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DE69634904D1 - Negativstrand rna virus mit selbständiger replikationsaktivität - Google Patents

Negativstrand rna virus mit selbständiger replikationsaktivität

Info

Publication number
DE69634904D1
DE69634904D1 DE69634904T DE69634904T DE69634904D1 DE 69634904 D1 DE69634904 D1 DE 69634904D1 DE 69634904 T DE69634904 T DE 69634904T DE 69634904 T DE69634904 T DE 69634904T DE 69634904 D1 DE69634904 D1 DE 69634904D1
Authority
DE
Germany
Prior art keywords
self
rna virus
replication activity
active replication
negative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69634904T
Other languages
English (en)
Other versions
DE69634904T2 (de
Inventor
Yoshiyuki Nagai
Atsushi Kato
Fukashi Murai
Makoto Asakawa
Tsuneaki Sakata
Mamoru Hasegawa
Tatsuo Shioda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dnavec Research Inc
Original Assignee
Dnavec Research Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dnavec Research Inc filed Critical Dnavec Research Inc
Application granted granted Critical
Publication of DE69634904D1 publication Critical patent/DE69634904D1/de
Publication of DE69634904T2 publication Critical patent/DE69634904T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
    • C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18811—Sendai virus
    • C12N2760/18821—Viruses as such, e.g. new isolates, mutants or their genomic sequences
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18811—Sendai virus
    • C12N2760/18822—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18811—Sendai virus
    • C12N2760/18841—Use of virus, viral particle or viral elements as a vector
    • C12N2760/18843—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18811—Sendai virus
    • C12N2760/18851—Methods of production or purification of viral material
    • C12N2760/18852—Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE69634904T 1995-10-31 1996-10-22 Negativstrand rna virus mit selbständiger replikationsaktivität Expired - Lifetime DE69634904T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP30831595 1995-10-31
JP30831595 1995-10-31
PCT/JP1996/003068 WO1997016538A1 (en) 1995-10-31 1996-10-22 (-)-strand rna virus vector having autonomously replicating activity

Publications (2)

Publication Number Publication Date
DE69634904D1 true DE69634904D1 (de) 2005-08-04
DE69634904T2 DE69634904T2 (de) 2006-05-18

Family

ID=17979579

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69634904T Expired - Lifetime DE69634904T2 (de) 1995-10-31 1996-10-22 Negativstrand rna virus mit selbständiger replikationsaktivität

Country Status (9)

Country Link
US (2) US6723532B2 (de)
EP (2) EP0864645B9 (de)
KR (2) KR100552387B1 (de)
CN (1) CN1118569C (de)
AT (1) ATE298789T1 (de)
AU (1) AU7335196A (de)
DE (1) DE69634904T2 (de)
DK (1) DK0864645T3 (de)
WO (1) WO1997016538A1 (de)

Families Citing this family (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU7335296A (en) 1995-11-01 1997-05-22 Dnavec Research Inc. Recombinant sendai virus
WO2000001837A1 (en) * 1998-07-03 2000-01-13 Dnavec Research Inc. (-)-strand rna virus vector for nerve cell
US7241617B2 (en) 1998-07-03 2007-07-10 Dnavec Research, Inc. Sendai viral vectors comprising foreign genes inserted between the R1 and R2 Loci
AU5067599A (en) * 1998-08-11 2000-03-06 Dnavec Research Inc. Rna virus vector having contact infiltration capability
US6828138B1 (en) 1998-08-11 2004-12-07 Dnavec Research Inc. Recombinant sendai virus vector including a gene encoding a chemokine
US6544785B1 (en) 1998-09-14 2003-04-08 Mount Sinai School Of Medicine Of New York University Helper-free rescue of recombinant negative strand RNA viruses
DE69933528T2 (de) 1998-11-09 2007-08-09 Nippon Biologicals, Inc. Verfahren zur Cytokinproduktionn unter Verwendung eines Sendai Virus Expressionssystems
US6490775B1 (en) * 1999-04-23 2002-12-10 Veri-Tek Inc. Press operation verification system
ATE367445T1 (de) * 1999-05-18 2007-08-15 Dnavec Research Inc Viraler paramyxoviridae vektor mit einem defekten hüllprotein-gen
US20030166252A1 (en) * 1999-05-18 2003-09-04 Kaio Kitazato Paramyxovirus-derived RNP
US7226786B2 (en) 1999-05-18 2007-06-05 Dnavec Research Inc. Envelope gene-deficient Paramyxovirus vector
JP3748535B2 (ja) 1999-09-06 2006-02-22 株式会社ディナベック研究所 改変された転写開始配列を有するパラミクソウイルス
JP4838962B2 (ja) * 1999-11-02 2011-12-14 株式会社ディナベック研究所 気道上皮細胞への外因性遺伝子導入用組換えセンダイウイルスベクター
US7314614B1 (en) 1999-11-02 2008-01-01 Dnavec Research, Inc. Recombinant sendai virus vector for introducing exogenous genes to airway epithelia
JP4698913B2 (ja) 1999-11-19 2011-06-08 学校法人北里研究所 細胞融合変異型モルビリウイルスの作成法
KR100774796B1 (ko) * 2000-01-19 2007-11-07 가부시키가이샤 디나벡크 겐큐쇼 파라믹소바이러스 벡터의 혈관으로의 유전자 도입용도
JPWO2001072340A1 (ja) * 2000-03-30 2004-01-08 株式会社ディナベック研究所 センダイウイルスベクターを用いたａｉｄｓウイルスワクチン
CA2322057A1 (en) 2000-05-18 2001-11-18 Dnavec Research Inc. Paramyxovirus vectors used for transfer of foreign genes
WO2001092508A1 (en) * 2000-06-01 2001-12-06 Dnavec Research Inc. Pseudo-type retrovirus vector containing membrane protein having hemagglutinin activity
EP1297852A4 (de) * 2000-06-27 2004-12-29 Dnavec Research Inc Viraler vektor zur einbringung von genen in nierenzellen(03.02.03)
JPWO2002031138A1 (ja) * 2000-10-06 2004-02-19 株式会社ディナベック研究所 骨格筋に外来遺伝子を導入するためのパラミクソウイルスベクター
JP2002142770A (ja) * 2000-11-08 2002-05-21 Dnavec Research Inc 循環系への遺伝子送達用パラミクソウイルスベクター
AU2002224113A1 (en) 2000-11-27 2002-06-03 Dnavec Research Inc. Paramyxovirus vector encoding angiogenesis gene and utilization thereof
US7465456B2 (en) 2002-04-26 2008-12-16 Medimmune, Llc Multi plasmid system for the production of influenza virus
ES2526191T3 (es) 2002-04-26 2015-01-08 Medimmune, Llc Método para producir virus influenza B infeccioso en cultivo celular
AU2003234775A1 (en) 2002-04-30 2003-11-17 Dnavec Research Inc. Vector with modified protease-dependent tropism
US20050250718A1 (en) * 2002-04-30 2005-11-10 Dnavec Research Inc. Pharmaceutical- or gene-carrier compositions with reduced hemagglutinating activity
US20050191617A1 (en) * 2002-06-03 2005-09-01 Makoto Inoue Pramyxovirusl vectors encoding antibody and utilization thereof
EP1548101A4 (de) * 2002-09-04 2006-05-10 Dnavec Research Inc Verfahren zur herstellung eines viralen vektors, ein membranprotein enthaltend, welches mit hilfe von neuraminidase aus gram-positiven bakterien an sialinsäure als bestandteil des envelopes bindet
KR20050062634A (ko) * 2002-10-24 2005-06-23 가부시키가이샤 디나벡크 겐큐쇼 Ｔ 세포에 유전자를 도입하는 방법
CA2529647C (en) 2003-06-16 2013-08-13 Medimmune Vaccines, Inc. Influenza hemagglutinin and neuraminidase variants
KR20060028432A (ko) * 2003-06-30 2006-03-29 가부시키가이샤 디나벡크 겐큐쇼 고변이영역이 개변된 유전자를 탑재하는 마이너스가닥 ｒｎａ 바이러스 벡터
WO2005042737A1 (ja) 2003-11-04 2005-05-12 Dnavec Research Inc. 遺伝子導入された樹状細胞の製造方法
ES2345492T3 (es) 2003-12-23 2010-09-24 Medimmune, Llc Sistema multiplasmido para la produccion del virus de la gripe.
US7521043B2 (en) 2004-01-13 2009-04-21 Dnavec Research Inc. Gene therapy for tumors using minus-strand RNA viral vectors encoding immunostimulatory cytokines
WO2005071092A1 (ja) 2004-01-22 2005-08-04 Dnavec Research Inc. サイトメガロウイルスエンハンサーおよびニワトリβ-アクチンプロモーターを含むハイブリッドプロモーターを利用したマイナス鎖RNAウイルスベクターの製造方法
JPWO2005071085A1 (ja) * 2004-01-22 2007-09-06 株式会社ディナベック研究所 ウイルスベクターの製造方法
JPWO2005087269A1 (ja) * 2004-03-16 2008-01-24 株式会社ディナベック研究所 腫瘍増殖を抑制する方法
JPWO2005097988A1 (ja) * 2004-03-23 2008-02-28 株式会社ディナベック研究所 組織の維持および／または修復に関連する骨髄関連細胞
ES2393492T3 (es) 2004-05-25 2012-12-21 Medimmune, Llc Variantes de hemaglutinina y neuraminidasa de influenza
CN101006172B (zh) 2004-06-24 2012-09-05 株式会社载体研究所 包含导入了rna病毒的树突状细胞的抗癌剂
ES2527503T3 (es) 2005-03-08 2015-01-26 Medimmune, Llc Virus influenza reordenantes
CA2612168A1 (en) * 2005-06-14 2006-12-21 Dnavec Corporation Methods for producing antibodies
HUE028512T2 (en) * 2005-10-28 2016-12-28 Id Pharma Co Ltd Gene transfer to airway epithelial stem cell using RNA virus spike protein pseudotyped lentiviral vector
US20100167341A1 (en) * 2006-01-17 2010-07-01 Dnavec Corporation Novel protein expression system
EP2034014A1 (de) 2006-05-31 2009-03-11 Dnavec Corporation Therapeutikum gegen morbus alzheimer
CN101517079A (zh) 2006-07-13 2009-08-26 生物载体株式会社 非复制型副粘病毒科病毒载体
US7601356B2 (en) 2006-07-21 2009-10-13 Medimmune, Llc Methods and compositions for increasing replication capacity of an influenza virus
US20080069821A1 (en) 2006-08-09 2008-03-20 Medimmune Vaccines, Inc. Influenza Hemagglutinin And Neuraminidase Variants
JPWO2008029790A1 (ja) 2006-09-04 2010-01-21 協和発酵キリン株式会社 新規核酸
WO2008084319A2 (ja) 2006-12-18 2008-07-17 Kyowa Hakko Kirin Co., Ltd. 新規核酸
WO2008096811A1 (ja) 2007-02-07 2008-08-14 Dnavec Corporation 弱毒化マイナス鎖rnaウイルス
US20100203027A1 (en) 2007-04-27 2010-08-12 Kyushu Univeristy National University Viral vector for gene therapy
JP5666905B2 (ja) 2007-06-18 2015-02-12 メディミューン，エルエルシー ヘマグルチニンポリペプチド中に変化を有するインフルエンザｂウイルス
EP2208499A4 (de) 2007-10-03 2011-12-28 Kyowa Hakko Kirin Co Ltd Nukleinsäure zur regulierung der zellproliferation
JPWO2009148137A1 (ja) 2008-06-04 2011-11-04 協和発酵キリン株式会社 肥満細胞の脱顆粒を制御する核酸
JP2011527581A (ja) 2008-07-11 2011-11-04 メディミューン，エルエルシー インフルエンザ赤血球凝集素およびノイラミニダーゼ変異体
EP2322611B1 (de) 2008-07-16 2016-06-01 IP Pharma Co., Ltd. Verfahren zur herstellung einer neuprogrammierten zelle anhand eines chromosomal unintegrierten virusvektors
JPWO2010050586A1 (ja) 2008-10-31 2012-03-29 ディナベック株式会社 組み換え蛋白質の発現を増強する方法
RU2535970C2 (ru) 2009-02-12 2014-12-20 МЕДИММЬЮН, ЭлЭлСи Варианты гемагглютинина и нейраминидазы гриппа
US8945576B2 (en) 2010-01-08 2015-02-03 Kyoto University Vaccine for treatment of tautopathy
AU2011297075B2 (en) 2010-08-30 2014-07-17 Dnavec Corporation Composition for inducing pluripotent stem cell, and use thereof
CN105916980B (zh) 2013-09-24 2025-09-16 株式会社爱迪药业 用于改进诱导多能干细胞的效率的方法
CN110234347A (zh) 2016-11-17 2019-09-13 国立传染病研究所长代表日本国 使用了非感染性副粘病毒粒子的传染病疫苗
US12215334B2 (en) 2017-07-21 2025-02-04 I'rom Group Co., Ltd. Polynucleotide for modifying target sequence and use thereof
EP3744847A4 (de) 2018-01-22 2021-12-08 Japan as Represented by The Director-General of National Institute of Infectious Diseases Selektives cd8-positives t-zellinduzierendes impfstoffantigen
WO2022050419A1 (ja) 2020-09-04 2022-03-10 Ｈｅａｒｔｓｅｅｄ株式会社 ｉＰＳ細胞の品質改善剤、ｉＰＳ細胞の製造方法、ｉＰＳ細胞、及びｉＰＳ細胞製造用組成物
JPWO2022138964A1 (de) 2020-12-25 2022-06-30
WO2023210616A1 (ja) 2022-04-25 2023-11-02 ときわバイオ株式会社 Ｒｎａウイルス由来のキメラエンベロープタンパク質及び該タンパク質を持つｒｎａウイルスベクター

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5166057A (en) * 1989-08-28 1992-11-24 The Mount Sinai School Of Medicine Of The City University Of New York Recombinant negative strand rna virus expression-systems
AU7007491A (en) * 1990-02-02 1991-08-08 Schweiz. Serum- & Impfinstitut Bern Cdna corresponding to the genome of negative-strand rna viruses, and process for the production of infectious negative-strand rna viruses
JP3029272B2 (ja) 1990-05-29 2000-04-04 邦忠 下遠野 構造蛋白質遺伝子、組換えベクター、組換えウイルス、ポリペプチドおよびポリペプチドの製造方法
US5665362A (en) 1990-09-25 1997-09-09 Cantab Pharmaceuticals Research Limited Viral vaccines
US5318898A (en) * 1991-04-02 1994-06-07 Genetics Institute, Inc. Production of recombinant bone-inducing proteins
JPH0585943A (ja) 1991-07-18 1993-04-06 Tonen Corp 組換えワクシニアウイルスを用いる非ａ非ｂ型肝炎ウイルス遺伝子の発現および非ａ非ｂ型肝炎ワクチン
JPH05301895A (ja) 1992-04-22 1993-11-16 Nippon Zeon Co Ltd ハイブリッド抗原タンパク質、それを発現する組み換えウイルス、及びその製造方法
ZA937164B (en) * 1992-09-28 1994-05-23 Commw Scient Ind Res Org Delivery system
US5516720A (en) 1994-02-14 1996-05-14 United Microelectronics Corporation Stress relaxation in dielectric before metallization
DE69532369T3 (de) 1994-07-18 2010-11-04 Conzelmann, Karl-Klaus, Prof. Dr. Rekombinantes infektiöses nicht-in-Segmente-geteiltes, negativ-Strange-RNS-Virus
US5716821A (en) 1994-09-30 1998-02-10 Uab Research Foundation Prevention and treatment of respiratory tract disease
US5789229A (en) 1994-09-30 1998-08-04 Uab Research Foundation Stranded RNA virus particles
DE69510207T3 (de) 1995-08-09 2007-02-15 Schweiz. Serum- & Impfinstitut Bern Verfahren zur Herstellung von infektiösen minussträngigen RNA-Viren
KR0179554B1 (ko) * 1995-11-30 1999-04-15 김주용 반도체 소자의 소자분리절연막 형성방법
JP2000509280A (ja) 1996-05-01 2000-07-25 アメリカ合衆国 組換えｄｎａ由来ヌクレオキャプシドタンパク質を用いるウイルストランスフェクタントの作製

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US20020100066A1 (en) 2002-07-25
HK1018287A1 (en) 1999-12-17
EP1325960A3 (de) 2004-09-15
CN1207123A (zh) 1999-02-03
AU7335196A (en) 1997-05-22
CN1118569C (zh) 2003-08-20
KR100754091B1 (ko) 2007-08-31
US20020081706A1 (en) 2002-06-27
US6723532B2 (en) 2004-04-20
EP0864645B1 (de) 2005-06-29
EP1325960A2 (de) 2003-07-09
DK0864645T3 (da) 2005-10-24
WO1997016538A1 (en) 1997-05-09
US6645760B2 (en) 2003-11-11
EP0864645A1 (de) 1998-09-16
EP0864645B9 (de) 2006-03-22
KR19990067232A (ko) 1999-08-16
ATE298789T1 (de) 2005-07-15
EP0864645A4 (de) 2000-01-26
KR100552387B1 (ko) 2006-04-21
KR20050084302A (ko) 2005-08-26

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