DE69703294D1 - Zusammensetzungen die konjugate von cis-docosahexaenoic-säure und taxotere enthalten - Google Patents
Zusammensetzungen die konjugate von cis-docosahexaenoic-säure und taxotere enthaltenInfo
- Publication number
- DE69703294D1 DE69703294D1 DE69703294T DE69703294T DE69703294D1 DE 69703294 D1 DE69703294 D1 DE 69703294D1 DE 69703294 T DE69703294 T DE 69703294T DE 69703294 T DE69703294 T DE 69703294T DE 69703294 D1 DE69703294 D1 DE 69703294D1
- Authority
- DE
- Germany
- Prior art keywords
- taxotere
- compositions
- docosahexaenoic acid
- conjugate containing
- containing cis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epoxy Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US65142996A | 1996-05-22 | 1996-05-22 | |
| PCT/US1997/008866 WO1997044026A1 (en) | 1996-05-22 | 1997-05-22 | Compositions comprising conjugates of cis-docosahexaenoic acid and taxotere |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69703294D1 true DE69703294D1 (de) | 2000-11-16 |
| DE69703294T2 DE69703294T2 (de) | 2001-05-17 |
Family
ID=24612833
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69703294T Expired - Lifetime DE69703294T2 (de) | 1996-05-22 | 1997-05-22 | Zusammensetzungen die konjugate von cis-docosahexaenoic-säure und taxotere enthalten |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6080877A (de) |
| EP (1) | EP0914116B1 (de) |
| JP (1) | JP4172726B2 (de) |
| AT (1) | ATE196844T1 (de) |
| CA (1) | CA2255615C (de) |
| DE (1) | DE69703294T2 (de) |
| DK (1) | DK0914116T3 (de) |
| ES (1) | ES2151277T3 (de) |
| WO (1) | WO1997044026A1 (de) |
Families Citing this family (69)
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| US7288665B1 (en) * | 1997-08-18 | 2007-10-30 | Florida State University | Process for selective derivatization of taxanes |
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| US6413533B1 (en) * | 1998-05-07 | 2002-07-02 | The University Of Tennessee Research Corporation | Method for chemoprevention of prostate cancer |
| US20030130316A1 (en) * | 2000-03-20 | 2003-07-10 | Steiner Mitchell S. | Method for chemoprevention of prostate cancer |
| US20040092602A1 (en) * | 1998-05-07 | 2004-05-13 | Steiner Mitchell S. | Method for treatment and chemoprevention of prostate cancer |
| US6632447B1 (en) * | 1998-05-07 | 2003-10-14 | The University Of Tennessee Research Corporation | Method for chemoprevention of prostate cancer |
| US20040186185A1 (en) * | 1998-05-07 | 2004-09-23 | Steiner Mitchell S. | Method for treatment and chemoprevention of prostate cancer |
| DE69919695T2 (de) * | 1998-06-05 | 2005-09-15 | Board of Regents, The University of Texas System, Austin | Texaphyrin-konjugate und ihre anwendiung |
| GB9904386D0 (en) * | 1999-02-25 | 1999-04-21 | Pharmacia & Upjohn Spa | Antitumour synergistic composition |
| HK1040486A1 (zh) * | 1999-03-09 | 2002-06-14 | Luitpold Pharmaceuticals, Inc. | 脂肪酸-抗癌共軛和其用途 |
| US7235583B1 (en) * | 1999-03-09 | 2007-06-26 | Luitpold Pharmaceuticals, Inc., | Fatty acid-anticancer conjugates and uses thereof |
| WO2001077137A1 (en) * | 2000-04-12 | 2001-10-18 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| WO2000067802A1 (en) * | 1999-05-10 | 2000-11-16 | Protarga, Inc. | Fatty acid-n-substituted indol-3-glyoxyl-amide compositions and uses thereof |
| CZ302498B6 (cs) * | 1999-11-15 | 2011-06-15 | Pharma Mar, S. A. | Farmaceutický prípravek obsahující aplidin pro lécení rakovinových onemocnení |
| HK1049997B (en) | 1999-11-24 | 2007-02-23 | Immunogen, Inc. | Cytotoxic agents comprising taxanes and their therapeutic use |
| JP2003522172A (ja) * | 2000-02-02 | 2003-07-22 | フロリダ・ステイト・ユニバーシティ・リサーチ・ファウンデイション・インコーポレイテッド | 抗腫瘍剤としてのｃ１０エステル置換タキサン |
| AR030188A1 (es) * | 2000-02-02 | 2003-08-13 | Univ Florida State Res Found | Compuestos de taxano sustituidos con esteres en el c7; composiciones farmaceuticas que los contienen y proceso para tratar un sujeto mamifero que sufre de una condicion que responde a los taxanos |
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| UA76718C2 (uk) * | 2000-06-30 | 2006-09-15 | Фарма Мар, С.А. | Протипухлинні похідні аплідину |
| US6624317B1 (en) | 2000-09-25 | 2003-09-23 | The University Of North Carolina At Chapel Hill | Taxoid conjugates as antimitotic and antitumor agents |
| CZ2003993A3 (cs) * | 2000-10-12 | 2004-02-18 | Pharma Mar, S. A. | Léčivo pro léčení rakoviny podáváním aplidinu nebo analogu aplidinu a protektoru kosterního svalstva |
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| IL157993A0 (en) | 2001-03-23 | 2004-03-28 | Napro Biotherapeutics Inc | Molecular conjugates for use in cancer treatment and methods for the preparation thereof |
| EP1401477A4 (de) * | 2001-05-25 | 2005-02-02 | Human Genome Sciences | Chemokin-beta-1-fusionsproteine |
| CA2354471A1 (en) * | 2001-07-31 | 2003-01-31 | Florida State University Research Foundation, Inc. | C10 ester substituted taxanes |
| CA2354486A1 (en) * | 2001-07-31 | 2003-01-31 | Florida State University Research Foundation, Inc. | C7 ester substituted taxanes |
| SG129990A1 (en) * | 2001-08-01 | 2007-03-20 | Univ Florida State Res Found | C10 ester substituted taxanes |
| SG125889A1 (en) * | 2001-08-01 | 2006-10-30 | Univ Florida State Res Found | C7 ester subsituted taxanes |
| US20050004012A1 (en) * | 2001-10-19 | 2005-01-06 | Ramon Mangues | Use of aplidine for the treatment of pancreatic cancer |
| US20080249183A1 (en) * | 2001-11-29 | 2008-10-09 | Steiner Mitchell S | Treatment of androgen-deprivation induced osteoporosis |
| EP2277889B1 (de) | 2001-12-21 | 2014-07-09 | Human Genome Sciences, Inc. | Fusionsproteine von Albumin und Interferon beta |
| US7390898B2 (en) | 2002-08-02 | 2008-06-24 | Immunogen Inc. | Cytotoxic agents containing novel potent taxanes and their therapeutic use |
| BR0313197A (pt) | 2002-08-02 | 2005-08-09 | Immunogen Inc | Agentes citotóxicos contendo potentes taxanos e seu uso terapêutico |
| EP1594530A4 (de) | 2003-01-22 | 2006-10-11 | Human Genome Sciences Inc | Albuminfusionsproteine |
| ATE406171T1 (de) * | 2003-03-12 | 2008-09-15 | Dana Farber Cancer Inst Inc | Aplidine zur behandlung von multiplem myelom |
| JP4669393B2 (ja) * | 2003-05-26 | 2011-04-13 | 浩 前田 | 抗腫瘍剤及びその製造方法 |
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| US7820839B2 (en) * | 2003-10-30 | 2010-10-26 | The Research Foundation Of State University Of New York | Taxoid-fatty acid conjugates and pharmaceutical compositions thereof |
| PE20050693A1 (es) | 2004-02-13 | 2005-09-27 | Univ Florida State Res Found | Taxanos sustituidos con esteres de ciclopentilo en c10 |
| WO2005087222A1 (en) | 2004-03-05 | 2005-09-22 | Florida State University Research Foundation, Inc. | C7 lactyloxy-substituted taxanes |
| US20100173864A1 (en) | 2004-03-29 | 2010-07-08 | Cheng Jin Q | Compositions including triciribine and one or more platinum compounds and methods of use thereof |
| US20100009929A1 (en) | 2004-03-29 | 2010-01-14 | Cheng Jin Q | Compositions including triciribine and bortezomib and derivatives thereof and methods of use thereof |
| US20100009928A1 (en) | 2004-03-29 | 2010-01-14 | Cheng Jin Q | Compositions including triciribine and taxanes and methods of use thereof |
| US20110008327A1 (en) | 2004-03-29 | 2011-01-13 | Cheng Jin Q | Compositions including triciribine and epidermal growth factor receptor inhibitor compounds or salts thereof and methods of use thereof |
| US20100028339A1 (en) | 2004-03-29 | 2010-02-04 | Cheng Jin Q | Compositions including triciribine and trastuzumab and methods of use thereof |
| CA2561513C (en) | 2004-03-29 | 2019-02-26 | University Of South Florida | Effective treatment of tumors and cancer with triciribine and related compounds |
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| US20060270641A1 (en) * | 2005-05-31 | 2006-11-30 | Steiner Mitchell S | Method for chemoprevention of prostate cancer |
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| US20080051380A1 (en) | 2006-08-25 | 2008-02-28 | Auerbach Alan H | Methods and compositions for treating cancer |
| UA99836C2 (en) * | 2007-09-26 | 2012-10-10 | Маунт Синай Скул Оф Медсин | Azacytidine analogue and using thereof |
| JP2011517455A (ja) | 2008-03-31 | 2011-06-09 | フロリダ・ステイト・ユニバーシティ・リサーチ・ファウンデイション・インコーポレイテッド | Ｃ（１０）エチルエステルおよびｃ（１０）シクロプロピルエステル置換タキサン |
| GB201604316D0 (en) | 2016-03-14 | 2016-04-27 | Avexxin As | Combination therapy |
| CN109310771A (zh) * | 2016-06-03 | 2019-02-05 | 埃维克辛公司 | 包含多不饱和酮与皮质甾类化合物的联合疗法 |
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-
1997
- 1997-05-22 EP EP97926722A patent/EP0914116B1/de not_active Expired - Lifetime
- 1997-05-22 JP JP54281097A patent/JP4172726B2/ja not_active Expired - Fee Related
- 1997-05-22 DE DE69703294T patent/DE69703294T2/de not_active Expired - Lifetime
- 1997-05-22 AT AT97926722T patent/ATE196844T1/de not_active IP Right Cessation
- 1997-05-22 ES ES97926722T patent/ES2151277T3/es not_active Expired - Lifetime
- 1997-05-22 WO PCT/US1997/008866 patent/WO1997044026A1/en not_active Ceased
- 1997-05-22 DK DK97926722T patent/DK0914116T3/da active
- 1997-05-22 CA CA002255615A patent/CA2255615C/en not_active Expired - Fee Related
- 1997-06-03 US US08/868,476 patent/US6080877A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP0914116A1 (de) | 1999-05-12 |
| JP4172726B2 (ja) | 2008-10-29 |
| JP2000511188A (ja) | 2000-08-29 |
| CA2255615A1 (en) | 1997-11-27 |
| AU3142497A (en) | 1997-12-09 |
| US6080877A (en) | 2000-06-27 |
| WO1997044026A1 (en) | 1997-11-27 |
| DK0914116T3 (da) | 2000-11-20 |
| EP0914116B1 (de) | 2000-10-11 |
| AU722912B2 (en) | 2000-08-17 |
| DE69703294T2 (de) | 2001-05-17 |
| ES2151277T3 (es) | 2000-12-16 |
| CA2255615C (en) | 2006-08-29 |
| ATE196844T1 (de) | 2000-10-15 |
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Owner name: LUITPOLD PHARMACEUTICALS, INC., SHIRLEY, N.Y., US |