DE69622889D1 - Substituierte 4-(1h-benzimidazol-2-yl)(1,4)diazepane für die behandlung von allergischen krankheiten - Google Patents
Substituierte 4-(1h-benzimidazol-2-yl)(1,4)diazepane für die behandlung von allergischen krankheitenInfo
- Publication number
- DE69622889D1 DE69622889D1 DE69622889T DE69622889T DE69622889D1 DE 69622889 D1 DE69622889 D1 DE 69622889D1 DE 69622889 T DE69622889 T DE 69622889T DE 69622889 T DE69622889 T DE 69622889T DE 69622889 D1 DE69622889 D1 DE 69622889D1
- Authority
- DE
- Germany
- Prior art keywords
- diazepane
- benzimidazol
- substituted
- treatment
- allergic diseases
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- SSPVIXHPLKDPNO-UHFFFAOYSA-N 2-(1,4-diazepan-1-yl)-1h-benzimidazole Chemical class C1CCNCCN1C1=NC2=CC=CC=C2N1 SSPVIXHPLKDPNO-UHFFFAOYSA-N 0.000 title 1
- 230000000172 allergic effect Effects 0.000 title 1
- 208000010668 atopic eczema Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US58000495A | 1995-12-20 | 1995-12-20 | |
| US73641196A | 1996-10-24 | 1996-10-24 | |
| PCT/US1996/019524 WO1997022604A1 (en) | 1995-12-20 | 1996-12-04 | Novel substituted 4-(1h-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic diseases |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69622889D1 true DE69622889D1 (de) | 2002-09-12 |
| DE69622889T2 DE69622889T2 (de) | 2003-04-10 |
Family
ID=27077922
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69622889T Expired - Fee Related DE69622889T2 (de) | 1995-12-20 | 1996-12-04 | Substituierte 4-(1h-benzimidazol-2-yl)(1,4)diazepane für die behandlung von allergischen krankheiten |
Country Status (19)
| Country | Link |
|---|---|
| EP (1) | EP0874843B1 (de) |
| JP (1) | JP2000500772A (de) |
| KR (1) | KR20000064487A (de) |
| CN (1) | CN1080262C (de) |
| AR (1) | AR005120A1 (de) |
| AT (1) | ATE221883T1 (de) |
| AU (1) | AU707914B2 (de) |
| BR (1) | BR9612074A (de) |
| CA (1) | CA2241827C (de) |
| DE (1) | DE69622889T2 (de) |
| DK (1) | DK0874843T3 (de) |
| ES (1) | ES2177827T3 (de) |
| IL (1) | IL125002A0 (de) |
| MX (1) | MX9804991A (de) |
| NO (1) | NO316932B1 (de) |
| NZ (1) | NZ325581A (de) |
| PT (1) | PT874843E (de) |
| TW (1) | TW335395B (de) |
| WO (1) | WO1997022604A1 (de) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6423704B2 (en) | 1995-12-20 | 2002-07-23 | Aventis Pharmaceuticals Inc. | Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic diseases |
| US6194406B1 (en) * | 1995-12-20 | 2001-02-27 | Aventis Pharmaceuticals Inc. | Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic disease |
| GB9600235D0 (en) | 1996-01-05 | 1996-03-06 | Pfizer Ltd | Therapeutic agents |
| US6552188B2 (en) * | 2001-06-29 | 2003-04-22 | Kowa Co., Ltd. | Unsymmetrical cyclic diamine compound |
| ES2525319T3 (es) | 2004-05-07 | 2014-12-22 | Janssen Pharmaceutica Nv | Derivados de pirrolidin-2-ona y piperidin-2-ona como inhibidores de 11-beta-hidroxiesteroide deshidrogenasa |
| PL1747198T3 (pl) | 2004-05-07 | 2008-11-28 | Janssen Pharmaceutica Nv | Pochodne adamantylopirolidyn-2-onu jako inhibitory 11ß-dehydrogenazy hydroksysteroidowej |
| DE602005017159D1 (de) | 2004-08-30 | 2009-11-26 | Janssen Pharmaceutica Nv | Oxysteroid-dehydrogenase-inhibitoren |
| UA87328C2 (en) | 2004-08-30 | 2009-07-10 | Янссен Фармацевтика Н.В. | N-2 adamantanyl-2-phenoxy-acetamide derivatives as 11-beta hydroxysteroid dehydrogenase inhibitors |
| EP1786774B1 (de) | 2004-08-30 | 2009-10-14 | Janssen Pharmaceutica N.V. | Derivate von tricyclischem lactam als 11-beta-hydroxysteroid-dehydrogenase-inhibitoren |
| AU2008208920A1 (en) | 2007-01-24 | 2008-07-31 | Glaxo Group Limited | Pharmaceutical compositions comprising 3, 5-diamin0-6- (2, 3-dichl0phenyl) -l, 2, 4-triazine or R(-) -2, 4-diamino-5- (2, 3-dichlorophenyl) -6-fluoromethyl pyrimidine and an NK1 |
| CN105646306B (zh) * | 2015-12-11 | 2020-06-30 | 广东莱佛士制药技术有限公司 | 一种4-甲硫基苯乙酸的制备方法 |
| EP3886854A4 (de) | 2018-11-30 | 2022-07-06 | Nuvation Bio Inc. | Pyrrol- und pyrazolverbindungen und verfahren zu deren verwendung |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2676054B1 (fr) * | 1991-05-03 | 1993-09-03 | Sanofi Elf | Nouveaux composes n-alkylenepiperidino et leurs enantiomeres, procede pour leur preparation et compositions pharmaceutiques les contenant. |
| FR2676055B1 (fr) * | 1991-05-03 | 1993-09-03 | Sanofi Elf | Composes polycycliques amines et leurs enantiomeres, procede pour leur preparation et compositions pharmaceutiques les contenant. |
| DK0696280T3 (da) * | 1993-05-06 | 1998-01-12 | Merrell Pharma Inc | Substituerede pyrrolidin-3-yl-alkyl-piperidiner anvendelige som tachykinin-antagonister |
| CA2161876A1 (en) * | 1993-05-20 | 1994-12-08 | Den-Ichi Momose | 1-(2-benzimidazolyl)-1,5-diazacyclooctane compounds |
| ES2132709T3 (es) * | 1994-08-25 | 1999-08-16 | Merrell Pharma Inc | Nuevas piperidinas substituidas utiles para el tratamiento de las enfermedades alergicas. |
-
1996
- 1996-12-04 NZ NZ325581A patent/NZ325581A/xx unknown
- 1996-12-04 JP JP9522863A patent/JP2000500772A/ja active Pending
- 1996-12-04 KR KR1019980704684A patent/KR20000064487A/ko not_active Abandoned
- 1996-12-04 CN CN96199141A patent/CN1080262C/zh not_active Expired - Fee Related
- 1996-12-04 AU AU14119/97A patent/AU707914B2/en not_active Ceased
- 1996-12-04 WO PCT/US1996/019524 patent/WO1997022604A1/en not_active Ceased
- 1996-12-04 AT AT96944267T patent/ATE221883T1/de not_active IP Right Cessation
- 1996-12-04 DE DE69622889T patent/DE69622889T2/de not_active Expired - Fee Related
- 1996-12-04 ES ES96944267T patent/ES2177827T3/es not_active Expired - Lifetime
- 1996-12-04 EP EP96944267A patent/EP0874843B1/de not_active Expired - Lifetime
- 1996-12-04 DK DK96944267T patent/DK0874843T3/da active
- 1996-12-04 IL IL12500296A patent/IL125002A0/xx unknown
- 1996-12-04 PT PT96944267T patent/PT874843E/pt unknown
- 1996-12-04 BR BR9612074A patent/BR9612074A/pt unknown
- 1996-12-04 CA CA002241827A patent/CA2241827C/en not_active Expired - Fee Related
- 1996-12-18 AR ARP960105741A patent/AR005120A1/es active IP Right Grant
- 1996-12-21 TW TW085115838A patent/TW335395B/zh active
-
1998
- 1998-06-19 MX MX9804991A patent/MX9804991A/es not_active IP Right Cessation
- 1998-06-19 NO NO19982867A patent/NO316932B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2241827C (en) | 2002-04-30 |
| CA2241827A1 (en) | 1997-06-26 |
| NO982867L (no) | 1998-08-19 |
| DE69622889T2 (de) | 2003-04-10 |
| AU707914B2 (en) | 1999-07-22 |
| NO982867D0 (no) | 1998-06-19 |
| PT874843E (pt) | 2002-12-31 |
| KR20000064487A (ko) | 2000-11-06 |
| AR005120A1 (es) | 1999-04-14 |
| DK0874843T3 (da) | 2002-11-25 |
| NZ325581A (en) | 2000-03-27 |
| BR9612074A (pt) | 1999-03-30 |
| ES2177827T3 (es) | 2002-12-16 |
| IL125002A0 (en) | 1999-01-26 |
| EP0874843A1 (de) | 1998-11-04 |
| CN1207097A (zh) | 1999-02-03 |
| WO1997022604A1 (en) | 1997-06-26 |
| AU1411997A (en) | 1997-07-14 |
| EP0874843B1 (de) | 2002-08-07 |
| HK1017684A1 (en) | 1999-11-26 |
| MX9804991A (es) | 1998-09-30 |
| ATE221883T1 (de) | 2002-08-15 |
| JP2000500772A (ja) | 2000-01-25 |
| CN1080262C (zh) | 2002-03-06 |
| NO316932B1 (no) | 2004-06-28 |
| TW335395B (en) | 1998-07-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |