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DE60104825D1 - Verfahren zur herstellung von 6-substituierten (s)-nikotin-derivaten und zwischenverbindungen - Google Patents

Verfahren zur herstellung von 6-substituierten (s)-nikotin-derivaten und zwischenverbindungen

Info

Publication number
DE60104825D1
DE60104825D1 DE60104825T DE60104825T DE60104825D1 DE 60104825 D1 DE60104825 D1 DE 60104825D1 DE 60104825 T DE60104825 T DE 60104825T DE 60104825 T DE60104825 T DE 60104825T DE 60104825 D1 DE60104825 D1 DE 60104825D1
Authority
DE
Germany
Prior art keywords
producing
substituted
intermediate compounds
nicotine derivatives
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60104825T
Other languages
English (en)
Other versions
DE60104825T2 (de
Inventor
Anette Johansson
Torgny Svensson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
INDEPENDENT PHARMACEUTICA C AB
Original Assignee
INDEPENDENT PHARMACEUTICA C AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by INDEPENDENT PHARMACEUTICA C AB filed Critical INDEPENDENT PHARMACEUTICA C AB
Publication of DE60104825D1 publication Critical patent/DE60104825D1/de
Application granted granted Critical
Publication of DE60104825T2 publication Critical patent/DE60104825T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE60104825T 2000-03-21 2001-03-21 Verfahren zur herstellung von 6-substituierten (s)-nikotin-derivaten und zwischenverbindungen Expired - Lifetime DE60104825T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE0000933A SE0000933D0 (sv) 2000-03-21 2000-03-21 Method of producing 6-substituted (S)-nicotine derivatives and intermediate compounds
SE0000933 2000-03-21
PCT/SE2001/000599 WO2001070730A1 (en) 2000-03-21 2001-03-21 Method of producing 6-substituted (s)-nicotine derivatives and intermediate compounds

Publications (2)

Publication Number Publication Date
DE60104825D1 true DE60104825D1 (de) 2004-09-16
DE60104825T2 DE60104825T2 (de) 2005-09-29

Family

ID=20278889

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60104825T Expired - Lifetime DE60104825T2 (de) 2000-03-21 2001-03-21 Verfahren zur herstellung von 6-substituierten (s)-nikotin-derivaten und zwischenverbindungen

Country Status (13)

Country Link
US (1) US6747156B2 (de)
EP (1) EP1265888B1 (de)
JP (1) JP4370073B2 (de)
AT (1) ATE273295T1 (de)
AU (2) AU2001244913B2 (de)
CA (1) CA2402748C (de)
DE (1) DE60104825T2 (de)
ES (1) ES2225507T3 (de)
HK (1) HK1051854B (de)
PT (1) PT1265888E (de)
SE (1) SE0000933D0 (de)
TR (1) TR200402787T4 (de)
WO (1) WO2001070730A1 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005232129A (ja) * 2004-02-23 2005-09-02 Air Water Chemical Inc 芳香族性アセチレン類の製造方法
WO2007001448A2 (en) 2004-11-04 2007-01-04 Massachusetts Institute Of Technology Coated controlled release polymer particles as efficient oral delivery vehicles for biopharmaceuticals
US9267937B2 (en) 2005-12-15 2016-02-23 Massachusetts Institute Of Technology System for screening particles
CA2648099C (en) 2006-03-31 2012-05-29 The Brigham And Women's Hospital, Inc System for targeted delivery of therapeutic agents
EP2019691B1 (de) 2006-05-15 2020-08-12 Massachusetts Institute of Technology Polymere für funktionelle partikel
US9381477B2 (en) * 2006-06-23 2016-07-05 Massachusetts Institute Of Technology Microfluidic synthesis of organic nanoparticles
US20100144845A1 (en) * 2006-08-04 2010-06-10 Massachusetts Institute Of Technology Oligonucleotide systems for targeted intracellular delivery
EP2144600A4 (de) * 2007-04-04 2011-03-16 Massachusetts Inst Technology Poly (aminsäure)-zielmoleküle
EP3424525A1 (de) 2007-10-12 2019-01-09 Massachusetts Institute Of Technology Impfstoffnanotechnologie
US8591905B2 (en) 2008-10-12 2013-11-26 The Brigham And Women's Hospital, Inc. Nicotine immunonanotherapeutics
US8343497B2 (en) 2008-10-12 2013-01-01 The Brigham And Women's Hospital, Inc. Targeting of antigen presenting cells with immunonanotherapeutics
US8277812B2 (en) 2008-10-12 2012-10-02 Massachusetts Institute Of Technology Immunonanotherapeutics that provide IgG humoral response without T-cell antigen
US8343498B2 (en) 2008-10-12 2013-01-01 Massachusetts Institute Of Technology Adjuvant incorporation in immunonanotherapeutics
JP6324068B2 (ja) 2010-05-26 2018-05-23 セレクタ バイオサイエンシーズ インコーポレーテッドＳｅｌｅｃｔａ Ｂｉｏｓｃｉｅｎｃｅｓ，Ｉｎｃ． 合成ナノキャリア混合ワクチン
TWI578997B (zh) * 2010-06-04 2017-04-21 輝瑞疫苗有限責任公司 用於預防或治療菸鹼成癮之共軛體
AU2014210682B2 (en) * 2010-06-04 2015-10-08 Pfizer Vaccines Llc Conjugates for the prevention or treatment of nicotine addiction
US9994443B2 (en) 2010-11-05 2018-06-12 Selecta Biosciences, Inc. Modified nicotinic compounds and related methods
CN109172819A (zh) 2011-07-29 2019-01-11 西莱克塔生物科技公司 产生体液和细胞毒性t淋巴细胞（ctl）免疫应答的合成纳米载体
US9303013B2 (en) 2014-05-16 2016-04-05 Pfizer Inc. Conjugates and associated methods of producing them for the prevention or treatment of nicotine addiction

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4155909A (en) * 1977-06-13 1979-05-22 Philip Morris Incorporated 2-Alkyl nicotinoids and processes for their production
US4465833A (en) * 1980-10-15 1984-08-14 Hughes Aircraft Company Process for preparing ethynylated benzoic acid derivatives
DE4020053A1 (de) * 1990-01-31 1991-08-01 Bayer Ag Verfahren zur herstellung von 2-chlor-5-methyl-pyridin
DE4020052A1 (de) 1990-06-23 1992-01-02 Bayer Ag Verfahren zur herstellung von 2-chlor-5-methyl-pyridin
US5502194A (en) * 1992-02-19 1996-03-26 Bayer Aktiengesellschaft Process for the preparation of 2-halogeno-pyridine derivatives
KR100309871B1 (ko) 1999-02-24 2001-10-29 윤종용 (-)피리도벤즈옥사진 카르복실산 유도체의 제조방법
SE9801923D0 (sv) 1998-05-29 1998-05-29 Independent Pharmaceutical Ab Nicotine vaccine
US20040079259A1 (en) 2002-10-29 2004-04-29 Felix Manig Method of manufacturing cementitious materials
FR2849657B1 (fr) 2003-01-03 2005-07-15 Arjo Wiggins Feuille possedant un aspect iridescent, et son procede de fabrication

Also Published As

Publication number Publication date
ATE273295T1 (de) 2004-08-15
PT1265888E (pt) 2004-11-30
US6747156B2 (en) 2004-06-08
EP1265888A1 (de) 2002-12-18
HK1051854A1 (en) 2003-08-22
SE0000933D0 (sv) 2000-03-21
JP4370073B2 (ja) 2009-11-25
TR200402787T4 (tr) 2004-11-22
HK1051854B (en) 2005-02-18
EP1265888B1 (de) 2004-08-11
AU2001244913B2 (en) 2005-08-11
US20030187270A1 (en) 2003-10-02
CA2402748A1 (en) 2001-09-27
ES2225507T3 (es) 2005-03-16
WO2001070730A1 (en) 2001-09-27
AU4491301A (en) 2001-10-03
JP2003529568A (ja) 2003-10-07
DE60104825T2 (de) 2005-09-29
CA2402748C (en) 2010-02-16

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