DE60322425D1 - Antikrebszubereitung enthaltend dmxaa - Google Patents
Antikrebszubereitung enthaltend dmxaaInfo
- Publication number
- DE60322425D1 DE60322425D1 DE60322425T DE60322425T DE60322425D1 DE 60322425 D1 DE60322425 D1 DE 60322425D1 DE 60322425 T DE60322425 T DE 60322425T DE 60322425 T DE60322425 T DE 60322425T DE 60322425 D1 DE60322425 D1 DE 60322425D1
- Authority
- DE
- Germany
- Prior art keywords
- compounds
- dmxaa
- acetic acid
- rectification containing
- rectification
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nutrition Science (AREA)
- Organic Chemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Control Of Eletrric Generators (AREA)
- Fittings On The Vehicle Exterior For Carrying Loads, And Devices For Holding Or Mounting Articles (AREA)
- Portable Nailing Machines And Staplers (AREA)
- Pyrane Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0225508A GB2394658A (en) | 2002-11-01 | 2002-11-01 | Oral anti-cancer composition |
| PCT/GB2003/004688 WO2004039363A1 (en) | 2002-11-01 | 2003-10-30 | Anti-cancer composition comprising dmxaa or related compound |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE60322425D1 true DE60322425D1 (de) | 2008-09-04 |
Family
ID=9947036
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60322425T Expired - Lifetime DE60322425D1 (de) | 2002-11-01 | 2003-10-30 | Antikrebszubereitung enthaltend dmxaa |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US7585893B2 (de) |
| EP (1) | EP1572194B1 (de) |
| JP (1) | JP2006508091A (de) |
| AT (1) | ATE401882T1 (de) |
| AU (1) | AU2003282215A1 (de) |
| CY (1) | CY1108292T1 (de) |
| DE (1) | DE60322425D1 (de) |
| DK (1) | DK1572194T3 (de) |
| ES (1) | ES2311740T3 (de) |
| GB (1) | GB2394658A (de) |
| PT (1) | PT1572194E (de) |
| SI (1) | SI1572194T1 (de) |
| WO (1) | WO2004039363A1 (de) |
Families Citing this family (65)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2265948T3 (es) * | 1999-06-14 | 2007-03-01 | Cancer Research Technology Limited | Terapia para el cancer. |
| AU2001282717A1 (en) | 2000-07-28 | 2002-02-13 | Cancer Research Technology Limited | Cancer treatment by combination therapy |
| GB0121285D0 (en) | 2001-09-03 | 2001-10-24 | Cancer Res Ventures Ltd | Anti-cancer combinations |
| GB2386836B (en) * | 2002-03-22 | 2006-07-26 | Cancer Res Ventures Ltd | Anti-cancer combinations |
| GB2394658A (en) | 2002-11-01 | 2004-05-05 | Cancer Rec Tech Ltd | Oral anti-cancer composition |
| GB0321999D0 (en) * | 2003-09-19 | 2003-10-22 | Cancer Rec Tech Ltd | Anti-cancer combinations |
| FI4070800T3 (fi) * | 2004-12-22 | 2025-01-14 | Merck Serono Sa | Kladribiinikuuri multippeliskleroosin hoitoa varten |
| EP1917011A1 (de) * | 2005-08-26 | 2008-05-07 | Antisoma PLC | Kombinationen aus dmxaa zur behandlung von krebs |
| EP1976567B1 (de) | 2005-12-28 | 2020-05-13 | The Scripps Research Institute | Natürliche antisense- und nicht-kodierende rna-transkripte als arzneitargets |
| CA2649810A1 (en) | 2006-05-24 | 2007-11-29 | Laboratoires Serono S.A. | Cladribine regimen for treating multiple sclerosis |
| WO2008130623A1 (en) | 2007-04-19 | 2008-10-30 | Brandeis University | Manipulation of fluids, fluid components and reactions in microfluidic systems |
| WO2010040112A2 (en) | 2008-10-03 | 2010-04-08 | Curna, Inc. | Treatment of apolipoprotein-a1 related diseases by inhibition of natural antisense transcript to apolipoprotein-a1 |
| US20110201678A1 (en) * | 2008-10-17 | 2011-08-18 | Masse Craig E | Xanthenone-4-Acetic Acid Derivatives |
| EP2370581B1 (de) | 2008-12-04 | 2016-08-03 | CuRNA, Inc. | Behandlung von erkrankungen im zusammenhang mit dem vaskulären endothelialen wachstumsfaktor (vegf) mittels hemmung des natürlichen antisense-transkripts gegen vegf |
| MX358603B (es) | 2008-12-04 | 2018-08-28 | Curna Inc | Tratamiento de enfermedades relacionadas con un gen supresor de tumor mediante inhibicion del transcrito antisentido natural para el gen. |
| RU2620970C2 (ru) | 2008-12-04 | 2017-05-30 | КьюРНА,Инк., | Лечение связанных с эритропоэтином (еро) заболеваний путем ингибирования природного антисмыслового транскрипта к еро |
| EP3009150B1 (de) | 2009-02-12 | 2019-11-13 | CuRNA, Inc. | Behandlung von erkrankungen im zusammenhang mit dem brain-derived neurotrophen faktor (bdnf) mittels hemmung des natürlichen antisense-transkripts gegen bdnf |
| WO2010107733A2 (en) | 2009-03-16 | 2010-09-23 | Curna, Inc. | Treatment of nuclear factor (erythroid-derived 2)-like 2 (nrf2) related diseases by inhibition of natural antisense transcript to nrf2 |
| ES2627763T3 (es) | 2009-03-17 | 2017-07-31 | Curna, Inc. | Tratamiento de enfermedades relacionadas con el homólogo tipo delta 1 (dlk1) por inhibición de transcrito antisentido natural a dlk1 |
| US9155754B2 (en) | 2009-05-06 | 2015-10-13 | Curna, Inc. | Treatment of ABCA1 gene related diseases by inhibition of a natural antisense transcript to ABCA1 |
| EP2427552B1 (de) | 2009-05-06 | 2016-11-16 | CuRNA, Inc. | Behandlung von tristetraprolin (ttp)-bedingten erkrankungen mittels hemmung des natürlichen antisense-transkripts gegen ttp |
| CA2761248C (en) | 2009-05-08 | 2023-03-14 | Joseph Collard | Treatment of dystrophin family related diseases by inhibition of natural antisense transcript to dmd family |
| DK2432881T3 (en) | 2009-05-18 | 2018-02-26 | Curna Inc | TREATMENT OF REPROGRAMMING FACTOR-RELATED DISEASES BY INHIBITING NATURAL ANTISENSE TRANSCRIPTS TO A REPROGRAMMING FACTOR |
| WO2010135695A2 (en) | 2009-05-22 | 2010-11-25 | Curna, Inc. | TREATMENT OF TRANSCRIPTION FACTOR E3 (TFE3) and INSULIN RECEPTOR SUBSTRATE 2 (IRS2) RELATED DISEASES BY INHIBITION OF NATURAL ANTISENSE TRANSCRIPT TO TFE3 |
| ES2618576T3 (es) | 2009-05-28 | 2017-06-21 | Curna, Inc. | Tratamiento de enfermedades relacionadas con un gen antivírico mediante la inhibición de una transcripción antisentido natural a un gen antivírico |
| KR101702689B1 (ko) | 2009-06-16 | 2017-02-06 | 큐알엔에이, 인크. | Pon1에 대한 천연 안티센스 전사체의 억제에 의한 파라옥소나제 1(pon1) 관련된 질환의 치료 |
| KR101801404B1 (ko) | 2009-06-16 | 2017-12-20 | 큐알엔에이, 인크. | 콜라겐 유전자에 대한 천연 안티센스 전사체의 억제에 의한 콜라겐 유전자 관련된 질환의 치료 |
| JP6073133B2 (ja) | 2009-06-24 | 2017-02-01 | クルナ・インコーポレーテッド | 腫瘍壊死因子受容体2(tnfr2)に対する天然アンチセンス転写物の抑制によるtnfr2関連疾患の治療 |
| ES2583691T3 (es) | 2009-06-26 | 2016-09-21 | Curna, Inc. | Tratamiento de enfermedades relacionadas con un gen del síndrome de Down mediante la inhibición de una transcripción antisentido natural a un gen del síndrome de Down |
| US20120252869A1 (en) | 2009-07-24 | 2012-10-04 | Opko Curna, Llc | Treatment of sirtuin (sirt) related diseases by inhibition of natural antisense transcript to a sirtuin (sirt) |
| KR101802536B1 (ko) | 2009-08-05 | 2017-11-28 | 큐알엔에이, 인크. | 인슐린 유전자 (ins)에 대한 자연 안티센스 전사체의 저해에 의한 인슐린 유전자 (ins) 관련된 질환의 치료 |
| WO2011019815A2 (en) | 2009-08-11 | 2011-02-17 | Curna, Inc. | Treatment of adiponectin (adipoq) related diseases by inhibition of natural antisense transcript to an adiponectin (adipoq) |
| CN102482670B (zh) | 2009-08-21 | 2018-06-15 | 库尔纳公司 | 通过抑制‘hsp70-相互作用蛋白的c末端’(chip)的天然反义转录物而治疗chip相关疾病 |
| CA2771172C (en) | 2009-08-25 | 2021-11-30 | Opko Curna, Llc | Treatment of 'iq motif containing gtpase activating protein' (iqgap) related diseases by inhibition of natural antisense transcript to iqgap |
| ES2664591T3 (es) | 2009-09-25 | 2018-04-20 | Curna, Inc. | Tratamiento de enfermedades relacionadas con la filagrina (flg) mediante la modulación de la expresión y actividad del gen FLG |
| NO2513310T3 (de) | 2009-12-16 | 2018-03-31 | ||
| JP5934106B2 (ja) | 2009-12-23 | 2016-06-15 | カッパーアールエヌエー,インコーポレイテッド | 肝細胞増殖因子(hgf)に対する天然アンチセンス転写物の阻害によるhgf関連性疾患の治療 |
| EP2515947B1 (de) | 2009-12-23 | 2021-10-06 | CuRNA, Inc. | Behandlung von durch das uncoupling protein 2 (ucp2) bedingten erkrankungen mittels hemmung des natürlichen antisense-transkripts für ucp2 |
| EP2519634B1 (de) | 2009-12-29 | 2016-06-01 | CuRNA, Inc. | Behandlung von durch das tumorprotein 63 (p63) vermittelten erkrankungen durch das natürliche antisense-transkript für p63 |
| JP5993744B2 (ja) | 2009-12-29 | 2016-09-14 | カッパーアールエヌエー,インコーポレイテッド | 核呼吸因子1(nrf1)に対する天然アンチセンス転写物の阻害による核呼吸因子1関連疾患の治療 |
| US20120289583A1 (en) | 2009-12-31 | 2012-11-15 | Curna, Inc. | Treatment of insulin receptor substrate 2 (irs2) related diseases by inhibition of natural antisense transcript to irs2 and transcription factor e3 (tfe3) |
| NO2521784T3 (de) | 2010-01-04 | 2018-05-05 | ||
| CA2786056C (en) | 2010-01-06 | 2023-03-14 | Curna, Inc. | Treatment of pancreatic developmental gene related diseases by inhibition of natural antisense transcript to a pancreatic developmental gene |
| EP2524039B1 (de) | 2010-01-11 | 2017-11-29 | CuRNA, Inc. | Behandlung von krankheiten im zusammenhang mit dem sexualhormonbindenden globulin (shgb) mittels hemmung des natürlichen antisense-transkripts gegen shbg |
| WO2011091390A2 (en) | 2010-01-25 | 2011-07-28 | Opko Curna, Llc | Treatment of rnase h1 related diseases by inhibition of natural antisense transcript to rnase h1 |
| WO2011103528A2 (en) | 2010-02-22 | 2011-08-25 | Opko Curna Llc | Treatment of pyrroline-5-carboxylate reductase 1 (pycr1) related diseases by inhibition of natural antisense transcript to pycr1 |
| EP2553098B1 (de) | 2010-04-02 | 2017-10-11 | CuRNA, Inc. | Behandlung von durch den koloniestimulierenden faktor 3 (csf3) vermittelten erkrankungen durch hemmung des natürlichen antisense-transkripts für csf3 |
| RU2610661C2 (ru) | 2010-04-09 | 2017-02-14 | Курна, Инк. | Лечение заболеваний, связанных с фактором роста фибробластов 21 (fgf21), путем ингибирования природного антисмыслового транскрипта к fgf21 |
| KR101915115B1 (ko) | 2010-05-03 | 2018-11-05 | 큐알엔에이, 인크. | 시르투인 (sirt)에 대한 자연 안티센스 전사체의 저해에 의한 시르투인 (sirt) 관련된 질환의 치료 |
| TWI586356B (zh) | 2010-05-14 | 2017-06-11 | 可娜公司 | 藉由抑制par4天然反股轉錄本治療par4相關疾病 |
| DK2576783T3 (en) | 2010-05-26 | 2018-03-12 | Curna Inc | TREATMENT OF ATONAL HOMOLOGY 1- (ATOH1) RELATED DISEASES BY INHIBITION OF NATURAL ANTISENCE TRANSCRIPTS AT ATOH1 |
| ES2664585T3 (es) | 2010-05-26 | 2018-04-20 | Curna, Inc. | Tratamiento de enfermedades relacionadas con metionina sulfóxido reductasa (MSRA) mediante inhibición del transcrito antisentido natural a MSRA |
| JP6023705B2 (ja) | 2010-06-23 | 2016-11-09 | カッパーアールエヌエー,インコーポレイテッド | ナトリウムチャネル、電位依存性、αサブユニット(SCNA)に対する天然アンチセンス転写物の阻害によるSCNA関連疾患の治療 |
| CN103068982B (zh) | 2010-07-14 | 2017-06-09 | 库尔纳公司 | 通过抑制盘状大同系物(dlg)的天然反义转录物而治疗dlg相关疾病 |
| JP5986998B2 (ja) | 2010-10-06 | 2016-09-06 | カッパーアールエヌエー,インコーポレイテッド | シアリダーゼ4(neu4)への天然アンチセンス転写物の阻害によるneu4関連疾患の治療 |
| WO2012054723A2 (en) | 2010-10-22 | 2012-04-26 | Opko Curna Llc | Treatment of alpha-l-iduronidase (idua) related diseases by inhibition of natural antisense transcript to idua |
| US10000752B2 (en) | 2010-11-18 | 2018-06-19 | Curna, Inc. | Antagonat compositions and methods of use |
| ES2657590T3 (es) | 2010-11-23 | 2018-03-06 | Curna, Inc. | Tratamiento de enfermedades relacionadas con nanog mediante inhibición del transcrito antisentido natural a nanog |
| EP2718439B1 (de) | 2011-06-09 | 2017-08-09 | CuRNA, Inc. | Behandlung von frataxin (fxn)-bedingten erkrankungen mittels hemmung des natürlichen antisense-transkripts gegen fxn |
| KR101991980B1 (ko) | 2011-09-06 | 2019-06-21 | 큐알엔에이, 인크. | 소형 분자로 전압-개폐된 나트륨 채널 (SCNxA)의 알파 아단위에 관련된 질환의 치료 |
| CN110438125A (zh) | 2012-03-15 | 2019-11-12 | 科纳公司 | 通过抑制脑源神经营养因子(bdnf)的天然反义转录物治疗bdnf相关疾病 |
| JP7495345B2 (ja) | 2017-11-24 | 2024-06-04 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング | 進行型多発性硬化症の処置における使用のためのクラドリビン処方計画 |
| US20240226284A1 (en) | 2020-09-10 | 2024-07-11 | Merck Patent Gmbh | Novel treatment regimen for the treatment of autoimmune disorders |
| EP4241791A1 (de) | 2022-03-07 | 2023-09-13 | InnaTher Gene Therapy S.à.r.l. | Kombinierte gen- und strahlentherapie zur behandlung von krebs |
| EP4241790A1 (de) | 2022-03-07 | 2023-09-13 | InnaTher Gene Therapy S.à.r.l. | Expressionssystem zur behandlung von krebs |
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| GB9903404D0 (en) | 1999-02-16 | 1999-04-07 | Angiogene Pharm Ltd | Methods of treatment and compositions useful for the treatment of diseases involving angiogenesis |
| ATE289586T1 (de) * | 1999-03-01 | 2005-03-15 | Pfizer Prod Inc | Oxamsäuren mit einer cyanogruppe als liganden für den thyroidrezeptor |
| ES2265948T3 (es) | 1999-06-14 | 2007-03-01 | Cancer Research Technology Limited | Terapia para el cancer. |
| US6806257B1 (en) | 1999-10-20 | 2004-10-19 | Board Of Trustees Of Southern Illinois University | Flavones as inducible nitric oxide synthase inhibitors, cyclooxygenase-2 inhibitors and potassium channel activators |
| WO2001034197A2 (en) | 1999-11-11 | 2001-05-17 | Eli Lilly And Company | Oncolytic combinations for the treatment of cancer |
| CA2390789A1 (en) | 1999-11-11 | 2001-05-17 | Eli Lilly And Company | Oncolytic combinations for the treatment of cancer |
| PL355172A1 (en) | 1999-11-11 | 2004-04-05 | Eli Lilly And Company | Oncolytic combinations for the treatment of cancer |
| AU1916601A (en) | 1999-11-11 | 2001-06-06 | Eli Lilly And Company | Oncolytic combinations for the treatment of cancer |
| WO2001060365A1 (en) | 2000-02-17 | 2001-08-23 | Merck & Co., Inc. | Treatment or prevention of prostate cancer with a cox-2 selective inhibiting drug |
| JP2001247459A (ja) | 2000-03-03 | 2001-09-11 | Oakland Uniservices Ltd | 癌の組み合わせ療法 |
| AU2001282717A1 (en) | 2000-07-28 | 2002-02-13 | Cancer Research Technology Limited | Cancer treatment by combination therapy |
| GB0121285D0 (en) | 2001-09-03 | 2001-10-24 | Cancer Res Ventures Ltd | Anti-cancer combinations |
| GB2386836B (en) | 2002-03-22 | 2006-07-26 | Cancer Res Ventures Ltd | Anti-cancer combinations |
| GB2394658A (en) | 2002-11-01 | 2004-05-05 | Cancer Rec Tech Ltd | Oral anti-cancer composition |
| GB0321999D0 (en) | 2003-09-19 | 2003-10-22 | Cancer Rec Tech Ltd | Anti-cancer combinations |
| EP1917011A1 (de) | 2005-08-26 | 2008-05-07 | Antisoma PLC | Kombinationen aus dmxaa zur behandlung von krebs |
| GB0517387D0 (en) | 2005-08-26 | 2005-10-05 | Antisoma Res Ltd | Combinations for the treatment of cancer |
-
2002
- 2002-11-01 GB GB0225508A patent/GB2394658A/en not_active Withdrawn
-
2003
- 2003-10-30 SI SI200331387T patent/SI1572194T1/sl unknown
- 2003-10-30 EP EP03773835A patent/EP1572194B1/de not_active Expired - Lifetime
- 2003-10-30 WO PCT/GB2003/004688 patent/WO2004039363A1/en not_active Ceased
- 2003-10-30 AT AT03773835T patent/ATE401882T1/de active
- 2003-10-30 PT PT03773835T patent/PT1572194E/pt unknown
- 2003-10-30 DK DK03773835T patent/DK1572194T3/da active
- 2003-10-30 ES ES03773835T patent/ES2311740T3/es not_active Expired - Lifetime
- 2003-10-30 JP JP2004547801A patent/JP2006508091A/ja active Pending
- 2003-10-30 DE DE60322425T patent/DE60322425D1/de not_active Expired - Lifetime
- 2003-10-30 AU AU2003282215A patent/AU2003282215A1/en not_active Abandoned
-
2005
- 2005-04-28 US US11/116,798 patent/US7585893B2/en not_active Expired - Fee Related
-
2008
- 2008-08-25 CY CY20081100909T patent/CY1108292T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US7585893B2 (en) | 2009-09-08 |
| DK1572194T3 (da) | 2008-08-25 |
| AU2003282215A1 (en) | 2004-05-25 |
| EP1572194A1 (de) | 2005-09-14 |
| ES2311740T3 (es) | 2009-02-16 |
| GB2394658A (en) | 2004-05-05 |
| WO2004039363A1 (en) | 2004-05-13 |
| PT1572194E (pt) | 2008-11-03 |
| SI1572194T1 (sl) | 2008-12-31 |
| CY1108292T1 (el) | 2014-02-12 |
| ATE401882T1 (de) | 2008-08-15 |
| JP2006508091A (ja) | 2006-03-09 |
| GB0225508D0 (en) | 2002-12-11 |
| EP1572194B1 (de) | 2008-07-23 |
| US20060009505A1 (en) | 2006-01-12 |
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