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DE69531356D1 - Kristallisierung von levobupivacaine und deren analogen - Google Patents

Kristallisierung von levobupivacaine und deren analogen

Info

Publication number
DE69531356D1
DE69531356D1 DE69531356T DE69531356T DE69531356D1 DE 69531356 D1 DE69531356 D1 DE 69531356D1 DE 69531356 T DE69531356 T DE 69531356T DE 69531356 T DE69531356 T DE 69531356T DE 69531356 D1 DE69531356 D1 DE 69531356D1
Authority
DE
Germany
Prior art keywords
pct
levobupivacaine
crystalization
analogs
sec
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69531356T
Other languages
English (en)
Other versions
DE69531356T2 (de
Inventor
Marianne Langston
Mark Skead
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Darwin Discovery Ltd
Original Assignee
Darwin Discovery Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB9421476A external-priority patent/GB9421476D0/en
Priority claimed from GBGB9504926.8A external-priority patent/GB9504926D0/en
Application filed by Darwin Discovery Ltd filed Critical Darwin Discovery Ltd
Application granted granted Critical
Publication of DE69531356D1 publication Critical patent/DE69531356D1/de
Publication of DE69531356T2 publication Critical patent/DE69531356T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Non-Silver Salt Photosensitive Materials And Non-Silver Salt Photography (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Epoxy Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
DE69531356T 1994-10-25 1995-10-23 Kristallisierung von levobupivacaine und deren analogen Expired - Lifetime DE69531356T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB9421476A GB9421476D0 (en) 1994-10-25 1994-10-25 Process and salt
GB9421476 1994-10-25
GB9504926 1995-03-10
GBGB9504926.8A GB9504926D0 (en) 1995-03-10 1995-03-10 Crystallisation
PCT/GB1995/002513 WO1996012699A1 (en) 1994-10-25 1995-10-23 Crystallisation of levobupivacaine and analogues thereof

Publications (2)

Publication Number Publication Date
DE69531356D1 true DE69531356D1 (de) 2003-08-28
DE69531356T2 DE69531356T2 (de) 2004-05-27

Family

ID=26305863

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69531356T Expired - Lifetime DE69531356T2 (de) 1994-10-25 1995-10-23 Kristallisierung von levobupivacaine und deren analogen

Country Status (16)

Country Link
US (1) US5994548A (de)
EP (1) EP0788480B1 (de)
JP (1) JP3911545B2 (de)
AT (1) ATE245629T1 (de)
AU (1) AU698637B2 (de)
CA (1) CA2200355C (de)
DE (1) DE69531356T2 (de)
DK (1) DK0788480T3 (de)
ES (1) ES2202375T3 (de)
FI (1) FI117438B (de)
HU (1) HU227420B1 (de)
MX (1) MX9703024A (de)
NO (1) NO309266B1 (de)
PL (1) PL183210B1 (de)
PT (1) PT788480E (de)
WO (1) WO1996012699A1 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR0002246A (pt) 2000-04-06 2003-04-15 Cristalia Prod Quimicos Farm Processo de obtenção dos enantiÈmeros da bupivacaìna racêmica, processo de obtenção de composições farmacêuticas a base de levobupivacaìna: composições farmacêuticas a base de levobupivacaìna formuladas nas formas básicas ou sais farmaceuticamente aceitáveis e utilização das composições farmacêuticas a base de levobupivacaìna formuladas nas formas básicas ou sais farmaceuticamente aceitáveis
BRPI0104491B8 (pt) * 2001-10-10 2021-05-25 Cristalia Produtos Quim Farmaceuticos Ltda n-(2,6-dimetilfenil)-1-propil-2-piperidinocarboxamida; processo de obtenção dos enantiômeros; mistura não racêmica dos anantiômeros e seu processo de obtenção e composição farmacêutica.
US20040001889A1 (en) 2002-06-25 2004-01-01 Guohua Chen Short duration depot formulations
US8133507B2 (en) 2002-12-13 2012-03-13 Durect Corporation Oral drug delivery system
US7094812B2 (en) * 2003-04-24 2006-08-22 Xerox Corporations Colorant compositions
US6790267B1 (en) * 2003-04-24 2004-09-14 Xerox Corporation Colorant compositions
PL2415484T3 (pl) 2004-09-17 2014-11-28 Durect Corp Kompozycja znieczulająca miejscowo o przedłużonym uwalnianiu zawierająca SAIB
US20070027105A1 (en) 2005-07-26 2007-02-01 Alza Corporation Peroxide removal from drug delivery vehicle
WO2007123405A1 (en) * 2006-04-25 2007-11-01 Dishman Pharmaceuticals And Chemicals Ltd. Ropivacaine hydrochloride anhydrate and the preparation thereof
EP2117521B1 (de) 2006-11-03 2012-06-27 Durect Corporation Transdermale abgabesysteme mit bupivacain
AU2008347158B8 (en) 2007-12-06 2013-08-22 Durect Corporation Oral pharmaceutical dosage forms
PL2234974T3 (pl) * 2008-01-15 2012-09-28 Pharmathen Sa Sposób otrzymywania związku (s)-1-alkilo-2', 6'-pipekoloksylidydu
US20100260844A1 (en) 2008-11-03 2010-10-14 Scicinski Jan J Oral pharmaceutical dosage forms
CN103073484B (zh) * 2013-01-28 2014-10-22 山东诚创医药技术开发有限公司 一种甲哌卡因及其光学对映体的制备方法
EP2983468A4 (de) 2013-03-15 2016-09-07 Durect Corp Zusammensetzungen mit rheologiemodifikator zur reduzierung der auflösungsvariabilität
CA3028450A1 (en) 2016-07-06 2018-01-11 Durect Corporation Oral dosage form with drug composition, barrier layer and drug layer
CA3048485C (en) * 2016-12-26 2022-07-19 Cellix Bio Private Limited Compositions and methods for the treatment of chronic pain
BR112022013784A2 (pt) 2020-01-13 2022-10-11 Durect Corp Sistemas de distribuição de fármacos de liberação prolongada com impurezas reduzidas e métodos relacionados
KR20230145053A (ko) 2021-01-12 2023-10-17 듀렉트 코퍼레이션 지속 방출 약물 전달 시스템 및 관련 방법

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE341404B (de) * 1967-05-18 1971-12-27 Sterling Drug Inc
US4695576A (en) * 1984-07-09 1987-09-22 Astra Lake Medel Aktiebolag L-N-n-propylpipecolic acid-2,6-xylidide

Also Published As

Publication number Publication date
CA2200355C (en) 2007-03-06
MX9703024A (es) 1997-10-31
AU698637B2 (en) 1998-11-05
HUT77631A (hu) 1998-06-29
US5994548A (en) 1999-11-30
JP3911545B2 (ja) 2007-05-09
EP0788480A1 (de) 1997-08-13
WO1996012699A1 (en) 1996-05-02
DE69531356T2 (de) 2004-05-27
FI971711L (fi) 1997-04-22
ATE245629T1 (de) 2003-08-15
JPH10507464A (ja) 1998-07-21
CA2200355A1 (en) 1996-05-02
PT788480E (pt) 2003-12-31
NO971903D0 (no) 1997-04-24
PL319829A1 (en) 1997-09-01
HU227420B1 (en) 2011-05-30
ES2202375T3 (es) 2004-04-01
FI117438B (fi) 2006-10-13
AU3704895A (en) 1996-05-15
FI971711A0 (fi) 1997-04-22
NO971903L (no) 1997-04-24
EP0788480B1 (de) 2003-07-23
NO309266B1 (no) 2001-01-08
PL183210B1 (pl) 2002-06-28
DK0788480T3 (da) 2003-09-29

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Legal Events

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