[go: up one dir, main page]

DE69534102D1 - Dynamische teilchengrössenkontrolle für aerolisierte arzeneiverabreichung - Google Patents

Dynamische teilchengrössenkontrolle für aerolisierte arzeneiverabreichung

Info

Publication number
DE69534102D1
DE69534102D1 DE69534102T DE69534102T DE69534102D1 DE 69534102 D1 DE69534102 D1 DE 69534102D1 DE 69534102 T DE69534102 T DE 69534102T DE 69534102 T DE69534102 T DE 69534102T DE 69534102 D1 DE69534102 D1 DE 69534102D1
Authority
DE
Germany
Prior art keywords
arzeneiver
aerolized
delivery
particle size
size check
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69534102T
Other languages
English (en)
Other versions
DE69534102T2 (de
Inventor
J Lloyd
M Lloyd
M Rubsamen
A Schuster
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aradigm Corp
Original Assignee
Aradigm Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aradigm Corp filed Critical Aradigm Corp
Application granted granted Critical
Publication of DE69534102D1 publication Critical patent/DE69534102D1/de
Publication of DE69534102T2 publication Critical patent/DE69534102T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/001—Particle size control
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/005—Sprayers or atomisers specially adapted for therapeutic purposes using ultrasonics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/04—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised
    • A61M11/041—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised using heaters
    • A61M11/042—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised using heaters electrical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
    • A61M15/0046—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier
    • A61M15/0051—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier the dosages being arranged on a tape, e.g. strips
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A61M15/0068—Indicating or counting the number of dispensed doses or of remaining doses
    • A61M15/008—Electronic counters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
    • A61M16/10—Preparation of respiratory gases or vapours
    • A61M16/1075—Preparation of respiratory gases or vapours by influencing the temperature
    • A61M16/108—Preparation of respiratory gases or vapours by influencing the temperature before being humidified or mixed with a beneficial agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J7/00—Devices for administering medicines orally, e.g. spoons; Pill counting devices; Arrangements for time indication or reminder for taking medicine
    • A61J7/04—Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers
    • A61J7/0409—Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers with timers
    • A61J7/0427—Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers with timers with direct interaction with a dispensing or delivery system
    • A61J7/0445—Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers with timers with direct interaction with a dispensing or delivery system for preventing drug dispensing during a predetermined time period
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0085—Inhalators using ultrasonics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
    • A61M16/0003—Accessories therefor, e.g. sensors, vibrators, negative pressure
    • A61M2016/0015—Accessories therefor, e.g. sensors, vibrators, negative pressure inhalation detectors
    • A61M2016/0018—Accessories therefor, e.g. sensors, vibrators, negative pressure inhalation detectors electrical
    • A61M2016/0021—Accessories therefor, e.g. sensors, vibrators, negative pressure inhalation detectors electrical with a proportional output signal, e.g. from a thermistor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
    • A61M16/0003—Accessories therefor, e.g. sensors, vibrators, negative pressure
    • A61M2016/003—Accessories therefor, e.g. sensors, vibrators, negative pressure with a flowmeter
    • A61M2016/0033—Accessories therefor, e.g. sensors, vibrators, negative pressure with a flowmeter electrical
    • A61M2016/0039—Accessories therefor, e.g. sensors, vibrators, negative pressure with a flowmeter electrical in the inspiratory circuit
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/50—General characteristics of the apparatus with microprocessors or computers
    • A61M2205/52—General characteristics of the apparatus with microprocessors or computers with memories providing a history of measured variating parameters of apparatus or patient

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Anesthesiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Emergency Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE1995634102 1994-09-27 1995-09-27 Dynamische teilchengrössenkontrolle für aerolisierte arzeneiverabreichung Expired - Lifetime DE69534102T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US313461 1994-09-27
US08/313,461 US5522385A (en) 1994-09-27 1994-09-27 Dynamic particle size control for aerosolized drug delivery
PCT/US1995/012744 WO1996009846A1 (en) 1994-09-27 1995-09-27 Dynamic particle size control for aerosolized drug delivery

Publications (2)

Publication Number Publication Date
DE69534102D1 true DE69534102D1 (de) 2005-04-28
DE69534102T2 DE69534102T2 (de) 2006-03-23

Family

ID=23215785

Family Applications (1)

Application Number Title Priority Date Filing Date
DE1995634102 Expired - Lifetime DE69534102T2 (de) 1994-09-27 1995-09-27 Dynamische teilchengrössenkontrolle für aerolisierte arzeneiverabreichung

Country Status (7)

Country Link
US (2) US5522385A (de)
EP (2) EP0783337B1 (de)
JP (2) JP3596619B2 (de)
AU (1) AU708307B2 (de)
CA (1) CA2201129A1 (de)
DE (1) DE69534102T2 (de)
WO (1) WO1996009846A1 (de)

Families Citing this family (241)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6250300B1 (en) * 1992-12-11 2001-06-26 Ab Astra System for dispensing pharmaceutically active compounds
US7448375B2 (en) * 1993-01-29 2008-11-11 Aradigm Corporation Method of treating diabetes mellitus in a patient
US5915378A (en) * 1993-01-29 1999-06-29 Aradigm Corporation Creating an aerosolized formulation of insulin
US5888477A (en) * 1993-01-29 1999-03-30 Aradigm Corporation Use of monomeric insulin as a means for improving the bioavailability of inhaled insulin
US5743250A (en) 1993-01-29 1998-04-28 Aradigm Corporation Insulin delivery enhanced by coached breathing
US5873358A (en) * 1993-01-29 1999-02-23 Aradigm Corporation Method of maintaining a diabetic patient's blood glucose level in a desired range
US6131567A (en) * 1993-01-29 2000-10-17 Aradigm Corporation Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin
US5970973A (en) * 1993-01-29 1999-10-26 Aradigm Corporation Method of delivering insulin lispro
US5507277A (en) 1993-01-29 1996-04-16 Aradigm Corporation Lockout device for controlled release of drug from patient-activateddispenser
US6024090A (en) * 1993-01-29 2000-02-15 Aradigm Corporation Method of treating a diabetic patient by aerosolized administration of insulin lispro
US5792057A (en) * 1993-05-21 1998-08-11 Aradigm Corporation Ventilation imaging using a fine particle aerosol generator
AUPM411494A0 (en) * 1994-02-25 1994-03-24 Central Sydney Area Health Service Method and device for the provocation of upper or lower airway narrowing and/or the induction of sputum
AU709572B2 (en) * 1994-10-28 1999-09-02 Aradigm Corporation Device and method of creating aerosolized mist of respiratory drug
US5758637A (en) * 1995-08-31 1998-06-02 Aerogen, Inc. Liquid dispensing apparatus and methods
US5829436A (en) * 1996-02-05 1998-11-03 Aradigm Corporation Ventilation imaging using a fine particle aerosol generator
CA2245079A1 (en) * 1996-02-05 1997-08-07 Fred Silverstein Ventilation imaging using a fine particle aerosol generator
ES2205210T3 (es) * 1996-04-29 2004-05-01 Quadrant Technologies Ltd. Procedimientos de inhalacion de polvos secos.
US6595202B2 (en) 1996-05-13 2003-07-22 Universidad De Sevilla Device and method for creating aerosols for drug delivery
US6405936B1 (en) 1996-05-13 2002-06-18 Universidad De Sevilla Stabilized capillary microjet and devices and methods for producing same
US6386463B1 (en) 1996-05-13 2002-05-14 Universidad De Sevilla Fuel injection nozzle and method of use
US6792940B2 (en) * 1996-05-13 2004-09-21 Universidad De Sevilla Device and method for creating aerosols for drug delivery
US6299145B1 (en) 1996-05-13 2001-10-09 Universidad De Sevilla Device and method for fluid aeration via gas forced through a liquid within an orifice of a pressure chamber
US6187214B1 (en) 1996-05-13 2001-02-13 Universidad De Seville Method and device for production of components for microfabrication
ES2140998B1 (es) 1996-05-13 2000-10-16 Univ Sevilla Procedimiento de atomizacion de liquidos.
US6197835B1 (en) 1996-05-13 2001-03-06 Universidad De Sevilla Device and method for creating spherical particles of uniform size
US6196525B1 (en) 1996-05-13 2001-03-06 Universidad De Sevilla Device and method for fluid aeration via gas forced through a liquid within an orifice of a pressure chamber
US6189803B1 (en) 1996-05-13 2001-02-20 University Of Seville Fuel injection nozzle and method of use
US5770152A (en) * 1996-11-18 1998-06-23 Aradigm Corporation Collapsible container for measuring particles in a sample fluid
US6131570A (en) * 1998-06-30 2000-10-17 Aradigm Corporation Temperature controlling device for aerosol drug delivery
US5906202A (en) * 1996-11-21 1999-05-25 Aradigm Corporation Device and method for directing aerosolized mist to a specific area of the respiratory tract
US6694975B2 (en) 1996-11-21 2004-02-24 Aradigm Corporation Temperature controlling device for aerosol drug delivery
US5829435A (en) * 1997-02-24 1998-11-03 Aradigm Corporation Prefilter for prevention of clogging of a nozzle in the generation of an aerosol and prevention of administration of undesirable particles
US6349719B2 (en) 1997-02-24 2002-02-26 Aradigm Corporation Formulation and devices for monitoring the efficacy of the delivery of aerosols
US6192882B1 (en) 1997-02-24 2001-02-27 Aradigm Corporation Formulation and devices for monitoring the efficacy of the delivery of aerosols
US5855564A (en) * 1997-08-20 1999-01-05 Aradigm Corporation Aerosol extrusion mechanism
AU743440B2 (en) 1997-12-17 2002-01-24 Universidad De Sevilla Device and method for creating aerosols for drug delivery
US6598603B1 (en) * 1997-12-31 2003-07-29 Astra Aktiebolag Method for treating respiratory diseases
WO1999034839A1 (en) 1998-01-06 1999-07-15 Cerus Corporation Methods for quenching pathogen inactivators in biological materials
US6158431A (en) * 1998-02-13 2000-12-12 Tsi Incorporated Portable systems and methods for delivery of therapeutic material to the pulmonary system
US7244714B1 (en) * 1998-06-12 2007-07-17 Aradigm Corporation Methods of delivering aerosolized polynucleotides to the respiratory tract
US6234167B1 (en) * 1998-10-14 2001-05-22 Chrysalis Technologies, Incorporated Aerosol generator and methods of making and using an aerosol generator
US6450189B1 (en) 1998-11-13 2002-09-17 Universidad De Sevilla Method and device for production of components for microfabrication
US6354516B1 (en) 1999-11-02 2002-03-12 Aradigm Corporation Pore structures for reduced pressure aerosolization
JP2002532430A (ja) * 1998-12-17 2002-10-02 パソゲネシス コーポレイション エアゾール化抗生物質を用いる重篤な慢性気管支炎（気管支拡張症）の処置方法
US6315112B1 (en) * 1998-12-18 2001-11-13 Smithkline Beecham Corporation Method and package for storing a pressurized container containing a drug
US6352152B1 (en) * 1998-12-18 2002-03-05 Smithkline Beecham Corporation Method and package for storing a pressurized container containing a drug
US20030209453A1 (en) * 2001-06-22 2003-11-13 Herman Craig Steven Method and package for storing a pressurized container containing a drug
US6390291B1 (en) 1998-12-18 2002-05-21 Smithkline Beecham Corporation Method and package for storing a pressurized container containing a drug
TWI277425B (en) 1999-04-13 2007-04-01 Lilly Co Eli Pulmonary administration of dry powder formulations for treating infertility
US20020061281A1 (en) * 1999-07-06 2002-05-23 Osbakken Robert S. Aerosolized anti-infectives, anti-inflammatories, and decongestants for the treatment of sinusitis
US6576224B1 (en) * 1999-07-06 2003-06-10 Sinuspharma, Inc. Aerosolized anti-infectives, anti-inflammatories, and decongestants for the treatment of sinusitis
US6799576B2 (en) * 1999-07-16 2004-10-05 Aradigm Corporation System for effecting smoking cessation
ATE345875T1 (de) 1999-09-15 2006-12-15 Aradigm Corp Porenstrukturen zur niederdruckaerosolisierung
KR100702878B1 (ko) * 1999-10-29 2007-04-04 넥타르 테라퓨틱스 개선된 분산성을 갖는 건조 분말 조성물
DE19953317C1 (de) * 1999-11-05 2001-02-01 Pari Gmbh Inhalationsvernebler
US20040089561A1 (en) * 1999-11-23 2004-05-13 Herman Craig Steven Method and package for storing a pressurized container containing a drug
GB9929486D0 (en) * 1999-12-15 2000-02-09 Glaxo Group Ltd Inhalation delivery apparatus and method
KR100773323B1 (ko) 2000-01-10 2007-11-05 맥시겐 홀딩스 리미티드 지-씨에스에프 접합체
GB0003197D0 (en) * 2000-02-11 2000-04-05 Aid Medic Ltd Improvements in and relating to controlling drug delivery
US6883516B2 (en) 2000-04-27 2005-04-26 Chrysalis Technologies Incorporated Method for generating an aerosol with a predetermined and/or substantially monodispersed particle size distribution
MY136453A (en) * 2000-04-27 2008-10-31 Philip Morris Usa Inc "improved method and apparatus for generating an aerosol"
GB0015043D0 (en) * 2000-06-21 2000-08-09 Glaxo Group Ltd Medicament dispenser
SE517225C2 (sv) * 2000-09-21 2002-05-14 Microdrug Ag Optimering av en elektrostatiskt doserad inhalator för torrt pulver
AU2002223028A1 (en) * 2000-10-20 2002-05-06 Glaxo Group Limited Inhaler
US6681998B2 (en) 2000-12-22 2004-01-27 Chrysalis Technologies Incorporated Aerosol generator having inductive heater and method of use thereof
US6491233B2 (en) * 2000-12-22 2002-12-10 Chrysalis Technologies Incorporated Vapor driven aerosol generator and method of use thereof
US6799572B2 (en) 2000-12-22 2004-10-05 Chrysalis Technologies Incorporated Disposable aerosol generator system and methods for administering the aerosol
US6501052B2 (en) 2000-12-22 2002-12-31 Chrysalis Technologies Incorporated Aerosol generator having multiple heating zones and methods of use thereof
US7077130B2 (en) * 2000-12-22 2006-07-18 Chrysalis Technologies Incorporated Disposable inhaler system
US6701921B2 (en) * 2000-12-22 2004-03-09 Chrysalis Technologies Incorporated Aerosol generator having heater in multilayered composite and method of use thereof
US6904912B2 (en) * 2001-01-31 2005-06-14 The United States Of America As Represented By The Secretary Of The Army Automated inhalation toxicology exposure system
WO2002074806A2 (en) 2001-02-27 2002-09-26 Maxygen Aps New interferon beta-like molecules
WO2002088841A1 (en) 2001-04-25 2002-11-07 Matsushita Electric Industrial Co., Ltd. Projection display device
EP1392262A1 (de) 2001-05-24 2004-03-03 Alexza Molecular Delivery Corporation Verabreichung von arzneimittel-estern durch inhalation
US20030138508A1 (en) * 2001-12-18 2003-07-24 Novack Gary D. Method for administering an analgesic
US20030051728A1 (en) 2001-06-05 2003-03-20 Lloyd Peter M. Method and device for delivering a physiologically active compound
US7458374B2 (en) 2002-05-13 2008-12-02 Alexza Pharmaceuticals, Inc. Method and apparatus for vaporizing a compound
WO2002094242A1 (en) * 2001-05-24 2002-11-28 Alexza Molecular Delivery Corporation Delivery of rizatriptan or zolmitriptan through an inhalation route
US7645442B2 (en) 2001-05-24 2010-01-12 Alexza Pharmaceuticals, Inc. Rapid-heating drug delivery article and method of use
US7090830B2 (en) 2001-05-24 2006-08-15 Alexza Pharmaceuticals, Inc. Drug condensation aerosols and kits
US20070122353A1 (en) 2001-05-24 2007-05-31 Hale Ron L Drug condensation aerosols and kits
US7498019B2 (en) 2001-05-24 2009-03-03 Alexza Pharmaceuticals, Inc. Delivery of compounds for the treatment of headache through an inhalation route
AU2002310085B2 (en) 2001-05-24 2008-09-04 Alexza Pharmaceuticals, Inc. Delivery of alprazolam, estazolam, midazolam or triazolam through an inhalation route
US7585493B2 (en) 2001-05-24 2009-09-08 Alexza Pharmaceuticals, Inc. Thin-film drug delivery article and method of use
DE10136555A1 (de) * 2001-07-27 2003-02-13 Boehringer Ingelheim Int Optimierte Verfahren zur Bestimmung der Aerosol-Partikelgrößenverteilung und Vorrichtung zur Durchführung derartiger Verfahren
DE10136554A1 (de) * 2001-07-27 2003-02-13 Boehringer Ingelheim Int Verfahren zur Bestimmung der Aerosol-Partikelgrößenverteilung und Vorrichtung zur Durchführung eines derartigen Verfahrens
DE10141650C1 (de) 2001-08-24 2002-11-28 Lohmann Therapie Syst Lts Transdermales Therapeutisches System mit Fentanyl bzw. verwandten Substanzen
US6568390B2 (en) 2001-09-21 2003-05-27 Chrysalis Technologies Incorporated Dual capillary fluid vaporizing device
US6640050B2 (en) 2001-09-21 2003-10-28 Chrysalis Technologies Incorporated Fluid vaporizing device having controlled temperature profile heater/capillary tube
WO2003041693A1 (en) 2001-11-09 2003-05-22 Alexza Molecular Delivery Corporation Delivery of diazepam through an inhalation route
AU2002364508A1 (en) * 2001-11-21 2003-06-10 Alexza Molecular Delivery Corporation Open-celled substrates for drug delivery
EP1446102A1 (de) 2001-11-21 2004-08-18 Alexza Molecular Delivery Corporation Verabreichung von koffein durch inhalation
US6681769B2 (en) 2001-12-06 2004-01-27 Crysalis Technologies Incorporated Aerosol generator having a multiple path heater arrangement and method of use thereof
US6804458B2 (en) 2001-12-06 2004-10-12 Chrysalis Technologies Incorporated Aerosol generator having heater arranged to vaporize fluid in fluid passage between bonded layers of laminate
TWI324518B (en) * 2001-12-19 2010-05-11 Nektar Therapeutics Pulmonary delivery of aminoglycosides
US6701922B2 (en) 2001-12-20 2004-03-09 Chrysalis Technologies Incorporated Mouthpiece entrainment airflow control for aerosol generators
GB0204829D0 (en) * 2002-03-01 2002-04-17 Glaxo Group Ltd A fluid dispensing device
US6705316B2 (en) 2002-03-11 2004-03-16 Battelle Pulmonary Therapeutics, Inc. Pulmonary dosing system and method
US6985798B2 (en) * 2002-05-10 2006-01-10 Oriel Therapeutics, Inc. Dry powder dose filling systems and related methods
US7118010B2 (en) * 2002-05-10 2006-10-10 Oriel Therapeutics, Inc. Apparatus, systems and related methods for dispensing and /or evaluating dry powders
US7677411B2 (en) * 2002-05-10 2010-03-16 Oriel Therapeutics, Inc. Apparatus, systems and related methods for processing, dispensing and/or evaluatingl dry powders
US6889690B2 (en) * 2002-05-10 2005-05-10 Oriel Therapeutics, Inc. Dry powder inhalers, related blister devices, and associated methods of dispensing dry powder substances and fabricating blister packages
EP1503744A1 (de) 2002-05-13 2005-02-09 Alexza Molecular Delivery Corporation Verabreichung von aminenhaltigen arzneistoffen durch inhalation
US20050232899A1 (en) * 2002-05-31 2005-10-20 Aradigm Corporation Compositions methods and systems for pulmonary delivery of recombinant human interferon alpha-2b
US6830744B2 (en) 2002-05-31 2004-12-14 Aradigm Corporation Compositions methods and systems for pulmonary delivery of recombinant human interferon alpha-2b
AU2003251760A1 (en) * 2002-06-27 2004-01-19 Oriel Therapeutics, Inc. Apparatus and methods for dispensing dry powders
US7056494B2 (en) 2002-09-03 2006-06-06 Kos Pharmaceuticals, Inc. Method of treating a systemic disease
CA2497845C (en) * 2002-09-06 2012-08-14 Chrysalis Technologies Incorporated Liquid aerosol formulations and aerosol generating devices and methods for generating aerosols
US6923179B2 (en) * 2002-09-06 2005-08-02 Philip Morris Usa Inc. Aerosol generating devices and methods for generating aerosols having controlled particle sizes
US20040055595A1 (en) * 2002-09-19 2004-03-25 Noymer Peter D. Aerosol drug delivery system employing formulation pre-heating
CA2507158A1 (en) * 2002-11-26 2004-06-10 Alexza Molecular Delivery Corporation Treatment of headache with antipsychotics delivered by inhalation
US20040105818A1 (en) 2002-11-26 2004-06-03 Alexza Molecular Delivery Corporation Diuretic aerosols and methods of making and using them
US7550133B2 (en) 2002-11-26 2009-06-23 Alexza Pharmaceuticals, Inc. Respiratory drug condensation aerosols and methods of making and using them
EP1567164B1 (de) * 2002-11-26 2009-01-14 Alexza Pharmaceuticals, Inc. Verwendung von loxapine für die herstellung eines mittels zur behandlung von schmerz
US7913688B2 (en) * 2002-11-27 2011-03-29 Alexza Pharmaceuticals, Inc. Inhalation device for producing a drug aerosol
MXPA05007156A (es) * 2002-12-31 2005-09-21 Nektar Therapeutics Formulacion farmaceuticas aerosolizable para terapia para infecciones fungicas.
US20040187864A1 (en) * 2003-03-24 2004-09-30 Cindet, Llc Inhalation device and method
GB0308771D0 (en) * 2003-04-16 2003-05-21 Univ Loughborough Pulmonary drug delivery
US20050079166A1 (en) 2003-05-21 2005-04-14 Alexza Molecular Delivery Corporation Self-contained heating unit and drug-supply unit employing same
US7367334B2 (en) 2003-08-27 2008-05-06 Philip Morris Usa Inc. Fluid vaporizing device having controlled temperature profile heater/capillary tube
US7342660B2 (en) * 2003-09-25 2008-03-11 Deka Products Limited Partnership Detection system and method for aerosol delivery
US7021560B2 (en) 2003-09-25 2006-04-04 Deka Products Limited Partnership System and method for aerosol delivery
US7451761B2 (en) * 2003-10-27 2008-11-18 Oriel Therapeutics, Inc. Dry powder inhalers, related blister package indexing and opening mechanisms, and associated methods of dispensing dry powder substances
US7377277B2 (en) * 2003-10-27 2008-05-27 Oriel Therapeutics, Inc. Blister packages with frames and associated methods of fabricating dry powder drug containment systems
EP1701714A2 (de) * 2004-01-07 2006-09-20 Nektar Therapeutics Verbesserte zusammensetzungen mit verzögerter freisetzung für die pulmonale verabreichung von insulin
WO2005079755A2 (en) * 2004-02-12 2005-09-01 Nektar Therapeutics Interleukin-13 antagonist powders, spray-dried particles, and methods
DE102004009435A1 (de) * 2004-02-24 2005-12-08 Boehringer Ingelheim International Gmbh Zerstäuber
US8056556B2 (en) * 2004-04-12 2011-11-15 Hewlett-Packard Development Company, L.P. Inhaler nozzle maintenance apparatus and method
US7723306B2 (en) * 2004-05-10 2010-05-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg Spray-dried powder comprising at least one 1,4 O-linked saccharose-derivative and methods for their preparation
US7611709B2 (en) * 2004-05-10 2009-11-03 Boehringer Ingelheim Pharma Gmbh And Co. Kg 1,4 O-linked saccharose derivatives for stabilization of antibodies or antibody derivatives
US7727962B2 (en) * 2004-05-10 2010-06-01 Boehringer Ingelheim Pharma Gmbh & Co. Kg Powder comprising new compositions of oligosaccharides and methods for their preparation
US7540286B2 (en) 2004-06-03 2009-06-02 Alexza Pharmaceuticals, Inc. Multiple dose condensation aerosol devices and methods of forming condensation aerosols
ES2399279T3 (es) 2004-06-18 2013-03-27 Novartis Ag Formulaciones de tobramicina para el tratamiento de infecciones endobronquiales
US7581540B2 (en) 2004-08-12 2009-09-01 Alexza Pharmaceuticals, Inc. Aerosol drug delivery device incorporating percussively activated heat packages
PT1838355E (pt) 2004-10-29 2013-11-07 Cerus Corp Métodos de inibição melhorados destinados a um processo de inativação de glóbulos vermelhos
UA95446C2 (ru) 2005-05-04 2011-08-10 Іллюміджен Байосайєнсіз, Інк. Мутаци в генах oas1
KR100857596B1 (ko) * 2005-08-23 2008-09-09 삼성전자주식회사 나노입자 생성장치
EP1919954B1 (de) 2005-08-30 2016-10-19 University of Miami Immunmodulierende tumornekrosefaktor-rezeptor-25 (tnfr25)-agonisten, antagonisten und immuntoxine
US20070068524A1 (en) * 2005-09-28 2007-03-29 Microdrug Ag Inhaler for moisture sensitive drugs
JP5096363B2 (ja) * 2005-12-16 2012-12-12 ネクター セラピューティックス Ｇｌｐ−１のポリマ複合体
US8375987B2 (en) * 2005-12-22 2013-02-19 Donovan B. Yeates Concentrator for increasing the particle concentration in an aerosol flow
US8596268B2 (en) 2005-12-22 2013-12-03 Donovan B. Yeates Method of operating a compact, low flow resistance aerosol generator
US7802569B2 (en) * 2005-12-22 2010-09-28 Kaer Biotherapeutics Corporation Aerosol processing and inhalation method and system for high dose rate aerosol drug delivery
US8616532B2 (en) 2005-12-22 2013-12-31 Donovan B. Yeates Flow conditioner for a compact, low flow resistance aerosol generator
US8820662B2 (en) 2005-12-22 2014-09-02 Donovan B. Yeates Nozzle and nozzle holder for an aerosol generator
JP4869719B2 (ja) * 2006-01-30 2012-02-08 株式会社新日本科学 動物実験用の試験物質投与システム
EP1993633B1 (de) 2006-02-09 2016-11-09 Deka Products Limited Partnership Pumpsysteme und verfahren zur flüssigkeitsabgabe mit krafteinwirkungsanordnung
MX2008013404A (es) * 2006-04-19 2008-12-03 Organon Nv Aparato de suministro de fármacos.
JP2008099758A (ja) 2006-10-18 2008-05-01 Canon Inc 吸入装置
US20080138397A1 (en) * 2006-10-24 2008-06-12 Aradigm Corporation Processes for taste-masking of inhaled formulations
WO2008097645A1 (en) * 2007-02-08 2008-08-14 Aerovectrx Corporation Aerosol delivery systems and methods
JP2008212436A (ja) 2007-03-06 2008-09-18 Canon Inc 吸入装置
ES2594867T3 (es) * 2007-03-09 2016-12-23 Alexza Pharmaceuticals, Inc. Unidad de calentamiento para usar en un dispositivo de administración de fármaco
EP2157992B1 (de) 2007-06-15 2016-12-14 iDTx Systems, Inc. Arzneimittelabgabe- und überwachungssystem für einen ventilator
US8875697B2 (en) 2007-07-24 2014-11-04 Ric Investments, Llc Drug delivery apparatus and method
EP2207584A2 (de) * 2007-10-25 2010-07-21 Novartis Ag Pulveraufbereitung von einheitsdosis-arzneimittelpackungen
JP2009106467A (ja) 2007-10-30 2009-05-21 Canon Inc 吸入装置
CA2904458C (en) 2007-11-30 2017-07-25 Wolfgang Fraunhofer Protein formulations and methods of making same
WO2009105445A1 (en) * 2008-02-18 2009-08-27 Virginia Commonwealth University Effective delivery of nanoparticles and micrometer-sized pharmaceutical aerosols to the lung through enhanced condensational growth
EA023596B1 (ru) 2008-04-09 2016-06-30 Сирус Корпорейшн Способы обработки композиции эритроцитов для инактивации патогена
US8251876B2 (en) 2008-04-22 2012-08-28 Hill-Rom Services, Inc. Breathing exercise apparatus
WO2010033220A2 (en) * 2008-09-19 2010-03-25 Nektar Therapeutics Modified therapeutics peptides, methods of their preparation and use
WO2010033207A1 (en) 2008-09-19 2010-03-25 Nektar Therapeutics Polymer conjugates of therapeutic peptides
CA2757500A1 (en) 2009-04-01 2010-10-07 Promedior, Inc. Pulmonary and nasal delivery of serum amyloid p
WO2010142017A1 (en) 2009-06-09 2010-12-16 Defyrus, Inc . Administration of interferon for prophylaxis against or treatment of pathogenic infection
US20110124589A1 (en) 2009-11-24 2011-05-26 Gilead Sciences, Inc. Inhaled fosfomycin/tobramycin for the treatment of chronic obstructive pulmonary disease
WO2011081937A1 (en) 2009-12-15 2011-07-07 Gilead Sciences, Inc. Corticosteroid-beta-agonist-muscarinic antagonist compounds for use in therapy
US8367829B2 (en) 2010-05-10 2013-02-05 Gilead Sciences, Inc. Bi-functional pyrazolopyridine compounds
WO2011143105A1 (en) 2010-05-10 2011-11-17 Gilead Sciences, Inc. Bifunctional quinoline derivatives
US8869793B1 (en) 2010-05-18 2014-10-28 Idtx Systems, Inc. Compact self-contained automated MDI adapters or units for ventilators
CA2800834C (en) 2010-06-24 2018-10-23 Gilead Sciences, Inc. Pyrazolo [1,5-a] pyrimidines as antiviral agents
US10154923B2 (en) 2010-07-15 2018-12-18 Eyenovia, Inc. Drop generating device
BR122020020745B8 (pt) 2010-07-22 2023-10-31 Gilead Sciences Inc Composto antiviral para o tratamento de infecções por paramyxoviridae e composição farmacêutica que o compreende
PL3409314T3 (pl) * 2010-08-24 2021-07-05 Trudell Medical International Urządzenie do dostarczania aerosolu
US20120048963A1 (en) 2010-08-26 2012-03-01 Alexza Pharmaceuticals, Inc. Heat Units Using a Solid Fuel Capable of Undergoing an Exothermic Metal Oxidation-Reduction Reaction Propagated without an Igniter
TW201305185A (zh) 2010-09-13 2013-02-01 Gilead Sciences Inc 用於抗病毒治療之２’－氟取代之碳－核苷類似物
WO2012154483A1 (en) 2011-05-06 2012-11-15 Gilead Sciences, Inc. Dry powder fosfomycin/tobramycin formulation for inhalation
AR086745A1 (es) 2011-06-27 2014-01-22 Parion Sciences Inc 3,5-diamino-6-cloro-n-(n-(4-(4-(2-(hexil(2,3,4,5,6-pentahidroxihexil)amino)etoxi)fenil)butil)carbamimidoil)pirazina-2-carboxamida
JP5979471B2 (ja) * 2012-01-11 2016-08-24 大日本印刷株式会社 噴霧デバイス用の液体カートリッジ、液体カートリッジパッケージ、噴霧デバイス及び噴霧デバイス用のメッシュ付容器
EP2809780B1 (de) 2012-02-01 2018-05-02 Protalix Ltd. Inhalierbare flüssige formulierungen der dnase i
US9180271B2 (en) 2012-03-05 2015-11-10 Hill-Rom Services Pte. Ltd. Respiratory therapy device having standard and oscillatory PEP with nebulizer
US20150044305A1 (en) 2012-03-07 2015-02-12 Advanced Inhalation Therapies (Ait) Ltd. Inhalation of nitric oxide for treating respiratory diseases
ES2621217T3 (es) 2012-03-13 2017-07-03 Gilead Sciences, Inc. Análogos de carba-nucleósido 2'-sustituidos para tratamiento antivírico
LT2838900T (lt) 2012-04-17 2019-11-11 Gilead Sciences Inc Junginiai ir būdai, skirti priešvirusinei terapijai
ES2675588T3 (es) 2012-05-29 2018-07-11 Parion Sciences, Inc. Dendrímero como aminoamidas que posee actividad de bloqueador de canal de sodio para el tratamiento del ojo seco y otras enfermedades mucosas
US10034988B2 (en) 2012-11-28 2018-07-31 Fontem Holdings I B.V. Methods and devices for compound delivery
ES2674665T3 (es) 2012-12-17 2018-07-03 Parion Sciences, Inc. Compuestos de 3,5-diamino-6-cloro-N-(N-(4-fenilbutilo)carbamimidoilo)-pirazina-2-carboxamida
KR102258469B1 (ko) 2012-12-17 2021-05-31 패리온 사이언스 인코퍼레이티드 불충분한 점막 수화에 의해 유발되는 질환의 치료에 유용한 클로로-피라진 카르복스아미드 유도체
NZ709197A (en) 2012-12-17 2020-06-26 Parion Sciences Inc 3,5-diamino-6-chloro-n-(n-(4-phenylbutyl)carbamimidoyl) pyrazine-2- carboxamide compounds
CA2908158A1 (en) * 2013-04-04 2014-10-09 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services, Centers For Disease Control And Prevention Nasal aerosol delivery system
US9303330B2 (en) 2013-06-07 2016-04-05 General Electric Company Method for manufacturing fluid handling discs with porous mesh plates for use in ultrasonic mesh nebulizers
WO2015042412A1 (en) 2013-09-20 2015-03-26 E-Nicotine Technology. Inc. Devices and methods for modifying delivery devices
UA119050C2 (uk) 2013-11-11 2019-04-25 Ґілеад Саєнсиз, Інк. ПІРОЛО[1.2-f][1.2.4]ТРИАЗИНИ, ЯКІ ВИКОРИСТОВУЮТЬСЯ ДЛЯ ЛІКУВАННЯ РЕСПІРАТОРНО-СИНЦИТІАЛЬНИХ ВІРУСНИХ ІНФЕКЦІЙ
US10173025B2 (en) 2014-04-21 2019-01-08 Idtx Systems, Inc. Automated drug delivery systems
US11273271B2 (en) 2014-07-01 2022-03-15 Aerami Therapeutics, Inc. Aerosolization system with flow restrictor and feedback device
US10471222B2 (en) * 2014-07-01 2019-11-12 Dance Biopharm Inc. Aerosolization system with flow restrictor and feedback device
TWI678369B (zh) 2014-07-28 2019-12-01 美商基利科學股份有限公司 用於治療呼吸道合胞病毒感染之噻吩並［３,２-ｄ］嘧啶、呋喃並［３,２-ｄ］嘧啶及吡咯並［３,２-ｄ］嘧啶化合物類
TWI673283B (zh) 2014-08-21 2019-10-01 美商基利科學股份有限公司 ２’－氯胺基嘧啶酮及嘧啶二酮核苷類
US10737042B2 (en) 2014-08-26 2020-08-11 Michael Edward Breede Thermal modulation of an inhalable medicament
US10300228B2 (en) * 2014-08-26 2019-05-28 Innovosciences, Llc Thermal modulation of an inhalable medicament
US10561814B2 (en) 2014-11-19 2020-02-18 Idtx Systems, Inc. Automated drug dispensing systems with automated HME bypass for ventilator circuits
CN107406837A (zh) 2015-01-04 2017-11-28 波塔力克斯有限公司 修饰的dna酶及其用途
CN113633856A (zh) 2015-03-11 2021-11-12 艾利斯达医药品公司 气道中的防静电材料用于热气溶胶凝结方法的用途
US10905836B2 (en) 2015-04-02 2021-02-02 Hill-Rom Services Pte. Ltd. Manifold for respiratory device
EP3368110B1 (de) 2015-10-30 2020-12-02 Johnson & Johnson Consumer Inc. Vernebelungsvorrichtung mit aseptischem aerosol
KR102678412B1 (ko) 2015-10-30 2024-06-27 존슨 앤드 존슨 컨수머 인코포레이티드 무균 에어로졸 미스팅 장치
RU2721489C2 (ru) * 2015-10-30 2020-05-19 Джонсон энд Джонсон Консьюмер Инк. Асептический аэрозольный туманообразователь
MA43112A (fr) 2015-10-30 2018-09-05 Johnson & Johnson Consumer Inc Pulvérisateur d'aérosol aseptique de dose unitaire
US11285274B2 (en) 2016-05-03 2022-03-29 Pneuma Respiratory, Inc. Methods for the systemic delivery of therapeutic agents to the pulmonary system using a droplet delivery device
US11285284B2 (en) 2016-05-03 2022-03-29 Pneuma Respiratory, Inc. Methods for treatment of pulmonary lung diseases with improved therapeutic efficacy and improved dose efficiency
EP3452152B1 (de) 2016-05-03 2025-07-02 Pneuma Respiratory, Inc. Tröpfchenabgabevorrichtung zur erzeugung und abgabe von tröpfchen an das lungensystem
US20210236745A1 (en) * 2016-05-03 2021-08-05 Pneuma Respiratory, Inc. Droplet delivery device for delivery of fluids to the pulmonary system and methods of use
WO2017192782A1 (en) 2016-05-03 2017-11-09 Pneuma Respiratory, Inc. Systems and methods comprising a droplet delivery device and a breathing assist device for therapeutic treatment
USD814629S1 (en) * 2016-10-31 2018-04-03 Delta Electronics, Inc. Mouthpiece
EP4223335A3 (de) 2017-05-19 2023-11-08 Pneuma Respiratory, Inc. Vorrichtung zur ausgabe von trockenpulver und verfahren zur verwendung
KR102643190B1 (ko) 2017-06-10 2024-03-04 아이노비아 인코포레이티드 유체를 취급하기 위한, 그리고 눈에 유체를 전달하기 위한 디바이스들
US11738158B2 (en) 2017-10-04 2023-08-29 Pneuma Respiratory, Inc. Electronic breath actuated in-line droplet delivery device and methods of use
EP4344719A3 (de) 2017-10-17 2024-06-05 Pneuma Respiratory, Inc. Nasale arzneimittelabgabevorrichtung und verwendungsverfahren
JP2021502178A (ja) 2017-11-08 2021-01-28 ニューマ・リスパイラトリー・インコーポレイテッド 小容積アンプルを有して呼吸により電気的に作動するインライン液滴送達装置および使用方法
EA037169B1 (ru) * 2017-12-26 2021-02-15 Общество с ограниченной ответственностью "Научно-производственный Инновационный внедренческий центр" Способ генерации лекарственного средства в виде аэрозоля
MX2020007997A (es) 2018-02-02 2020-12-03 Alexza Pharmaceuticals Inc Dispositivo electrico de aerosol de condensacion.
US11998681B2 (en) 2019-07-03 2024-06-04 Airja, Inc. Aerosol delivery devices and methods of using same
CA3145730A1 (en) * 2019-07-03 2021-01-07 Airja, Inc. Aerosol delivery devices and methods of using same
WO2021023522A1 (en) * 2019-08-02 2021-02-11 Stamford Devices Limited Buccal administration of aerosol
WO2021102085A1 (en) * 2019-11-22 2021-05-27 The Trustees Of Princeton University High-throughput monodisperse aerosols of micro-shell particles
JP2023506781A (ja) 2019-12-11 2023-02-20 アイノビア・インコーポレイテッド 眼に流体を送達するためのシステム及び装置並びに使用方法
PL4081305T3 (pl) 2019-12-24 2025-02-10 Carna Biosciences, Inc. Związki modulujące kinazę diacyloglicerolową
US12030903B2 (en) 2020-02-18 2024-07-09 Gilead Sciences, Inc. Antiviral compounds
TWI775313B (zh) 2020-02-18 2022-08-21 美商基利科學股份有限公司 抗病毒化合物
TWI791193B (zh) 2020-02-18 2023-02-01 美商基利科學股份有限公司 抗病毒化合物
TWI794742B (zh) 2020-02-18 2023-03-01 美商基利科學股份有限公司 抗病毒化合物
IL297327B1 (en) 2020-05-01 2025-09-01 Gilead Sciences Inc 4,2-dioxopyrimidine compounds CD73 inhibitors
IL299002A (en) 2020-06-27 2023-02-01 Crescenta Biosciences New compounds for regulating cell metabolism and their uses
PL4359046T3 (pl) 2021-06-22 2025-10-13 Pneuma Respiratory, Inc. Urządzenie do podawania kropelkowego z wyrzutem wypychającym
AU2022298639C1 (en) 2021-06-23 2025-07-17 Gilead Sciences, Inc. Diacylglyercol kinase modulating compounds
CA3222595A1 (en) 2021-06-23 2022-12-29 Gilead Sciences, Inc. Diacylglyercol kinase modulating compounds
EP4359415A1 (de) 2021-06-23 2024-05-01 Gilead Sciences, Inc. Diacylglyercolkinase modulierende verbindungen
PE20242071A1 (es) 2021-06-23 2024-10-18 Gilead Sciences Inc Compuestos moduladores de diacilglicerol quinasa
AU2022376954A1 (en) 2021-10-29 2024-05-02 Gilead Sciences, Inc. Cd73 compounds
US12138243B2 (en) 2021-12-31 2024-11-12 Crescenta Biosciences Antiviral use of FABP4 modulating compounds
EP4558199A1 (de) 2022-07-18 2025-05-28 Pneuma Respiratory, Inc. Aerosolerzeugungssystem mit geringer schrittgrösse und hoher auflösung und verfahren

Family Cites Families (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL297349A (de) * 1962-08-31
US3187748A (en) * 1963-04-29 1965-06-08 Merck And Company Inc Inhalation-actuated aerosol device
DE1575050A1 (de) * 1966-01-12 1972-04-13 Misto Gen Equipment Co Ultraschall-Nebelerzeugungsgeraet
US3456646A (en) * 1967-01-19 1969-07-22 Dart Ind Inc Inhalation-actuated aerosol dispensing device
US3565070A (en) * 1969-02-28 1971-02-23 Riker Laboratories Inc Inhalation actuable aerosol dispenser
NO134730L (de) * 1971-07-19 1900-01-01
US3812854A (en) * 1972-10-20 1974-05-28 A Michaels Ultrasonic nebulizer
US3913631A (en) * 1974-06-20 1975-10-21 I E R A M Inst Europ De Rech E Aerosol device
US3991304A (en) * 1975-05-19 1976-11-09 Hillsman Dean Respiratory biofeedback and performance evaluation system
US3948264A (en) * 1975-05-21 1976-04-06 Mead Johnson & Company Inhalation device
GB1518998A (en) * 1975-08-28 1978-07-26 Gillette Co Packaging flowable materials
SU764682A1 (ru) * 1978-03-28 1980-09-23 Всесоюзный Научно-Исследовательский Институт Медицинского Приборостроения Генератор электроаэрозолей
US4256071A (en) * 1979-01-29 1981-03-17 Deseret Automotive Research, Inc. Torch chamber apparatus and method for a spark plug of an internal combustion engine
US4256017A (en) * 1979-04-05 1981-03-17 The Bendix Corporation Differential area electrohydraulic doser actuator
US4274403A (en) * 1979-08-29 1981-06-23 Struve Roger L Inhaler
DE3274065D1 (de) * 1981-07-08 1986-12-11 Draco Ab Powder inhalator
AU553251B2 (en) * 1981-10-15 1986-07-10 Matsushita Electric Industrial Co., Ltd. Arrangement for ejecting liquid
NO160330C (no) * 1982-10-08 1989-04-12 Glaxo Group Ltd Anordning for aa administrere medikamenter til pasienter og medikamentpakning for anordningen.
US4564748A (en) * 1982-10-29 1986-01-14 Respiratory Care, Inc. Variable temperature heating control system for inhalation therapy apparatus
US4469255A (en) * 1982-11-19 1984-09-04 Cook International, Inc. Automatic and adjustable valving mechanism
US4523589A (en) * 1983-06-29 1985-06-18 Krauser Robert S Method and apparatus for treating ailments
US4649911A (en) * 1983-09-08 1987-03-17 Baylor College Of Medicine Small particle aerosol generator for treatment of respiratory disease including the lungs
US4699136A (en) * 1983-12-22 1987-10-13 Krauser Robert S Method and apparatus for treating ailments
SU1353440A1 (ru) * 1985-11-21 1987-11-23 Всесоюзный Научно-Исследовательский Институт Медицинского Приборостроения Распылитель
NZ219021A (en) * 1986-01-27 1989-06-28 Gea Farmaceutisk Fabrik As Inhaler: medicine discharged intermittently during each inhalation
DE3627222A1 (de) * 1986-08-11 1988-02-18 Siemens Ag Ultraschall-taschenzerstaeubergeraet
EP0257956B2 (de) * 1986-08-19 2000-11-22 Genentech, Inc. Verwendung von Polypeptidwuchsstoffen und Zytokinen zur Herstellung eines Geräts und einer Dispersion
US4832012A (en) * 1987-07-08 1989-05-23 Vortran Medical Technology, Inc. Intermittent signal actuated nebulizer
US5063921A (en) * 1987-11-12 1991-11-12 Cimco, Inc. Nebulizer heater
US4963327A (en) * 1988-03-23 1990-10-16 Z-Gard, Inc. Oxygen generating module
US4922901A (en) * 1988-09-08 1990-05-08 R. J. Reynolds Tobacco Company Drug delivery articles utilizing electrical energy
US4984158A (en) * 1988-10-14 1991-01-08 Hillsman Dean Metered dose inhaler biofeedback training and evaluation system
US5060671A (en) 1989-12-01 1991-10-29 Philip Morris Incorporated Flavor generating article
US5152456A (en) * 1989-12-12 1992-10-06 Bespak, Plc Dispensing apparatus having a perforate outlet member and a vibrating device
US5201308A (en) * 1990-02-14 1993-04-13 Newhouse Michael T Powder inhaler
SG45171A1 (en) * 1990-03-21 1998-01-16 Boehringer Ingelheim Int Atomising devices and methods
US5042472A (en) * 1990-10-15 1991-08-27 Merck & Co., Inc. Powder inhaler device
GB9023282D0 (en) * 1990-10-25 1990-12-05 Riker Laboratories Inc Inhalation device
FR2673142A1 (fr) 1991-02-21 1992-08-28 Ribal Annick Dispositif de soudure autonome, portatif pour poches plastiques.
US5404871A (en) * 1991-03-05 1995-04-11 Aradigm Delivery of aerosol medications for inspiration
US5450336A (en) 1991-03-05 1995-09-12 Aradigm Corporation Method for correcting the drift offset of a transducer
US5394866A (en) 1991-03-05 1995-03-07 Aradigm Corporation Automatic aerosol medication delivery system and methods
US5186164A (en) * 1991-03-15 1993-02-16 Puthalath Raghuprasad Mist inhaler
GB9109064D0 (en) * 1991-04-26 1991-06-12 Dunne Miller Weston Ltd Dispensing device
US5327883A (en) * 1991-05-20 1994-07-12 Dura Pharmaceuticals, Inc. Apparatus for aerosolizing powdered medicine and process and using
ES2141108T3 (es) * 1991-07-02 2000-03-16 Inhale Inc Metodo y dispositivo para proporcionar medicamentos en aerosol.
DE4134665A1 (de) * 1991-10-19 1993-04-22 Solvay Deutschland Medizinisches inhalationssystem
US5396884A (en) * 1991-11-15 1995-03-14 Cimco, Inc. High flow rate humidifier with baffle plates
GB9125699D0 (en) * 1991-12-03 1992-01-29 Glaxo Group Ltd Device
US5363842A (en) * 1991-12-20 1994-11-15 Circadian, Inc. Intelligent inhaler providing feedback to both patient and medical professional
EP0558879B1 (de) * 1992-03-04 1997-05-14 Astra Aktiebolag Wegwerfinhalator
DE59303719D1 (de) * 1992-06-05 1996-10-17 Hoechst Ag Inhalator
FR2700697B1 (fr) * 1993-01-27 1997-01-24 Fact Anal Scp Inhalateur electrique de poche.
US5743250A (en) * 1993-01-29 1998-04-28 Aradigm Corporation Insulin delivery enhanced by coached breathing
US5372148A (en) * 1993-02-24 1994-12-13 Philip Morris Incorporated Method and apparatus for controlling the supply of energy to a heating load in a smoking article
US5497763A (en) * 1993-05-21 1996-03-12 Aradigm Corporation Disposable package for intrapulmonary delivery of aerosolized formulations

Also Published As

Publication number Publication date
JPH10506037A (ja) 1998-06-16
JP2004290688A (ja) 2004-10-21
EP1181944A3 (de) 2003-12-10
US5522385A (en) 1996-06-04
EP0783337A1 (de) 1997-07-16
AU708307B2 (en) 1999-07-29
DE69534102T2 (de) 2006-03-23
EP0783337B1 (de) 2005-03-23
JP3596619B2 (ja) 2004-12-02
EP1181944A2 (de) 2002-02-27
WO1996009846A1 (en) 1996-04-04
EP0783337A4 (de) 1998-12-02
US5957124A (en) 1999-09-28
AU3859095A (en) 1996-04-19
CA2201129A1 (en) 1996-04-04

Similar Documents

Publication Publication Date Title
DE69534102D1 (de) Dynamische teilchengrössenkontrolle für aerolisierte arzeneiverabreichung
FI972554L (fi) Hiukkasten antomuoto
DE69510046D1 (de) Abgabevorrichtung
DE69501586D1 (de) Abgabevorrichtung
DE69530823D1 (de) Ölausgleichsregelung in klimaanlage
DE69530746D1 (de) Flugzeugbremse
NO991405D0 (no) Belagt partikkelformulering
ITMI940674A0 (it) Struttura di dispositivo di frenata, particolarmente per pattini con ruote in linea
DE69733467D1 (de) Adsorbtionsvorrichtung und absorbens für immunuglobine und deren komplexe
DE69812707D1 (de) Nicht-bleichende achselzusammensetzungen
DE69738399D1 (de) Gasbetriebenes gerät für teilchenabgabe
DE59504531D1 (de) Zuführ- und Verteilsystem für Gegenstände
DE69515792D1 (de) Gleiteinheit für Bremse
FI965288A7 (fi) Jarru
DE69411018D1 (de) Komponentenzulieferungsanlage
ITTV940051A0 (it) Struttura di dispositivo frenante particolarmente per pattini.
IT237237Y1 (it) Disposizione di collegamento nella costruzione di automobili
NO980088D0 (no) Reklameanordning for jernbane o.l.
DE69516200D1 (de) Aerodynamische Stabilisier- und Bremsvorrichtung für Abwurfkörper
KR950023397U (ko) 철도 차량용 받침목
KR960004845U (ko) 화물운반용 수레
KR950023396U (ko) 철도 차량용 받침목
KR960013582U (ko) 디스크 브레이크의 피스턴 삽입장치
KR960030781U (ko) 화물 운반용 밀차
KR960002310U (ko) 첵크밸브구조

Legal Events

Date Code Title Description
8364 No opposition during term of opposition