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FR2680511B1 - Derives n-substitues de la quinoleine, leur procede de preparation, intermediaires obtenus, leur application comme medicaments et les compositions les renfermant. - Google Patents

Derives n-substitues de la quinoleine, leur procede de preparation, intermediaires obtenus, leur application comme medicaments et les compositions les renfermant.

Info

Publication number
FR2680511B1
FR2680511B1 FR9110433A FR9110433A FR2680511B1 FR 2680511 B1 FR2680511 B1 FR 2680511B1 FR 9110433 A FR9110433 A FR 9110433A FR 9110433 A FR9110433 A FR 9110433A FR 2680511 B1 FR2680511 B1 FR 2680511B1
Authority
FR
France
Prior art keywords
medicaments
substituted
application
preparation process
compositions containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR9110433A
Other languages
English (en)
Other versions
FR2680511A1 (fr
Inventor
Francois Clemence
Michel Fortin
Jean-Luc Haesslein
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Priority to FR9110433A priority Critical patent/FR2680511B1/fr
Priority to IL10055591A priority patent/IL100555A/xx
Priority to MA22697A priority patent/MA22410A1/fr
Priority to JP04759492A priority patent/JP3599350B2/ja
Priority to AT92400294T priority patent/ATE187964T1/de
Priority to ES92400294T priority patent/ES2141098T3/es
Priority to DK92400294T priority patent/DK0498721T3/da
Priority to PT92400294T priority patent/PT498721E/pt
Priority to DE69230449T priority patent/DE69230449T2/de
Priority to EP92400294A priority patent/EP0498721B1/fr
Priority to SU5010859A priority patent/RU2125047C1/ru
Priority to IE039592A priority patent/IE920395A1/en
Priority to HU9200367A priority patent/HUT64524A/hu
Priority to KR1019920001715A priority patent/KR100334208B1/ko
Priority to FI920504A priority patent/FI103574B/fi
Priority to OA60146A priority patent/OA09528A/fr
Priority to PL92293414A priority patent/PL169672B1/pl
Priority to CA002060843A priority patent/CA2060843A1/fr
Priority to NZ241546A priority patent/NZ241546A/en
Priority to BR929200432A priority patent/BR9200432A/pt
Priority to CN92100765A priority patent/CN1064076A/zh
Priority to CS1992357A priority patent/CZ291217B6/cs
Priority to TW081101181A priority patent/TW214554B/zh
Publication of FR2680511A1 publication Critical patent/FR2680511A1/fr
Application granted granted Critical
Publication of FR2680511B1 publication Critical patent/FR2680511B1/fr
Priority to US08/964,182 priority patent/US5985894A/en
Priority to GR20000400410T priority patent/GR3032711T3/el
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/233—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/36—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C07D237/28—Cinnolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FR9110433A 1991-02-07 1991-08-20 Derives n-substitues de la quinoleine, leur procede de preparation, intermediaires obtenus, leur application comme medicaments et les compositions les renfermant. Expired - Fee Related FR2680511B1 (fr)

Priority Applications (25)

Application Number Priority Date Filing Date Title
FR9110433A FR2680511B1 (fr) 1991-08-20 1991-08-20 Derives n-substitues de la quinoleine, leur procede de preparation, intermediaires obtenus, leur application comme medicaments et les compositions les renfermant.
IL10055591A IL100555A (en) 1991-02-07 1991-12-30 N-substituted quinoline derivatives their preparation their use for the preparation of medicaments and the pharmaceutical compositions containing them
MA22697A MA22410A1 (fr) 1991-02-07 1992-02-04 Nouveaux derives n-substitues de la quinoleine, leur procede de preparation, les nouveaux intermediaires , leur application et les compositions les renfermant
JP04759492A JP3599350B2 (ja) 1991-02-07 1992-02-04 新規なｎ−置換キノリン誘導体、それらの製造法、それらの薬剤としての使用及びそれらを含有する製薬組成物
ES92400294T ES2141098T3 (es) 1991-02-07 1992-02-05 Derivados n-sustituidos de la quinolina, su procedimiento de preparacion, su aplicacion como medicamentos, y composiciones farmaceuticas que los contienen.
DK92400294T DK0498721T3 (da) 1991-02-07 1992-02-05 Nye N-substituerede quinolinforbindelser, fremgangsmåde til deres fremstilling, mellemprodukter deraf, deres anvendelse som
PT92400294T PT498721E (pt) 1991-02-07 1992-02-05 Derivados n-substituidos da quinoleina, seu processo de preparacao, sua aplicacao a titulo de medicamentos e composicoes farmaceuticas que os contem
DE69230449T DE69230449T2 (de) 1991-02-07 1992-02-05 N-substituierte Chinolinderivate, Verfahren zur Herstellung, ihre Verwendung als Arzneimittel und diese enthaltende pharmazeutische Zusammensetzungen
EP92400294A EP0498721B1 (fr) 1991-02-07 1992-02-05 Dérivés N-substitués de la quinoléine, leur procédé de préparation, leur application à titre de médicaments et les compositions pharmaceutiques les renfermant
AT92400294T ATE187964T1 (de) 1991-02-07 1992-02-05 N-substituierte chinolinderivate, verfahren zur herstellung, ihre verwendung als arzneimittel und diese enthaltende pharmazeutische zusammensetzungen
KR1019920001715A KR100334208B1 (ko) 1991-02-07 1992-02-06 신규한n-치환퀴놀린유도체,그의제조방법,신규중간체,약제로서의그의용도및그를함유하는제약조성물
HU9200367A HUT64524A (en) 1991-02-07 1992-02-06 Process for the production of novel n-substituted kinoline derivatives and of medical preparations containing them
SU5010859A RU2125047C1 (ru) 1991-02-07 1992-02-06 N-производные хинолина или их аддитивные соли с неорганическими и органическими кислотами или с неорганическими и органическими основаниями, способы их получения и фармацевтическая композиция на их основе
FI920504A FI103574B (fi) 1991-02-07 1992-02-06 Menetelmä terapeuttisesti käyttökelpoisten, N-substituoitujen kinoliin i- ja kinnoliinijohdannaisten valmistamiseksi
IE039592A IE920395A1 (en) 1991-02-07 1992-02-06 New n-substituted quinoline derivatives, their preparation¹process, the new intermediates obtained, their use as¹medicaments and the pharmaceutical compositions containing¹them
NZ241546A NZ241546A (en) 1991-02-07 1992-02-07 N-substituted quinoline and cinnoline derivatives, preparation and pharmaceutical compositions thereof
PL92293414A PL169672B1 (pl) 1991-02-07 1992-02-07 Sposób wytwarzania nowych N-podstawionych pochodnych chinoliny PL PL
CA002060843A CA2060843A1 (fr) 1991-02-07 1992-02-07 Derives n-substitues de la quinoleine, leur procede de preparation, les nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions pharmaceutiques les renfermants
OA60146A OA09528A (fr) 1991-02-07 1992-02-07 Nouveaux dérivés N-substitues de la quinoléine leur procédé de préparation les nouveaux intermédiaires obtenus leur application à titre de médicaments et les compositions pharmaceutiques les renfermant
BR929200432A BR9200432A (pt) 1991-02-07 1992-02-07 Processo para preparar produtos e processo de preparacao de composicoes farmaceuticas
CN92100765A CN1064076A (zh) 1991-02-07 1992-02-07 N-取代的喹啉衍生物、其制法、中间 体、用途和组合物
CS1992357A CZ291217B6 (cs) 1991-02-07 1992-02-07 N-Substituované deriváty chinolinu, způsob jejich přípravy, tyto deriváty jako léčiva, farmaceutické kompozice tyto deriváty obsahující a pouľití těchto derivátů pro přípravu léčiva
TW081101181A TW214554B (fr) 1991-02-07 1992-02-18
US08/964,182 US5985894A (en) 1991-02-07 1997-11-04 N-substituted quinolines
GR20000400410T GR3032711T3 (en) 1991-02-07 2000-02-18 N-substituted quinoline derivatives, process for their preparation, intermediates obtained, their use as pharmaceuticals and pharmaceutical compositions containing them.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9110433A FR2680511B1 (fr) 1991-08-20 1991-08-20 Derives n-substitues de la quinoleine, leur procede de preparation, intermediaires obtenus, leur application comme medicaments et les compositions les renfermant.

Publications (2)

Publication Number Publication Date
FR2680511A1 FR2680511A1 (fr) 1993-02-26
FR2680511B1 true FR2680511B1 (fr) 1995-05-19

Family

ID=9416271

Family Applications (1)

Application Number Title Priority Date Filing Date
FR9110433A Expired - Fee Related FR2680511B1 (fr) 1991-02-07 1991-08-20 Derives n-substitues de la quinoleine, leur procede de preparation, intermediaires obtenus, leur application comme medicaments et les compositions les renfermant.

Country Status (1)

Country Link
FR (1) FR2680511B1 (fr)

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1419789A (en) * 1972-08-02 1975-12-31 Pfizer 2-trifluoromethyl-4-quinolinols
GB1432649A (fr) * 1973-09-07 1976-04-22 Ici Ltd
GB1472767A (en) * 1974-11-07 1977-05-04 Ici Ltd Process for the preparation of cinnoline derivatives
FR2377400A2 (fr) * 1977-01-18 1978-08-11 Roussel Uclaf Nouveaux derives de l'acide 3-quinoleine carboxylique, leur procede de preparation et leur application comme medicament
NZ193167A (en) * 1979-03-27 1984-08-24 Boots Co Plc Quinoline derivatives and pharmaceutical compositions
JPS58219166A (ja) * 1982-06-14 1983-12-20 Nippon Shinyaku Co Ltd ４−キノロン誘導体
JPS6461461A (en) * 1987-09-01 1989-03-08 Otsuka Pharma Co Ltd Benzohetero ring derivative
US5081121A (en) * 1988-05-24 1992-01-14 Tatsushi Osawa 4(1h)-quinolone derivatives

Also Published As

Publication number Publication date
FR2680511A1 (fr) 1993-02-26

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CD Change of name or company name
TP Transmission of property
ST Notification of lapse