DE60329520D1 - Verfahren zur herstellung von quaternäre n-alkyl morphinan alkaloid salzen - Google Patents
Verfahren zur herstellung von quaternäre n-alkyl morphinan alkaloid salzenInfo
- Publication number
- DE60329520D1 DE60329520D1 DE60329520T DE60329520T DE60329520D1 DE 60329520 D1 DE60329520 D1 DE 60329520D1 DE 60329520 T DE60329520 T DE 60329520T DE 60329520 T DE60329520 T DE 60329520T DE 60329520 D1 DE60329520 D1 DE 60329520D1
- Authority
- DE
- Germany
- Prior art keywords
- preparation
- morphinan alkaloid
- quaternary
- alkaloid salts
- alkyl morphinan
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 229930013053 morphinan alkaloid Natural products 0.000 title abstract 3
- -1 MORPHINAN ALKALOID SALTS Chemical class 0.000 title abstract 2
- 239000002904 solvent Substances 0.000 abstract 5
- 150000001350 alkyl halides Chemical class 0.000 abstract 1
- INAXVFBXDYWQFN-XHSDSOJGSA-N morphinan Chemical class C1C2=CC=CC=C2[C@]23CCCC[C@H]3[C@@H]1NCC2 INAXVFBXDYWQFN-XHSDSOJGSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
- C07D489/08—Oxygen atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US42474802P | 2002-11-08 | 2002-11-08 | |
| US42558002P | 2002-11-12 | 2002-11-12 | |
| PCT/US2003/035463 WO2004043964A2 (en) | 2002-11-08 | 2003-11-05 | Process for the preparation of quaternary n-alkyl morphinan alkaloid salts |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE60329520D1 true DE60329520D1 (de) | 2009-11-12 |
Family
ID=32314554
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60329520T Expired - Lifetime DE60329520D1 (de) | 2002-11-08 | 2003-11-05 | Verfahren zur herstellung von quaternäre n-alkyl morphinan alkaloid salzen |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US7285665B2 (de) |
| EP (1) | EP1562953B1 (de) |
| JP (1) | JP2006509745A (de) |
| AT (1) | ATE444295T1 (de) |
| AU (1) | AU2003290630B2 (de) |
| CA (1) | CA2504262C (de) |
| DE (1) | DE60329520D1 (de) |
| ES (1) | ES2332453T3 (de) |
| MX (1) | MXPA05004759A (de) |
| PT (1) | PT1562953E (de) |
| WO (1) | WO2004043964A2 (de) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HRP20150037T4 (hr) | 2003-04-08 | 2022-09-02 | Progenics Pharmaceuticals, Inc. | Farmaceutske formulacije koje sadrže metilnaltrekson |
| ES2714198T3 (es) | 2005-03-07 | 2019-05-27 | Univ Chicago | Uso de antagonistas opioideos para atenuar la proliferación y la migración de células endoteliales |
| US8524731B2 (en) | 2005-03-07 | 2013-09-03 | The University Of Chicago | Use of opioid antagonists to attenuate endothelial cell proliferation and migration |
| US8518962B2 (en) | 2005-03-07 | 2013-08-27 | The University Of Chicago | Use of opioid antagonists |
| US9662325B2 (en) | 2005-03-07 | 2017-05-30 | The University Of Chicago | Use of opioid antagonists to attenuate endothelial cell proliferation and migration |
| AR057325A1 (es) * | 2005-05-25 | 2007-11-28 | Progenics Pharm Inc | Sintesis de (s)-n-metilnaltrexona, composiciones farmaceuticas y usos |
| AU2013200437B2 (en) * | 2005-05-25 | 2015-01-15 | Progenics Pharmaceuticals, Inc. | (S)-N-methylnaltrexone, process for its synthesis and its pharmaceutical use |
| AR057035A1 (es) | 2005-05-25 | 2007-11-14 | Progenics Pharm Inc | SíNTESIS DE (R)-N-METILNALTREXONA, COMPOSICIONES FARMACÉUTICAS Y USOS |
| TWI489984B (zh) | 2006-08-04 | 2015-07-01 | Wyeth Corp | 用於非經腸道傳輸化合物之配方及其用途 |
| TW200815451A (en) * | 2006-08-04 | 2008-04-01 | Wyeth Corp | 6-carboxy-normorphinan derivatives, synthesis and uses thereof |
| NZ575620A (en) | 2006-09-20 | 2010-11-26 | Mallinckrodt Inc | Preparation of substituted morphinan-6-ones and salts and intermediates thereof |
| FR2906252B1 (fr) | 2006-09-21 | 2008-11-28 | Sanofi Aventis Sa | Procede de preparation d'halogenures de n-aklyl naltrexone |
| US20090047279A1 (en) * | 2006-11-22 | 2009-02-19 | Progenics Pharmaceuticals, Inc. | (R)-N-Stereoisomers of 7,8-Saturated-4,5-Epoxy-Morphinanium Analogs |
| CA2670386A1 (en) * | 2006-11-22 | 2008-05-29 | Progenics Pharmaceuticals, Inc. | Processes for synthesizing quaternary 4,5-epoxy-morphinan analogs and isolating their n-stereoisomers |
| AU2008223328B2 (en) | 2007-03-06 | 2012-10-11 | SpecGx LLC | Process for the preparation of quaternary N-alkyl morphinan alkaloid salts |
| US9040726B2 (en) | 2007-03-06 | 2015-05-26 | Mallinckrodt Llc | Process for the preparation of quaternary N-alkyl morphinan alkaloid salts |
| CA2865389A1 (en) * | 2007-03-29 | 2008-10-09 | Progenics Pharmaceuticals, Inc. | Crystal forms and uses thereof |
| SI2139890T1 (sl) | 2007-03-29 | 2014-12-31 | Wyeth Llc | Antagonisti perifernih opioidnih receptorjev in njih uporaba |
| CL2008000905A1 (es) | 2007-03-29 | 2008-08-22 | Progenics Pharm Inc | Compuestos derivados de morfina, antagonistas del receptor opioide periferico; metodo de preparacion; composicion farmaceutica; y uso para reducir los efectos de la actividad opioide endogena. |
| WO2008138383A1 (de) * | 2007-05-16 | 2008-11-20 | Cilag Ag | Verfahren zur herstellung von n-methylnaltrexonbromid |
| WO2009009292A2 (en) * | 2007-07-11 | 2009-01-15 | Mallinckrodt Inc. | Crystalline forms of naltrexone methobromide |
| EP2019105A1 (de) | 2007-07-19 | 2009-01-28 | Siegfried Ltd. | Verfahren zur Herstellung von quaternären N-Alkyl-Morphin- oder Morphinan- Alkaloidderivaten |
| EA020658B1 (ru) * | 2007-08-09 | 2014-12-30 | Ренссилэйер Политекник Инститьют | Четвертичные опиоидные карбоксамиды |
| WO2009070733A1 (en) * | 2007-11-26 | 2009-06-04 | Pharmacofore, Inc. | Peripheral phenolic opioid antagonist |
| WO2009099411A1 (en) | 2008-02-06 | 2009-08-13 | Progenics Pharmaceuticals, Inc. | Preparation and use of (r),(r)-2,2'-bis-methylnaltrexone |
| JP2011512360A (ja) * | 2008-02-14 | 2011-04-21 | アルカーメス，インコーポレイテッド | 選択的オピオイド化合物 |
| AU2009225434B2 (en) | 2008-03-21 | 2014-05-22 | The University Of Chicago | Treatment with opioid antagonists and mTOR inhibitors |
| EP2285780B1 (de) | 2008-05-27 | 2015-08-26 | Mallinckrodt LLC | Verfahren und verbindungen zur herstellung von normorphinanen |
| CN101607963B (zh) | 2008-06-20 | 2013-04-03 | 重庆医药工业研究院有限责任公司 | 吗啡喃衍生物及其制备方法 |
| US9458109B2 (en) | 2008-09-03 | 2016-10-04 | Mallinckrodt Llc | Substituted berbines and processes for their synthesis |
| CA2676881C (en) | 2008-09-30 | 2017-04-25 | Wyeth | Peripheral opioid receptor antagonists and uses thereof |
| EP2398806A1 (de) | 2009-02-23 | 2011-12-28 | Mallinckrodt LLC | (+)-morphinanium-n-oxide und verfahren zu ihrer herstellung |
| CN102325775A (zh) | 2009-02-23 | 2012-01-18 | 马林克罗特公司 | (+)-6-羟基-吗啡喃或(+)-6-氨基-吗啡喃衍生物 |
| US8946419B2 (en) | 2009-02-23 | 2015-02-03 | Mallinckrodt Llc | (+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives |
| KR20120088537A (ko) | 2009-04-24 | 2012-08-08 | 브럭 유니버시티 | 모르피난 및 모르피논 화합물의 제조방법 |
| US8829020B2 (en) | 2009-07-16 | 2014-09-09 | Mallinckrodt Llc | Compounds and compositions for use in phototherapy and in treatment of ocular neovascular disease and cancers |
| JP2013529595A (ja) | 2010-06-11 | 2013-07-22 | ローズ テクノロジーズ | 第３級アミンのｎ−脱アルキル化方法 |
| WO2011154827A2 (en) | 2010-06-11 | 2011-12-15 | Rhodes Technologies | Transition metal-catalyzed processes for the preparation of n-allyl compounds and use thereof |
| PL2753622T3 (pl) | 2011-09-08 | 2016-07-29 | SpecGx LLC | Wytwarzanie alkaloidów bez oddzielania związków pośrednich |
| WO2015082932A1 (en) | 2013-12-05 | 2015-06-11 | The University Of Bath | Novel opioid compounds and their uses |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3101339A (en) | 1958-10-30 | 1963-08-20 | Boehringer Sohn Ingelheim | Quaternary salts of normorphine and its acylated derivatives |
| US4141897A (en) | 1976-12-20 | 1979-02-27 | Research Corporation | N-dealkylation of N-alkyl-14-hydroxymorphinans and derivatives thereof |
| US4176186A (en) * | 1978-07-28 | 1979-11-27 | Boehringer Ingelheim Gmbh | Quaternary derivatives of noroxymorphone which relieve intestinal immobility |
| PL124001B1 (en) | 1980-01-25 | 1982-12-31 | Inst Przemyslu Zielarskiego | Process for preparing quaternary halides of n-alkylor n-aralkyl- derivatives of tropanic and isoquinolylic alkaloids |
| US4322426A (en) | 1980-04-28 | 1982-03-30 | E. I. Du Pont De Nemours And Company | 17-Substituted-6-desoxy-7,8-dihydro-6α-methylnoroxymorphone narcotic antagonists |
| US4535157A (en) | 1983-11-01 | 1985-08-13 | Key Pharmaceuticals, Inc. | Process for making 6-desoxy-6-methylenenaloxone and 6-desoxy-6-methylenenaltrexone |
| US5668285A (en) | 1986-10-31 | 1997-09-16 | The United States Of America As Represented By The Department Of Health And Human Services | Total synthesis of northebaine, normophine, noroxymorphone enantiomers and derivatives via N-Nor intermediates |
| DE4132159A1 (de) | 1991-09-27 | 1993-04-01 | Boehringer Ingelheim Kg | 14-hydroxy-n-(2-methoxyethyl)-7,8-dihydromorphin und -norisomorphin, verfahren zu deren herstellung und deren verwendung als arzneimittel |
| US5574159A (en) | 1992-02-03 | 1996-11-12 | Delta Pharmaceuticals, Inc. | Opioid compounds and methods for making therefor |
| US5352680A (en) | 1992-07-15 | 1994-10-04 | Regents Of The University Of Minnesota | Delta opioid receptor antagonists to block opioid agonist tolerance and dependence |
| AU5171293A (en) | 1992-10-14 | 1994-05-09 | Regents Of The University Of Colorado, The | Ion-pairing of drugs for improved efficacy and delivery |
| SE9401728D0 (sv) | 1994-05-18 | 1994-05-18 | Astra Ab | New compounds II |
| US5869669A (en) | 1996-07-26 | 1999-02-09 | Penick Corporation | Preparation of 14-hydroxynormorphinones from normorphinone dienol acylates |
| US5756851A (en) | 1996-10-21 | 1998-05-26 | Albemarle Corporation | Production of nabumetone or precursors thereof |
| GB9713703D0 (en) | 1997-06-30 | 1997-09-03 | Johnson Matthey Plc | Preparation of opiates |
| WO2001014382A1 (en) * | 1999-08-23 | 2001-03-01 | Toray Industries, Inc. | Analgesics containing as the active ingredient quaternary ammonium salt derivatives of morphinan |
| DE10229842A1 (de) | 2002-07-03 | 2004-02-05 | Helmut Prof. Dr. Schmidhammer | Morphinanderivate und deren quartäre Ammoniumsalze substituiert in Position 14, Herstellungsverfahren und Verwendung |
-
2003
- 2003-11-05 WO PCT/US2003/035463 patent/WO2004043964A2/en not_active Ceased
- 2003-11-05 US US10/530,446 patent/US7285665B2/en not_active Expired - Lifetime
- 2003-11-05 ES ES03783211T patent/ES2332453T3/es not_active Expired - Lifetime
- 2003-11-05 JP JP2004551830A patent/JP2006509745A/ja active Pending
- 2003-11-05 CA CA2504262A patent/CA2504262C/en not_active Expired - Lifetime
- 2003-11-05 MX MXPA05004759A patent/MXPA05004759A/es active IP Right Grant
- 2003-11-05 PT PT03783211T patent/PT1562953E/pt unknown
- 2003-11-05 AT AT03783211T patent/ATE444295T1/de active
- 2003-11-05 AU AU2003290630A patent/AU2003290630B2/en not_active Expired
- 2003-11-05 EP EP03783211A patent/EP1562953B1/de not_active Expired - Lifetime
- 2003-11-05 DE DE60329520T patent/DE60329520D1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| WO2004043964A3 (en) | 2004-08-26 |
| PT1562953E (pt) | 2009-11-19 |
| ATE444295T1 (de) | 2009-10-15 |
| CA2504262A1 (en) | 2004-05-27 |
| JP2006509745A (ja) | 2006-03-23 |
| CA2504262C (en) | 2012-01-10 |
| EP1562953A2 (de) | 2005-08-17 |
| US7285665B2 (en) | 2007-10-23 |
| EP1562953B1 (de) | 2009-09-30 |
| AU2003290630B2 (en) | 2009-01-29 |
| AU2003290630A1 (en) | 2004-06-03 |
| WO2004043964A2 (en) | 2004-05-27 |
| MXPA05004759A (es) | 2005-08-02 |
| US20060014771A1 (en) | 2006-01-19 |
| ES2332453T3 (es) | 2010-02-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |