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DE69533214D1 - 2,3-Dihydro-1H-isoindolderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Hemmer der Serotoninwiederaufnahme - Google Patents

2,3-Dihydro-1H-isoindolderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Hemmer der Serotoninwiederaufnahme

Info

Publication number
DE69533214D1
DE69533214D1 DE69533214T DE69533214T DE69533214D1 DE 69533214 D1 DE69533214 D1 DE 69533214D1 DE 69533214 T DE69533214 T DE 69533214T DE 69533214 T DE69533214 T DE 69533214T DE 69533214 D1 DE69533214 D1 DE 69533214D1
Authority
DE
Germany
Prior art keywords
dihydro
preparation
serotonin reuptake
inhibitors
isoindole derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69533214T
Other languages
English (en)
Other versions
DE69533214T2 (de
Inventor
Gregory Shutske
Kevin J Kapples
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Aventis Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharmaceuticals Inc filed Critical Aventis Pharmaceuticals Inc
Publication of DE69533214D1 publication Critical patent/DE69533214D1/de
Application granted granted Critical
Publication of DE69533214T2 publication Critical patent/DE69533214T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
DE69533214T 1994-08-11 1995-08-07 2,3-Dihydro-1H-isoindolderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Hemmer der Serotoninwiederaufnahme Expired - Lifetime DE69533214T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/288,844 US5567718A (en) 1994-08-11 1994-08-11 2,3-dihydro-1h-isoindole derivatives and their use as serotonin reuptake inhibitors
US288844 1994-08-11

Publications (2)

Publication Number Publication Date
DE69533214D1 true DE69533214D1 (de) 2004-08-05
DE69533214T2 DE69533214T2 (de) 2005-07-21

Family

ID=23108905

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69533214T Expired - Lifetime DE69533214T2 (de) 1994-08-11 1995-08-07 2,3-Dihydro-1H-isoindolderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Hemmer der Serotoninwiederaufnahme

Country Status (9)

Country Link
US (5) US5567718A (de)
EP (1) EP0703232B1 (de)
JP (1) JP3339996B2 (de)
AT (1) ATE270287T1 (de)
CA (1) CA2155796C (de)
DE (1) DE69533214T2 (de)
DK (1) DK0703232T3 (de)
ES (1) ES2219652T3 (de)
PT (1) PT703232E (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9714432A (pt) * 1996-12-23 2000-05-02 Hoeschst Marion Roussel Inc Derivados de 3-aril-2-(1-substituìdo-4-piperidinil)-1(1-di(oxo-3h-bezo [d]-isoatiazol, sua preparação e seu uso como moduladores de função neurotransmissora
US6004977A (en) * 1996-12-27 1999-12-21 Hoechst Marion Roussel, Inc. N-(pyridinylamino) isoindolines and related compounds
US6339093B1 (en) * 1999-10-08 2002-01-15 Hoffmann-La Roche Inc. Isoquinoline derivatives
WO2004052858A2 (en) * 2002-12-06 2004-06-24 Eli Lilly And Company Inhibitors of monoamine uptake
WO2007054453A2 (en) * 2005-11-11 2007-05-18 F. Hoffmann-La Roche Ag Carbocyclic fused cyclic amines as inhibitors of the coagulation factor xa
US8110681B2 (en) 2006-03-17 2012-02-07 The United States Of America As Represented By The Secretary, Department Of Health And Human Services Compounds for the treatment of spinal muscular atrophy and other uses
AU2008304231A1 (en) * 2007-09-27 2009-04-02 Albany Molecular Research, Inc. Isoindoline compounds for the treatment of spinal muscular atrophy and other uses

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3084167A (en) * 1954-12-09 1963-04-02 Geschickter Fund Med Res Isoindoles
US2957872A (en) * 1957-10-21 1960-10-25 Ciba Pharm Prod Inc Phthalimidines and process for manufacturing same
US3031458A (en) * 1958-02-05 1962-04-24 Ciba Pharm Prod Inc Isoindolines
DE1135461B (de) * 1959-05-08 1962-08-30 Knoll Ag Verfahren zur Herstellung von basisch substituierten Phthalimidinen
US3322631A (en) * 1965-06-30 1967-05-30 Merck & Co Inc Method of treatment of hypertension
SE368009B (de) * 1971-09-16 1974-06-17 Kabi Ab
GB1416872A (en) * 1972-03-10 1975-12-10 Wyeth John & Brother Ltd 4-aminoquinoline derivatives
BE795730A (fr) * 1972-04-01 1973-08-21 Knoll Ag Composition antiarythmique
GB1425578A (en) * 1972-10-21 1976-02-18 Wyeth John & Brother Ltd Piperidine derivatives
US3875165A (en) * 1973-02-22 1975-04-01 Wyeth John & Brother Ltd (4-Quinolylamino)-(N-piperidyl)benzamides and N-{8 (quinolylamino)-benzoyl{9 piperidines
US4053615A (en) * 1972-10-21 1977-10-11 John Wyeth & Brother Limited Phthalimidopiperidines and anti-convulsant compositions thereof
DK141752B (da) * 1974-07-31 1980-06-09 Ciba Geigy Ag Aalogifremgangsmåde til fremstilling af piperidiner eller salte deraf.
US4000287A (en) * 1974-12-16 1976-12-28 Ciba-Geigy Corporation Isoindolinopiperidines
DD123741A5 (de) * 1975-03-06 1977-01-12
AT345806B (de) * 1975-03-06 1978-10-10 Thomae Gmbh Dr K Verfahren zur herstellung neuer substituierter arylalkylamine und deren salze
IT1090353B (it) * 1976-12-22 1985-06-26 Monsanto Co Ftalimmidi sostituite per regolare la crescita di piante
US4072499A (en) * 1976-12-22 1978-02-07 Monsanto Company Use of pyridyl phthalimides as plant growth regulants
US4115398A (en) * 1977-01-05 1978-09-19 Kowa Company Ltd. Isoindoline derivatives and the acid addition salts thereof and process for the preparation of same
US4124375A (en) * 1977-10-12 1978-11-07 Monsanto Company Substituted phthalimides for regulating the growth of plants
US4309541A (en) * 1978-09-20 1982-01-05 Ciba-Geigy Corporation Piperidinyl-lactams
US4291042A (en) * 1979-01-26 1981-09-22 John Wyeth & Brother Limited Antidepressant piperidine derivatives
SE7907121L (sv) * 1979-08-27 1981-02-28 Astra Laekemedel Ab Ftalimidinderivat
DE3030695A1 (de) * 1980-08-14 1982-03-18 Farmigea S.P.A., Pisa (beta) -diaethylaminoaethylphthalimide mit lokalanaesthetischer und antiarrytmischer akktivitaet, verfahren zu deren herstellung und arzneimittel, welche diese enthalten
GB2082569A (en) * 1980-08-21 1982-03-10 Farmigea Spa Phthalimides
US4724235A (en) * 1981-05-20 1988-02-09 A. H. Robins Company, Incorporated N-(arylthioalkyl)-N'-(aminoalkyl)ureas useful in the treatment of arrhythmia
DK623586A (da) * 1985-12-27 1987-06-28 Eisai Co Ltd Piperidinderivater eller salte deraf og farmaceutiske kompositioner indeholdende forbindelserne
EP0326105A1 (de) * 1988-01-25 1989-08-02 Henning Morgan Henderson Dampfkochgerät
JP2699511B2 (ja) * 1988-01-29 1998-01-19 武田薬品工業株式会社 置換アミン類
FR2628425B1 (fr) * 1988-03-08 1992-04-03 Rhone Poulenc Sante Derives d'isoindolinone, leurs procedes de preparation et les medicaments les contenant
US5026707A (en) * 1988-05-23 1991-06-25 Eli Lilly And Company Ring-substituted 2-amino-1,2,3,4-tetrahydronaphthalenes
US5114976A (en) * 1989-01-06 1992-05-19 Norden Michael J Method for treating certain psychiatric disorders and certain psychiatric symptoms
US5053413A (en) * 1989-09-05 1991-10-01 G. D. Searle & Co. N-benzylpiperidineisoindolinones
FR2667068B1 (fr) * 1990-09-26 1994-09-09 Adir Nouvelles amines alkyl heterocycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
US5595872A (en) * 1992-03-06 1997-01-21 Bristol-Myers Squibb Company Nucleic acids encoding microsomal trigyceride transfer protein
ES2136291T3 (es) * 1994-05-18 1999-11-16 Nisshin Flour Milling Co Derivados de pirimidina.

Also Published As

Publication number Publication date
ATE270287T1 (de) 2004-07-15
ES2219652T3 (es) 2004-12-01
EP0703232A2 (de) 1996-03-27
EP0703232A3 (de) 1996-10-09
US5874458A (en) 1999-02-23
US5869685A (en) 1999-02-09
CA2155796A1 (en) 1996-02-12
US5869502A (en) 1999-02-09
CA2155796C (en) 2004-10-19
PT703232E (pt) 2004-09-30
DK0703232T3 (da) 2004-10-04
JPH0859655A (ja) 1996-03-05
DE69533214T2 (de) 2005-07-21
EP0703232B1 (de) 2004-06-30
US5567718A (en) 1996-10-22
US5874583A (en) 1999-02-23
JP3339996B2 (ja) 2002-10-28

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: AVENTISUB II INC., GREENVILLE, DEL., US

8328 Change in the person/name/address of the agent

Representative=s name: DERZEIT KEIN VERTRETER BESTELLT