DE69619661D1 - 1,3-dihydro-1-(phenylalkyl)-2h-imidazol-2-on-derivate mit pde iv-und cytokin-inhibisender aktivität - Google Patents

1,3-dihydro-1-(phenylalkyl)-2h-imidazol-2-on-derivate mit pde iv-und cytokin-inhibisender aktivität

Info

Publication number: DE69619661D1
Authority: DE; Germany
Prior art keywords: cytokin; pde; phenylalkyl; imidazol; dihydro
Prior art date: 1995-04-06
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE69619661T

Other languages

English (en)

Other versions

DE69619661T2 (de

Inventor

Jean Freyne

Stanislas Diels

Gil Jose Ignacio Andres

Gadea Francisco Javi Fernandez

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Janssen Pharmaceutica NV

Original Assignee

Janssen Pharmaceutica NV

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-04-06

Filing date

1996-03-28

Publication date

2002-04-11

1996-03-28 Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV

2002-04-11 Application granted granted Critical

2002-04-11 Publication of DE69619661D1 publication Critical patent/DE69619661D1/de

2002-10-31 Publication of DE69619661T2 publication Critical patent/DE69619661T2/de

2016-03-29 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/30—Oxygen or sulfur atoms
- C07D233/32—One oxygen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/30—Oxygen or sulfur atoms
- C07D233/32—One oxygen atom
- C07D233/36—One oxygen atom with hydrocarbon radicals, substituted by nitrogen atoms, attached to ring nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/30—Oxygen or sulfur atoms
- C07D233/32—One oxygen atom
- C07D233/38—One oxygen atom with acyl radicals or hetero atoms directly attached to ring nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/70—One oxygen atom

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Pulmonology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Dermatology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

DE69619661T 1995-04-06 1996-03-28 1,3-dihydro-1-(phenylalkyl)-2h-imidazol-2-on-derivate mit pde iv-und cytokin-inhibisender aktivität Expired - Lifetime DE69619661T2 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP95200868		1995-04-06
EP95202898		1995-10-26
PCT/EP1996/001394 WO1996031485A1 (en)	1995-04-06	1996-03-28	1,3-dihydro-1-(phenylalkyl)-2h-imidazol-2-one derivatives having pdeiv and cytokine activity

Publications (2)

Publication Number	Publication Date
DE69619661D1 true DE69619661D1 (de)	2002-04-11
DE69619661T2 DE69619661T2 (de)	2002-10-31

Family

ID=26139205

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE69619661T Expired - Lifetime DE69619661T2 (de)	1995-04-06	1996-03-28	1,3-dihydro-1-(phenylalkyl)-2h-imidazol-2-on-derivate mit pde iv-und cytokin-inhibisender aktivität

Country Status (26)

Country	Link
US (2)	US5994376A (de)
EP (1)	EP0819122B1 (de)
JP (1)	JP4562101B2 (de)
KR (1)	KR100406628B1 (de)
CN (1)	CN1068591C (de)
AR (1)	AR002732A1 (de)
AT (1)	ATE214052T1 (de)
AU (1)	AU702947B2 (de)
CA (1)	CA2216653C (de)
CY (1)	CY2328B1 (de)
CZ (1)	CZ293127B6 (de)
DE (1)	DE69619661T2 (de)
DK (1)	DK0819122T3 (de)
ES (1)	ES2174064T3 (de)
HR (1)	HRP960155A2 (de)
HU (1)	HU223324B1 (de)
IL (1)	IL117807A (de)
MX (1)	MX9707652A (de)
MY (1)	MY119254A (de)
NO (1)	NO314339B1 (de)
NZ (1)	NZ304877A (de)
PL (1)	PL187375B1 (de)
PT (1)	PT819122E (de)
SI (1)	SI0819122T1 (de)
TW (1)	TW332201B (de)
WO (1)	WO1996031485A1 (de)

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US5703098A (en) *	1994-12-30	1997-12-30	Celgene Corporation	Immunotherapeutic imides/amides
TW332201B (en)	1995-04-06	1998-05-21	Janssen Pharmaceutica Nv	1,3-Dihydro-1-(phenylalkyl)-2H-imidazol-2-one derivatives
ES2196308T3 (es) *	1996-10-02	2003-12-16	Janssen Pharmaceutica Nv	Derivado de 2-cianoiminoimidazol que inhiben la pde iv.
JP2002508001A (ja) *	1997-07-10	2002-03-12	ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ	Ｉｌ−５インヒビターとしての６−アザウラシル誘導体
US6017926A (en) *	1997-12-17	2000-01-25	Merck & Co., Inc.	Integrin receptor antagonists
AU760771B2 (en)	1998-04-01	2003-05-22	Janssen Pharmaceutica N.V.	PDE IV inhibiting pyridine derivatives
EP1071645A4 (de) *	1998-04-14	2003-04-02	Smithkline Beecham Corp	Verbdinungen zur hemmung von phosphodiesterase isoenzym 4 (pde 4)
US6118017A (en) *	1998-04-14	2000-09-12	Smithkline Beecham Corporation	Substituted-(3-cyclopentyloxy-4-methoxyphenyl)-3-phenylcyanocyclobutan-1-one
WO2000031053A1 (en) *	1998-11-23	2000-06-02	Janssen Pharmaceutica N.V.	Il-5 inhibiting 6-azauracil derivatives
ES2289835T3 (es)	1998-12-18	2008-02-01	Janssen Pharmaceutica N.V.	Derivados del 6-azauracilo que inhiben la il-5.
AU2001290884B2 (en)	2000-09-13	2005-12-15	Merck & Co., Inc.	Alpha V integrin receptor antagonists
ES2427930T3 (es)	2001-05-23	2013-11-04	Mitsubishi Tanabe Pharma Corporation	Composición terapéutica para el tratamiento regenerativo de enfermedades de los cartílagos
JP4510384B2 (ja)	2001-05-23	2010-07-21	田辺三菱製薬株式会社	骨折治癒促進用組成物
US6706739B2 (en) *	2001-08-21	2004-03-16	National Health Research Institute	Imidazolidinone compounds
SE0200667D0 (sv) *	2002-03-05	2002-03-05	A & Science Invest Ab	Novel use of cytokine inhibitors
GB0326407D0 (en) *	2003-11-12	2003-12-17	Glaxo Group Ltd	Chemical compounds
GB0412865D0 (en) *	2004-06-09	2004-07-14	Glaxo Group Ltd	Chemical compounds
CN1997367B (zh) *	2004-07-05	2010-11-24	同和药品株式会社	预防和治疗过敏性炎症的组合物
AR057455A1 (es) *	2005-07-22	2007-12-05	Merck & Co Inc	Inhibidores de la transcriptasa reversa de vih y composicion farmaceutica
EP1987009A1 (de) *	2006-01-30	2008-11-05	Euro-Celtique S.A.	Cycloharnstoffverbindung als calciumkanalblocker
US7674811B2 (en)	2006-03-14	2010-03-09	Ranbaxy Laboratories Limited	5-lipoxygenase inhibitors
US7390772B2 (en) *	2006-05-18	2008-06-24	International Flavor & Fragrances Inc.	1-phenyl-spiro[2.5]octane-1-carbonitrile analogues their use in fragrance formulations
EP2155226A4 (de) *	2007-06-14	2010-07-28	Univ California	Verbindungen zur hemmung der proteinaggregation und verfahren zu deren herstellung und verwendung
MX339950B (es) *	2010-03-12	2016-06-20	Omeros Corp	Inhibidores de fosfodiesterasa 10 (pde10) y composiciones y metodos relacionados.
NZ716494A (en)	2014-04-28	2017-07-28	Omeros Corp	Processes and intermediates for the preparation of a pde10 inhibitor
NZ630803A (en)	2014-04-28	2016-03-31	Omeros Corp	Optically active pde10 inhibitor
WO2016172573A1 (en)	2015-04-24	2016-10-27	Omeros Corporation	Pde10 inhibitors and related compositions and methods
JP2018535969A (ja)	2015-11-04	2018-12-06	オメロスコーポレーション	Ｐｄｅ１０阻害剤の固体状態形態

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NL285394A (de) *	1961-11-17
US3184060A (en)	1963-02-13	1965-05-18	Owens Illinois Glass Co	Packaging tacky latex emulsion paints in containers manufactured from polyolefinic maerials
IE913855A1 (en) *	1990-11-06	1992-05-22	Smithkline Beecham Corp	Imidazolidinone compounds
ES2192192T3 (es) *	1992-12-02	2003-10-01	Pfizer	Dieteres de catecol como inhibidores selectivos de pde iv.
TW263495B (de) *	1992-12-23	1995-11-21	Celltech Ltd
GB9304920D0 (en) *	1993-03-10	1993-04-28	Celltech Ltd	Chemical compounds
TW332201B (en)	1995-04-06	1998-05-21	Janssen Pharmaceutica Nv	1,3-Dihydro-1-(phenylalkyl)-2H-imidazol-2-one derivatives

1996
- 1996-03-22 TW TW085103447A patent/TW332201B/zh not_active IP Right Cessation
- 1996-03-28 AU AU52755/96A patent/AU702947B2/en not_active Expired
- 1996-03-28 DE DE69619661T patent/DE69619661T2/de not_active Expired - Lifetime
- 1996-03-28 KR KR1019970706853A patent/KR100406628B1/ko not_active Expired - Lifetime
- 1996-03-28 PL PL96322654A patent/PL187375B1/pl unknown
- 1996-03-28 MX MX9707652A patent/MX9707652A/es unknown
- 1996-03-28 JP JP52995996A patent/JP4562101B2/ja not_active Expired - Lifetime
- 1996-03-28 ES ES96909150T patent/ES2174064T3/es not_active Expired - Lifetime
- 1996-03-28 EP EP96909150A patent/EP0819122B1/de not_active Expired - Lifetime
- 1996-03-28 HU HU9801575A patent/HU223324B1/hu active IP Right Grant
- 1996-03-28 SI SI9630434T patent/SI0819122T1/xx unknown
- 1996-03-28 NZ NZ304877A patent/NZ304877A/en not_active IP Right Cessation
- 1996-03-28 AT AT96909150T patent/ATE214052T1/de active
- 1996-03-28 CA CA002216653A patent/CA2216653C/en not_active Expired - Lifetime
- 1996-03-28 DK DK96909150T patent/DK0819122T3/da active
- 1996-03-28 WO PCT/EP1996/001394 patent/WO1996031485A1/en not_active Ceased
- 1996-03-28 CZ CZ19973149A patent/CZ293127B6/cs not_active IP Right Cessation
- 1996-03-28 CN CN96193101A patent/CN1068591C/zh not_active Expired - Lifetime
- 1996-03-28 PT PT96909150T patent/PT819122E/pt unknown
- 1996-03-28 US US08/930,296 patent/US5994376A/en not_active Expired - Lifetime
- 1996-04-02 HR HR95202898.3A patent/HRP960155A2/hr not_active Application Discontinuation
- 1996-04-03 AR ARP960102076A patent/AR002732A1/es active IP Right Grant
- 1996-04-03 IL IL11780796A patent/IL117807A/en not_active IP Right Cessation
- 1996-04-05 MY MYPI96001300A patent/MY119254A/en unknown
1997
- 1997-10-06 NO NO19974602A patent/NO314339B1/no not_active IP Right Cessation
1999
- 1999-07-27 US US09/362,007 patent/US6403805B1/en not_active Expired - Lifetime
2002
- 2002-07-15 CY CY0200043A patent/CY2328B1/xx unknown

Also Published As

Publication number	Publication date
AU702947B2 (en)	1999-03-11
CZ314997A3 (cs)	1998-12-16
DE69619661T2 (de)	2002-10-31
DK0819122T3 (da)	2002-07-01
NO974602D0 (no)	1997-10-06
NZ304877A (en)	1999-06-29
SI0819122T1 (en)	2002-06-30
CN1068591C (zh)	2001-07-18
IL117807A (en)	2001-06-14
PL187375B1 (pl)	2004-06-30
EP0819122A1 (de)	1998-01-21
HK1007880A1 (en)	1999-04-30
CY2328B1 (en)	2004-02-06
US6403805B1 (en)	2002-06-11
HU223324B1 (hu)	2004-06-28
AR002732A1 (es)	1998-04-29
CA2216653A1 (en)	1996-10-10
TW332201B (en)	1998-05-21
CN1181072A (zh)	1998-05-06
HUP9801575A3 (en)	1999-03-01
HRP960155A2 (en)	1997-10-31
AU5275596A (en)	1996-10-23
ES2174064T3 (es)	2002-11-01
PL322654A1 (en)	1998-02-16
ATE214052T1 (de)	2002-03-15
MX9707652A (es)	1997-11-29
NO974602L (no)	1997-10-06
IL117807A0 (en)	1996-08-04
PT819122E (pt)	2002-08-30
CA2216653C (en)	2009-05-26
US5994376A (en)	1999-11-30
KR19980703449A (ko)	1998-11-05
JP4562101B2 (ja)	2010-10-13
EP0819122B1 (de)	2002-03-06
JPH11503136A (ja)	1999-03-23
US20020068830A1 (en)	2002-06-06
MY119254A (en)	2005-04-30
HUP9801575A2 (hu)	1999-01-28
CZ293127B6 (cs)	2004-02-18
WO1996031485A1 (en)	1996-10-10
NO314339B1 (no)	2003-03-10
KR100406628B1 (ko)	2004-05-31

Publication	Publication Date	Title
DE69619661D1 (de)	2002-04-11	1,3-dihydro-1-(phenylalkyl)-2h-imidazol-2-on-derivate mit pde iv-und cytokin-inhibisender aktivität
NL350016I1 (nl)	2004-02-02	3-Aryl-4-hydroxy-delta#3-dihydrofuranon-en 3-aryl-4-hydroxy-delta#3-dihydrothiofenon-derivaten.
PT900210E (pt)	2005-06-30	Derivados azahexano heterociclicos com actividade antviral
NO932176D0 (no)	1993-06-14	Kinolin-, naftyridin- og pyridobenzoksazinderivater
DE68929361D1 (de)	2002-01-31	Oligoribonukleotid-Derivate und Verwendung davon als Antiviral Arzneimittel
FI945042A7 (fi)	1994-10-26	1-piperatsino-1,2-dihydroindeenijohdannaiset
FI970502L (fi)	1997-04-04	Makrofagiperäinen kemokiini ja kemokiinijohdannaisia
GR3036420T3 (en)	2001-11-30	Novel benzimidazole derivatives having cgmp-phosphodisterase inhibiting activity
NO932146D0 (no)	1993-06-11	Benzimidazolderivater
FI934004A7 (fi)	1994-03-16	7-isoindolinyylikinoloni- ja naftyridonijohdannaiset
NO905485D0 (no)	1990-12-19	Benzazepin- og benzotiazepin-derivater.
FI952722A7 (fi)	1995-06-02	Allergian vastaisia triatsolobentsatsepiinijohdannaisia
DE69424051D1 (de)	2000-05-25	Rapamycin-derivat mit antimikrobe, antikrebs und immunomodulatorischer aktivität
DE69637363D1 (de)	2008-01-24	1,3-dihydro-1-(phenylalkenyl)-2h-imidazol-2 on-derivate mit pde iv und cytokin-inhibirendes aktivität
DE69635224D1 (de)	2006-02-09	1,3-dihydro-2h-imidazol-2-on-derivate mit pdeiv und cytokin inhibierender aktivität
FI933544A7 (fi)	1993-08-11	Tiadiatsiinikarboksamidijohdannaiset, menetelmät niiden valmistamiseks i ja lääkkeet
MA22916A1 (fr)	1993-12-31	Derives de 2-imidazoline-5-ones et 2-imidazoline-5-thiones fongicides.
FI951996A7 (fi)	1995-04-26	4-kinolinyylijohdannaiset, joilla on Helicobakteerin vastaista aktiivisuutta
FI934665L (fi)	1994-04-23	Aryliden-1-azacykloalkaner och arylalkyl-1-azacyckloalkaner, deras salter, dessa foereningar innehaollande laekemedel och deras anvaendning och framstaellning
ITMI922071A0 (it)	1992-09-07	Derivati xantonici, loro preparazione ed attivita'
KR970019252U (ko)	1997-05-26	보안기능을 갖는 모니터
NO970498D0 (no)	1997-02-04	Benzimidazolderivater med dopaminergisk aktivitet
ATE104289T1 (de)	1994-04-15	Aminoethylthiazole und aminoethyloxazol-derivate.
NO920307L (no)	1993-07-26	Nye dihydro-isokinolinderivater med farmasoeytisk virkning
NO940122D0 (no)	1994-01-13	Nye adenosinderivater

Legal Events

Date	Code	Title	Description
2003-04-03	8364	No opposition during term of opposition