[go: up one dir, main page]

DE68917024D1 - 4(1H)-Chinolonderivate. - Google Patents

4(1H)-Chinolonderivate.

Info

Publication number
DE68917024D1
DE68917024D1 DE68917024T DE68917024T DE68917024D1 DE 68917024 D1 DE68917024 D1 DE 68917024D1 DE 68917024 T DE68917024 T DE 68917024T DE 68917024 T DE68917024 T DE 68917024T DE 68917024 D1 DE68917024 D1 DE 68917024D1
Authority
DE
Germany
Prior art keywords
quinolone derivatives
quinolone
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE68917024T
Other languages
English (en)
Inventor
Tatsushi C O Kirin Beer Osawa
Hideo C O Kirin Beer Kabu Ohta
Kohji C O Kirin Beer K Akimoto
Katsuhiko C O Kirin Bee Harada
Hiroshi C O Kirin Beer Ka Soga
Yasuhiro C O Kirin Beer Jinno
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kirin Brewery Co Ltd
Original Assignee
Kirin Brewery Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP1120991A external-priority patent/JPH02288864A/ja
Application filed by Kirin Brewery Co Ltd filed Critical Kirin Brewery Co Ltd
Application granted granted Critical
Publication of DE68917024D1 publication Critical patent/DE68917024D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/233—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/24—Oxygen atoms attached in position 8
    • C07D215/26—Alcohols; Ethers thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/36—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE68917024T 1988-05-24 1989-05-23 4(1H)-Chinolonderivate. Expired - Lifetime DE68917024D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP12624988 1988-05-24
JP3328089 1989-02-13
JP1120991A JPH02288864A (ja) 1988-05-24 1989-05-15 ４（１ｈ）キノロン誘導体

Publications (1)

Publication Number Publication Date
DE68917024D1 true DE68917024D1 (de) 1994-09-01

Family

ID=27288021

Family Applications (1)

Application Number Title Priority Date Filing Date
DE68917024T Expired - Lifetime DE68917024D1 (de) 1988-05-24 1989-05-23 4(1H)-Chinolonderivate.

Country Status (3)

Country Link
US (1) US5081121A (de)
EP (1) EP0343574B1 (de)
DE (1) DE68917024D1 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL100555A (en) * 1991-02-07 2000-08-31 Hoechst Marion Roussel Inc N-substituted quinoline derivatives their preparation their use for the preparation of medicaments and the pharmaceutical compositions containing them
FR2672597B1 (fr) * 1991-02-07 1995-05-19 Roussel Uclaf Nouveaux derives n-substitues de la quinoleine, leur procede de preparation, les nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant.
FR2680511B1 (fr) * 1991-08-20 1995-05-19 Roussel Uclaf Derives n-substitues de la quinoleine, leur procede de preparation, intermediaires obtenus, leur application comme medicaments et les compositions les renfermant.
FR2684671B1 (fr) * 1991-11-20 1995-05-19 Roussel Uclaf Nouveaux derives de la quinoleine, leur procede de preparation et intermediaires et leur application a titre de medicaments.
US5250691A (en) * 1991-09-09 1993-10-05 E. R. Squibb & Sons, Inc. Heteroaryl derivatives of monocyclic beta-lactam antibiotics
AU4780793A (en) * 1992-07-22 1994-02-14 Genelabs Technologies, Inc. 2-aryl-4-quinolones as antitumor compounds
ES2049652B1 (es) * 1992-09-16 1994-10-01 Genesis Para La Investigacion Procedimiento para la preparacion de un acido quinolin carboxilico.
ES2050613B1 (es) * 1992-10-16 1996-03-16 Iteve S A Nuevo procedimiento para la preparacion de derivados del acido 1-ciclopropil-3-quinolincarboxilico.
JP3676415B2 (ja) * 1994-03-01 2005-07-27 石原産業株式会社 ５，７−ジクロロ−４−ヒドロキシキノリンの製造方法
US5571822A (en) * 1994-09-30 1996-11-05 The University Of North Carolina At Chapel Hill Antitumor compounds
WO1996011187A1 (en) * 1994-10-07 1996-04-18 Zenyaku Kogyo Kabushiki Kaisha Thioquinolone derivative
ATE244225T1 (de) 1997-04-18 2003-07-15 Kirin Brewery Verfahren zur herstellung von chinolinderivaten
ATE277017T1 (de) * 1999-08-30 2004-10-15 Maruishi Pharma 1,2-disubstituierte 1,4-dihydro-4-oxochinolin- verbindungen
EP1732541A4 (de) 2004-04-07 2008-03-05 Takeda Pharmaceutical Cyclische verbindungen
TWI366565B (en) * 2007-06-06 2012-06-21 Otsuka Pharma Co Ltd Quinolone compound and pharmaceutical composition
GB0716532D0 (en) 2007-08-24 2007-10-03 Angeletti P Ist Richerche Bio Therapeutic compounds
US8877752B2 (en) * 2011-10-28 2014-11-04 University Of South Florida 4(1H)-quinolones having antimalarial activity with reduced chemical resistance
CA3108484A1 (en) * 2017-08-04 2019-02-07 Anthony Stewart Campbell Inhibitors of microbially induced amyloid

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2558211A (en) * 1949-04-14 1951-06-26 Lilly Co Eli Preparation of 4-hydroxyquinoline compounds
US3178348A (en) * 1961-02-08 1965-04-13 Norwich Pharma Co Hypotensive quinolines
GB1188365A (en) * 1967-05-04 1970-04-15 May & Baker Ltd Quinoline Derivatives
US4168311A (en) * 1973-12-10 1979-09-18 Hoechst Aktiengesellschaft Hydroxyquinoline carbamates and n-oxide hydroxyquinoline carbamates and their use as insecticides
DE2905877A1 (de) * 1979-02-16 1980-08-28 Boehringer Mannheim Gmbh Neue aminopropanolderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
ZA801575B (en) * 1979-03-27 1981-03-25 Boots Co Ltd Therapeutic agents
GB2085441B (en) * 1980-09-26 1984-10-17 Boots The Co Ltd Therapeutic agents
DE3576686D1 (de) * 1984-08-15 1990-04-26 Boots Co Ltd Chinolinone, verfahren zu ihrer herstellung und die sie enthaltenden pharmazeutischen praeparate.
FR2582514B1 (fr) * 1985-05-30 1988-02-19 Rhone Poulenc Sante Medicaments a base d'amides, nouveaux amides et leur preparation
GB8515209D0 (en) * 1985-06-15 1985-07-17 Boots Co Plc Therapeutic agents

Also Published As

Publication number Publication date
US5081121A (en) 1992-01-14
EP0343574A1 (de) 1989-11-29
EP0343574B1 (de) 1994-07-27

Similar Documents

Publication Publication Date Title
NL300161I2 (nl) Carbostyrilderivaten.
DE69009785D1 (de) Carbostyrilderivate.
DE69132519D1 (de) Quinolin-Derivate
DE69008682D1 (de) Guanidinobenzolderivate.
DE68917024D1 (de) 4(1H)-Chinolonderivate.
DE3872153D1 (de) 25-hydroxy-vitamin-d3-derivate.
ATE124407T1 (de) Chromanderivate.
FI883963A7 (fi) Isoxazol- -karbolinderivat.
ATE119146T1 (de) Substituierte bicycloheptadionderivate.
ATE116985T1 (de) Chromanderivate.
DE69017657D1 (de) Pyridinderivate.
FI934710A7 (fi) 4-aryyli-3-(heteroaryyliureido)kinoliinijohdannaisia
NO891027L (no) Kinolinderivater.
FI883959A7 (fi) 3'-demetoxiepipodofyllotoxin -glukosidderivat.
FI880814A7 (fi) Imidazodiazepin-derivat.
FI901383A7 (fi) Kinoliinijohdannaisia
DE59000510D1 (de) N-phenyltetrahydroindazolderivate.
DE69005904D1 (de) Phenylpyrimidonderivate.
FI904891L (fi) Fenylsulfonderivat.
DE59003499D1 (de) 3-Cyano-4-phenyl-pyrrol-Derivate.
DE3861208D1 (de) Hydroxyalkyl-triazolyl-derivate.
FI881802L (fi) Tiadiazolylacetamidocefemderivat.
FI885920L (fi) Piperidinylcyklopentylheptensyra -derivat innehaollande vattenhaltiga sammansaettningar.
DE69015726D1 (de) Piperidylthiocarbapenem-Derivate.
DE69004991D1 (de) Diphenyldiacetylenderivate.

Legal Events

Date Code Title Description
8332 No legal effect for de