DE60119514D1 - Amidderivate der 2-amino-3-hydroxy-4-tert-leucyl-amino-5-phenyl-pentansäure - Google Patents
Amidderivate der 2-amino-3-hydroxy-4-tert-leucyl-amino-5-phenyl-pentansäureInfo
- Publication number
- DE60119514D1 DE60119514D1 DE60119514T DE60119514T DE60119514D1 DE 60119514 D1 DE60119514 D1 DE 60119514D1 DE 60119514 T DE60119514 T DE 60119514T DE 60119514 T DE60119514 T DE 60119514T DE 60119514 D1 DE60119514 D1 DE 60119514D1
- Authority
- DE
- Germany
- Prior art keywords
- amino
- leucyl
- tert
- hydroxy
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- AOUVJTVPZLSMQO-HRDQMINSSA-N (6S)-2,2,6-triamino-4-benzyl-3-hydroxy-7,7-dimethyl-5-oxooctanoic acid Chemical class CC(C)(C)[C@H](N)C(=O)C(C(O)C(N)(N)C(O)=O)CC1=CC=CC=C1 AOUVJTVPZLSMQO-HRDQMINSSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 241001465754 Metazoa Species 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0215—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing natural amino acids, forming a peptide bond via their side chain functional group, e.g. epsilon-Lys, gamma-Glu
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Dermatology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0012795 | 2000-05-25 | ||
| GBGB0012795.1A GB0012795D0 (en) | 2000-05-25 | 2000-05-25 | Organic compounds |
| PCT/EP2001/005952 WO2001089282A2 (en) | 2000-05-25 | 2001-05-23 | 2-amino-3-hydroxy-4-tert-leucyl-amino-5-phenyl-pentanoic acid amide derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60119514D1 true DE60119514D1 (de) | 2006-06-14 |
| DE60119514T2 DE60119514T2 (de) | 2006-10-05 |
Family
ID=9892401
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60119514T Expired - Fee Related DE60119514T2 (de) | 2000-05-25 | 2001-05-23 | Amidderivate der 2-amino-3-hydroxy-4-tert-leucyl-amino-5-phenyl-pentansäure |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US20030166572A1 (de) |
| EP (1) | EP1290012B1 (de) |
| JP (1) | JP2003533541A (de) |
| AT (1) | ATE325809T1 (de) |
| AU (1) | AU2001266019A1 (de) |
| CA (1) | CA2405871A1 (de) |
| DE (1) | DE60119514T2 (de) |
| ES (1) | ES2261422T3 (de) |
| GB (1) | GB0012795D0 (de) |
| PT (1) | PT1290012E (de) |
| WO (1) | WO2001089282A2 (de) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2507484A1 (en) * | 2002-11-27 | 2004-06-17 | Elan Pharmaceuticals, Inc. | Substituted ureas and carbamates |
| GB0504950D0 (en) * | 2005-03-10 | 2005-04-20 | Novartis Ag | Organic compositions |
| EP1865950B1 (de) | 2005-04-07 | 2013-08-28 | Centre National de la Recherche Scientifique | Verbindungen zur regulierung der proteasomaktivität |
| WO2009106574A2 (en) * | 2008-02-28 | 2009-09-03 | Novartis Ag | Combinations for treating hiv-associated pain |
| EP2399129B1 (de) | 2009-02-20 | 2015-11-25 | Michael P. Lisanti | Verfahren zur diagnose bzw. prognose eines neoplasmas einschliesslich der bestimmung des expressionsgrads eines proteins in stromazellen neben dem neoplasma |
| US10085987B2 (en) | 2012-01-27 | 2018-10-02 | Thomas Jefferson University | MCT protein inhibitor-related prognostic and therapeutic methods |
| US10022372B2 (en) | 2013-04-19 | 2018-07-17 | Thomas Jefferson University | Caveolin-1 related methods for treating glioblastoma with temozolomide |
| SG11202010925UA (en) * | 2018-05-29 | 2020-12-30 | Omeros Corp | Masp-2 inhibitors and methods of use |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5538997A (en) * | 1993-03-12 | 1996-07-23 | Sandoz Ltd. | 2,4-diamino-3-hydroxycarboxylic acid derivatives |
| EP0982317A1 (de) * | 1998-08-26 | 2000-03-01 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Bivalente Proteasome Inhibitore |
| ES2223512T3 (es) * | 1999-04-27 | 2005-03-01 | Novartis Ag | Uso de derivados de acidos 2,4-diamino-3-hidroxicarboxilicos como inhibidores de la proteasoma. |
-
2000
- 2000-05-25 GB GBGB0012795.1A patent/GB0012795D0/en not_active Ceased
-
2001
- 2001-05-23 PT PT01943442T patent/PT1290012E/pt unknown
- 2001-05-23 EP EP01943442A patent/EP1290012B1/de not_active Expired - Lifetime
- 2001-05-23 AU AU2001266019A patent/AU2001266019A1/en not_active Abandoned
- 2001-05-23 AT AT01943442T patent/ATE325809T1/de not_active IP Right Cessation
- 2001-05-23 ES ES01943442T patent/ES2261422T3/es not_active Expired - Lifetime
- 2001-05-23 WO PCT/EP2001/005952 patent/WO2001089282A2/en not_active Ceased
- 2001-05-23 CA CA002405871A patent/CA2405871A1/en not_active Abandoned
- 2001-05-23 JP JP2001585538A patent/JP2003533541A/ja active Pending
- 2001-05-23 US US10/258,901 patent/US20030166572A1/en not_active Abandoned
- 2001-05-23 DE DE60119514T patent/DE60119514T2/de not_active Expired - Fee Related
-
2006
- 2006-05-15 US US11/434,398 patent/US20060205673A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| ATE325809T1 (de) | 2006-06-15 |
| AU2001266019A1 (en) | 2001-12-03 |
| US20060205673A1 (en) | 2006-09-14 |
| ES2261422T3 (es) | 2006-11-16 |
| WO2001089282A2 (en) | 2001-11-29 |
| US20030166572A1 (en) | 2003-09-04 |
| EP1290012B1 (de) | 2006-05-10 |
| DE60119514T2 (de) | 2006-10-05 |
| CA2405871A1 (en) | 2001-11-29 |
| PT1290012E (pt) | 2006-09-29 |
| JP2003533541A (ja) | 2003-11-11 |
| EP1290012A2 (de) | 2003-03-12 |
| GB0012795D0 (en) | 2000-07-19 |
| WO2001089282A3 (en) | 2002-05-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8328 | Change in the person/name/address of the agent |
Representative=s name: KROHER, STROBEL RECHTS- UND PATENTANWAELTE, 80336 |
|
| R119 | Application deemed withdrawn, or ip right lapsed, due to non-payment of renewal fee |
Ref document number: 1290012 Country of ref document: EP |
|
| R082 | Change of representative |
Ref document number: 1290012 Country of ref document: EP Representative=s name: DR. SCHOEN & PARTNER, 80336 MUENCHEN, DE |