DE60328901D1 - Verfahren zur herstellung von 4-(3'-chlor-4'-fluoranilino)-7-methoxy-6-(3-morpholinopropoxy)chinazolin - Google Patents
Verfahren zur herstellung von 4-(3'-chlor-4'-fluoranilino)-7-methoxy-6-(3-morpholinopropoxy)chinazolinInfo
- Publication number
- DE60328901D1 DE60328901D1 DE60328901T DE60328901T DE60328901D1 DE 60328901 D1 DE60328901 D1 DE 60328901D1 DE 60328901 T DE60328901 T DE 60328901T DE 60328901 T DE60328901 T DE 60328901T DE 60328901 D1 DE60328901 D1 DE 60328901D1
- Authority
- DE
- Germany
- Prior art keywords
- morpholinopropoxy
- methoxy
- chloro
- fluoranilino
- chinazoline
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 4
- -1 3-MORPHOLINOPROPOXY Chemical class 0.000 title 1
- 150000003246 quinazolines Chemical class 0.000 abstract 2
- FYCDMKYKGPHRFW-UHFFFAOYSA-N 4-methoxy-5-(3-morpholin-4-ylpropoxy)-2-nitrobenzonitrile Chemical compound COC1=CC([N+]([O-])=O)=C(C#N)C=C1OCCCN1CCOCC1 FYCDMKYKGPHRFW-UHFFFAOYSA-N 0.000 abstract 1
- WFUBWLXSYCFZEH-UHFFFAOYSA-N 7-methoxy-6-(3-morpholin-4-ylpropoxy)-1h-quinazolin-4-one Chemical compound COC1=CC=2N=CNC(=O)C=2C=C1OCCCN1CCOCC1 WFUBWLXSYCFZEH-UHFFFAOYSA-N 0.000 abstract 1
- 238000001311 chemical methods and process Methods 0.000 abstract 1
- XGALLCVXEZPNRQ-UHFFFAOYSA-N gefitinib Chemical compound C=12C=C(OCCCN3CCOCC3)C(OC)=CC2=NC=NC=1NC1=CC=C(F)C(Cl)=C1 XGALLCVXEZPNRQ-UHFFFAOYSA-N 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/88—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/88—Oxygen atoms
- C07D239/90—Oxygen atoms with acyclic radicals attached in position 2 or 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/94—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0221245.4A GB0221245D0 (en) | 2002-09-13 | 2002-09-13 | Chemical process |
| PCT/GB2003/003923 WO2004024703A1 (en) | 2002-09-13 | 2003-09-09 | Process for the preparation of 4- (3’-chloro-4’-fluoroanilino) -7-methoxy-6- (3-morpholinopropoxy) quinazoline |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE60328901D1 true DE60328901D1 (de) | 2009-10-01 |
Family
ID=9943998
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60328901T Expired - Lifetime DE60328901D1 (de) | 2002-09-13 | 2003-09-09 | Verfahren zur herstellung von 4-(3'-chlor-4'-fluoranilino)-7-methoxy-6-(3-morpholinopropoxy)chinazolin |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US7705145B2 (de) |
| EP (1) | EP1546119B1 (de) |
| JP (2) | JP4527534B2 (de) |
| KR (1) | KR101114134B1 (de) |
| CN (3) | CN102030722B (de) |
| AT (1) | ATE440088T1 (de) |
| AU (1) | AU2003263348B2 (de) |
| BR (1) | BRPI0314238B8 (de) |
| CA (1) | CA2498122C (de) |
| CY (1) | CY1110511T1 (de) |
| DE (1) | DE60328901D1 (de) |
| DK (1) | DK1546119T3 (de) |
| ES (1) | ES2329567T3 (de) |
| GB (1) | GB0221245D0 (de) |
| IL (1) | IL167209A (de) |
| MX (1) | MXPA05002601A (de) |
| NO (1) | NO330009B1 (de) |
| NZ (1) | NZ538552A (de) |
| PT (1) | PT1546119E (de) |
| SI (1) | SI1546119T1 (de) |
| WO (1) | WO2004024703A1 (de) |
| ZA (1) | ZA200501892B (de) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005070909A1 (en) * | 2004-01-22 | 2005-08-04 | Natco Pharma Limited | An improved process for the preparation of gefitinib |
| EP2155656A2 (de) * | 2007-04-16 | 2010-02-24 | Cipla Limited | Verfahren zur herstellung von gefitinib |
| CN101463012B (zh) * | 2007-12-18 | 2011-06-08 | 上海百灵医药科技有限公司 | 一种吉非替尼的制备方法 |
| CN101215274B (zh) * | 2007-12-27 | 2011-05-04 | 上海北卡医药技术有限公司 | N取代吗啉类有机化合物的制备工艺 |
| CN101570516B (zh) * | 2009-04-14 | 2011-01-05 | 重庆威尔德·浩瑞医药化工有限公司 | 一种制备4-(3-氯-4-氟苯基胺基)-7-甲氧基-6-[3-(4-吗啉基)丙氧基]喹唑啉的方法 |
| CN101863844B (zh) * | 2009-04-16 | 2012-10-03 | 欧美嘉股份有限公司 | 6,7-取代基-4-苯胺类喹唑啉的合成方法 |
| CN102120731B (zh) * | 2010-01-09 | 2015-01-07 | 浙江华海药业股份有限公司 | 一种制备4-(3-氯-4-氟苯基胺基)-7-甲氧基-6-(3-吗啉丙氧基)喹唑啉的新方法 |
| CN102659716B (zh) * | 2012-05-02 | 2014-09-10 | 北京国联诚辉医药技术有限公司 | 4-甲氧基-2-胺基-3-[3-(4-吗啉基)丙氧基]苯腈的制备方法及吉非替尼的制备工艺 |
| KR101457453B1 (ko) * | 2012-05-31 | 2014-11-04 | 주식회사 종근당 | 게피티닙의 제조방법 및 이의 제조에 사용되는 중간체 |
| CN103073509A (zh) * | 2012-12-31 | 2013-05-01 | 广东先强药业有限公司 | 一类喹唑啉衍生物的制备方法 |
| CN103910690A (zh) * | 2013-01-06 | 2014-07-09 | 上海科胜药物研发有限公司 | 一种吉非替尼新晶型及其制备方法 |
| JP6020191B2 (ja) * | 2013-01-21 | 2016-11-02 | 富士ゼロックス株式会社 | 表示制御装置及びプログラム |
| CN103254156B (zh) * | 2013-05-10 | 2015-08-26 | 苏州明锐医药科技有限公司 | 阿法替尼中间体的制备方法 |
| CN103304491A (zh) * | 2013-06-17 | 2013-09-18 | 连云港盛和生物科技有限公司 | 一种吉非替尼的制备方法 |
| CN104130199A (zh) * | 2013-08-07 | 2014-11-05 | 安徽安腾药业有限责任公司 | 制备7-甲氧基-6-(3-吗啉-4-基丙氧基)喹唑啉-4(3h)-酮的方法 |
| CN105254614B (zh) * | 2015-11-16 | 2017-08-15 | 山东罗欣药业集团股份有限公司 | 一种凡德他尼化合物的合成方法 |
| CN109384747A (zh) * | 2018-10-26 | 2019-02-26 | 苏州立新制药有限公司 | 吉非替尼相关物质及其制备和检测方法 |
| CN112300082B (zh) * | 2019-07-26 | 2022-04-26 | 暨南大学 | 一种苯基哌嗪喹唑啉类化合物或其药学上可接受的盐、制法与用途 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU661533B2 (en) | 1992-01-20 | 1995-07-27 | Astrazeneca Ab | Quinazoline derivatives |
| GB9508538D0 (en) * | 1995-04-27 | 1995-06-14 | Zeneca Ltd | Quinazoline derivatives |
| ES2289791T3 (es) | 1997-08-22 | 2008-02-01 | Astrazeneca Ab | Derivados de oxindolilquinazolina como inhibidores de la angiogenesis. |
| JP3505991B2 (ja) | 1998-02-13 | 2004-03-15 | 宇部興産株式会社 | ４，５−ジ置換アントラニルアミドの製造法 |
| JP3740835B2 (ja) | 1998-04-03 | 2006-02-01 | 宇部興産株式会社 | ６，７−ジ置換−２，４−ジオキソキナゾリンの製造法 |
| AU6578900A (en) * | 1999-07-07 | 2001-01-30 | Astrazeneca Uk Limited | Quinazoline derivatives |
| ES2305081T3 (es) * | 2000-06-28 | 2008-11-01 | Astrazeneca Ab | Derivados de quinozolina sustituidos y su uso como inhibidores. |
| AU2002222606A1 (en) | 2000-12-12 | 2002-06-24 | Ube Industries Ltd. | Process for producing mononitrated aromatic ether compound |
| AU2002357621A1 (en) | 2001-12-19 | 2003-06-30 | Ube Industries, Ltd. | Process for producing quinazolin-4-one and derivative thereof |
| WO2003064377A1 (en) | 2002-01-29 | 2003-08-07 | Ube Industries, Ltd. | 4,5-substituted-2-formylaminobenzamides and processes for their production and conversion |
| US20050130995A1 (en) | 2002-02-06 | 2005-06-16 | Ube Industries, Ltd. | Process for producing 4-aminoquinazoline compound |
-
2002
- 2002-09-13 GB GBGB0221245.4A patent/GB0221245D0/en not_active Ceased
-
2003
- 2003-09-09 JP JP2004535657A patent/JP4527534B2/ja not_active Expired - Lifetime
- 2003-09-09 DK DK03795077T patent/DK1546119T3/da active
- 2003-09-09 KR KR1020057004294A patent/KR101114134B1/ko not_active Expired - Lifetime
- 2003-09-09 MX MXPA05002601A patent/MXPA05002601A/es active IP Right Grant
- 2003-09-09 CA CA2498122A patent/CA2498122C/en not_active Expired - Fee Related
- 2003-09-09 CN CN2010105455522A patent/CN102030722B/zh not_active Expired - Lifetime
- 2003-09-09 ES ES03795077T patent/ES2329567T3/es not_active Expired - Lifetime
- 2003-09-09 AU AU2003263348A patent/AU2003263348B2/en not_active Expired
- 2003-09-09 CN CNB038215500A patent/CN100429204C/zh not_active Expired - Lifetime
- 2003-09-09 CN CN2008102128004A patent/CN101348471B/zh not_active Expired - Lifetime
- 2003-09-09 SI SI200331674T patent/SI1546119T1/sl unknown
- 2003-09-09 EP EP03795077A patent/EP1546119B1/de not_active Expired - Lifetime
- 2003-09-09 BR BRPI0314238A patent/BRPI0314238B8/pt not_active IP Right Cessation
- 2003-09-09 PT PT03795077T patent/PT1546119E/pt unknown
- 2003-09-09 AT AT03795077T patent/ATE440088T1/de active
- 2003-09-09 WO PCT/GB2003/003923 patent/WO2004024703A1/en not_active Ceased
- 2003-09-09 US US10/527,461 patent/US7705145B2/en not_active Expired - Fee Related
- 2003-09-09 DE DE60328901T patent/DE60328901D1/de not_active Expired - Lifetime
- 2003-09-09 NZ NZ538552A patent/NZ538552A/en not_active IP Right Cessation
-
2005
- 2005-03-01 NO NO20051104A patent/NO330009B1/no not_active IP Right Cessation
- 2005-03-02 IL IL167209A patent/IL167209A/en active IP Right Grant
- 2005-03-04 ZA ZA2005/01892A patent/ZA200501892B/en unknown
-
2009
- 2009-10-15 CY CY20091101076T patent/CY1110511T1/el unknown
-
2010
- 2010-03-18 JP JP2010061976A patent/JP2010209071A/ja active Pending
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |