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NO974602L - 1,3-Dihydro-1-(fenylalkyl)-2H-imidazol-2-onderivater med PDE IV- og cytokinaktivitet - Google Patents

1,3-Dihydro-1-(fenylalkyl)-2H-imidazol-2-onderivater med PDE IV- og cytokinaktivitet

Info

Publication number
NO974602L
NO974602L NO974602A NO974602A NO974602L NO 974602 L NO974602 L NO 974602L NO 974602 A NO974602 A NO 974602A NO 974602 A NO974602 A NO 974602A NO 974602 L NO974602 L NO 974602L
Authority
NO
Norway
Prior art keywords
pde
phenylalkyl
dihydro
imidazole
derivatives
Prior art date
Application number
NO974602A
Other languages
English (en)
Other versions
NO314339B1 (no
NO974602D0 (no
Inventor
Eddy Jean Edgard Freyne
Gaston Stanislas Marcell Diels
Jose Ignacio Andres Gil
Francisco Javier Fernand Gadea
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of NO974602D0 publication Critical patent/NO974602D0/no
Publication of NO974602L publication Critical patent/NO974602L/no
Publication of NO314339B1 publication Critical patent/NO314339B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/30—Oxygen or sulfur atoms
    • C07D233/32—One oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/30—Oxygen or sulfur atoms
    • C07D233/32—One oxygen atom
    • C07D233/36—One oxygen atom with hydrocarbon radicals, substituted by nitrogen atoms, attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/30—Oxygen or sulfur atoms
    • C07D233/32—One oxygen atom
    • C07D233/38—One oxygen atom with acyl radicals or hetero atoms directly attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/70—One oxygen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
NO19974602A 1995-04-06 1997-10-06 1,3-Dihydro-1-(fenylalkyl)-2H-imidazol-2-onderivater med PDE IV- og cytokinaktivitet NO314339B1 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP95200868 1995-04-06
EP95202898 1995-10-26
PCT/EP1996/001394 WO1996031485A1 (en) 1995-04-06 1996-03-28 1,3-dihydro-1-(phenylalkyl)-2h-imidazol-2-one derivatives having pdeiv and cytokine activity

Publications (3)

Publication Number Publication Date
NO974602D0 NO974602D0 (no) 1997-10-06
NO974602L true NO974602L (no) 1997-10-06
NO314339B1 NO314339B1 (no) 2003-03-10

Family

ID=26139205

Family Applications (1)

Application Number Title Priority Date Filing Date
NO19974602A NO314339B1 (no) 1995-04-06 1997-10-06 1,3-Dihydro-1-(fenylalkyl)-2H-imidazol-2-onderivater med PDE IV- og cytokinaktivitet

Country Status (26)

Country Link
US (2) US5994376A (no)
EP (1) EP0819122B1 (no)
JP (1) JP4562101B2 (no)
KR (1) KR100406628B1 (no)
CN (1) CN1068591C (no)
AR (1) AR002732A1 (no)
AT (1) ATE214052T1 (no)
AU (1) AU702947B2 (no)
CA (1) CA2216653C (no)
CY (1) CY2328B1 (no)
CZ (1) CZ293127B6 (no)
DE (1) DE69619661T2 (no)
DK (1) DK0819122T3 (no)
ES (1) ES2174064T3 (no)
HR (1) HRP960155A2 (no)
HU (1) HU223324B1 (no)
IL (1) IL117807A (no)
MX (1) MX9707652A (no)
MY (1) MY119254A (no)
NO (1) NO314339B1 (no)
NZ (1) NZ304877A (no)
PL (1) PL187375B1 (no)
PT (1) PT819122E (no)
SI (1) SI0819122T1 (no)
TW (1) TW332201B (no)
WO (1) WO1996031485A1 (no)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5703098A (en) * 1994-12-30 1997-12-30 Celgene Corporation Immunotherapeutic imides/amides
TW332201B (en) 1995-04-06 1998-05-21 Janssen Pharmaceutica Nv 1,3-Dihydro-1-(phenylalkyl)-2H-imidazol-2-one derivatives
WO1998014432A1 (en) * 1996-10-02 1998-04-09 Janssen Pharmaceutica N.V. Pde iv inhibiting 2-cyanoiminoimidazole derivatives
CA2294533A1 (en) * 1997-07-10 1999-01-21 Janssen Pharmaceutica N.V. 6-azauracil derivatives as il-5 inhibitors
US6017926A (en) * 1997-12-17 2000-01-25 Merck & Co., Inc. Integrin receptor antagonists
AU760771B2 (en) * 1998-04-01 2003-05-22 Janssen Pharmaceutica N.V. PDE IV inhibiting pyridine derivatives
CA2328250A1 (en) * 1998-04-14 1999-10-21 Cornelia Jutta Forster Phosphodiesterase isoenzyme denominated 4 (pde 4) inhibiting compounds
US6118017A (en) * 1998-04-14 2000-09-12 Smithkline Beecham Corporation Substituted-(3-cyclopentyloxy-4-methoxyphenyl)-3-phenylcyanocyclobutan-1-one
ATE238287T1 (de) 1998-11-23 2003-05-15 Janssen Pharmaceutica Nv 6-azauracilderivate als il-5 inhibitoren
UA73107C2 (en) 1998-12-18 2005-06-15 Janssen Pharmaceutica Nv Derivatives of 6-azaurcyle inhibiting il-5
CA2421792A1 (en) * 2000-09-13 2002-03-21 Merck & Co., Inc. Alpha v integrin receptor antagonists
KR20040007596A (ko) * 2001-05-23 2004-01-24 다나베 세이야꾸 가부시키가이샤 골절 치료 촉진용 조성물
US20040180900A1 (en) * 2001-05-23 2004-09-16 Masaharu Takigawa Therapeutic composition for repairing chondropathy
US6706739B2 (en) * 2001-08-21 2004-03-16 National Health Research Institute Imidazolidinone compounds
SE0200667D0 (sv) * 2002-03-05 2002-03-05 A & Science Invest Ab Novel use of cytokine inhibitors
GB0326407D0 (en) * 2003-11-12 2003-12-17 Glaxo Group Ltd Chemical compounds
GB0412865D0 (en) * 2004-06-09 2004-07-14 Glaxo Group Ltd Chemical compounds
KR100682199B1 (ko) * 2004-07-05 2007-02-12 동화약품공업주식회사 알러지성 염증 질환의 예방 및 치료용 조성물
AR057455A1 (es) * 2005-07-22 2007-12-05 Merck & Co Inc Inhibidores de la transcriptasa reversa de vih y composicion farmaceutica
US8354434B2 (en) * 2006-01-30 2013-01-15 Purdue Pharma L.P. Cyclourea compounds as calcium channel blockers
US7674811B2 (en) 2006-03-14 2010-03-09 Ranbaxy Laboratories Limited 5-lipoxygenase inhibitors
US7390772B2 (en) * 2006-05-18 2008-06-24 International Flavor & Fragrances Inc. 1-phenyl-spiro[2.5]octane-1-carbonitrile analogues their use in fragrance formulations
US8450481B2 (en) * 2007-06-14 2013-05-28 The Regents Of The University Of California Compounds for inhibiting protein aggregation, and methods for making and using them
BR112012022910B1 (pt) * 2010-03-12 2021-08-10 Omeros Corporation Compostos inibidores de pde10, composição farmacêutica compreendendo os referidos compostos e uso dos mesmos para tratar distúrbios neurológicos em um animal de sangue quente
NZ716462A (en) 2014-04-28 2017-11-24 Omeros Corp Optically active pde10 inhibitor
NZ716494A (en) 2014-04-28 2017-07-28 Omeros Corp Processes and intermediates for the preparation of a pde10 inhibitor
AU2016250843A1 (en) 2015-04-24 2017-10-12 Omeros Corporation PDE10 inhibitors and related compositions and methods
JP2018535969A (ja) 2015-11-04 2018-12-06 オメロス コーポレーション Ｐｄｅ１０阻害剤の固体状態形態

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL285394A (no) * 1961-11-17
US3184060A (en) 1963-02-13 1965-05-18 Owens Illinois Glass Co Packaging tacky latex emulsion paints in containers manufactured from polyolefinic maerials
WO1992007567A1 (en) * 1990-11-06 1992-05-14 Smithkline Beecham Corporation Imidazolidinone compounds
AU673569B2 (en) * 1992-12-02 1996-11-14 Pfizer Inc. Catechol diethers as selective PDE-IV inhibitors
TW263495B (no) * 1992-12-23 1995-11-21 Celltech Ltd
GB9304920D0 (en) * 1993-03-10 1993-04-28 Celltech Ltd Chemical compounds
TW332201B (en) 1995-04-06 1998-05-21 Janssen Pharmaceutica Nv 1,3-Dihydro-1-(phenylalkyl)-2H-imidazol-2-one derivatives

Also Published As

Publication number Publication date
DE69619661D1 (de) 2002-04-11
CN1181072A (zh) 1998-05-06
NZ304877A (en) 1999-06-29
DE69619661T2 (de) 2002-10-31
HUP9801575A2 (hu) 1999-01-28
PL322654A1 (en) 1998-02-16
HRP960155A2 (en) 1997-10-31
KR19980703449A (ko) 1998-11-05
CN1068591C (zh) 2001-07-18
HU223324B1 (hu) 2004-06-28
IL117807A (en) 2001-06-14
MX9707652A (es) 1997-11-29
US20020068830A1 (en) 2002-06-06
CZ293127B6 (cs) 2004-02-18
CY2328B1 (en) 2004-02-06
ATE214052T1 (de) 2002-03-15
EP0819122B1 (en) 2002-03-06
SI0819122T1 (en) 2002-06-30
NO314339B1 (no) 2003-03-10
KR100406628B1 (ko) 2004-05-31
WO1996031485A1 (en) 1996-10-10
AU702947B2 (en) 1999-03-11
CA2216653C (en) 2009-05-26
US6403805B1 (en) 2002-06-11
AR002732A1 (es) 1998-04-29
IL117807A0 (en) 1996-08-04
TW332201B (en) 1998-05-21
MY119254A (en) 2005-04-30
NO974602D0 (no) 1997-10-06
AU5275596A (en) 1996-10-23
HK1007880A1 (en) 1999-04-30
JPH11503136A (ja) 1999-03-23
CA2216653A1 (en) 1996-10-10
CZ314997A3 (cs) 1998-12-16
PL187375B1 (pl) 2004-06-30
DK0819122T3 (da) 2002-07-01
ES2174064T3 (es) 2002-11-01
EP0819122A1 (en) 1998-01-21
JP4562101B2 (ja) 2010-10-13
PT819122E (pt) 2002-08-30
HUP9801575A3 (en) 1999-03-01
US5994376A (en) 1999-11-30

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