Date Title
DE69809739D1 (de) Organometallische komplexe
FI935913A7 (fi) Metalloseeniyhdisteitä, joissa on fluorenyylityyppisiä lignandeja
DE60139497D1 (de) Ableitung von p-wellen in elektrokardiogrammsignäle mit überlappenden komplexen
PT820312E (pt) Complexos radiofarmaceuticos ternarios
HUP0400256A3 (en) Modified tie-2-receptor ligands
DE59700049D1 (de) Polymerisationskatalysatoren mit beta-Diketiminat-Liganden
DE59711533D1 (de) Insulinderivate mit erhöhter Zinkbindung
DE69709897D1 (de) Phosphin-liganden
TR199501528A1 (tr) Pirol türevleri.
EP0719144A4 (de) Trans-platin(iv)-komplexe
NO995294D0 (no) Olefinpolymerer fremstilt med substituerte indenylinneholdende metalkomplekser
DE69716443D1 (de) Antitumor-wirksame bis-platin komplexe mit polymethylen-derivaten als liganden
DE69528814D1 (de) Form mit eingebautem Zähler
DE69836362D1 (de) Tiefpassfilter mit Summierfunktion
EP0856009A4 (de) Cd6 ligand
ATE229966T1 (de) Bis-platin komplexe mit polyamin-liganden als antitumorales mittel
NO932212D0 (no) Polyaminmedikament-harpikskomplekser
DE69713471D1 (de) Substituierte benzoldithiol-metallkomplexe
NO20002159D0 (no) Piperazin-cyklodekstrin-komplekser
DE69714358D1 (de) 9,10-disubstituierte campothecinderivate mit antitumoraktivität
EP1053307A4 (de) Podocalyxin-ähnliche sialomucine mit selektin-ligand aktivität
DK0926953T3 (da) Halogenpropargylinkonklusionskomplekser
NO20000422D0 (no) Katalysatorer basert på fulven-metallkomplekser
DE69809877D1 (de) Baggerfahrzeug mit rutschlenkung
ATE228522T1 (de) Dinukleare fluoroaryl-aluminium-alkylkomplexe