NO20051685L - In vitro peptidekspresjonsbibliotek - Google Patents
In vitro peptidekspresjonsbibliotekInfo
- Publication number
- NO20051685L NO20051685L NO20051685A NO20051685A NO20051685L NO 20051685 L NO20051685 L NO 20051685L NO 20051685 A NO20051685 A NO 20051685A NO 20051685 A NO20051685 A NO 20051685A NO 20051685 L NO20051685 L NO 20051685L
- Authority
- NO
- Norway
- Prior art keywords
- library
- peptide expression
- expression library
- vitro peptide
- making
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 4
- 238000000338 in vitro Methods 0.000 title abstract 2
- 108020004414 DNA Proteins 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 230000004568 DNA-binding Effects 0.000 abstract 1
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
- 238000002955 isolation Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1075—Isolating an individual clone by screening libraries by coupling phenotype to genotype, not provided for in other groups of this subclass
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/80—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Computational Biology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
Det er beskrevet en fremgangsmåte for å fremstille in vitro peptid-ekspresjonsbibliotek, og for isoleringen av nukleotidsekvenser som koder for peptider av interesse, hvori peptidet eller proteiner er spesifikt assosiert med DNA-et som koder for dem gjennom ikke-kovalent binding av protein:DNA. Fremgangsmåten beskriver hvordan å lage biblioteket i seg selv, DNA-molekyler som koder for biblioteket og anvendelser av ekspresjonsbiblioteket
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0220759A GB0220759D0 (en) | 2002-09-06 | 2002-09-06 | Display library |
| GB0304521A GB0304521D0 (en) | 2003-02-27 | 2003-02-27 | Display library |
| GB0304657A GB0304657D0 (en) | 2003-02-28 | 2003-02-28 | Display library |
| PCT/GB2003/003860 WO2004022746A1 (en) | 2002-09-06 | 2003-09-05 | In vitro peptide expression libraray |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20051685L true NO20051685L (no) | 2005-06-06 |
| NO332949B1 NO332949B1 (no) | 2013-02-04 |
Family
ID=31982028
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20051685A NO332949B1 (no) | 2002-09-06 | 2005-04-05 | Fremgangsmate for fremstilling av et in vitro peptidekspresjonsbibliotek av DNA-bundne peptider |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US7842476B2 (no) |
| EP (2) | EP2385118A1 (no) |
| JP (1) | JP4664677B2 (no) |
| KR (1) | KR101051245B1 (no) |
| CN (1) | CN100351375C (no) |
| AT (1) | ATE488586T1 (no) |
| AU (1) | AU2003260786B2 (no) |
| CA (1) | CA2497496C (no) |
| DE (1) | DE60335000D1 (no) |
| DK (1) | DK1534830T3 (no) |
| IL (1) | IL166903A (no) |
| NO (1) | NO332949B1 (no) |
| PT (1) | PT1534830E (no) |
| WO (1) | WO2004022746A1 (no) |
Families Citing this family (64)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0418651D0 (en) * | 2004-08-20 | 2004-09-22 | Medical Res Council | Method |
| GB0505420D0 (en) * | 2005-03-16 | 2005-04-20 | Isogenica Ltd | Stable ligand selection method |
| GB0515115D0 (en) * | 2005-07-22 | 2005-08-31 | Isogenica Ltd | Peptide characterisation |
| GB0806562D0 (en) | 2008-04-10 | 2008-05-14 | Fermentas Uab | Production of nucleic acid |
| CN102177438A (zh) | 2008-07-25 | 2011-09-07 | 理查德·W·瓦格纳 | 蛋白筛选方法 |
| RS55218B1 (sr) | 2008-10-31 | 2017-02-28 | Janssen Biotech Inc | Kompozicije fibronektin tip iii skalno baziranih domena, metode i upotrebe |
| US20120004185A1 (en) | 2009-02-27 | 2012-01-05 | Atyr Pharma, Inc. | Polypeptide structural motifs associated with cell signaling activity |
| GB201000352D0 (en) | 2010-01-11 | 2010-02-24 | Isogenica Ltd | Antimicrobial peptides |
| WO2011139714A2 (en) | 2010-04-26 | 2011-11-10 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of cysteinyl-trna synthetase |
| CN103096911B (zh) | 2010-04-27 | 2018-05-29 | Atyr 医药公司 | 与异亮氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现 |
| EP2563382B1 (en) | 2010-04-27 | 2017-06-07 | aTyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of threonyl trna synthetases |
| AU2011248489B2 (en) | 2010-04-28 | 2016-10-06 | Pangu Biopharma Limited | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of alanyl tRNA synthetases |
| JP6008838B2 (ja) | 2010-04-29 | 2016-10-19 | エータイアー ファーマ, インコーポレイテッド | アスパラギニルtRNA合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見 |
| EP2563383B1 (en) | 2010-04-29 | 2017-03-01 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of valyl trna synthetases |
| KR101863033B1 (ko) | 2010-04-30 | 2018-06-01 | 얀센 바이오테크 인코포레이티드 | 안정화된 파이브로넥틴 도메인 조성물, 방법 및 용도 |
| CN103108655B (zh) | 2010-05-03 | 2017-04-05 | Atyr 医药公司 | 与丝氨酰‑tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现 |
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| AU2011248355B2 (en) | 2010-05-03 | 2017-01-19 | Pangu Biopharma Limited | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of Arginyl-tRNA synthetases |
| AU2011248230B2 (en) | 2010-05-03 | 2016-10-06 | Pangu Biopharma Limited | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of methionyl-tRNA synthetases |
| JP6008843B2 (ja) | 2010-05-04 | 2016-10-19 | エータイアー ファーマ, インコーポレイテッド | グルタミル−プロリルtRNA合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見 |
| JP6008844B2 (ja) | 2010-05-04 | 2016-10-19 | エータイアー ファーマ, インコーポレイテッド | p38MULTI−tRNA合成酵素複合体のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見 |
| CN103200953B (zh) | 2010-05-14 | 2017-02-15 | Atyr 医药公司 | 与苯丙氨酰‑β‑tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现 |
| CA2799480C (en) | 2010-05-17 | 2020-12-15 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of leucyl-trna synthetases |
| AU2011258106B2 (en) | 2010-05-27 | 2017-02-23 | Pangu Biopharma Limited | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glutaminyl-tRNA synthetases |
| EP2575857B1 (en) | 2010-06-01 | 2018-01-24 | aTyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of lysyl-trna synthetases |
| WO2012021249A2 (en) | 2010-07-12 | 2012-02-16 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of histidyl-trna synthetases |
| US8999321B2 (en) | 2010-07-12 | 2015-04-07 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glycyl-tRNA synthetases |
| KR102099730B1 (ko) | 2010-07-12 | 2020-04-16 | 에이티와이알 파마, 인코포레이티드 | 아스파르틸trna 합성효소의 단백질 단편에 관련된 치료적, 진단적, 및 항체 조성물의 혁신적 발견 |
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| GB201013284D0 (en) | 2010-08-06 | 2010-09-22 | Isogenica Ltd | Scaffold peptides |
| CN103108650A (zh) | 2010-08-25 | 2013-05-15 | Atyr医药公司 | 与酪氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现 |
| AU2011311956C1 (en) | 2010-10-06 | 2017-06-15 | Pangu Biopharma Limited | Innovative discovery of therapeutic, diagnostic, and antibody compositions related protein fragments of tryptophanyl tRNA synthetases |
| EP2647704B1 (en) | 2010-12-01 | 2017-11-01 | Mitsubishi Tanabe Pharma Corporation | Polynucleotide construct capable of presenting fab in acellular translation system, and method for manufacturing and screening fab using same |
| US9714419B2 (en) | 2011-08-09 | 2017-07-25 | Atyr Pharma, Inc. | PEGylated tyrosyl-tRNA synthetase polypeptides |
| KR102035713B1 (ko) | 2011-09-27 | 2019-10-24 | 얀센 바이오테크 인코포레이티드 | 대체 결합 표면을 가진 피브로넥틴 유형 iii 반복체 기반의 단백질 스캐폴드 |
| US20130090247A1 (en) | 2011-10-11 | 2013-04-11 | Biolauncher Ltd. | Methods and systems for identification of binding pharmacophores |
| US20130090266A1 (en) | 2011-10-11 | 2013-04-11 | Biolauncher Ltd. | Methods and systems for optimization of peptide screening |
| US20130090265A1 (en) | 2011-10-11 | 2013-04-11 | Biolauncher Ltd. | Systems and methods for generation of context-specific, molecular field-based amino acid substitution matrices |
| WO2013086228A1 (en) | 2011-12-06 | 2013-06-13 | Atyr Pharma, Inc. | Pegylated aspartyl-trna synthetase polypeptides |
| WO2013086216A1 (en) | 2011-12-06 | 2013-06-13 | Atyr Pharma, Inc. | Improved aspartyl-trna synthetases |
| WO2013115926A2 (en) | 2011-12-29 | 2013-08-08 | Atyr Pharma, Inc. | Aspartyl-trna synthetase-fc conjugates |
| GB2500243A (en) * | 2012-03-15 | 2013-09-18 | Isogenica Ltd | Identifying members of immobilised peptide libraries comprising protein-DNA complexes |
| US9695228B2 (en) | 2012-11-21 | 2017-07-04 | Janssen Biotech, Inc. | EGFR and c-Met fibronectin type III domain binding molecules |
| SG11201503938VA (en) | 2012-11-21 | 2015-06-29 | Janssen Biotech Inc | BISPECIFIC EGFR/c-Met ANTIBODIES |
| ES2847383T3 (es) | 2013-03-15 | 2021-08-03 | Atyr Pharma Inc | Conjugados de Fc-histidil-ARNt sintetasa |
| CA2926262C (en) | 2013-10-14 | 2025-06-17 | Janssen Biotech, Inc. | CYSTEINE MODIFIED TYPE III FIBRONECTIN DOMAIN BINDING MOLECULES (FN3) |
| CN107614703A (zh) | 2015-02-27 | 2018-01-19 | 香港大学 | Dna展示及其方法 |
| DK3280432T3 (da) | 2015-04-06 | 2021-04-26 | Subdomain Llc | Polypeptider indeholdende de novo-bindingsdomæner og anvendelser deraf |
| CN107849116A (zh) | 2015-05-06 | 2018-03-27 | 詹森生物科技公司 | 前列腺特异性膜抗原结合iii型纤连蛋白结构域 |
| EP3463430B1 (en) * | 2016-06-03 | 2025-01-01 | Janssen Biotech, Inc. | Serum albumin-binding fibronectin type iii domains |
| EP3471750A4 (en) | 2016-06-21 | 2020-02-26 | Janssen Biotech, Inc. | Cysteine engineered fibronectin type iii domain binding molecules |
| WO2018052828A1 (en) | 2016-09-14 | 2018-03-22 | Janssen Biotech, Inc. | Chimeric antigen receptors comprising bcma-specific fibronectin type iii domains and uses thereof |
| EP3554562A4 (en) | 2016-12-14 | 2020-11-04 | Janssen Biotech, Inc. | DOMAINS OF TYPE III FIBRONECTIN BINDING TO CD8A |
| EP3554535A4 (en) | 2016-12-14 | 2020-10-21 | Janssen Biotech, Inc. | PD-L1 BINDING FIBRONECTIN TYPE III DOMAINS |
| US10611823B2 (en) | 2016-12-14 | 2020-04-07 | Hanssen Biotech, Inc | CD137 binding fibronectin type III domains |
| CA3057619A1 (en) | 2017-03-22 | 2018-09-27 | Research Corporation Technologies, Inc. | Engineered stable ch2 polypeptides |
| AU2018256435B2 (en) | 2017-04-20 | 2025-03-13 | Atyr Pharma, Inc. | Compositions and methods for treating lung inflammation |
| US11078263B2 (en) | 2017-08-25 | 2021-08-03 | Janssen Biotech, Inc. | Fc γ RIII binding fibronectin type III domains, their conjugates and multispecific molecules comprising them |
| WO2021076543A1 (en) | 2019-10-14 | 2021-04-22 | Aro Biotherapeutics Company | Epcam binding fibronectin type iii domains |
| WO2021076574A2 (en) | 2019-10-14 | 2021-04-22 | Aro Biotherapeutics Company | Fn3 domain-sirna conjugates and uses thereof |
| CN119119240A (zh) | 2019-10-14 | 2024-12-13 | Aro生物疗法公司 | 结合cd71的纤维粘连蛋白iii型结构域 |
| EP4076505A4 (en) | 2019-12-18 | 2024-01-24 | ARO Biotherapeutics Company | SERUM ALBUM BINDING FIBRONECTIN TYPE III DOMAIN AND USES THEREOF |
| BR112023021325A2 (pt) | 2021-04-14 | 2023-12-19 | Aro Biotherapeutics Company | Domínios de fibronectina tipo iii de ligação a cd71 |
| AU2022258584A1 (en) | 2021-04-14 | 2023-10-12 | Aro Biotherapeutics Company | Fn3 domain-sirna conjugates and uses thereof |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1991005058A1 (en) | 1989-10-05 | 1991-04-18 | Glenn Kawasaki | Cell-free synthesis and isolation of novel genes and polypeptides |
| DK0593618T3 (da) * | 1991-06-27 | 1998-11-23 | Genelabs Tech Inc | Screeningsassay til påvisning af DNA-bindende molekyler |
| US5733731A (en) | 1991-10-16 | 1998-03-31 | Affymax Technologies N.V. | Peptide library and screening method |
| GB9703369D0 (en) | 1997-02-18 | 1997-04-09 | Lindqvist Bjorn H | Process |
| ES2209145T5 (es) * | 1997-05-28 | 2009-10-30 | Crescendo Biologics Ltd. | Complejos de ribosomas como particulas de seleccion para el desarrollo in vitro y evolucion de proteinas. |
| CA2792122C (en) | 1997-07-07 | 2015-09-08 | Medical Research Council | In vitro sorting method |
| GB9718455D0 (en) | 1997-09-02 | 1997-11-05 | Mcgregor Duncan P | Chimeric binding peptide library screening method |
| GB9900298D0 (en) | 1999-01-07 | 1999-02-24 | Medical Res Council | Optical sorting method |
| CA2367212A1 (en) | 1999-04-01 | 2000-10-12 | Innogenetics N.V. | A polypeptide structure for use as a scaffold |
| WO2002046395A1 (fr) | 2000-12-07 | 2002-06-13 | Keio University | Proteine a c-terminaison modifiee et procede permettant d'obtenir cette proteine, agent de modification et matrice de traduction necessaire a la production d'une proteine a c-terminaison modifiee, et procede de detection de l'interaction proteique avec l'utilisation de ladite proteine |
| JP4963142B2 (ja) | 2000-12-14 | 2012-06-27 | 学校法人慶應義塾 | 遺伝子型と表現型の対応付け分子とその構成要素、および対応付け分子の製造方法と利用方法 |
| WO2003014734A1 (fr) | 2001-08-07 | 2003-02-20 | Keio University | Procede de detection d'une interaction entre une substance et une proteine, procede d'analyse de la proteine interagissant avec la substance et procede de formation d'un complexe contenant la substance et la proteine interagissant avec cette substance |
| US20060156511A1 (en) * | 2005-01-19 | 2006-07-20 | Li Yuan J | Caster |
-
2003
- 2003-09-05 AU AU2003260786A patent/AU2003260786B2/en not_active Ceased
- 2003-09-05 JP JP2004533653A patent/JP4664677B2/ja not_active Expired - Fee Related
- 2003-09-05 AT AT03793896T patent/ATE488586T1/de active
- 2003-09-05 CA CA2497496A patent/CA2497496C/en not_active Expired - Fee Related
- 2003-09-05 PT PT03793896T patent/PT1534830E/pt unknown
- 2003-09-05 EP EP10010747A patent/EP2385118A1/en not_active Withdrawn
- 2003-09-05 DE DE60335000T patent/DE60335000D1/de not_active Expired - Lifetime
- 2003-09-05 KR KR1020057003832A patent/KR101051245B1/ko not_active Expired - Lifetime
- 2003-09-05 WO PCT/GB2003/003860 patent/WO2004022746A1/en not_active Ceased
- 2003-09-05 EP EP03793896A patent/EP1534830B1/en not_active Expired - Lifetime
- 2003-09-05 US US10/526,479 patent/US7842476B2/en not_active Expired - Lifetime
- 2003-09-05 CN CNB038211343A patent/CN100351375C/zh not_active Expired - Lifetime
- 2003-09-05 DK DK03793896.6T patent/DK1534830T3/da active
-
2005
- 2005-02-15 IL IL166903A patent/IL166903A/en active IP Right Grant
- 2005-04-05 NO NO20051685A patent/NO332949B1/no not_active IP Right Cessation
-
2010
- 2010-10-21 US US12/909,420 patent/US8679781B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CA2497496A1 (en) | 2004-03-18 |
| ATE488586T1 (de) | 2010-12-15 |
| JP2005537795A (ja) | 2005-12-15 |
| HK1072957A1 (en) | 2005-09-16 |
| NO332949B1 (no) | 2013-02-04 |
| EP2385118A1 (en) | 2011-11-09 |
| IL166903A (en) | 2012-06-28 |
| KR20050057216A (ko) | 2005-06-16 |
| DK1534830T3 (da) | 2011-02-14 |
| DE60335000D1 (de) | 2010-12-30 |
| US7842476B2 (en) | 2010-11-30 |
| WO2004022746A1 (en) | 2004-03-18 |
| US8679781B2 (en) | 2014-03-25 |
| EP1534830B1 (en) | 2010-11-17 |
| CN100351375C (zh) | 2007-11-28 |
| AU2003260786B2 (en) | 2008-03-13 |
| KR101051245B1 (ko) | 2011-07-21 |
| CN1681924A (zh) | 2005-10-12 |
| EP1534830A1 (en) | 2005-06-01 |
| JP4664677B2 (ja) | 2011-04-06 |
| US20120149591A1 (en) | 2012-06-14 |
| US20060035232A1 (en) | 2006-02-16 |
| PT1534830E (pt) | 2011-01-31 |
| CA2497496C (en) | 2012-05-15 |
| AU2003260786A1 (en) | 2004-03-29 |
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