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DE60335000D1 - In vitro peptid-expressionsbank - Google Patents

In vitro peptid-expressionsbank

Info

Publication number
DE60335000D1
DE60335000D1 DE60335000T DE60335000T DE60335000D1 DE 60335000 D1 DE60335000 D1 DE 60335000D1 DE 60335000 T DE60335000 T DE 60335000T DE 60335000 T DE60335000 T DE 60335000T DE 60335000 D1 DE60335000 D1 DE 60335000D1
Authority
DE
Germany
Prior art keywords
peptide expression
vitro peptide
library
expression bank
making
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60335000T
Other languages
English (en)
Inventor
Duncan Mcgregor
Richard Odegrip
Kevin Fitzgerald
Rosemarie Hederer
Bill Eldridge
Chris Ullman
Philip Kuhlman
David Coomber
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Isogenica Ltd
Original Assignee
Isogenica Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0220759A external-priority patent/GB0220759D0/en
Priority claimed from GB0304521A external-priority patent/GB0304521D0/en
Priority claimed from GB0304657A external-priority patent/GB0304657D0/en
Application filed by Isogenica Ltd filed Critical Isogenica Ltd
Application granted granted Critical
Publication of DE60335000D1 publication Critical patent/DE60335000D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1075—Isolating an individual clone by screening libraries by coupling phenotype to genotype, not provided for in other groups of this subclass
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/80—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Plant Pathology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
DE60335000T 2002-09-06 2003-09-05 In vitro peptid-expressionsbank Expired - Lifetime DE60335000D1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB0220759A GB0220759D0 (en) 2002-09-06 2002-09-06 Display library
GB0304521A GB0304521D0 (en) 2003-02-27 2003-02-27 Display library
GB0304657A GB0304657D0 (en) 2003-02-28 2003-02-28 Display library
PCT/GB2003/003860 WO2004022746A1 (en) 2002-09-06 2003-09-05 In vitro peptide expression libraray

Publications (1)

Publication Number Publication Date
DE60335000D1 true DE60335000D1 (de) 2010-12-30

Family

ID=31982028

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60335000T Expired - Lifetime DE60335000D1 (de) 2002-09-06 2003-09-05 In vitro peptid-expressionsbank

Country Status (14)

Country Link
US (2) US7842476B2 (de)
EP (2) EP2385118A1 (de)
JP (1) JP4664677B2 (de)
KR (1) KR101051245B1 (de)
CN (1) CN100351375C (de)
AT (1) ATE488586T1 (de)
AU (1) AU2003260786B2 (de)
CA (1) CA2497496C (de)
DE (1) DE60335000D1 (de)
DK (1) DK1534830T3 (de)
IL (1) IL166903A (de)
NO (1) NO332949B1 (de)
PT (1) PT1534830E (de)
WO (1) WO2004022746A1 (de)

Families Citing this family (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0418651D0 (en) 2004-08-20 2004-09-22 Medical Res Council Method
GB0505420D0 (en) * 2005-03-16 2005-04-20 Isogenica Ltd Stable ligand selection method
GB0515115D0 (en) 2005-07-22 2005-08-31 Isogenica Ltd Peptide characterisation
GB0806562D0 (en) 2008-04-10 2008-05-14 Fermentas Uab Production of nucleic acid
ES2752025T3 (es) * 2008-07-25 2020-04-02 Wagner Richard W Métodos de cribado de proteínas
EP3128048B1 (de) 2008-10-31 2018-11-28 Janssen Biotech, Inc. Auf fibronectin-typ-iii-domain basierende gerüstzusammensetzungen, verfahren und verwendung
WO2010099477A2 (en) 2009-02-27 2010-09-02 Atyr Pharma, Inc. Polypeptide structural motifs associated with cell signaling activity
GB201000352D0 (en) 2010-01-11 2010-02-24 Isogenica Ltd Antimicrobial peptides
WO2011139714A2 (en) 2010-04-26 2011-11-10 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of cysteinyl-trna synthetase
CN103096911B (zh) 2010-04-27 2018-05-29 Atyr 医药公司 与异亮氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现
CN103096910A (zh) 2010-04-27 2013-05-08 Atyr医药公司 与苏氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现
CN103097524B (zh) 2010-04-28 2016-08-03 Atyr医药公司 与丙氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现
AU2011248457B2 (en) 2010-04-29 2017-02-16 Pangu Biopharma Limited Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of valyl tRNA synthetases
CN103097523B (zh) 2010-04-29 2016-09-28 Atyr医药公司 与天冬酰胺酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现
RU2767543C2 (ru) 2010-04-30 2022-03-17 Янссен Байотек, Инк. Композиции на основе стабилизированных фибронектиновых доменов, способы и области их применения
CA2797978C (en) 2010-05-03 2019-12-03 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of methionyl-trna synthetases
EP2566515B1 (de) 2010-05-03 2017-08-02 aTyr Pharma, Inc. Innovative entdeckung von therapeutischen und diagnostischen mitteln sowie antikörperzusammensetzungen im zusammenhang mit proteinfragmenten von arginyl-trna-synthetasen
WO2011140132A2 (en) 2010-05-03 2011-11-10 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of phenylalanyl-alpha-trna synthetases
US8946157B2 (en) 2010-05-03 2015-02-03 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of seryl-tRNA synthetases
JP6008843B2 (ja) 2010-05-04 2016-10-19 エータイアー ファーマ， インコーポレイテッド グルタミル−プロリルｔＲＮＡ合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見
CN102985103A (zh) 2010-05-04 2013-03-20 Atyr医药公司 与p38多-tRNA合成酶复合物相关的治疗、诊断和抗体组合物的创新发现
US8945541B2 (en) 2010-05-14 2015-02-03 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of phenylalanyl-beta-tRNA synthetases
WO2011146410A2 (en) 2010-05-17 2011-11-24 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of leucyl-trna synthetases
CA2800375C (en) 2010-05-27 2021-03-09 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glutaminyl-trna synthetases
CN103118694B (zh) 2010-06-01 2016-08-03 Atyr医药公司 与赖氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的发现
CA2804424C (en) 2010-07-12 2021-03-30 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of histidyl-trna synthetases
CA2804416C (en) 2010-07-12 2020-04-28 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glycyl-trna synthetases
US8999321B2 (en) 2010-07-12 2015-04-07 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glycyl-tRNA synthetases
KR102099730B1 (ko) 2010-07-12 2020-04-16 에이티와이알 파마, 인코포레이티드 아스파르틸­trna 합성효소의 단백질 단편에 관련된 치료적, 진단적, 및 항체 조성물의 혁신적 발견
GB201013284D0 (en) 2010-08-06 2010-09-22 Isogenica Ltd Scaffold peptides
CA2808539C (en) 2010-08-25 2021-05-25 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of tyrosyl-trna synthetases
CA2812795C (en) 2010-10-06 2021-08-31 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related protein fragments of tryptophanyl trna synthetases
EP2647704B1 (de) 2010-12-01 2017-11-01 Mitsubishi Tanabe Pharma Corporation Polynukleotidkonstrukt zur präsentation von fab in einem zellulären übersetzungssystem sowie verfahren zur herstellung und zum screening von fab damit
US9714419B2 (en) 2011-08-09 2017-07-25 Atyr Pharma, Inc. PEGylated tyrosyl-tRNA synthetase polypeptides
CN103827361A (zh) 2011-09-27 2014-05-28 詹森生物科技公司 具有可供选择的结合表面的基于iii型纤连蛋白重复的蛋白质支架
US20130090266A1 (en) 2011-10-11 2013-04-11 Biolauncher Ltd. Methods and systems for optimization of peptide screening
US20130090247A1 (en) 2011-10-11 2013-04-11 Biolauncher Ltd. Methods and systems for identification of binding pharmacophores
US20130090265A1 (en) 2011-10-11 2013-04-11 Biolauncher Ltd. Systems and methods for generation of context-specific, molecular field-based amino acid substitution matrices
US9816084B2 (en) 2011-12-06 2017-11-14 Atyr Pharma, Inc. Aspartyl-tRNA synthetases
US9822353B2 (en) 2011-12-06 2017-11-21 Atyr Pharma, Inc. PEGylated aspartyl-tRNA synthetase polypeptides
CN104220461A (zh) 2011-12-29 2014-12-17 Atyr医药公司 天冬氨酰-tRNA合成酶-FC缀合物
GB2500243A (en) * 2012-03-15 2013-09-18 Isogenica Ltd Identifying members of immobilised peptide libraries comprising protein-DNA complexes
US9695228B2 (en) 2012-11-21 2017-07-04 Janssen Biotech, Inc. EGFR and c-Met fibronectin type III domain binding molecules
ES2700231T3 (es) 2012-11-21 2019-02-14 Janssen Biotech Inc Anticuerpos de EGFR/c-Met biespecíficos
JP6397479B2 (ja) 2013-03-15 2018-09-26 エータイアー ファーマ， インコーポレイテッド ヒスチジル−ｔＲＮＡシンテターゼＦｃコンジュゲート
MX378238B (es) 2013-10-14 2025-03-10 Janssen Biotech Inc Moléculas de unión con dominios de fibronectina de tipo iii modificadas con cisteína.
CN107614703A (zh) 2015-02-27 2018-01-19 香港大学 Dna展示及其方法
KR102788389B1 (ko) 2015-04-06 2025-03-31 서브도메인, 엘엘씨 드 노보 결합 도메인 함유 폴리펩티드 및 그의 용도
KR102625793B1 (ko) 2015-05-06 2024-01-15 얀센 바이오테크 인코포레이티드 전립선 특이적 막 항원 결합 피브로넥틴 iii형 도메인
SG11201810687SA (en) * 2016-06-03 2018-12-28 Janssen Biotech Inc Serum albumin-binding fibronectin type iii domains
MA45412A (fr) 2016-06-21 2021-05-26 Janssen Biotech Inc Molécules de liaison au domaine de fibronectine de type iii modifiées par la cystéine
CN109715199A (zh) 2016-09-14 2019-05-03 詹森生物科技公司 包含bcma特异性iii型纤连蛋白结构域的嵌合抗原受体及其用途
EP3554535A4 (de) 2016-12-14 2020-10-21 Janssen Biotech, Inc. Pd-l1-bindende fibronectin-typ iii-domänen
RU2759952C2 (ru) 2016-12-14 2021-11-19 Янссен Байотек, Инк. Cd8a-связывающие домены типа iii фибронектина
WO2018111978A1 (en) 2016-12-14 2018-06-21 Janssen Biotech, Inc. Cd137 binding fibronectin type iii domains
WO2018175383A1 (en) 2017-03-22 2018-09-27 Research Corporation Technologies, Inc. Engineered stable ch2 polypeptides
CN110536694A (zh) 2017-04-20 2019-12-03 Atyr 医药公司 用于治疗肺部炎症的组合物和方法
US11078263B2 (en) 2017-08-25 2021-08-03 Janssen Biotech, Inc. Fc γ RIII binding fibronectin type III domains, their conjugates and multispecific molecules comprising them
WO2021076546A1 (en) 2019-10-14 2021-04-22 Aro Biotherapeutics Company Cd71 binding fibronectin type iii domains
WO2021076543A1 (en) 2019-10-14 2021-04-22 Aro Biotherapeutics Company Epcam binding fibronectin type iii domains
US11781138B2 (en) 2019-10-14 2023-10-10 Aro Biotherapeutics Company FN3 domain-siRNA conjugates and uses thereof
CA3161723A1 (en) 2019-12-18 2021-06-24 Karyn O'neil Serum albumin-binding fibronectin type iii domains and uses thereof
AU2022258584A1 (en) 2021-04-14 2023-10-12 Aro Biotherapeutics Company Fn3 domain-sirna conjugates and uses thereof
KR20240034160A (ko) 2021-04-14 2024-03-13 에이알오 바이오테라퓨틱스 컴패니 Cd71 결합 피브로넥틴 3형 도메인

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0494955B1 (de) 1989-10-05 1998-07-15 Optein, Inc. Zellfreie synthese und isolierung von genen und polypeptiden
CA2112130C (en) * 1991-06-27 1996-08-06 Cynthia A. Edwards Screening assay for the detection of dna-binding molecules
US5733731A (en) 1991-10-16 1998-03-31 Affymax Technologies N.V. Peptide library and screening method
GB9703369D0 (en) * 1997-02-18 1997-04-09 Lindqvist Bjorn H Process
US6620587B1 (en) 1997-05-28 2003-09-16 Discerna Limited Ribosome complexes as selection particles for in vitro display and evolution of proteins
DE69841997D1 (de) 1997-07-07 2010-12-23 Medical Res Council London In-vitro-Sortierverfahren
GB9718455D0 (en) * 1997-09-02 1997-11-05 Mcgregor Duncan P Chimeric binding peptide library screening method
GB9900298D0 (en) 1999-01-07 1999-02-24 Medical Res Council Optical sorting method
EP1163339A1 (de) 1999-04-01 2001-12-19 Innogenetics N.V. Eine polypeptidstruktur zur verwendung als gerüst
WO2002046395A1 (fr) 2000-12-07 2002-06-13 Keio University Proteine a c-terminaison modifiee et procede permettant d'obtenir cette proteine, agent de modification et matrice de traduction necessaire a la production d'une proteine a c-terminaison modifiee, et procede de detection de l'interaction proteique avec l'utilisation de ladite proteine
JP4963142B2 (ja) 2000-12-14 2012-06-27 学校法人慶應義塾 遺伝子型と表現型の対応付け分子とその構成要素、および対応付け分子の製造方法と利用方法
JP3706942B2 (ja) 2001-08-07 2005-10-19 学校法人慶應義塾 物質と蛋白質との間の相互作用の検出方法、物質と相互作用する蛋白質のスクリーニング方法、及び、物質とその物質と相互作用する蛋白質との複合体の形成方法
US20060156511A1 (en) * 2005-01-19 2006-07-20 Li Yuan J Caster

Also Published As

Publication number Publication date
CA2497496C (en) 2012-05-15
KR101051245B1 (ko) 2011-07-21
KR20050057216A (ko) 2005-06-16
EP1534830B1 (de) 2010-11-17
JP2005537795A (ja) 2005-12-15
HK1072957A1 (en) 2005-09-16
EP2385118A1 (de) 2011-11-09
AU2003260786B2 (en) 2008-03-13
CA2497496A1 (en) 2004-03-18
NO20051685L (no) 2005-06-06
US20060035232A1 (en) 2006-02-16
CN1681924A (zh) 2005-10-12
IL166903A (en) 2012-06-28
US20120149591A1 (en) 2012-06-14
US7842476B2 (en) 2010-11-30
CN100351375C (zh) 2007-11-28
NO332949B1 (no) 2013-02-04
EP1534830A1 (de) 2005-06-01
JP4664677B2 (ja) 2011-04-06
US8679781B2 (en) 2014-03-25
WO2004022746A1 (en) 2004-03-18
PT1534830E (pt) 2011-01-31
ATE488586T1 (de) 2010-12-15
AU2003260786A1 (en) 2004-03-29
DK1534830T3 (da) 2011-02-14

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