DE69713284D1 - Triazol-Derivate als Arzneimittel - Google Patents

Triazol-Derivate als Arzneimittel

Info

Publication number: DE69713284D1
Authority: DE; Germany
Prior art keywords: medicines; triazole derivatives; triazole; derivatives
Prior art date: 1996-02-02
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

DE69713284T

Other languages

English (en)

Other versions

DE69713284T2 (de

Inventor

W Murtiashaw

Stuart Green

T Stephenson

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Pfizer Ltd Great Britain

Pfizer Research and Development Co NV SA

Original Assignee

Pfizer Ltd Great Britain

Pfizer Research and Development Co NV SA

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-02-02

Filing date

1997-01-27

Publication date

2002-07-18

1997-01-27 Application filed by Pfizer Ltd Great Britain, Pfizer Research and Development Co NV SA filed Critical Pfizer Ltd Great Britain

2002-07-18 Application granted granted Critical

2002-07-18 Publication of DE69713284D1 publication Critical patent/DE69713284D1/de

2003-03-27 Publication of DE69713284T2 publication Critical patent/DE69713284T2/de

2017-01-28 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having three nitrogen atoms as the only ring hetero atoms
- C07F9/6518—Five-membered rings
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Plural Heterocyclic Compounds (AREA)

DE69713284T 1996-02-02 1997-01-27 Triazol-Derivate als Arzneimittel Expired - Fee Related DE69713284T2 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB9602080.5A GB9602080D0 (en)	1996-02-02	1996-02-02	Pharmaceutical compounds
PCT/EP1997/000445 WO1997028169A1 (en)	1996-02-02	1997-01-27	Triazole derivatives useful in therapy

Publications (2)

Publication Number	Publication Date
DE69713284D1 true DE69713284D1 (de)	2002-07-18
DE69713284T2 DE69713284T2 (de)	2003-03-27

Family

ID=10787975

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE69713284T Expired - Fee Related DE69713284T2 (de)	1996-02-02	1997-01-27	Triazol-Derivate als Arzneimittel

Country Status (42)

Country	Link
US (4)	US6790957B2 (de)
EP (1)	EP0880533B1 (de)
JP (1)	JP2959846B2 (de)
KR (1)	KR100283546B1 (de)
CN (1)	CN1085213C (de)
AP (1)	AP678A (de)
AT (1)	ATE219089T1 (de)
AU (1)	AU709781B2 (de)
BG (1)	BG63946B1 (de)
BR (1)	BR9707257A (de)
CA (1)	CA2240777C (de)
CO (1)	CO4761066A1 (de)
CZ (1)	CZ291431B6 (de)
DE (1)	DE69713284T2 (de)
DK (1)	DK0880533T3 (de)
DZ (1)	DZ2172A1 (de)
ES (1)	ES2175336T3 (de)
GB (1)	GB9602080D0 (de)
GT (1)	GT199700016A (de)
HN (1)	HN1997000012A (de)
HR (1)	HRP970063B1 (de)
HU (1)	HU226133B1 (de)
ID (1)	ID15858A (de)
IL (3)	IL124865A (de)
IS (1)	IS1995B (de)
MY (1)	MY116849A (de)
NO (1)	NO323771B1 (de)
NZ (1)	NZ330654A (de)
OA (1)	OA10711A (de)
PL (1)	PL187237B1 (de)
PT (1)	PT880533E (de)
RS (1)	RS49526B (de)
RU (1)	RU2176244C2 (de)
SA (1)	SA97170578B1 (de)
SI (1)	SI0880533T1 (de)
SK (1)	SK283136B6 (de)
TN (1)	TNSN97023A1 (de)
TR (1)	TR199801440T2 (de)
TW (1)	TW434247B (de)
UA (1)	UA46828C2 (de)
WO (1)	WO1997028169A1 (de)
ZA (1)	ZA97826B (de)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
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GB9602080D0 (en) *	1996-02-02	1996-04-03	Pfizer Ltd	Pharmaceutical compounds
GB9713149D0 (en)	1997-06-21	1997-08-27	Pfizer Ltd	Pharmaceutical formulations
DE19751525C2 (de)	1997-11-20	2003-02-13	Bat Cigarettenfab Gmbh	Verfahren und Vorrichtung zur Regelung der Ausgangsfeuchte von Tabak
US6265584B1 (en)	1998-05-22	2001-07-24	Bristol-Myers Squibb Company	Water soluble prodrugs of azole compounds
WO2000030655A1 (en)	1998-11-20	2000-06-02	Bristol-Myers Squibb Company	Water soluble prodrugs of azole compounds
US6235728B1 (en)	1999-02-19	2001-05-22	Bristol-Myers Squibb Company	Water-soluble prodrugs of azole compounds
KR20010050557A (ko)	1999-09-29	2001-06-15	타이도 나오카타	아졸 유도체 또는 그의 염
US6362172B2 (en) *	2000-01-20	2002-03-26	Bristol-Myers Squibb Company	Water soluble prodrugs of azole compounds
US6448401B1 (en) *	2000-11-20	2002-09-10	Bristol-Myers Squibb Company	Process for water soluble azole compounds
US7540402B2 (en) *	2001-06-29	2009-06-02	Kva, Inc.	Method for controlling weld metal microstructure using localized controlled cooling of seam-welded joints
US7323572B2 (en)	2002-07-16	2008-01-29	Pfizer Inc	Process for controlling the hydrate mix of a compound
WO2005006860A2 (en) *	2003-07-18	2005-01-27	The Board Of Governors For Higher Education State Of Rhode Island And Providence Plantations	Azole derivatives and methods for making the same
KR20070085093A (ko) *	2004-03-24	2007-08-27	파스젠, 엘엘씨.	Ａｍｐ-활성화 단백질 키나아제의 약리학적 저해에 의한신규한 신경 보호 방법
CN1303073C (zh) *	2005-05-31	2007-03-07	中国人民解放军第二军医大学	取代三唑酮苄胺三唑醇类抗真菌化合物及其制备方法
ES2432360T3 (es) *	2005-12-20	2013-12-03	Eisai R&D Management Co., Ltd.	Procedimiento para la producción de profármaco de azol soluble en agua
ES2533007T3 (es)	2005-12-27	2015-04-06	Otsuka Pharmaceutical Co., Ltd.	Compuesto de benzoacepina soluble en agua y su composición farmacéutica
ES2351365T3 (es) *	2006-02-22	2011-02-03	EISAI R&D MANAGEMENT CO., LTD.	Composición farmacéutica estabilizada.
KR100889937B1 (ko) *	2007-08-06	2009-03-20	한미약품 주식회사	보리코나졸의 제조방법
US20110123627A1 (en) *	2008-04-15	2011-05-26	Larry Yun Fang	High density compositions containing posaconazole and formulations comprising the same
CN101575330B (zh) *	2008-05-05	2012-10-31	丽珠医药集团股份有限公司	伏立康唑广谱抗真菌药物化合物、其组合物及用途
WO2011064558A2 (en)	2009-11-30	2011-06-03	Cipla Limited	Pharmaceutical composition
EP2723452A2 (de)	2011-06-22	2014-04-30	Vyome Biosciences Pvt Ltd	Konjugatbasierte antimykotische und antibakterielle prodrugs
EP2561863A1 (de)	2011-08-22	2013-02-27	Farmaprojects, S.A.U.	Pharmazeutische Zusammensetzungen mit Voriconazol
ES2774267T3 (es) *	2012-01-20	2020-07-20	Mycovia Pharmaceuticals Inc	Compuestos inhibidores de metaloenzimas
SMT202300324T1 (it) *	2012-03-19	2023-11-13	Cidara Therapeutics Inc	Regimi di dosaggio per composti della classe delle echinocandine
CN103864844B (zh) *	2012-12-09	2016-10-05	正大天晴药业集团股份有限公司	一种福司氟康唑的制备方法
CN103304600B (zh) *	2013-03-04	2018-05-25	陕西合成药业股份有限公司	一种伏立康唑磷酸酯三水合物及其制备方法和用途
US20140275122A1 (en)	2013-03-14	2014-09-18	Fresenius Kabi Usa, Llc	Voriconazole Formulations
RU2719579C2 (ru) *	2013-03-14	2020-04-21	Сидара Терапьютикс, Инк.	Режимы дозирования для соединений класса эхинокандинов
MX2015016675A (es)	2013-06-04	2016-07-15	Vyome Biosciences Pvt Ltd	Particulas recubiertas y composiciones que comprenden las mismas.
CN103524560A (zh) *	2013-09-28	2014-01-22	陕西合成药业有限公司	伏立康磷酸酯钠水合物及其多晶型
CN104650140B (zh) *	2013-11-18	2017-11-10	正大天晴药业集团股份有限公司	一种高纯度福司氟康唑的制备方法
AU2015212312A1 (en)	2014-01-29	2016-08-18	Vyome Therapeutics Limited	Treatments for resistant acne
CN104860992A (zh) *	2014-02-25	2015-08-26	陕西合成药业股份有限公司	一种高纯度福司氟康唑制备方法
CN105985377A (zh) *	2015-02-09	2016-10-05	陕西合成药业股份有限公司	一种福司氟康唑盐水合物及其制备方法
CN106279280A (zh) *	2015-05-25	2017-01-04	西藏卫信康医药股份有限公司	一种化合物及其制备方法和应用
CN106518922A (zh) *	2015-09-12	2017-03-22	陕西合成药业股份有限公司	一种三唑类化合物及其制备方法和用途
CN106546668A (zh) *	2015-09-22	2017-03-29	陕西合成药业股份有限公司	一种分离福司氟康唑或其药用盐有关物质的hplc方法
CN105237569B (zh) *	2015-10-21	2017-07-25	西南科技大学	一种制备2，4‑二氟‑α，α‑二（1氢‑1，2，4‑三唑‑1‑基甲基）苯甲醇磷酸二苄酯的合成方法
CN105753902B (zh) *	2016-04-11	2017-08-25	浙江诚意药业股份有限公司	一种福司氟康唑的制备方法
CN108676031A (zh) *	2018-05-29	2018-10-19	重庆威鹏药业有限公司	水溶性三唑类抗真菌膦酸化合物及其制备方法和应用
CN111171075B (zh) *	2020-04-03	2022-07-12	北京四环生物制药有限公司	一种福司氟康唑的制备方法

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US4528284A (en) *	1982-10-15	1985-07-09	Ciba-Geigy Corporation	Fungicidal 2-(azolylmethyl-1'-yl)-2-aryl-2-(cyano, alkoxycarbonyl, alkylthiocarbonyl and aminocarbonyl)-2-phosphorus acid esters
US4952232A (en) *	1987-04-29	1990-08-28	E. I. Du Pont De Nemours And Company	Antifungal carbinols
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1996
- 1996-02-02 GB GBGB9602080.5A patent/GB9602080D0/en active Pending
- 1996-12-27 TW TW085116150A patent/TW434247B/zh not_active IP Right Cessation
1997
- 1997-01-27 EP EP97902288A patent/EP0880533B1/de not_active Expired - Lifetime
- 1997-01-27 PT PT97902288T patent/PT880533E/pt unknown
- 1997-01-27 WO PCT/EP1997/000445 patent/WO1997028169A1/en not_active Ceased
- 1997-01-27 CA CA002240777A patent/CA2240777C/en not_active Expired - Fee Related
- 1997-01-27 ES ES97902288T patent/ES2175336T3/es not_active Expired - Lifetime
- 1997-01-27 JP JP9527312A patent/JP2959846B2/ja not_active Expired - Lifetime
- 1997-01-27 CZ CZ19982420A patent/CZ291431B6/cs not_active IP Right Cessation
- 1997-01-27 DK DK97902288T patent/DK0880533T3/da active
- 1997-01-27 SK SK1022-98A patent/SK283136B6/sk not_active IP Right Cessation
- 1997-01-27 UA UA98094671A patent/UA46828C2/uk unknown
- 1997-01-27 PL PL97328436A patent/PL187237B1/pl not_active IP Right Cessation
- 1997-01-27 AT AT97902288T patent/ATE219089T1/de not_active IP Right Cessation
- 1997-01-27 HU HU9900949A patent/HU226133B1/hu not_active IP Right Cessation
- 1997-01-27 SI SI9730341T patent/SI0880533T1/xx unknown
- 1997-01-27 DE DE69713284T patent/DE69713284T2/de not_active Expired - Fee Related
- 1997-01-27 BR BR9707257A patent/BR9707257A/pt active Search and Examination
- 1997-01-27 TR TR1998/01440T patent/TR199801440T2/xx unknown
- 1997-01-27 KR KR1019980705961A patent/KR100283546B1/ko not_active Expired - Fee Related
- 1997-01-27 NZ NZ330654A patent/NZ330654A/xx unknown
- 1997-01-27 AU AU15985/97A patent/AU709781B2/en not_active Ceased
- 1997-01-27 HN HN1997000012A patent/HN1997000012A/es unknown
- 1997-01-27 IL IL12486597A patent/IL124865A/en not_active IP Right Cessation
- 1997-01-27 SA SA97170578A patent/SA97170578B1/ar unknown
- 1997-01-27 RU RU98116435/04A patent/RU2176244C2/ru not_active IP Right Cessation
- 1997-01-27 CN CN97192005A patent/CN1085213C/zh not_active Expired - Lifetime
- 1997-01-28 RS YU2997A patent/RS49526B/sr unknown
- 1997-01-29 DZ DZ970017A patent/DZ2172A1/fr active
- 1997-01-29 TN TNTNSN97023A patent/TNSN97023A1/fr unknown
- 1997-01-30 AP APAP/P/1997/000923A patent/AP678A/en active
- 1997-01-30 GT GT199700016A patent/GT199700016A/es unknown
- 1997-01-31 ID IDP970289A patent/ID15858A/id unknown
- 1997-01-31 ZA ZA97826A patent/ZA97826B/xx unknown
- 1997-01-31 MY MYPI97000389A patent/MY116849A/en unknown
- 1997-01-31 CO CO97004868A patent/CO4761066A1/es unknown
- 1997-01-31 HR HR970063A patent/HRP970063B1/xx not_active IP Right Cessation
1998
- 1998-06-11 IL IL13313598A patent/IL133135A/xx not_active IP Right Cessation
- 1998-06-26 IS IS4785A patent/IS1995B/is unknown
- 1998-07-06 BG BG102603A patent/BG63946B1/bg unknown
- 1998-07-10 OA OA9800110A patent/OA10711A/en unknown
- 1998-08-03 NO NO19983560A patent/NO323771B1/no not_active IP Right Cessation
1999
- 1999-11-25 IL IL13313599A patent/IL133135A0/xx unknown
2003
- 2003-01-09 US US10/339,087 patent/US6790957B2/en not_active Expired - Fee Related
2004
- 2004-03-26 US US10/810,100 patent/US6977302B2/en not_active Expired - Fee Related
2005
- 2005-01-28 US US11/046,266 patent/US20050130940A1/en not_active Abandoned
2006
- 2006-09-29 US US11/540,375 patent/US20070027115A1/en not_active Abandoned

Also Published As

Publication number	Publication date
SK283136B6 (sk)	2003-03-04
DK0880533T3 (da)	2002-07-15
BG63946B1 (bg)	2003-07-31
HK1018217A1 (en)	1999-12-17
PT880533E (pt)	2002-09-30
HRP970063A2 (en)	1998-06-30
ID15858A (id)	1997-08-14
YU2997A (sh)	2000-10-30
DE69713284T2 (de)	2003-03-27
KR19990082233A (ko)	1999-11-25
CN1210540A (zh)	1999-03-10
OA10711A (en)	2001-06-04
WO1997028169A1 (en)	1997-08-07
US20040236105A1 (en)	2004-11-25
UA46828C2 (uk)	2002-06-17
RU2176244C2 (ru)	2001-11-27
PL187237B1 (pl)	2004-06-30
IL124865A (en)	2002-03-10
HUP9900949A3 (en)	2001-08-28
RS49526B (sr)	2006-12-15
US20050130940A1 (en)	2005-06-16
JPH10512599A (ja)	1998-12-02
AP9700923A0 (en)	1997-01-31
TR199801440T2 (xx)	1998-10-21
DZ2172A1 (fr)	2002-12-01
PL328436A1 (en)	1999-02-01
BR9707257A (pt)	1999-04-06
CA2240777C (en)	2002-06-11
JP2959846B2 (ja)	1999-10-06
SI0880533T1 (en)	2002-08-31
GT199700016A (es)	1998-07-24
HUP9900949A2 (hu)	2001-05-28
IL133135A0 (en)	2001-03-19
CZ242098A3 (cs)	1999-05-12
EP0880533A1 (de)	1998-12-02
ZA97826B (en)	1998-07-31
CZ291431B6 (cs)	2003-03-12
US20070027115A1 (en)	2007-02-01
IS4785A (is)	1998-06-26
NO983560L (no)	1998-08-03
ES2175336T3 (es)	2002-11-16
KR100283546B1 (ko)	2001-04-02
TNSN97023A1 (fr)	2005-03-15
CN1085213C (zh)	2002-05-22
HRP970063B1 (en)	2001-12-31
IL133135A (en)	2003-07-06
TW434247B (en)	2001-05-16
BG102603A (en)	1999-03-31
AU709781B2 (en)	1999-09-09
EP0880533B1 (de)	2002-06-12
MY116849A (en)	2004-04-30
HN1997000012A (es)	1997-06-26
HU226133B1 (en)	2008-05-28
IL124865A0 (en)	1999-01-26
SA97170578B1 (ar)	2006-01-28
IS1995B (is)	2005-03-15
CA2240777A1 (en)	1997-08-07
US6977302B2 (en)	2005-12-20
AU1598597A (en)	1997-08-22
NO323771B1 (no)	2007-07-02
ATE219089T1 (de)	2002-06-15
SK102298A3 (en)	1999-08-06
US20030144250A1 (en)	2003-07-31
NO983560D0 (no)	1998-08-03
NZ330654A (en)	1999-08-30
US6790957B2 (en)	2004-09-14
GB9602080D0 (en)	1996-04-03
AP678A (en)	1998-09-28
CO4761066A1 (es)	1999-04-27

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